U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Glottis cancer

MedGen UID:
57560
•Concept ID:
C0153483
•
Neoplastic Process
Synonyms: Ca larynx - glottis; cancer of glottis; glottis cancer; Malignant Glottis Neoplasm; malignant glottis neoplasm; Malignant Glottis Tumor; malignant glottis tumor; malignant glottis tumour; Malignant neoplasm of glottis; Malignant Neoplasm of Glottis; malignant neoplasm of glottis; Malignant Neoplasm of the Glottis; malignant neoplasm of the glottis; Malignant tumor of glottis; Malignant Tumor of Glottis; malignant tumor of glottis; Malignant Tumor of the Glottis; malignant tumor of the glottis; malignant tumour of glottis; malignant tumour of the glottis
SNOMED CT: Ca larynx - glottis (187841006); Malignant tumor of glottis (187841006); Malignant neoplasm of glottis (187841006)
 
Monarch Initiative: MONDO:0002351

Definition

A malignant neoplasm that affects the glottic area of the larynx. The vast majority of cases represent squamous cell carcinomas. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGlottis cancer

Professional guidelines

PubMed

Survival study in early stages of glottis cancer, stratified by treatment.
Lois-Ortega Y, García-Curdi F, Vallés-Varela H, Muniesa-Del Campo A
Acta Otolaryngol 2022 Jul-Aug;142(7-8):627-633. Epub 2022 Aug 22 doi: 10.1080/00016489.2022.2110613. PMID: 36131532
Evaluation of treatment outcomes in patients with supraglottic laryngeal cancer in Ontario, Canada: A population-based study.
Hall SF, Griffiths RJ
Head Neck 2018 May;40(5):1024-1033. Epub 2018 Feb 7 doi: 10.1002/hed.25073. PMID: 29412495
Transoral surgery for laryngo-pharyngeal cancer - The paradigm shift of the head and cancer treatment.
Tateya I, Shiotani A, Satou Y, Tomifuji M, Morita S, Muto M, Ito J
Auris Nasus Larynx 2016 Feb;43(1):21-32. Epub 2015 Aug 19 doi: 10.1016/j.anl.2015.06.013. PMID: 26298233

Recent clinical studies

Etiology

Survival study in early stages of glottis cancer, stratified by treatment.
Lois-Ortega Y, García-Curdi F, Vallés-Varela H, Muniesa-Del Campo A
Acta Otolaryngol 2022 Jul-Aug;142(7-8):627-633. Epub 2022 Aug 22 doi: 10.1080/00016489.2022.2110613. PMID: 36131532
Serum expression of Vascular Endothelial-Cadherin, CD44, Human High mobility group B1, Kallikrein 6 proteins in different stages of laryngeal intraepithelial lesions and early glottis cancer.
Żurek M, Rzepakowska A, Kotuła I, Demkow U, Niemczyk K
PeerJ 2022;10:e13104. Epub 2022 Apr 19 doi: 10.7717/peerj.13104. PMID: 35462765Free PMC Article
Perceptual and acoustic voice analysis in patients with glottis cancer after endoscopic laser cordectomy.
Kosztyła-Hojna B, Łuczaj J, Berger G, Duchnowska E, Zdrojkowski M, Łobaczuk-Sitnik A, Biszewska J
Otolaryngol Pol 2020 Feb 5;74(3):23-28. doi: 10.5604/01.3001.0013.7850. PMID: 32398381
Role of Frozen Biopsy in Glottic Premalignant Lesions.
Jin YJ, Jeong WJ, Paik JH, Ahn SH
Pathol Oncol Res 2017 Jul;23(3):519-523. Epub 2016 Nov 5 doi: 10.1007/s12253-016-0143-9. PMID: 27817001
Standardisation of Target Volume Delineation for Carotid-sparing Intensity-modulated Radiotherapy in Early Glottis Cancer.
Gujral DM, Long M, Roe JW, Harrington KJ, Nutting CM
Clin Oncol (R Coll Radiol) 2017 Jan;29(1):42-50. Epub 2016 Nov 1 doi: 10.1016/j.clon.2016.09.017. PMID: 27815039Free PMC Article

Diagnosis

Survival study in early stages of glottis cancer, stratified by treatment.
Lois-Ortega Y, García-Curdi F, Vallés-Varela H, Muniesa-Del Campo A
Acta Otolaryngol 2022 Jul-Aug;142(7-8):627-633. Epub 2022 Aug 22 doi: 10.1080/00016489.2022.2110613. PMID: 36131532
Serum expression of Vascular Endothelial-Cadherin, CD44, Human High mobility group B1, Kallikrein 6 proteins in different stages of laryngeal intraepithelial lesions and early glottis cancer.
Żurek M, Rzepakowska A, Kotuła I, Demkow U, Niemczyk K
PeerJ 2022;10:e13104. Epub 2022 Apr 19 doi: 10.7717/peerj.13104. PMID: 35462765Free PMC Article
Phonatory compensation in patients with larynx cancer after CO2 laser cordectomy.
Kosztyła-Hojna B, Łuczaj J, Berger G, Duchnowska E, Zdrojkowski M, Łobaczuk-Sitnik A, Biszewska J
Otolaryngol Pol 2019 Oct 11;74(2):31-35. doi: 10.5604/01.3001.0013.5260. PMID: 32022703
Role of Frozen Biopsy in Glottic Premalignant Lesions.
Jin YJ, Jeong WJ, Paik JH, Ahn SH
Pathol Oncol Res 2017 Jul;23(3):519-523. Epub 2016 Nov 5 doi: 10.1007/s12253-016-0143-9. PMID: 27817001
Transoral surgery for laryngo-pharyngeal cancer - The paradigm shift of the head and cancer treatment.
Tateya I, Shiotani A, Satou Y, Tomifuji M, Morita S, Muto M, Ito J
Auris Nasus Larynx 2016 Feb;43(1):21-32. Epub 2015 Aug 19 doi: 10.1016/j.anl.2015.06.013. PMID: 26298233

Therapy

Phonatory compensation in patients with larynx cancer after CO2 laser cordectomy.
Kosztyła-Hojna B, Łuczaj J, Berger G, Duchnowska E, Zdrojkowski M, Łobaczuk-Sitnik A, Biszewska J
Otolaryngol Pol 2019 Oct 11;74(2):31-35. doi: 10.5604/01.3001.0013.5260. PMID: 32022703
Early Closure of a Phase 1 Clinical Trial for SABR in Early-Stage Glottic Cancer.
Kang BH, Yu T, Kim JH, Park JM, Kim JI, Chung EJ, Kwon SK, Kim JH, Wu HG
Int J Radiat Oncol Biol Phys 2019 Sep 1;105(1):104-109. Epub 2019 Mar 14 doi: 10.1016/j.ijrobp.2019.03.011. PMID: 30880271
Voice Profile Recovery and Quality of Life Changes After Microdirect Laryngoscopy in Three Categories of Glottis Lesions: Benign, Precancerous, and Malignant.
Rzepakowska A, Sielska-Badurek E, Cruz R, Sobol M, Osuch-Wójcikiewicz E, Niemczyk K
J Voice 2019 May;33(3):382.e11-382.e20. Epub 2017 Dec 1 doi: 10.1016/j.jvoice.2017.10.022. PMID: 29198815
Occupational asbestos exposure and risk of pleural mesothelioma, lung cancer, and laryngeal cancer in the prospective Netherlands cohort study.
Offermans NS, Vermeulen R, Burdorf A, Goldbohm RA, Kauppinen T, Kromhout H, van den Brandt PA
J Occup Environ Med 2014 Jan;56(1):6-19. doi: 10.1097/JOM.0000000000000060. PMID: 24351898
Larynx cancer in Slovakia and the role of anatomical subsites.
Severi G, Plesko I, Robertson C, Obsitnikova A, Boyle P
Oral Oncol 1999 Nov;35(6):564-70. doi: 10.1016/s1368-8375(99)00035-4. PMID: 10705091

Prognosis

Analysis of prognostic factors for Tis-2N0M0 early glottic cancer with different treatment methods.
Wang G, Li G, Wu J, Song P
Braz J Otorhinolaryngol 2022 May-Jun;88(3):375-380. Epub 2020 Aug 6 doi: 10.1016/j.bjorl.2020.06.013. PMID: 32830100Free PMC Article
Occult Lymph Node Metastasis in Early-Stage Glottic Cancer in the National Cancer Database.
Patel TR, Eggerstedt M, Toor J, Tajudeen BA, Husain I, Stenson K, Al-Khudari S
Laryngoscope 2021 Apr;131(4):E1139-E1146. Epub 2020 Aug 18 doi: 10.1002/lary.28995. PMID: 32809243
Perceptual and acoustic voice analysis in patients with glottis cancer after endoscopic laser cordectomy.
Kosztyła-Hojna B, Łuczaj J, Berger G, Duchnowska E, Zdrojkowski M, Łobaczuk-Sitnik A, Biszewska J
Otolaryngol Pol 2020 Feb 5;74(3):23-28. doi: 10.5604/01.3001.0013.7850. PMID: 32398381
Role of Frozen Biopsy in Glottic Premalignant Lesions.
Jin YJ, Jeong WJ, Paik JH, Ahn SH
Pathol Oncol Res 2017 Jul;23(3):519-523. Epub 2016 Nov 5 doi: 10.1007/s12253-016-0143-9. PMID: 27817001
Occupational asbestos exposure and risk of pleural mesothelioma, lung cancer, and laryngeal cancer in the prospective Netherlands cohort study.
Offermans NS, Vermeulen R, Burdorf A, Goldbohm RA, Kauppinen T, Kromhout H, van den Brandt PA
J Occup Environ Med 2014 Jan;56(1):6-19. doi: 10.1097/JOM.0000000000000060. PMID: 24351898

Clinical prediction guides

Occult Lymph Node Metastasis in Early-Stage Glottic Cancer in the National Cancer Database.
Patel TR, Eggerstedt M, Toor J, Tajudeen BA, Husain I, Stenson K, Al-Khudari S
Laryngoscope 2021 Apr;131(4):E1139-E1146. Epub 2020 Aug 18 doi: 10.1002/lary.28995. PMID: 32809243
Role of Frozen Biopsy in Glottic Premalignant Lesions.
Jin YJ, Jeong WJ, Paik JH, Ahn SH
Pathol Oncol Res 2017 Jul;23(3):519-523. Epub 2016 Nov 5 doi: 10.1007/s12253-016-0143-9. PMID: 27817001
Impaired vocal cord mobility in T2N0 glottic carcinoma: Suboptimal local control with Radiation alone.
Bhateja P, Ward MC, Hunter GH, Greskovich JF, Reddy CA, Nwizu TI, Lamarre E, Burkey BB, Adelstein DJ, Koyfman SA
Head Neck 2016 Dec;38(12):1832-1836. Epub 2016 Jun 14 doi: 10.1002/hed.24520. PMID: 27299502
Transoral surgery for laryngo-pharyngeal cancer - The paradigm shift of the head and cancer treatment.
Tateya I, Shiotani A, Satou Y, Tomifuji M, Morita S, Muto M, Ito J
Auris Nasus Larynx 2016 Feb;43(1):21-32. Epub 2015 Aug 19 doi: 10.1016/j.anl.2015.06.013. PMID: 26298233
Epidemiology and clinical characteristics of larynx and hypopharynx carcinoma: a comparative study in the Hainaut and review of the literature.
Dequanter D, Lothaire P, Zouaoui K, Brohée D
Acta Chir Belg 2012 Nov-Dec;112(6):423-5. doi: 10.1080/00015458.2012.11680866. PMID: 23397823

Recent systematic reviews

Standardisation of Target Volume Delineation for Carotid-sparing Intensity-modulated Radiotherapy in Early Glottis Cancer.
Gujral DM, Long M, Roe JW, Harrington KJ, Nutting CM
Clin Oncol (R Coll Radiol) 2017 Jan;29(1):42-50. Epub 2016 Nov 1 doi: 10.1016/j.clon.2016.09.017. PMID: 27815039Free PMC Article
Oncologic outcomes of transoral laser microsurgery for radiorecurrent laryngeal carcinoma: a systematic review and meta-analysis of English-language literature.
Ramakrishnan Y, Drinnan M, Kwong FN, Grant DG, Mehanna H, Jones T, Paleri V
Head Neck 2014 Feb;36(2):280-5. Epub 2013 Jun 14 doi: 10.1002/hed.23291. PMID: 23766141

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...