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Junctional Nevus

MedGen UID:
137762
•Concept ID:
C0334433
•
Neoplastic Process
Synonyms: Intra-epidermal nevus of skin; Intraepidermal nevus; Intraepidermal Nevus; Intraepidermal Nevus of Skin; Intraepidermal Nevus of the Skin; Junction nevus; Junction Nevus; Junctional melanocytic nevus; Junctional Melanocytic Nevus; Junctional melanocytic nevus of skin; Junctional melanocytoma; Junctional Melanocytoma; Junctional nevus; Junctional Nevus of Skin; Junctional Nevus of the Skin; Junctional Skin Nevus
SNOMED CT: Junctional melanocytic nevus (30494009); Intra-epidermal nevus of skin (254802006); Junctional melanocytic nevus of skin (254802006); Junctional nevus (30494009); Junction nevus (30494009); Intraepidermal nevus (30494009); Junctional melanocytoma (30494009)

Definition

A nevus characterized by the presence of an intraepidermal proliferation of nevus cells. The nevus cells form multiple nests in the dermal-epidermal junction. It presents as a small, slightly raised, pigmented skin lesion. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVJunctional Nevus

Professional guidelines

PubMed

Acral junctional nevus versus acral lentiginous melanoma in situ: a differential diagnosis that should be based on clinicopathologic correlation.
Bravo Puccio F, Chian C
Arch Pathol Lab Med 2011 Jul;135(7):847-52. doi: 10.5858/2010-0323-RAR.1. PMID: 21732773

Recent clinical studies

Etiology

Application of fluorescence in situ hybridization in distinguishing acral melanoma in situ from acral junctional melanocytic nevus on the volar skin in Japanese patients.
Takai S, Arai E, Shojiguchi N, Nakamura Y, Momose S, Fukuda T, Ishizawa K, Ogata D, Tsunemi Y, Nakamura K, Tsuchida T
J Dermatol 2023 May;50(5):637-645. Epub 2022 Dec 20 doi: 10.1111/1346-8138.16681. PMID: 36539950
Dermoscopic Image Classification of Pigmented Nevus under Deep Learning and the Correlation with Pathological Features.
Yang S, Shu C, Hu H, Ma G, Yang M
Comput Math Methods Med 2022;2022:9726181. Epub 2022 May 28 doi: 10.1155/2022/9726181. PMID: 35669372Free PMC Article
The use of radio-wave surgery: An underestimated method for small hyperpigmented flat or macular lesions on face.
Pekmezci E
J Cosmet Dermatol 2022 Oct;21(10):4691-4696. Epub 2022 May 10 doi: 10.1111/jocd.14995. PMID: 35427435
Acral junctional nevus versus acral lentiginous melanoma in situ: a differential diagnosis that should be based on clinicopathologic correlation.
Bravo Puccio F, Chian C
Arch Pathol Lab Med 2011 Jul;135(7):847-52. doi: 10.5858/2010-0323-RAR.1. PMID: 21732773
Clinicopathologic characteristics of premalignant and malignant melanocytic lesions of the conjunctiva.
Jakobiec FA, Folberg R, Iwamoto T
Ophthalmology 1989 Feb;96(2):147-66. doi: 10.1016/s0161-6420(89)32920-4. PMID: 2649838

Diagnosis

Dermatoscopy and Reflective Confocal Microscopy for Facial Seborrheic Keratosis, Verruca Plana, and Nevus Pigmentosus.
Lu Q, Wang S, Wu T, Jiang G
J Coll Physicians Surg Pak 2021 Apr;31(4):450-454. doi: 10.29271/jcpsp.2021.04.450. PMID: 33866733
Lentigo Maligna: Keys to Dermoscopic Diagnosis.
Bollea-Garlatti LA, Galimberti GN, Galimberti RL
Actas Dermosifiliogr 2016 Jul-Aug;107(6):489-97. Epub 2016 Feb 11 doi: 10.1016/j.ad.2016.01.001. PMID: 26875792
Acral junctional nevus versus acral lentiginous melanoma in situ: a differential diagnosis that should be based on clinicopathologic correlation.
Bravo Puccio F, Chian C
Arch Pathol Lab Med 2011 Jul;135(7):847-52. doi: 10.5858/2010-0323-RAR.1. PMID: 21732773
Combined mastocytoma-junctional nevus.
Northcutt AD, Tschen JA
Am J Dermatopathol 2004 Dec;26(6):478-81. doi: 10.1097/00000372-200412000-00007. PMID: 15618930
Benign conjunctival melanocytic lesions. Clinicopathologic features.
Folberg R, Jakobiec FA, Bernardino VB, Iwamoto T
Ophthalmology 1989 Apr;96(4):436-61. doi: 10.1016/s0161-6420(89)32878-8. PMID: 2657539

Therapy

Dermoscopic Image Classification of Pigmented Nevus under Deep Learning and the Correlation with Pathological Features.
Yang S, Shu C, Hu H, Ma G, Yang M
Comput Math Methods Med 2022;2022:9726181. Epub 2022 May 28 doi: 10.1155/2022/9726181. PMID: 35669372Free PMC Article
Flat pigmented macules on sun-damaged skin of the head/neck: junctional nevus, atypical lentiginous nevus, or melanoma in situ?
Zalaudek I, Cota C, Ferrara G, Moscarella E, Guitera P, Longo C, Piana S, Argenziano G
Clin Dermatol 2014 Jan-Feb;32(1):88-93. doi: 10.1016/j.clindermatol.2013.05.029. PMID: 24314381
Disseminated eruptive nevocellular nevi.
Bong HW, Lee SJ, Lee KH, Chung KY
J Dermatol 1995 Apr;22(4):292-7. doi: 10.1111/j.1346-8138.1995.tb03390.x. PMID: 7608388

Prognosis

The Histogenetic Model of Melanoma in the Modern Era of Personalized Medicine.
Roncati L, Piscioli F
Acta Dermatovenerol Croat 2020 Dec;28(7):236-237. PMID: 33834997
A retrospective cohort study of the diagnostic value of different subtypes of atypical pigment network on dermoscopy.
Shi K, Kim D, Mohan LS, Garfield EM, Quan VL, Zhang B, Panah E, Compres EV, Khan AU, Gerami P
J Am Acad Dermatol 2020 Oct;83(4):1028-1034. Epub 2020 May 21 doi: 10.1016/j.jaad.2020.05.080. PMID: 32446823
Lentigo Maligna: Keys to Dermoscopic Diagnosis.
Bollea-Garlatti LA, Galimberti GN, Galimberti RL
Actas Dermosifiliogr 2016 Jul-Aug;107(6):489-97. Epub 2016 Feb 11 doi: 10.1016/j.ad.2016.01.001. PMID: 26875792
Melanoma on dysplastic nevus spilus.
Grinspan D, Casala A, Abulafia J, Mascotto J, Allevato M
Int J Dermatol 1997 Jul;36(7):499-502. doi: 10.1046/j.1365-4362.1997.00076.x. PMID: 9268745
Pigmented conjunctival and scleral lesions.
Liesegang TJ
Mayo Clin Proc 1994 Feb;69(2):151-61. doi: 10.1016/s0025-6196(12)61042-8. PMID: 8309267

Clinical prediction guides

Dermoscopic Image Classification of Pigmented Nevus under Deep Learning and the Correlation with Pathological Features.
Yang S, Shu C, Hu H, Ma G, Yang M
Comput Math Methods Med 2022;2022:9726181. Epub 2022 May 28 doi: 10.1155/2022/9726181. PMID: 35669372Free PMC Article
The use of radio-wave surgery: An underestimated method for small hyperpigmented flat or macular lesions on face.
Pekmezci E
J Cosmet Dermatol 2022 Oct;21(10):4691-4696. Epub 2022 May 10 doi: 10.1111/jocd.14995. PMID: 35427435
Dermatoscopy and Reflective Confocal Microscopy for Facial Seborrheic Keratosis, Verruca Plana, and Nevus Pigmentosus.
Lu Q, Wang S, Wu T, Jiang G
J Coll Physicians Surg Pak 2021 Apr;31(4):450-454. doi: 10.29271/jcpsp.2021.04.450. PMID: 33866733
Solitary pigmented lesions in oral mucosa in Latin American children: A case series.
Pennacchiotti G, Oviedo C, Ortega-Pinto A
Pediatr Dermatol 2018 May;35(3):374-377. Epub 2018 Mar 24 doi: 10.1111/pde.13465. PMID: 29573458
Junctional nevus of the oral mucosa. Light and electron microscopic observations.
Silverman S Jr, Greenspan JS, Christie TM
Oral Surg Oral Med Oral Pathol 1975 Feb;39(2):259-67. doi: 10.1016/0030-4220(75)90227-3. PMID: 804149

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