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Benign melanocytic skin nevus

MedGen UID:
264151
Concept ID:
C1456781
Neoplastic Process
Synonyms: Benign Melanocytic Nevus; benign melanocytic nevus; Benign melanocytic nevus of skin; Benign Melanocytic Nevus of Skin; benign melanocytic nevus of skin; Benign Melanocytic Nevus of the Skin; benign melanocytic nevus of the skin; benign melanocytic skin nevus; Benign melanoma; Benign Mole; benign mole; Benign Nevus of Skin; benign nevus of skin; Benign Nevus of the Skin; benign nevus of the skin; Benign Skin Melanocytic Nevus; Benign Skin Nevus; benign skin nevus; Hairy nevus; Melanocytic nevus; Nevus; Pigmented nevus
SNOMED CT: Benign melanocytic nevus of skin (400010006); Pigmented nevus (1163403006); Melanocytic nevus (1163403006); Hairy nevus (1163403006); Benign melanoma (1163403006); Nevus (1163403006)
 
Monarch Initiative: MONDO:0044794

Definition

A circumscribed proliferation of melanocytes in the skin. It is characterized by the absence of atypical or malignant cytological features, and absence of invasive features or metastatic potential. Variants include the Spitz nevus, halo nevus, blue nevus, and balloon cell nevus. [from NCI]

Professional guidelines

PubMed

Ingrassia JP, Stein JA, Levine A, Liebman TN
Dermatol Surg 2023 Oct 1;49(10):926-931. Epub 2023 Aug 8 doi: 10.1097/DSS.0000000000003891. PMID: 37556446
Paasch U, Zidane M, Baron JM, Bund T, Cappius HJ, Drosner M, Feise K, Fischer T, Gauglitz G, Gerber PA, Grunewald S, Herberger K, Jung A, Karsai S, Kautz G, Philipp C, Schädel D, Seitz AT, Nast A
J Dtsch Dermatol Ges 2022 Sep;20(9):1248-1267. Epub 2022 Sep 13 doi: 10.1111/ddg.14879. PMID: 36098675
Nakamura Y, Fujisawa Y
Curr Treat Options Oncol 2018 Jun 27;19(8):42. doi: 10.1007/s11864-018-0560-y. PMID: 29951919

Recent clinical studies

Etiology

Alos L, Carrasco A, Teixidó C, Szumera-Ciećkiewicz A, Vicente A, Massi D, Carrera C
Pathol Res Pract 2024 Apr;256:155262. Epub 2024 Mar 11 doi: 10.1016/j.prp.2024.155262. PMID: 38518732
Alsayyah A
Pathol Res Pract 2023 Sep;249:154734. Epub 2023 Aug 4 doi: 10.1016/j.prp.2023.154734. PMID: 37573619
Yeh I
Pathology 2023 Mar;55(2):178-186. Epub 2022 Dec 27 doi: 10.1016/j.pathol.2022.12.341. PMID: 36642570
Ruggieri M, Polizzi A, Catanzaro S, Bianco ML, Praticò AD, Di Rocco C
Childs Nerv Syst 2020 Oct;36(10):2571-2596. Epub 2020 Oct 13 doi: 10.1007/s00381-020-04770-9. PMID: 33048248
Bsirini C, Smoller BR
Singapore Med J 2018 Nov;59(11):602-607. Epub 2018 May 18 doi: 10.11622/smedj.2018041. PMID: 29774360Free PMC Article

Diagnosis

Yeh I
Pathology 2023 Mar;55(2):178-186. Epub 2022 Dec 27 doi: 10.1016/j.pathol.2022.12.341. PMID: 36642570
Maher NG, Scolyer RA, Colebatch AJ
Pathology 2023 Mar;55(2):169-177. Epub 2022 Dec 29 doi: 10.1016/j.pathol.2022.12.344. PMID: 36635156
Yeh I, Busam KJ
Histopathology 2022 Jan;80(1):122-134. doi: 10.1111/his.14583. PMID: 34958498
Lezcano C, Jungbluth AA, Nehal KS, Hollmann TJ, Busam KJ
Am J Surg Pathol 2018 Nov;42(11):1456-1465. doi: 10.1097/PAS.0000000000001134. PMID: 30045064Free PMC Article
Longo C, Scope A, Lallas A, Zalaudek I, Moscarella E, Gardini S, Argenziano G, Pellacani G
Dermatol Clin 2013 Oct;31(4):637-47, ix. Epub 2013 Aug 23 doi: 10.1016/j.det.2013.07.001. PMID: 24075551

Therapy

Colebatch AJ, Scolyer RA
Pathology 2018 Jan;50(1):16-23. Epub 2017 Nov 10 doi: 10.1016/j.pathol.2017.09.002. PMID: 29132722
Shain AH, Yeh I, Kovalyshyn I, Sriharan A, Talevich E, Gagnon A, Dummer R, North J, Pincus L, Ruben B, Rickaby W, D'Arrigo C, Robson A, Bastian BC
N Engl J Med 2015 Nov 12;373(20):1926-36. doi: 10.1056/NEJMoa1502583. PMID: 26559571
Hashimoto K, Amano M, Setoyama M
J Dermatol 2012 Nov;39(11):909-15. Epub 2012 Jul 4 doi: 10.1111/j.1346-8138.2012.01599.x. PMID: 22762690
Tanaka M
J Dermatol 2006 Aug;33(8):513-7. doi: 10.1111/j.1346-8138.2006.00126.x. PMID: 16923131
Busam KJ
Adv Anat Pathol 2005 Mar;12(2):92-102. doi: 10.1097/01.pap.0000155071.86944.a6. PMID: 15731577

Prognosis

Alos L, Carrasco A, Teixidó C, Szumera-Ciećkiewicz A, Vicente A, Massi D, Carrera C
Pathol Res Pract 2024 Apr;256:155262. Epub 2024 Mar 11 doi: 10.1016/j.prp.2024.155262. PMID: 38518732
Bsirini C, Smoller BR
Singapore Med J 2018 Nov;59(11):602-607. Epub 2018 May 18 doi: 10.11622/smedj.2018041. PMID: 29774360Free PMC Article
Islam MP
Handb Clin Neurol 2015;132:111-7. doi: 10.1016/B978-0-444-62702-5.00007-X. PMID: 26564074
Busam KJ
Clin Lab Med 2011 Jun;31(2):321-30. doi: 10.1016/j.cll.2011.03.009. PMID: 21549245
Kerl H, Soyer HP, Cerroni L, Wolf IH, Ackerman AB
Semin Diagn Pathol 1998 Aug;15(3):210-5. PMID: 9711671

Clinical prediction guides

Alsayyah A
Pathol Res Pract 2023 Sep;249:154734. Epub 2023 Aug 4 doi: 10.1016/j.prp.2023.154734. PMID: 37573619
de la Fouchardiere A
Pathology 2023 Mar;55(2):187-195. Epub 2022 Dec 28 doi: 10.1016/j.pathol.2022.12.342. PMID: 36641378
Colebatch AJ, Scolyer RA
Pathology 2018 Jan;50(1):16-23. Epub 2017 Nov 10 doi: 10.1016/j.pathol.2017.09.002. PMID: 29132722
Welzel J, Schuh S
J Dtsch Dermatol Ges 2017 Oct;15(10):999-1016. doi: 10.1111/ddg.13347. PMID: 28976087
Lencastre A, Lamas A, Sá D, Tosti A
Clin Dermatol 2013 Sep-Oct;31(5):587-93. doi: 10.1016/j.clindermatol.2013.06.016. PMID: 24079588

Recent systematic reviews

Scard C, Aubert H, Wargny M, Martin L, Barbarot S
J Eur Acad Dermatol Venereol 2023 Jan;37(1):32-39. Epub 2022 Oct 5 doi: 10.1111/jdv.18581. PMID: 36149403
Lai M, Muscianese M, Piana S, Chester J, Borsari S, Paolino G, Pellacani G, Longo C, Pampena R
J Eur Acad Dermatol Venereol 2022 Sep;36(9):1524-1540. Epub 2022 May 25 doi: 10.1111/jdv.18210. PMID: 35536546Free PMC Article
Ebbelaar CF, Jansen AML, Bloem LT, Blokx WAM
Virchows Arch 2021 Oct;479(4):773-783. Epub 2021 Apr 13 doi: 10.1007/s00428-021-03095-5. PMID: 33851238Free PMC Article

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