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B Lymphoblastic Leukemia/Lymphoma with BCR-ABL1-Like Features

MedGen UID:
1379338
•Concept ID:
C4329382
•
Neoplastic Process
Synonyms: B Lymphoblastic Leukemia/Lymphoma with BCR::ABL1-Like Features; B Lymphoblastic Leukemia/Lymphoma with Translocations Involving Tyrosine Kinases or Cytokine Receptors; B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like; B Lymphoblastic Leukemia/Lymphoma, Philadelphia-like; B-lymphoblastic leukemia lymphoma BCR-ABL1-like; B-Lymphoblastic Leukemia/Lymphoma with BCR-ABL1-Like Features; B-Lymphoblastic Leukemia/Lymphoma with BCR::ABL1-Like Features; B-Lymphoblastic Leukemia/Lymphoma, Philadelphia-like
SNOMED CT: B-lymphoblastic leukemia lymphoma BCR-ABL1-like (783744003)

Definition

B lymphoblastic leukemia/lymphoma characterized by a gene-expression profile similar to that of BCR-ABL1-positive B lymphoblastic leukemia/lymphoma, absence of the pathognomonic BCR-ABL1 rearrangement, alterations of lymphoid transcription factor genes, and a poor outcome. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVB Lymphoblastic Leukemia/Lymphoma with BCR-ABL1-Like Features

Professional guidelines

PubMed

Clinicopathologic characteristics, genetic features, and treatment options for acute lymphoblastic leukemia with JAK2 rearrangement-A 10-case study and literature review.
Zhang L, Shah B, Zhang Y, Tashkandi H, Xiao W, Fernandez-Pol S, Vergara-Lluri M, Hussaini M, Song J, Lancet J, Moscinski L, Yun S, Lu CM, Medeiros LJ, Tang G
Hum Pathol 2023 Jun;136:1-15. Epub 2023 Mar 22 doi: 10.1016/j.humpath.2023.03.002. PMID: 36958463

Recent clinical studies

Etiology

Emerging molecular subtypes and therapies in acute lymphoblastic leukemia.
Davis K, Sheikh T, Aggarwal N
Semin Diagn Pathol 2023 May;40(3):202-215. Epub 2023 Apr 9 doi: 10.1053/j.semdp.2023.04.003. PMID: 37120350
Genetic Alterations and Therapeutic Targeting of Philadelphia-Like Acute Lymphoblastic Leukemia.
Iacobucci I, Roberts KG
Genes (Basel) 2021 May 1;12(5) doi: 10.3390/genes12050687. PMID: 34062932Free PMC Article
BCR-ABL1-like B-lymphoblastic leukemia/lymphoma: Review of the entity and detection methodologies.
Conant JL, Czuchlewski DR
Int J Lab Hematol 2019 May;41 Suppl 1:126-130. doi: 10.1111/ijlh.13012. PMID: 31069976
Philadelphia chromosome-like acute lymphoblastic leukemia: A review of the genetic basis, clinical features, and therapeutic options.
Khan M, Siddiqi R, Tran TH
Semin Hematol 2018 Oct;55(4):235-241. Epub 2018 May 29 doi: 10.1053/j.seminhematol.2018.05.001. PMID: 30502852
Tyrosine kinase fusion genes in pediatric BCR-ABL1-like acute lymphoblastic leukemia.
Boer JM, Steeghs EM, Marchante JR, Boeree A, Beaudoin JJ, Beverloo HB, Kuiper RP, Escherich G, van der Velden VH, van der Schoot CE, de Groot-Kruseman HA, Pieters R, den Boer ML
Oncotarget 2017 Jan 17;8(3):4618-4628. doi: 10.18632/oncotarget.13492. PMID: 27894077Free PMC Article

Diagnosis

Updates on lymphoblastic leukemia/lymphoma classification and minimal/measurable residual disease analysis.
Kovach AE, Wood BL
Semin Diagn Pathol 2023 Nov;40(6):457-471. Epub 2023 Nov 4 doi: 10.1053/j.semdp.2023.10.001. PMID: 37953192
Emerging molecular subtypes and therapies in acute lymphoblastic leukemia.
Davis K, Sheikh T, Aggarwal N
Semin Diagn Pathol 2023 May;40(3):202-215. Epub 2023 Apr 9 doi: 10.1053/j.semdp.2023.04.003. PMID: 37120350
Genetic Alterations and Therapeutic Targeting of Philadelphia-Like Acute Lymphoblastic Leukemia.
Iacobucci I, Roberts KG
Genes (Basel) 2021 May 1;12(5) doi: 10.3390/genes12050687. PMID: 34062932Free PMC Article
BCR-ABL1-like B-lymphoblastic leukemia/lymphoma: Review of the entity and detection methodologies.
Conant JL, Czuchlewski DR
Int J Lab Hematol 2019 May;41 Suppl 1:126-130. doi: 10.1111/ijlh.13012. PMID: 31069976
Philadelphia chromosome-like acute lymphoblastic leukemia: A review of the genetic basis, clinical features, and therapeutic options.
Khan M, Siddiqi R, Tran TH
Semin Hematol 2018 Oct;55(4):235-241. Epub 2018 May 29 doi: 10.1053/j.seminhematol.2018.05.001. PMID: 30502852

Therapy

Genetic Alterations and Therapeutic Targeting of Philadelphia-Like Acute Lymphoblastic Leukemia.
Iacobucci I, Roberts KG
Genes (Basel) 2021 May 1;12(5) doi: 10.3390/genes12050687. PMID: 34062932Free PMC Article
Identification of RNPC3 as a novel JAK2 fusion partner gene in B-acute lymphoblastic leukemia refractory to combination therapy including ruxolitinib.
Chen X, Wang F, Zhang Y, Ma X, Liu M, Cao P, Zhou L, Wang L, Zhang X, Wang T, Liu H
Mol Genet Genomic Med 2020 Mar;8(3):e1110. Epub 2019 Dec 30 doi: 10.1002/mgg3.1110. PMID: 31885183Free PMC Article
Genomic and outcome analyses of Ph-like ALL in NCI standard-risk patients: a report from the Children's Oncology Group.
Roberts KG, Reshmi SC, Harvey RC, Chen IM, Patel K, Stonerock E, Jenkins H, Dai Y, Valentine M, Gu Z, Zhao Y, Zhang J, Payne-Turner D, Devidas M, Heerema NA, Carroll AJ, Raetz EA, Borowitz MJ, Wood BL, Mattano LA Jr, Maloney KW, Carroll WL, Loh ML, Willman CL, Gastier-Foster JM, Mullighan CG, Hunger SP
Blood 2018 Aug 23;132(8):815-824. Epub 2018 Jul 11 doi: 10.1182/blood-2018-04-841676. PMID: 29997224Free PMC Article
Genes commonly deleted in childhood B-cell precursor acute lymphoblastic leukemia: association with cytogenetics and clinical features.
Schwab CJ, Chilton L, Morrison H, Jones L, Al-Shehhi H, Erhorn A, Russell LJ, Moorman AV, Harrison CJ
Haematologica 2013 Jul;98(7):1081-8. Epub 2013 Mar 18 doi: 10.3324/haematol.2013.085175. PMID: 23508010Free PMC Article

Prognosis

Updates on lymphoblastic leukemia/lymphoma classification and minimal/measurable residual disease analysis.
Kovach AE, Wood BL
Semin Diagn Pathol 2023 Nov;40(6):457-471. Epub 2023 Nov 4 doi: 10.1053/j.semdp.2023.10.001. PMID: 37953192
Clinicopathologic characteristics, genetic features, and treatment options for acute lymphoblastic leukemia with JAK2 rearrangement-A 10-case study and literature review.
Zhang L, Shah B, Zhang Y, Tashkandi H, Xiao W, Fernandez-Pol S, Vergara-Lluri M, Hussaini M, Song J, Lancet J, Moscinski L, Yun S, Lu CM, Medeiros LJ, Tang G
Hum Pathol 2023 Jun;136:1-15. Epub 2023 Mar 22 doi: 10.1016/j.humpath.2023.03.002. PMID: 36958463
BCR-ABL1-like B-lymphoblastic leukemia/lymphoma: Review of the entity and detection methodologies.
Conant JL, Czuchlewski DR
Int J Lab Hematol 2019 May;41 Suppl 1:126-130. doi: 10.1111/ijlh.13012. PMID: 31069976
Philadelphia chromosome-like acute lymphoblastic leukemia: A review of the genetic basis, clinical features, and therapeutic options.
Khan M, Siddiqi R, Tran TH
Semin Hematol 2018 Oct;55(4):235-241. Epub 2018 May 29 doi: 10.1053/j.seminhematol.2018.05.001. PMID: 30502852
Tyrosine kinase fusion genes in pediatric BCR-ABL1-like acute lymphoblastic leukemia.
Boer JM, Steeghs EM, Marchante JR, Boeree A, Beaudoin JJ, Beverloo HB, Kuiper RP, Escherich G, van der Velden VH, van der Schoot CE, de Groot-Kruseman HA, Pieters R, den Boer ML
Oncotarget 2017 Jan 17;8(3):4618-4628. doi: 10.18632/oncotarget.13492. PMID: 27894077Free PMC Article

Clinical prediction guides

Independent prognostic value of BCR-ABL1-like signature and IKZF1 deletion, but not high CRLF2 expression, in children with B-cell precursor ALL.
van der Veer A, Waanders E, Pieters R, Willemse ME, Van Reijmersdal SV, Russell LJ, Harrison CJ, Evans WE, van der Velden VH, Hoogerbrugge PM, Van Leeuwen F, Escherich G, Horstmann MA, Mohammadi Khankahdani L, Rizopoulos D, De Groot-Kruseman HA, Sonneveld E, Kuiper RP, Den Boer ML
Blood 2013 Oct 10;122(15):2622-9. Epub 2013 Aug 23 doi: 10.1182/blood-2012-10-462358. PMID: 23974192Free PMC Article

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