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Balloon Cell Nevus

MedGen UID:
137759
•Concept ID:
C0334425
•
Neoplastic Process
Synonym: Balloon cell nevus
SNOMED CT: Balloon cell nevus (8276007)

Definition

An uncommon variant of melanocytic nevus. It presents as a small pigmented skin lesion. It is characterized by the presence of large melanocytes with clear, foamy or finely vacuolated cytoplasm. It may recur if it is not completely excised. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBalloon Cell Nevus

Professional guidelines

PubMed

The role of lymphatic mapping and sentinel node biopsy in the management of atypical and anomalous melanocytic lesions.
Cochran AJ, Binder S, Morton DL
J Cutan Pathol 2010 Apr;37 Suppl 1:54-9. doi: 10.1111/j.1600-0560.2010.01509.x. PMID: 20482676

Recent clinical studies

Etiology

Immunohistochemical studies of atypical conjunctival melanocytic nevi.
Jakobiec FA, Colby K, Bajart AM, Saragas SJ, Moulin A
Arch Ophthalmol 2009 Aug;127(8):970-80. doi: 10.1001/archophthalmol.2009.171. PMID: 19667333

Diagnosis

Dermoscopy and reflectance confocal microscopy of balloon cell nevi: a series of 10 cases.
Fusano M, Soglia S, Gianotti R, Bencini PL
Int J Dermatol 2021 Jun;60(6):708-711. Epub 2021 Feb 13 doi: 10.1111/ijd.15460. PMID: 33580719
Balloon cell nevus in children: Report of three cases of the scalp and review.
Micali G, Verzì AE, Puglisi DF, Quattrocchi E, Caltabiano R, Lacarrubba F
Pediatr Dermatol 2021 Jan;38(1):198-201. Epub 2020 Sep 28 doi: 10.1111/pde.14372. PMID: 32985713
Balloon cell nevus of the iris.
Morcos MW, Odashiro A, Bazin R, Pereira PR, O'Meara A, Burnier MN Jr
Pathol Res Pract 2014 Dec;210(12):1160-3. Epub 2014 May 16 doi: 10.1016/j.prp.2014.04.026. PMID: 24951244
Clear cell fibrous papule: report of a case mimicking a balloon cell nevus.
Chiang YY, Tsai HH, Lee WR, Wang KH
J Cutan Pathol 2009 Mar;36(3):381-4. doi: 10.1111/j.1600-0560.2008.01038.x. PMID: 19220636
Balloon cell malignant melanoma of the skin. A clinicopathologic study of 34 cases with histochemical, immunohistochemical, and ultrastructural observations.
Kao GF, Helwig EB, Graham JH
Cancer 1992 Jun 15;69(12):2942-52. doi: 10.1002/1097-0142(19920615)69:12<2942::aid-cncr2820691213>3.0.co;2-0. PMID: 1591688

Prognosis

Nodal melanocytic nevus with balloon-cell change (nodal balloon-cell nevus).
Urso C
J Cutan Pathol 2008 Jul;35(7):672-6. Epub 2008 Feb 29 doi: 10.1111/j.1600-0560.2007.00860.x. PMID: 18312441
Expression of the proliferation and apoptosis-associated CAS protein in benign and malignant cutaneous melanocytic lesions.
Böni R, Wellmann A, Man YG, Hofbauer G, Brinkmann U
Am J Dermatopathol 1999 Apr;21(2):125-8. doi: 10.1097/00000372-199904000-00003. PMID: 10218671
Balloon cell malignant melanoma of the skin. A clinicopathologic study of 34 cases with histochemical, immunohistochemical, and ultrastructural observations.
Kao GF, Helwig EB, Graham JH
Cancer 1992 Jun 15;69(12):2942-52. doi: 10.1002/1097-0142(19920615)69:12<2942::aid-cncr2820691213>3.0.co;2-0. PMID: 1591688

Clinical prediction guides

Balloon cell nevus of the iris.
Morcos MW, Odashiro A, Bazin R, Pereira PR, O'Meara A, Burnier MN Jr
Pathol Res Pract 2014 Dec;210(12):1160-3. Epub 2014 May 16 doi: 10.1016/j.prp.2014.04.026. PMID: 24951244
Balloon cell nevus of the soft palate: an immunohistochemical and ultrastructural study.
Ide F, Obara K, Enatsu K, Mishima K, Saito I
Pathol Int 2004 Nov;54(11):872-6. doi: 10.1111/j.1440-1827.2004.01760.x. PMID: 15533232
Balloon cell malignant melanoma of the skin. A clinicopathologic study of 34 cases with histochemical, immunohistochemical, and ultrastructural observations.
Kao GF, Helwig EB, Graham JH
Cancer 1992 Jun 15;69(12):2942-52. doi: 10.1002/1097-0142(19920615)69:12<2942::aid-cncr2820691213>3.0.co;2-0. PMID: 1591688

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