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B Lymphoblastic Leukemia/Lymphoma with BCR-ABL1-Like Features

MedGen UID:
1379338
•Concept ID:
C4329382
•
Neoplastic Process
Synonyms: B Lymphoblastic Leukemia/Lymphoma with BCR::ABL1-Like Features; B Lymphoblastic Leukemia/Lymphoma with Translocations Involving Tyrosine Kinases or Cytokine Receptors; B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like; B Lymphoblastic Leukemia/Lymphoma, Philadelphia-like; B-lymphoblastic leukemia lymphoma BCR-ABL1-like; B-Lymphoblastic Leukemia/Lymphoma with BCR-ABL1-Like Features; B-Lymphoblastic Leukemia/Lymphoma with BCR::ABL1-Like Features; B-Lymphoblastic Leukemia/Lymphoma, Philadelphia-like
SNOMED CT: B-lymphoblastic leukemia lymphoma BCR-ABL1-like (783744003)

Definition

B lymphoblastic leukemia/lymphoma characterized by a gene-expression profile similar to that of BCR-ABL1-positive B lymphoblastic leukemia/lymphoma, absence of the pathognomonic BCR-ABL1 rearrangement, alterations of lymphoid transcription factor genes, and a poor outcome. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVB Lymphoblastic Leukemia/Lymphoma with BCR-ABL1-Like Features

Recent clinical studies

Etiology

Emerging molecular subtypes and therapies in acute lymphoblastic leukemia.
Davis K, Sheikh T, Aggarwal N
Semin Diagn Pathol 2023 May;40(3):202-215. Epub 2023 Apr 9 doi: 10.1053/j.semdp.2023.04.003. PMID: 37120350
BCR-ABL1-like B-lymphoblastic leukemia/lymphoma: Review of the entity and detection methodologies.
Conant JL, Czuchlewski DR
Int J Lab Hematol 2019 May;41 Suppl 1:126-130. doi: 10.1111/ijlh.13012. PMID: 31069976

Diagnosis

Updates on lymphoblastic leukemia/lymphoma classification and minimal/measurable residual disease analysis.
Kovach AE, Wood BL
Semin Diagn Pathol 2023 Nov;40(6):457-471. Epub 2023 Nov 4 doi: 10.1053/j.semdp.2023.10.001. PMID: 37953192
Emerging molecular subtypes and therapies in acute lymphoblastic leukemia.
Davis K, Sheikh T, Aggarwal N
Semin Diagn Pathol 2023 May;40(3):202-215. Epub 2023 Apr 9 doi: 10.1053/j.semdp.2023.04.003. PMID: 37120350
BCR-ABL1-like B-lymphoblastic leukemia/lymphoma: Review of the entity and detection methodologies.
Conant JL, Czuchlewski DR
Int J Lab Hematol 2019 May;41 Suppl 1:126-130. doi: 10.1111/ijlh.13012. PMID: 31069976

Prognosis

Updates on lymphoblastic leukemia/lymphoma classification and minimal/measurable residual disease analysis.
Kovach AE, Wood BL
Semin Diagn Pathol 2023 Nov;40(6):457-471. Epub 2023 Nov 4 doi: 10.1053/j.semdp.2023.10.001. PMID: 37953192
BCR-ABL1-like B-lymphoblastic leukemia/lymphoma: Review of the entity and detection methodologies.
Conant JL, Czuchlewski DR
Int J Lab Hematol 2019 May;41 Suppl 1:126-130. doi: 10.1111/ijlh.13012. PMID: 31069976

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