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Glottis neoplasm

MedGen UID:
138026
•Concept ID:
C0345713
•
Neoplastic Process
Synonyms: Glottis Neoplasm; glottis neoplasm; glottis neoplasm (disease); Glottis Tumor; glottis tumor; glottis tumour; Neoplasm of glottis; Neoplasm of Glottis; neoplasm of glottis; Neoplasm of the Glottis; neoplasm of the glottis; Tumor of glottis; Tumor of Glottis; tumor of glottis; Tumor of the Glottis; tumor of the glottis; tumour of glottis; tumour of the glottis
SNOMED CT: Neoplasm of glottis (126693009); Tumor of glottis (126693009)
 
Monarch Initiative: MONDO:0002353

Definition

A benign or malignant neoplasm that affects the glottic area of the larynx. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGlottis neoplasm

Professional guidelines

PubMed

Surgical Treatment of Early Glottic Cancer.
Silver JA, Turkdogan S, Roy CF, Kost KM
Otolaryngol Clin North Am 2023 Apr;56(2):259-273. doi: 10.1016/j.otc.2022.12.009. PMID: 37030939
Treatment of early-stage laryngeal cancer: A comparison of treatment options.
Baird BJ, Sung CK, Beadle BM, Divi V
Oral Oncol 2018 Dec;87:8-16. Epub 2018 Oct 16 doi: 10.1016/j.oraloncology.2018.09.012. PMID: 30527248
Vocal fold leukoplakia: incidence, management, and prevention.
Parker NP
Curr Opin Otolaryngol Head Neck Surg 2017 Dec;25(6):464-468. doi: 10.1097/MOO.0000000000000406. PMID: 28857841

Recent clinical studies

Etiology

Surgical Management of Advanced Glottic Cancer.
Poonia SK, Nicolli E
Otolaryngol Clin North Am 2023 Apr;56(2):275-283. doi: 10.1016/j.otc.2022.12.007. PMID: 37030940
Surgical Treatment of Early Glottic Cancer.
Silver JA, Turkdogan S, Roy CF, Kost KM
Otolaryngol Clin North Am 2023 Apr;56(2):259-273. doi: 10.1016/j.otc.2022.12.009. PMID: 37030939
Mu-Opioid Receptor Expression in Laryngeal Cancer.
Lahav Y, Cohen O, Huszar M, Levy I, Cata JP, Halperin D, Shoffel-Havakuk H
J Voice 2023 May;37(3):433-439. Epub 2021 Mar 7 doi: 10.1016/j.jvoice.2021.02.018. PMID: 33750623
Radiotherapy in the management of glottic squamous cell carcinoma.
Mendenhall WM, Strojan P, Lee AWM, Rinaldo A, Eisbruch A, Ng WT, Smee R, Ferlito A
Head Neck 2020 Dec;42(12):3558-3567. Epub 2020 Sep 8 doi: 10.1002/hed.26419. PMID: 32896071
Laryngeal carcinomas.
Ennuyer A, Bataini P
Laryngoscope 1975 Sep;85(9):1467-76. doi: 10.1288/00005537-197509000-00007. PMID: 1177638

Diagnosis

Dysplastic Lesions of the Larynx.
Olson C, Alexander R, Stinnett S
Otolaryngol Clin North Am 2023 Apr;56(2):233-246. doi: 10.1016/j.otc.2023.01.001. PMID: 37030937
Mu-Opioid Receptor Expression in Laryngeal Cancer.
Lahav Y, Cohen O, Huszar M, Levy I, Cata JP, Halperin D, Shoffel-Havakuk H
J Voice 2023 May;37(3):433-439. Epub 2021 Mar 7 doi: 10.1016/j.jvoice.2021.02.018. PMID: 33750623
Laryngeal oncocytic cystadenoma and sudden death.
Gilbert JD, Byard RW
Forensic Sci Med Pathol 2022 Dec;18(4):554-556. Epub 2022 Sep 22 doi: 10.1007/s12024-022-00530-0. PMID: 36136290Free PMC Article
Prognosis of subglottic carcinoma: Is it really worse?
Coskun H, Mendenhall WM, Rinaldo A, Rodrigo JP, Suárez C, Strojan P, López F, Mondin V, Saba NF, Shaha AR, Smee R, Takes RP, Ferlito A
Head Neck 2019 Feb;41(2):511-521. Epub 2018 Jun 26 doi: 10.1002/hed.25172. PMID: 29947111
Laryngeal myxoma.
Nakamura A, Iguchi H, Kusuki M, Yamane H, Matsuda M, Osako S
Acta Otolaryngol 2008 Jan;128(1):110-2. doi: 10.1080/00016480701361970. PMID: 17851923

Therapy

Overview of glottic laryngeal cancer treatment recommendation changes in the NCCN guidelines from 2011 to 2022.
Arboleda LPA, Neves AB, Kohler HF, Vartanian JG, Candelária LM, Borges MF, Fernandes GA, de Carvalho GB, Kowalski LP, Brennan P, Santos-Silva AR, Curado MP
Cancer Rep (Hoboken) 2023 Aug;6(8):e1837. Epub 2023 Jun 7 doi: 10.1002/cnr2.1837. PMID: 37288471Free PMC Article
Treatment of early-stage laryngeal cancer: A comparison of treatment options.
Baird BJ, Sung CK, Beadle BM, Divi V
Oral Oncol 2018 Dec;87:8-16. Epub 2018 Oct 16 doi: 10.1016/j.oraloncology.2018.09.012. PMID: 30527248
Supratracheal partial laryngectomy: indications, oncologic and functional results.
Succo G, Fantini M, Rizzotto G
Curr Opin Otolaryngol Head Neck Surg 2017 Apr;25(2):127-132. doi: 10.1097/MOO.0000000000000344. PMID: 28169863
Therapy for recurrent respiratory papillomatosis.
Auborn KJ
Antivir Ther 2002 Mar;7(1):1-9. PMID: 12008782
Hypopharyngeal stenosis.
McConnel FM, Duck SW, Hester TR
Laryngoscope 1984 Sep;94(9):1162-4. doi: 10.1288/00005537-198409000-00006. PMID: 6472011

Prognosis

Prognosis of subglottic carcinoma: Is it really worse?
Coskun H, Mendenhall WM, Rinaldo A, Rodrigo JP, Suárez C, Strojan P, López F, Mondin V, Saba NF, Shaha AR, Smee R, Takes RP, Ferlito A
Head Neck 2019 Feb;41(2):511-521. Epub 2018 Jun 26 doi: 10.1002/hed.25172. PMID: 29947111
Treatment of early-stage laryngeal cancer: A comparison of treatment options.
Baird BJ, Sung CK, Beadle BM, Divi V
Oral Oncol 2018 Dec;87:8-16. Epub 2018 Oct 16 doi: 10.1016/j.oraloncology.2018.09.012. PMID: 30527248
Supraglottic laryngectomy.
Isaacs JH Jr, Slattery WH 3rd, Mendenhall WM, Cassisi NJ
Am J Otolaryngol 1998 Mar-Apr;19(2):118-23. doi: 10.1016/s0196-0709(98)90107-7. PMID: 9550444
Infantile subglottic hemangioma.
Seikaly H, Cuyler JP
J Otolaryngol 1994 Apr;23(2):135-7. PMID: 8028072
Laryngeal carcinomas.
Ennuyer A, Bataini P
Laryngoscope 1975 Sep;85(9):1467-76. doi: 10.1288/00005537-197509000-00007. PMID: 1177638

Clinical prediction guides

Paraglottic Space Invasion in Glottic Laryngeal Cancer: A Clinical-Pathological Study.
Fermi M, Lo Manto A, Di Massa G, Gallo G, Lupi M, Maiolo V, Montrone G, Lovato L, Presutti L, Mattioli F
Laryngoscope 2023 May;133(5):1184-1190. Epub 2022 Aug 6 doi: 10.1002/lary.30335. PMID: 37042776
Cancer-associated fibroblast-like fibroblasts in vocal fold leukoplakia suppress CD8(+)T cell functions by inducing IL-6 autocrine loop and interacting with Th17 cells.
Fang Y, Chen M, Li G, Yang Y, He P, Chen J, Cheng L, Wu H
Cancer Lett 2022 Oct 10;546:215839. Epub 2022 Aug 10 doi: 10.1016/j.canlet.2022.215839. PMID: 35961512
Narrow band imaging in transoral laser microsurgery (TLM) in moderately advanced (T2, T3) glottic cancer.
Piersiala K, Klimza H, Jackowska J, Majewska A, Wierzbicka M
Otolaryngol Pol 2018 Aug 31;72(5):17-23. doi: 10.5604/01.3001.0012.0486. PMID: 30460912
Vocal fold leukoplakia: incidence, management, and prevention.
Parker NP
Curr Opin Otolaryngol Head Neck Surg 2017 Dec;25(6):464-468. doi: 10.1097/MOO.0000000000000406. PMID: 28857841
Transglottic carcinoma.
Mittal B, Marks JE, Ogura JH
Cancer 1984 Jan 1;53(1):151-61. doi: 10.1002/1097-0142(19840101)53:1<151::aid-cncr2820530127>3.0.co;2-x. PMID: 6689996

Recent systematic reviews

Epidemiological, clinical and oncological outcomes of laryngeal verrucous carcinomas: a systematic review.
Lechien JR, Hans S
J Otolaryngol Head Neck Surg 2023 Dec 13;52(1):81. doi: 10.1186/s40463-023-00666-1. PMID: 38093339Free PMC Article
Voice quality after transoral CO(2) laser microsurgery (TOLMS): systematic review of literature.
Colizza A, Ralli M, D'Elia C, Greco A, de Vincentiis M
Eur Arch Otorhinolaryngol 2022 Sep;279(9):4247-4255. Epub 2022 May 3 doi: 10.1007/s00405-022-07418-3. PMID: 35505113Free PMC Article
Early glottic cancer recurrence: A critical review on its current management.
Locatello LG, Bruno C, Gallo O
Crit Rev Oncol Hematol 2021 Apr;160:103298. Epub 2021 Mar 11 doi: 10.1016/j.critrevonc.2021.103298. PMID: 33716199
Standardisation of Target Volume Delineation for Carotid-sparing Intensity-modulated Radiotherapy in Early Glottis Cancer.
Gujral DM, Long M, Roe JW, Harrington KJ, Nutting CM
Clin Oncol (R Coll Radiol) 2017 Jan;29(1):42-50. Epub 2016 Nov 1 doi: 10.1016/j.clon.2016.09.017. PMID: 27815039Free PMC Article
Laryngeal Verrucous Carcinoma.
Echanique KA, Desai SV, Marchiano E, Spinazzi EF, Strojan P, Baredes S, Eloy JA
Otolaryngol Head Neck Surg 2017 Jan;156(1):38-45. Epub 2016 Aug 9 doi: 10.1177/0194599816662631. PMID: 27484231

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