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Immature ovarian teratoma

MedGen UID:
138044
Concept ID:
C0346182
Neoplastic Process
Synonyms: Grade 2 Ovarian Teratoma; Immature Germ Cell Teratoma of Ovary; immature germ cell teratoma of ovary; Immature Germ Cell Teratoma of the Ovary; immature germ cell teratoma of the ovary; Immature Ovarian Teratoma; immature ovarian teratoma; immature teratoma; Immature Teratoma of Ovary; Immature teratoma of ovary; immature teratoma of ovary; Immature Teratoma of the Ovary; immature teratoma of the ovary; malignant germ cell teratoma of ovary; malignant germ cell teratoma of the ovary; malignant ovarian germ cell teratoma; malignant ovarian teratoma; malignant teratoma of ovary; Malignant teratoma of ovary; malignant teratoma of the ovary; Ovarian Germ Cell Immature Teratoma; ovarian germ cell immature teratoma; Ovarian Immature Germ Cell Teratoma; ovarian immature germ cell teratoma; Ovarian Immature Teratoma; Ovarian immature teratoma; ovarian immature teratoma; Ovarian malignant teratoma; ovarian malignant teratoma; ovary malignant teratoma
Modes of inheritance:
Unknown inheritance
MedGen UID:
989040
Concept ID:
CN307042
Finding
Source: Orphanet
Hereditary clinical entity whose mode of inheritance is unknown.
 
Monarch Initiative: MONDO:0018369
Orphanet: ORPHA398987

Definition

A rare ovarian germ cell tumor characterized by a unilateral large adnexal mass containing variable amounts of immature embryonal-type tissues (mostly in the form of neuroectodermal tubules and rosettes, sometimes with a component of cellular mitotically active glia), admixed with ectodermal and endodermal elements with varying degrees of maturation. Patients typically present in their first three decades of life with signs and symptoms related to mass effect. The tumor is often associated with the occurrence of innumerable miliary nodules of mature glia in the peritoneum (gliomatosis peritonei) and abdominal lymph nodes. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVImmature ovarian teratoma

Professional guidelines

PubMed

Wang D, Zhu S, Jia C, Cao D, Wu M, Shen K, Yang J, Pan L, Cheng N, Xiang Y
Gynecol Oncol 2020 Apr;157(1):94-100. Epub 2020 Jan 15 doi: 10.1016/j.ygyno.2019.12.042. PMID: 31954532
Jorge S, Jones NL, Chen L, Hou JY, Tergas AI, Burke WM, Ananth CV, Neugut AI, Herhshman DL, Wright JD
Gynecol Oncol 2016 Aug;142(2):261-6. Epub 2016 Jun 1 doi: 10.1016/j.ygyno.2016.05.024. PMID: 27222024Free PMC Article
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Recent clinical studies

Etiology

He Z, Lu Y, Xie C
BMC Pregnancy Childbirth 2022 Jun 27;22(1):519. doi: 10.1186/s12884-022-04857-y. PMID: 35761185Free PMC Article
Wang D, Zhu S, Jia C, Cao D, Wu M, Shen K, Yang J, Xiang Y
Int J Gynecol Cancer 2020 May;30(5):664-669. Epub 2020 Mar 15 doi: 10.1136/ijgc-2019-001116. PMID: 32179695
Wang D, Jia CW, Feng RE, Shi HH, Sun J
J Ovarian Res 2016 Jul 29;9(1):45. doi: 10.1186/s13048-016-0256-5. PMID: 27473411Free PMC Article
Fan Q, Huang H, Lian L, Lang J
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Diagnosis

Semiz HS, Sahin H, Unal S, Atici SD, Kose MF, Zeren EH
J Coll Physicians Surg Pak 2022 Dec;32(12):SS122-SS124. doi: 10.29271/jcpsp.2022.Supp0.SS122. PMID: 36597312
Xie S, Jia X, Li T, Xu Y, Wu W, Qiu Y, Yuan S, Peng X, Wang H
Medicine (Baltimore) 2022 Aug 5;101(31):e29727. doi: 10.1097/MD.0000000000029727. PMID: 35945757Free PMC Article
He Z, Lu Y, Xie C
BMC Pregnancy Childbirth 2022 Jun 27;22(1):519. doi: 10.1186/s12884-022-04857-y. PMID: 35761185Free PMC Article
Delangle R, Demeret S, Canlorbe G, Chelon L, Belghiti J, Gonthier C, Nikpayam M, Uzan C, Azaïs H
Arch Gynecol Obstet 2020 Aug;302(2):315-320. Epub 2020 Jun 17 doi: 10.1007/s00404-020-05645-9. PMID: 32556515
Jorge S, Jones NL, Chen L, Hou JY, Tergas AI, Burke WM, Ananth CV, Neugut AI, Herhshman DL, Wright JD
Gynecol Oncol 2016 Aug;142(2):261-6. Epub 2016 Jun 1 doi: 10.1016/j.ygyno.2016.05.024. PMID: 27222024Free PMC Article

Therapy

Dai Y, Zhang J, Ren H, Zhou X, Chen J, Cui L, Lang J, Guan H, Sun D
Am J Obstet Gynecol 2019 Nov;221(5):485.e1-485.e10. Epub 2019 May 22 doi: 10.1016/j.ajog.2019.05.026. PMID: 31128109
White JC, Liu J, Nahar A
J Pediatr Hematol Oncol 2018 Jan;40(1):e61-e63. doi: 10.1097/MPH.0000000000000905. PMID: 28692553
Faure-Conter C, Pashankar F
J Pediatr Hematol Oncol 2017 Oct;39(7):487-489. doi: 10.1097/MPH.0000000000000950. PMID: 28859031
Amsalem H, Nadjari M, Prus D, Hiller N, Benshushan A
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Nielsen SN, Gaffey TA, Malkasian GD Jr
Mayo Clin Proc 1986 Feb;61(2):110-5. doi: 10.1016/s0025-6196(12)65196-9. PMID: 3945108

Prognosis

Semiz HS, Sahin H, Unal S, Atici SD, Kose MF, Zeren EH
J Coll Physicians Surg Pak 2022 Dec;32(12):SS122-SS124. doi: 10.29271/jcpsp.2022.Supp0.SS122. PMID: 36597312
Xie S, Jia X, Li T, Xu Y, Wu W, Qiu Y, Yuan S, Peng X, Wang H
Medicine (Baltimore) 2022 Aug 5;101(31):e29727. doi: 10.1097/MD.0000000000029727. PMID: 35945757Free PMC Article
He Z, Lu Y, Xie C
BMC Pregnancy Childbirth 2022 Jun 27;22(1):519. doi: 10.1186/s12884-022-04857-y. PMID: 35761185Free PMC Article
Delangle R, Demeret S, Canlorbe G, Chelon L, Belghiti J, Gonthier C, Nikpayam M, Uzan C, Azaïs H
Arch Gynecol Obstet 2020 Aug;302(2):315-320. Epub 2020 Jun 17 doi: 10.1007/s00404-020-05645-9. PMID: 32556515
Jorge S, Jones NL, Chen L, Hou JY, Tergas AI, Burke WM, Ananth CV, Neugut AI, Herhshman DL, Wright JD
Gynecol Oncol 2016 Aug;142(2):261-6. Epub 2016 Jun 1 doi: 10.1016/j.ygyno.2016.05.024. PMID: 27222024Free PMC Article

Clinical prediction guides

Małgorzata SŻ, Anna KG, Reszeć J, Krawczuk-Rybak M
J Pediatr Adolesc Gynecol 2021 Dec;34(6):885-889. Epub 2021 Jul 24 doi: 10.1016/j.jpag.2021.07.009. PMID: 34314853
Jorge S, Jones NL, Chen L, Hou JY, Tergas AI, Burke WM, Ananth CV, Neugut AI, Herhshman DL, Wright JD
Gynecol Oncol 2016 Aug;142(2):261-6. Epub 2016 Jun 1 doi: 10.1016/j.ygyno.2016.05.024. PMID: 27222024Free PMC Article
Ikeda K, Tate G, Suzuki T, Mitsuya T
Diagn Cytopathol 2005 Jul;33(1):39-42. doi: 10.1002/dc.20259. PMID: 15945092
Best DH, Butz GM, Moller K, Coleman WB, Thomas DB
Int J Oncol 2004 Jul;25(1):17-25. PMID: 15201985
Roman H, Verspyck E, Sentilhes L, Barau G
Obstet Gynecol 2004 May;103(5 Pt 2):1108-10. doi: 10.1097/01.AOG.0000123244.53438.58. PMID: 15121625

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