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B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like

MedGen UID:
1379338
•Concept ID:
C4329382
•
Neoplastic Process
Synonyms: B Lymphoblastic Leukemia/Lymphoma with BCR-ABL1-Like Features; B Lymphoblastic Leukemia/Lymphoma with BCR::ABL1-Like Features; B Lymphoblastic Leukemia/Lymphoma with Translocations Involving Tyrosine Kinases or Cytokine Receptors; B Lymphoblastic Leukemia/Lymphoma, BCR::ABL1-Like; B Lymphoblastic Leukemia/Lymphoma, Philadelphia-like; B-lymphoblastic leukemia lymphoma BCR-ABL1-like; B-Lymphoblastic Leukemia/Lymphoma with BCR-ABL1-Like Features; B-Lymphoblastic Leukemia/Lymphoma with BCR::ABL1-Like Features; B-Lymphoblastic Leukemia/Lymphoma, Philadelphia-like
SNOMED CT: B-lymphoblastic leukemia lymphoma BCR-ABL1-like (783744003)

Definition

B lymphoblastic leukemia/lymphoma characterized by a gene-expression profile similar to that of BCR-ABL1-positive B lymphoblastic leukemia/lymphoma, absence of the pathognomonic BCR-ABL1 rearrangement, alterations of lymphoid transcription factor genes, and a poor outcome. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVB Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like

Professional guidelines

PubMed

Clinicopathologic characteristics, genetic features, and treatment options for acute lymphoblastic leukemia with JAK2 rearrangement-A 10-case study and literature review.
Zhang L, Shah B, Zhang Y, Tashkandi H, Xiao W, Fernandez-Pol S, Vergara-Lluri M, Hussaini M, Song J, Lancet J, Moscinski L, Yun S, Lu CM, Medeiros LJ, Tang G
Hum Pathol 2023 Jun;136:1-15. Epub 2023 Mar 22 doi: 10.1016/j.humpath.2023.03.002. PMID: 36958463
Clinical utility of fluorescence in situ hybridization-based diagnosis of BCR-ABL1 like (Philadelphia chromosome like) B-acute lymphoblastic leukemia.
Anagnostou T, Knudson RA, Pearce KE, Meyer RG, Pitel BA, Peterson JF, Baughn LB, Reichard KK, Ketterling RP, Kloft-Nelson SM, Knutson DL, Khan SP, Gangat N, Litzow MR, Hogan WJ, Wolanskyj A, Al-Kali A, Begna KH, Elliott M, Pardanani A, Foran J, Shah M, Tefferi A, Alkhateeb H, Halling K, Rodriguez V, Greipp PT, Patnaik MM
Am J Hematol 2020 Mar;95(3):E68-E72. Epub 2020 Jan 26 doi: 10.1002/ajh.25729. PMID: 31919873

Recent clinical studies

Etiology

Genomic Determinants of Outcome in Acute Lymphoblastic Leukemia.
Chang TC, Chen W, Qu C, Cheng Z, Hedges D, Elsayed A, Pounds SB, Shago M, Rabin KR, Raetz EA, Devidas M, Cheng C, Angiolillo A, Baviskar P, Borowitz M, Burke MJ, Carroll A, Carroll WL, Chen IM, Harvey R, Heerema N, Iacobucci I, Wang JR, Jeha S, Larsen E, Mattano L, Maloney K, Pui CH, Ramirez NC, Salzer W, Willman C, Winick N, Wood B, Hunger SP, Wu G, Mullighan CG, Loh ML
J Clin Oncol 2024 Oct 10;42(29):3491-3503. Epub 2024 Aug 9 doi: 10.1200/JCO.23.02238. PMID: 39121442Free PMC Article
Emerging molecular subtypes and therapies in acute lymphoblastic leukemia.
Davis K, Sheikh T, Aggarwal N
Semin Diagn Pathol 2023 May;40(3):202-215. Epub 2023 Apr 9 doi: 10.1053/j.semdp.2023.04.003. PMID: 37120350
BCR-ABL1-like B-lymphoblastic leukemia/lymphoma: Review of the entity and detection methodologies.
Conant JL, Czuchlewski DR
Int J Lab Hematol 2019 May;41 Suppl 1:126-130. doi: 10.1111/ijlh.13012. PMID: 31069976
Why and how to treat Ph-like ALL?
Roberts KG
Best Pract Res Clin Haematol 2018 Dec;31(4):351-356. Epub 2018 Sep 20 doi: 10.1016/j.beha.2018.09.003. PMID: 30466746
Philadelphia-Like Acute Lymphoblastic Leukemia in Adults.
Herold T, Gökbuget N
Curr Oncol Rep 2017 May;19(5):31. doi: 10.1007/s11912-017-0589-2. PMID: 28361222

Diagnosis

Genomic Determinants of Outcome in Acute Lymphoblastic Leukemia.
Chang TC, Chen W, Qu C, Cheng Z, Hedges D, Elsayed A, Pounds SB, Shago M, Rabin KR, Raetz EA, Devidas M, Cheng C, Angiolillo A, Baviskar P, Borowitz M, Burke MJ, Carroll A, Carroll WL, Chen IM, Harvey R, Heerema N, Iacobucci I, Wang JR, Jeha S, Larsen E, Mattano L, Maloney K, Pui CH, Ramirez NC, Salzer W, Willman C, Winick N, Wood B, Hunger SP, Wu G, Mullighan CG, Loh ML
J Clin Oncol 2024 Oct 10;42(29):3491-3503. Epub 2024 Aug 9 doi: 10.1200/JCO.23.02238. PMID: 39121442Free PMC Article
Updates on lymphoblastic leukemia/lymphoma classification and minimal/measurable residual disease analysis.
Kovach AE, Wood BL
Semin Diagn Pathol 2023 Nov;40(6):457-471. Epub 2023 Nov 4 doi: 10.1053/j.semdp.2023.10.001. PMID: 37953192
Emerging molecular subtypes and therapies in acute lymphoblastic leukemia.
Davis K, Sheikh T, Aggarwal N
Semin Diagn Pathol 2023 May;40(3):202-215. Epub 2023 Apr 9 doi: 10.1053/j.semdp.2023.04.003. PMID: 37120350
BCR-ABL1-like B-Acute Lymphoblastic Leukemia/Lymphoma: A Comprehensive Review.
Jain S, Abraham A
Arch Pathol Lab Med 2020 Feb;144(2):150-155. Epub 2019 Oct 23 doi: 10.5858/arpa.2019-0194-RA. PMID: 31644323
BCR-ABL1-like B-lymphoblastic leukemia/lymphoma: Review of the entity and detection methodologies.
Conant JL, Czuchlewski DR
Int J Lab Hematol 2019 May;41 Suppl 1:126-130. doi: 10.1111/ijlh.13012. PMID: 31069976

Therapy

Genetic Alterations and Therapeutic Targeting of Philadelphia-Like Acute Lymphoblastic Leukemia.
Iacobucci I, Roberts KG
Genes (Basel) 2021 May 1;12(5) doi: 10.3390/genes12050687. PMID: 34062932Free PMC Article
BCR/ABL1-like acute lymphoblastic leukemia: How to diagnose and treat?
Chiaretti S, Messina M, Foà R
Cancer 2019 Jan 15;125(2):194-204. Epub 2018 Dec 18 doi: 10.1002/cncr.31848. PMID: 30561755
Why and how to treat Ph-like ALL?
Roberts KG
Best Pract Res Clin Haematol 2018 Dec;31(4):351-356. Epub 2018 Sep 20 doi: 10.1016/j.beha.2018.09.003. PMID: 30466746
Philadelphia chromosome-like acute lymphoblastic leukemia: progress in a new cancer subtype.
Wells J, Jain N, Konopleva M
Clin Adv Hematol Oncol 2017 Jul;15(7):554-561. PMID: 28749919
BCR-ABL1-like acute lymphoblastic leukaemia: From bench to bedside.
Boer JM, den Boer ML
Eur J Cancer 2017 Sep;82:203-218. Epub 2017 Jul 12 doi: 10.1016/j.ejca.2017.06.012. PMID: 28709134

Prognosis

Updates on lymphoblastic leukemia/lymphoma classification and minimal/measurable residual disease analysis.
Kovach AE, Wood BL
Semin Diagn Pathol 2023 Nov;40(6):457-471. Epub 2023 Nov 4 doi: 10.1053/j.semdp.2023.10.001. PMID: 37953192
Clinical significance of novel subtypes of acute lymphoblastic leukemia in the context of minimal residual disease-directed therapy.
Jeha S, Choi J, Roberts KG, Pei D, Coustan-Smith E, Inaba H, Rubnitz JE, Ribeiro RC, Gruber TA, Raimondi SC, Karol SE, Qu C, Brady SW, Gu Z, Yang JJ, Cheng C, Downing JR, Evans WE, Relling MV, Campana D, Mullighan CG, Pui CH
Blood Cancer Discov 2021 Jul;2(4):326-337. doi: 10.1158/2643-3230.BCD-20-0229. PMID: 34250504Free PMC Article
BCR-ABL1-like B-lymphoblastic leukemia/lymphoma: Review of the entity and detection methodologies.
Conant JL, Czuchlewski DR
Int J Lab Hematol 2019 May;41 Suppl 1:126-130. doi: 10.1111/ijlh.13012. PMID: 31069976
BCR/ABL1-like acute lymphoblastic leukemia: How to diagnose and treat?
Chiaretti S, Messina M, Foà R
Cancer 2019 Jan 15;125(2):194-204. Epub 2018 Dec 18 doi: 10.1002/cncr.31848. PMID: 30561755
Philadelphia-Like Acute Lymphoblastic Leukemia in Adults.
Herold T, Gökbuget N
Curr Oncol Rep 2017 May;19(5):31. doi: 10.1007/s11912-017-0589-2. PMID: 28361222

Clinical prediction guides

Tyrosine kinase inhibitor response of ABL-class acute lymphoblastic leukemia: the role of kinase type and SH3 domain.
van Outersterp I, Tasian SK, Reichert CEJ, Boeree A, de Groot-Kruseman HA, Escherich G, Boer JM, den Boer ML
Blood 2024 May 23;143(21):2178-2189. doi: 10.1182/blood.2023023120. PMID: 38394665Free PMC Article
IGJ and SPATS2L immunohistochemistry sensitively and specifically identify BCR::ABL1+ and BCR::ABL1-like B-acute lymphoblastic leukaemia.
Gestrich CK, De Lancy SJ, Kresak A, Meyerson H, Pateva I, Yalley AK, Ryder C, Shetty S, Bledsoe J, Moore EM, Oduro KA Jr
Br J Haematol 2024 Jan;204(1):229-239. Epub 2023 Oct 23 doi: 10.1111/bjh.19142. PMID: 37871900
MUC4 expression by immunohistochemistry is a specific marker for BCR-ABL1+ and BCR-ABL1-like B-lymphoblastic leukemia.
Kaumeyer B, Fidai S, Sukhanova M, Yap KL, Segal J, Raca G, Stock W, McNeer J, Lager AM, Gurbuxani S
Leuk Lymphoma 2022 Jun;63(6):1436-1444. Epub 2022 Feb 16 doi: 10.1080/10428194.2022.2025797. PMID: 35171727
Have any strategies in Ph-like ALL been shown to be effective?
Aldoss I, Advani AS
Best Pract Res Clin Haematol 2021 Mar;34(1):101242. Epub 2021 Jan 11 doi: 10.1016/j.beha.2021.101242. PMID: 33762097
Philadelphia-like acute lymphoblastic leukemia is associated with minimal residual disease persistence and poor outcome. First report of the minimal residual disease-oriented GIMEMA LAL1913.
Chiaretti S, Messina M, Della Starza I, Piciocchi A, Cafforio L, Cavalli M, Taherinasab A, Ansuinelli M, Elia L, Albertini Petroni G, La Starza R, Canichella M, Lauretti A, Puzzolo MC, Pierini V, Santoro A, Spinelli O, Apicella V, Capria S, Di Raimondo F, De Fabritiis P, Papayannidis C, Candoni A, Cairoli R, Cerrano M, Fracchiolla N, Mattei D, Cattaneo C, Vitale A, Crea E, Fazi P, Mecucci C, Rambaldi A, Guarini A, Bassan R, Foà R
Haematologica 2021 Jun 1;106(6):1559-1568. doi: 10.3324/haematol.2020.247973. PMID: 32467145Free PMC Article

Recent systematic reviews

Prevalence and Clinical Outcome of Philadelphia-Like Acute Lymphoblastic Leukemia: Systematic Review and Meta-analysis.
Owattanapanich W, Rujirachun P, Ungprasert P, Buaboonnam J, Techavichit P
Clin Lymphoma Myeloma Leuk 2020 Jan;20(1):e22-e29. Epub 2019 Aug 27 doi: 10.1016/j.clml.2019.08.003. PMID: 31699654

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