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Sacral Chordoma

MedGen UID:
1378104
•Concept ID:
C4331269
•
Neoplastic Process

Definition

A chordoma that arises from the sacral area. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSacral Chordoma

Professional guidelines

PubMed

Chordoma: Genetics and Contemporary Management.
Desai R, Pelargos PE, Dunn IF
Int J Mol Sci 2024 May 28;25(11) doi: 10.3390/ijms25115877. PMID: 38892063Free PMC Article
Multidisciplinary approach of lumbo-sacral chordoma: From oncological treatment to reconstructive surgery.
Garofalo F, di Summa PG, Christoforidis D, Pracht M, Laudato P, Cherix S, Bouchaab H, Raffoul W, Demartines N, Matter M
J Surg Oncol 2015 Oct;112(5):544-54. doi: 10.1002/jso.24026. PMID: 26496212
Review of current treatment of sacral chordoma.
Chen KW, Yang HL, Kandimalla Y, Liu JY, Wang GL
Orthop Surg 2009 Aug;1(3):238-44. doi: 10.1111/j.1757-7861.2009.00027.x. PMID: 22009849Free PMC Article

Recent clinical studies

Etiology

Characterization of sacral chordoma and differential diagnosis from other sacral malignancy using [18F]FDG PET/CT.
Lee DY, Kim YI, Ryu JS, Kim W
Medicine (Baltimore) 2024 Apr 5;103(14):e37678. doi: 10.1097/MD.0000000000037678. PMID: 38579025Free PMC Article
Comparison of Oncologic Outcomes and Treatment-Related Toxicity of Carbon Ion Radiotherapy and En Bloc Resection for Sacral Chordoma.
Yolcu YU, Zreik J, Wahood W, Bhatti AUR, Bydon M, Houdek MT, Rose PS, Mahajan A, Petersen IA, Haddock MG, Ahmed SK, Laack NN, Jethwa K, Jeans EB, Imai R, Yamada S, Foote RL
JAMA Netw Open 2022 Jan 4;5(1):e2141927. doi: 10.1001/jamanetworkopen.2021.41927. PMID: 34994795Free PMC Article
The sacral chordoma margin.
Radaelli S, Fossati P, Stacchiotti S, Akiyama T, Asencio JM, Bandiera S, Boglione A, Boland P, Bolle S, Bruland Ø, Brunello A, Bruzzi P, Campanacci D, Cananzi F, Capanna R, Casadei R, Cordoba A, Court C, Dei Tos AP, DeLaney TF, De Paoli A, De Pas TM, Desai A, Di Brina L, Donati DM, Fabbri N, Fiore MR, Frezza A, Gambarotti M, Gasbarrini A, Georg P, Grignani G, Hindi N, Hug EB, Jones R, Kawai A, Krol AD, Le Grange F, Luzzati A, Marquina G, Martin-Benlloch JA, Mazzocco K, Navarria F, Navarria P, Parchi PD, Patel S, Pennacchioli E, Petrongari MG, Picci P, Pollock R, Porcu L, Quagliuolo V, Sangalli C, Scheipl S, Scotto GM, Spalek M, Steinmeier T, Timmermann B, Trama A, Uhl M, Valverde C, Varga PP, Verges R, Weber DC, Zoccali C, Casali PG, Sommer J, Gronchi A
Eur J Surg Oncol 2020 Aug;46(8):1415-1422. Epub 2020 Apr 27 doi: 10.1016/j.ejso.2020.04.028. PMID: 32402509
Surgical treatment of sacral chordoma: survival and prognostic factors.
Ruosi C, Colella G, Di Donato SL, Granata F, Di Salvatore MG, Fazioli F
Eur Spine J 2015 Nov;24 Suppl 7:912-7. Epub 2015 Oct 12 doi: 10.1007/s00586-015-4276-4. PMID: 26458933
A review of the surgical management of sacral chordoma.
Kayani B, Hanna SA, Sewell MD, Saifuddin A, Molloy S, Briggs TW
Eur J Surg Oncol 2014 Nov;40(11):1412-20. Epub 2014 Apr 25 doi: 10.1016/j.ejso.2014.04.008. PMID: 24793103

Diagnosis

Chordoma: Genetics and Contemporary Management.
Desai R, Pelargos PE, Dunn IF
Int J Mol Sci 2024 May 28;25(11) doi: 10.3390/ijms25115877. PMID: 38892063Free PMC Article
Sacral Chordoma: A Population-based Analysis of Epidemiology and Survival Outcomes.
Scampa M, Tessitore E, Dominguez DE, Hannouche D, Buchs NC, Kalbermatten DF, Oranges CM
Anticancer Res 2022 Feb;42(2):929-937. doi: 10.21873/anticanres.15552. PMID: 35093892
Metastatic saccrococcygeal chordoma.
Fatehi Hassanabad M, Mansouri A, Alotaibi NM, Hazrati LN, Bernstein M
J Clin Neurosci 2016 Jan;23:149-152. Epub 2015 Nov 18 doi: 10.1016/j.jocn.2015.05.036. PMID: 26602601
Sacral chordoma.
Behaeghe M, Denis A, Jans L, Verstraete K
JBR-BTR 2013 Jan-Feb;96(1):51. doi: 10.5334/jbr-btr.204. PMID: 23610894
Sacral chordoma.
Farsad K, Kattapuram SV, Sacknoff R, Ono J, Nielsen GP
Radiographics 2009 Sep-Oct;29(5):1525-30. doi: 10.1148/rg.295085215. PMID: 19755609

Therapy

Clinical Outcome of Sacral Chordoma Patients Treated with Pencil Beam Scanning Proton Therapy.
Walser M, Bojaxhiu B, Kawashiro S, Tran S, Beer J, Leiser D, Pica A, Bachtiary B, Weber DC
Clin Oncol (R Coll Radiol) 2021 Dec;33(12):e578-e585. Epub 2021 Jul 31 doi: 10.1016/j.clon.2021.07.012. PMID: 34340918
Stereotactic Body Radiation Therapy for Patients With Sacral Chordoma Who Previously Received Carbon Ion Therapy.
Ito K, Ogawa H
Int J Radiat Oncol Biol Phys 2021 Aug 1;110(5):1263-1264. doi: 10.1016/j.ijrobp.2018.11.029. PMID: 34273319
High-dose proton therapy and tomotherapy for the treatment of sacral chordoma: a retrospective monocentric study.
Beddok A, Saint-Martin C, Mammar H, Feuvret L, Helfre S, Bolle S, Froelich S, Goudjil F, Zefkili S, Amessis M, Peurien D, Cornet S, Dendale R, Alapetite C, Calugaru V
Acta Oncol 2021 Feb;60(2):245-251. Epub 2020 Oct 23 doi: 10.1080/0284186X.2020.1834140. PMID: 33095672
The sacral chordoma margin.
Radaelli S, Fossati P, Stacchiotti S, Akiyama T, Asencio JM, Bandiera S, Boglione A, Boland P, Bolle S, Bruland Ø, Brunello A, Bruzzi P, Campanacci D, Cananzi F, Capanna R, Casadei R, Cordoba A, Court C, Dei Tos AP, DeLaney TF, De Paoli A, De Pas TM, Desai A, Di Brina L, Donati DM, Fabbri N, Fiore MR, Frezza A, Gambarotti M, Gasbarrini A, Georg P, Grignani G, Hindi N, Hug EB, Jones R, Kawai A, Krol AD, Le Grange F, Luzzati A, Marquina G, Martin-Benlloch JA, Mazzocco K, Navarria F, Navarria P, Parchi PD, Patel S, Pennacchioli E, Petrongari MG, Picci P, Pollock R, Porcu L, Quagliuolo V, Sangalli C, Scheipl S, Scotto GM, Spalek M, Steinmeier T, Timmermann B, Trama A, Uhl M, Valverde C, Varga PP, Verges R, Weber DC, Zoccali C, Casali PG, Sommer J, Gronchi A
Eur J Surg Oncol 2020 Aug;46(8):1415-1422. Epub 2020 Apr 27 doi: 10.1016/j.ejso.2020.04.028. PMID: 32402509
Safety and Local Control of Radiation Therapy for Chordoma of the Spine and Sacrum: A Systematic Review.
Pennicooke B, Laufer I, Sahgal A, Varga PP, Gokaslan ZL, Bilsky MH, Yamada YJ
Spine (Phila Pa 1976) 2016 Oct 15;41 Suppl 20(Suppl 20):S186-S192. doi: 10.1097/BRS.0000000000001831. PMID: 27509195Free PMC Article

Prognosis

Chordoma: Genetics and Contemporary Management.
Desai R, Pelargos PE, Dunn IF
Int J Mol Sci 2024 May 28;25(11) doi: 10.3390/ijms25115877. PMID: 38892063Free PMC Article
Automated Segmentation of Sacral Chordoma and Surrounding Muscles Using Deep Learning Ensemble.
Boussioux L, Ma Y, Thomas NK, Bertsimas D, Shusharina N, Pursley J, Chen YL, DeLaney TF, Qian J, Bortfeld T
Int J Radiat Oncol Biol Phys 2023 Nov 1;117(3):738-749. Epub 2023 Jul 13 doi: 10.1016/j.ijrobp.2023.03.078. PMID: 37451472Free PMC Article
Sacral Chordoma: A Population-based Analysis of Epidemiology and Survival Outcomes.
Scampa M, Tessitore E, Dominguez DE, Hannouche D, Buchs NC, Kalbermatten DF, Oranges CM
Anticancer Res 2022 Feb;42(2):929-937. doi: 10.21873/anticanres.15552. PMID: 35093892
Metastatic saccrococcygeal chordoma.
Fatehi Hassanabad M, Mansouri A, Alotaibi NM, Hazrati LN, Bernstein M
J Clin Neurosci 2016 Jan;23:149-152. Epub 2015 Nov 18 doi: 10.1016/j.jocn.2015.05.036. PMID: 26602601
Chordoma cutis.
Rubin AI, Bagel J, Niedt G
J Am Acad Dermatol 2005 May;52(5 Suppl 1):S105-8. doi: 10.1016/j.jaad.2004.07.055. PMID: 15858504

Clinical prediction guides

Characterization of sacral chordoma and differential diagnosis from other sacral malignancy using [18F]FDG PET/CT.
Lee DY, Kim YI, Ryu JS, Kim W
Medicine (Baltimore) 2024 Apr 5;103(14):e37678. doi: 10.1097/MD.0000000000037678. PMID: 38579025Free PMC Article
Automated Segmentation of Sacral Chordoma and Surrounding Muscles Using Deep Learning Ensemble.
Boussioux L, Ma Y, Thomas NK, Bertsimas D, Shusharina N, Pursley J, Chen YL, DeLaney TF, Qian J, Bortfeld T
Int J Radiat Oncol Biol Phys 2023 Nov 1;117(3):738-749. Epub 2023 Jul 13 doi: 10.1016/j.ijrobp.2023.03.078. PMID: 37451472Free PMC Article
Sacral Chordoma: A Population-based Analysis of Epidemiology and Survival Outcomes.
Scampa M, Tessitore E, Dominguez DE, Hannouche D, Buchs NC, Kalbermatten DF, Oranges CM
Anticancer Res 2022 Feb;42(2):929-937. doi: 10.21873/anticanres.15552. PMID: 35093892
Clinical Outcome of Sacral Chordoma Patients Treated with Pencil Beam Scanning Proton Therapy.
Walser M, Bojaxhiu B, Kawashiro S, Tran S, Beer J, Leiser D, Pica A, Bachtiary B, Weber DC
Clin Oncol (R Coll Radiol) 2021 Dec;33(12):e578-e585. Epub 2021 Jul 31 doi: 10.1016/j.clon.2021.07.012. PMID: 34340918
Rehabilitation Management of Hemicorporectomy.
Cavalheiro DP, Marten Teixeira JE, Braga DM, Pessoa CV, Ceregatti M, McNeill Ingham SJ
PM R 2015 Jul;7(7):777-780. Epub 2015 Mar 17 doi: 10.1016/j.pmrj.2015.03.012. PMID: 25794625

Recent systematic reviews

Carbon Ion Radiotherapy for sacral chordoma: a systematic review of the literature.
Evangelisti G, Sartini F, Bandiera S, Barbanti Brodano G, Griffoni C, Girolami M, Pipola V, Gasbarrini A
J Biol Regul Homeost Agents 2020 Jul-Aug;34(4 Suppl. 3):353-361. Congress of the Italian Orthopaedic Research Society. PMID: 33261300
Comparison of Wide Margin and Inadequate Margin for Recurrence in Sacral Chordoma: A Meta-Analysis.
Yu X, Kou C, Bai W, Yu W, Zhu B, Zhang M, Hua W, Li Y, Duan R, Yin F
Spine (Phila Pa 1976) 2020 Jun 15;45(12):814-819. doi: 10.1097/BRS.0000000000003386. PMID: 31977678
Safety and Local Control of Radiation Therapy for Chordoma of the Spine and Sacrum: A Systematic Review.
Pennicooke B, Laufer I, Sahgal A, Varga PP, Gokaslan ZL, Bilsky MH, Yamada YJ
Spine (Phila Pa 1976) 2016 Oct 15;41 Suppl 20(Suppl 20):S186-S192. doi: 10.1097/BRS.0000000000001831. PMID: 27509195Free PMC Article

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