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B Lymphoblastic Leukemia/Lymphoma

MedGen UID:: 163575
•Concept ID:: C0862030
•: Neoplastic Process

Synonyms:	B lymphoblastic leukemia lymphoma; B-Cell Lymphoblastic Leukemia/Lymphoma; B-Lymphoblastic Leukemia/Lymphoma; Precursor B Lymphoblastic Leukemia/Lymphoma; Precursor B-Lymphoblastic Lymphoma/Leukemia
SNOMED CT:	B lymphoblastic leukemia lymphoma (1162660006)

Definition

A neoplasm of lymphoblasts committed to the B-cell lineage, typically composed of small to medium-sized blast cells. When the neoplasm involves predominantly the bone marrow and the peripheral blood, it is called B acute lymphoblastic leukemia. When it involves nodal or extranodal sites, it is called B lymphoblastic lymphoma. (WHO, 2001) [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVB Lymphoblastic Leukemia/Lymphoma

B-cell lymphoma
- B-cell lymphoma
  - B-cell lymphoma
    - B-cell lymphoma
      - B-cell lymphoma
        B-cell lymphoma
        B Lymphoblastic Leukemia/Lymphoma
        B Lymphoblastic Leukemia/Lymphoma, Not Otherwise Specified
        B Lymphoblastic Lymphoma
        Adult B Lymphoblastic Lymphoma
        B Lymphoblastic Lymphoma by Ann Arbor Stage
        Ann Arbor Stage I B Lymphoblastic Lymphoma
        Ann Arbor Stage II B Lymphoblastic Lymphoma
        Ann Arbor Stage III B Lymphoblastic Lymphoma
        Ann Arbor Stage IV B Lymphoblastic Lymphoma
        Childhood B Lymphoblastic Lymphoma
        Recurrent B Lymphoblastic Lymphoma
        Refractory B Lymphoblastic Lymphoma
        Splenic B Lymphoblastic Lymphoma
        B-cell acute lymphoblastic leukemia
        B Acute Lymphoblastic Leukemia with Intrachromosomal Amplification of Chromosome 21
        B Acute Lymphoblastic Leukemia with t(12;21)(p13.2;q22.1); ETV6-RUNX1
        B Acute Lymphoblastic Leukemia with t(1;19)(q23;p13.3); E2A-PBX1 (TCF3-PBX1)
        B Acute Lymphoblastic Leukemia with t(4;11)(q21;23)
        B Acute Lymphoblastic Leukemia with t(5;14)(q31.1;q32.3); IL3-IGH
        B Acute Lymphoblastic Leukemia with t(v;11q23.3); MLL Rearranged
        B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative
        B-cell adult acute lymphocytic leukemia
        Adult B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1
        B-cell childhood acute lymphoblastic leukemia
        Childhood B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1
        Hyperdiploid B Acute Lymphoblastic Leukemia
        Hypodiploid B Acute Lymphoblastic Leukemia
        Ph-positive acute lymphoblastic leukemia
        Recurrent B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1
        Refractory B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1
        Recurrent B Acute Lymphoblastic Leukemia
        Refractory B Acute Lymphoblastic Leukemia
        B-lymphoblastic leukemia/lymphoma with recurrent genetic abnormality
        B lymphoblastic leukemia lymphoma with hyperdiploidy
        B lymphoblastic leukemia lymphoma with t(12;21)(p13;q22); TEL-AML1 (ETV6-RUNX1)
        B Lymphoblastic Leukemia/Lymphoma with BCR-ABL1-Like Features
        B Lymphoblastic Leukemia/Lymphoma with t(9;22)(q34.1;q11.2); BCR-ABL1
        B Lymphoblastic Leukemia/Lymphoma with t(v;11q23.3); KMT2A Rearranged
        B-cell acute lymphoblastic leukemia with t(1;19)(q23;p13.3); E2A-PBX1 (TCF3-PBX1)
        B-lymphoblastic leukemia/lymphoma with hypodiploidy
        B-Lymphoblastic Leukemia/Lymphoma with Intrachromosomal Amplification of Chromosome 21
        B-lymphoblastic leukemia/lymphoma with t(5;14)(q31.1;q32.3)
        Cutaneous B Lymphoblastic Leukemia/Lymphoma

Professional guidelines

PubMed

Beyond the 2008 World Health Organization classification: the role of the hematopathology laboratory in the diagnosis and management of acute lymphoblastic leukemia.

McGregor S, McNeer J, Gurbuxani S
Semin Diagn Pathol 2012 Feb;29(1):2-11. doi: 10.1053/j.semdp.2011.07.004. PMID: 22372201 Free PMC Article

PAX-5: a valuable immunohistochemical marker in the differential diagnosis of lymphoid neoplasms.

Desouki MM, Post GR, Cherry D, Lazarchick J
Clin Med Res 2010 Jul;8(2):84-8. doi: 10.3121/cmr.2010.891. PMID: 20660931 Free PMC Article

See all (2)

Recent clinical studies

Etiology

Flow cytometric assessment for minimal/measurable residual disease in B lymphoblastic leukemia/lymphoma in the era of immunotherapy.

Chen X, Gao Q, Roshal M, Cherian S
Cytometry B Clin Cytom 2023 May;104(3):205-223. Epub 2023 Jan 22 doi: 10.1002/cyto.b.22113. PMID: 36683279

Lenalidomide-Associated Secondary B-Lymphoblastic Leukemia/Lymphoma-A Unique Entity.

Germans SK, Kulak O, Koduru P, Oliver D, Gagan J, Patel P, Anderson LD Jr, Fuda FS, Chen W, Jaso JM
Am J Clin Pathol 2020 Nov 4;154(6):816-827. doi: 10.1093/ajcp/aqaa109. PMID: 32880627

BCR-ABL1-like B-lymphoblastic leukemia/lymphoma: Review of the entity and detection methodologies.

Conant JL, Czuchlewski DR
Int J Lab Hematol 2019 May;41 Suppl 1:126-130. doi: 10.1111/ijlh.13012. PMID: 31069976

Advances in the molecular pathobiology of B-lymphoblastic leukemia.

Zhou Y, You MJ, Young KH, Lin P, Lu G, Medeiros LJ, Bueso-Ramos CE
Hum Pathol 2012 Sep;43(9):1347-62. Epub 2012 May 8 doi: 10.1016/j.humpath.2012.02.004. PMID: 22575265

Classification of acute leukemias.

Brunning RD
Semin Diagn Pathol 2003 Aug;20(3):142-53. doi: 10.1016/s0740-2570(03)00031-5. PMID: 14552428

See all (27)

Diagnosis

Genetics and Diagnostic Approach to Lymphoblastic Leukemia/Lymphoma.

Afkhami M, Ally F, Pullarkat V, Pillai RK
Cancer Treat Res 2021;181:17-43. doi: 10.1007/978-3-030-78311-2_2. PMID: 34626353

BCR-ABL1-like B-lymphoblastic leukemia/lymphoma: Review of the entity and detection methodologies.

Conant JL, Czuchlewski DR
Int J Lab Hematol 2019 May;41 Suppl 1:126-130. doi: 10.1111/ijlh.13012. PMID: 31069976

Hepatic Lymphoma Diagnosis.

Choi WT, Gill RM
Surg Pathol Clin 2018 Jun;11(2):389-402. Epub 2018 Mar 21 doi: 10.1016/j.path.2018.02.003. PMID: 29751882

Laboratory testing in BCR-ABL1-like (Philadelphia-like) B-lymphoblastic leukemia/lymphoma.

Siegele BJ, Nardi V
Am J Hematol 2018 Jul;93(7):971-977. Epub 2018 May 15 doi: 10.1002/ajh.25126. PMID: 29696694

Classification of acute leukemias.

Brunning RD
Semin Diagn Pathol 2003 Aug;20(3):142-53. doi: 10.1016/s0740-2570(03)00031-5. PMID: 14552428

See all (57)

Therapy

How Many Tests Does It Take to Diagnose a Triple-Hit B-Lymphoblastic Lymphoma? (Hint, It's A Lot).

Das M, Tsuchiya KD, Bohling SD, Davis B, Hwang S, Gardner RA, Chisholm KM
Pediatr Dev Pathol 2024 Mar-Apr;27(2):193-197. Epub 2023 Nov 30 doi: 10.1177/10935266231212337. PMID: 38032739

Lenalidomide-Associated Secondary B-Lymphoblastic Leukemia/Lymphoma-A Unique Entity.

Germans SK, Kulak O, Koduru P, Oliver D, Gagan J, Patel P, Anderson LD Jr, Fuda FS, Chen W, Jaso JM
Am J Clin Pathol 2020 Nov 4;154(6):816-827. doi: 10.1093/ajcp/aqaa109. PMID: 32880627

Lymphomatoid Granulomatosis in a 14-Year-Old Boy with Trisomy 21 and History of B-Lymphoblastic Leukemia/Lymphoma.

Matynia AP, Perkins SL, Li D
Fetal Pediatr Pathol 2018 Feb;37(1):7-14. Epub 2018 Jan 16 doi: 10.1080/15513815.2017.1379042. PMID: 29336635

Extramedullary B lymphoblastic leukemia/lymphoma (B-ALL/B-LBL): a diagnostic challenge.

Geethakumari PR, Hoffmann MS, Pemmaraju N, Hu S, Jorgensen JL, O'Brien S, Daver N
Clin Lymphoma Myeloma Leuk 2014 Aug;14(4):e115-8. Epub 2014 Feb 2 doi: 10.1016/j.clml.2014.01.004. PMID: 24589157 Free PMC Article

B-lymphoblastic leukemia/lymphoma associated with t(8;13)(p11;q12)/ ZMYM2 (ZNF198)-FGFR1 : rare case and review of the literature.

Trimaldi J, Carballido EM, Bowers JW, Anguiano AL, Zhang ZJ, Shah BD, Bruno S, List AF, Moscinski LC, Grady T, Agosti SJ, Kang L, Zhang L
Acta Haematol 2013;130(3):127-34. Epub 2013 Apr 16 doi: 10.1159/000347030. PMID: 23594707

See all (9)

Prognosis

Flow cytometric assessment for minimal/measurable residual disease in B lymphoblastic leukemia/lymphoma in the era of immunotherapy.

Chen X, Gao Q, Roshal M, Cherian S
Cytometry B Clin Cytom 2023 May;104(3):205-223. Epub 2023 Jan 22 doi: 10.1002/cyto.b.22113. PMID: 36683279

Genetics and Diagnostic Approach to Lymphoblastic Leukemia/Lymphoma.

Afkhami M, Ally F, Pullarkat V, Pillai RK
Cancer Treat Res 2021;181:17-43. doi: 10.1007/978-3-030-78311-2_2. PMID: 34626353

B Cell Lymphoma.

Meng X, Min Q, Wang JY
Adv Exp Med Biol 2020;1254:161-181. doi: 10.1007/978-981-15-3532-1_12. PMID: 32323276

BCR-ABL1-like B-lymphoblastic leukemia/lymphoma: Review of the entity and detection methodologies.

Conant JL, Czuchlewski DR
Int J Lab Hematol 2019 May;41 Suppl 1:126-130. doi: 10.1111/ijlh.13012. PMID: 31069976

Classification of acute leukemias.

Brunning RD
Semin Diagn Pathol 2003 Aug;20(3):142-53. doi: 10.1016/s0740-2570(03)00031-5. PMID: 14552428

See all (35)

Clinical prediction guides

15-color highly sensitive flow cytometry assay for post anti-CD19 targeted therapy (anti-CD19-CAR-T and blinatumomab) measurable residual disease assessment in B-lymphoblastic leukemia/lymphoma: Real-world applicability and challenges.

Chatterjee G, Dhende P, Raj S, Shetty V, Ghogale S, Deshpande N, Girase K, Patil J, Kalra A, Narula G, Dalvi K, Dhamne C, Moulik NR, Rajpal S, Patkar NV, Banavali S, Gujral S, Subramanian PG, Tembhare PR
Eur J Haematol 2024 Jan;112(1):122-136. Epub 2023 Sep 14 doi: 10.1111/ejh.14102. PMID: 37706583

Highly sensitive single tube B-lymphoblastic leukemia/lymphoma minimal/measurable residual disease test robust to surface antigen directed therapy.

Gao Q, Liu Y, Aypar U, Baik J, Londono D, Sun X, Zhang J, Zhang Y, Roshal M
Cytometry B Clin Cytom 2023 Jul;104(4):279-293. Epub 2023 Mar 30 doi: 10.1002/cyto.b.22120. PMID: 36999235 Free PMC Article

N-terminus DUX4-immunohistochemistry is a reliable methodology for the diagnosis of DUX4-fused B-lymphoblastic leukemia/lymphoma (N-terminus DUX4 IHC for DUX4-fused B-ALL).

Siegele BJ, Stemmer-Rachamimov AO, Lilljebjorn H, Fioretos T, Winters AC, Dal Cin P, Treece A, Gaskell A, Nardi V
Genes Chromosomes Cancer 2022 Aug;61(8):449-458. Epub 2022 Mar 7 doi: 10.1002/gcc.23033. PMID: 35218117

Lenalidomide-Associated Secondary B-Lymphoblastic Leukemia/Lymphoma-A Unique Entity.

Germans SK, Kulak O, Koduru P, Oliver D, Gagan J, Patel P, Anderson LD Jr, Fuda FS, Chen W, Jaso JM
Am J Clin Pathol 2020 Nov 4;154(6):816-827. doi: 10.1093/ajcp/aqaa109. PMID: 32880627

Advances in the molecular pathobiology of B-lymphoblastic leukemia.

Zhou Y, You MJ, Young KH, Lin P, Lu G, Medeiros LJ, Bueso-Ramos CE
Hum Pathol 2012 Sep;43(9):1347-62. Epub 2012 May 8 doi: 10.1016/j.humpath.2012.02.004. PMID: 22575265

See all (17)

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B Lymphoblastic Leukemia/Lymphoma

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

Related information

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