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Immature teratoma

MedGen UID:
90798
•Concept ID:
C0334520
•
Neoplastic Process
Synonyms: Immature Teratoma; Immature Teratomas; Malignant Teratoma; Malignant Teratomas; Teratoma, Immature; Teratoma, Malignant; Teratomas, Immature; Teratomas, Malignant
SNOMED CT: Malignant teratoma (189847002); Malignant immature teratoma (827161000); Immature teratoma, malignant (827161000); Embryonal teratoma (1157239001); Malignant teratoblastoma (1157239001); Malignant teratoma (1157239001)
 
Monarch Initiative: MONDO:0024746

Definition

A teratoma characterized by the presence of an extensive component of immature, fetal-type tissues. [from NCI]

Professional guidelines

PubMed

Management strategy for children with ovarian immature teratoma: results from a tertiary pediatric oncology center.
Ahmed G, Khalil SA, Elshafiey M, Abdelfattah N, Eid M, Zakaria AS, Elwakeel M, Elgendy A
World J Surg Oncol 2024 Jul 4;22(1):176. doi: 10.1186/s12957-024-03452-z. PMID: 38965563Free PMC Article
Recent advances in molecular biology and treatment strategies for intracranial germ cell tumors.
Huang X, Zhang R, Mao Y, Zhou LF, Zhang C
World J Pediatr 2016 Aug;12(3):275-282. Epub 2016 Jun 29 doi: 10.1007/s12519-016-0021-2. PMID: 27351562
Management of Ovarian Cancer In Younger Women.
Uma Devi K, Purushotham N, Jayashree N
Rev Recent Clin Trials 2015;10(4):263-9. doi: 10.2174/1574887110666150923112047. PMID: 26411956

Recent clinical studies

Etiology

Prognostic factors for pure ovarian immature teratoma and the role of adjuvant chemotherapy in stage I diseases.
Li S, Zhang X, Zhang T, Yin M, Cao D, Xiang Y, Yang J
Ann Med 2023;55(2):2273984. Epub 2023 Nov 1 doi: 10.1080/07853890.2023.2273984. PMID: 37909181Free PMC Article
Adjuvant and post-surgical treatment in non-epithelial ovarian cancer.
El Helali A, Kwok GST, Tse KY
Best Pract Res Clin Obstet Gynaecol 2022 Jan;78:74-85. Epub 2021 Aug 4 doi: 10.1016/j.bpobgyn.2021.06.001. PMID: 34493450
Germ Cell Tumors of the Female Genital Tract.
Euscher ED
Surg Pathol Clin 2019 Jun;12(2):621-649. doi: 10.1016/j.path.2019.01.005. PMID: 31097117
Persistent grunting respirations after birth.
Rocha GM, Flor-De-Lima FS, Guimaraes HA
Minerva Pediatr 2018 Jun;70(3):217-224. Epub 2016 Sep 8 doi: 10.23736/S0026-4946.16.04490-X. PMID: 27607482
Fourth-ventricular immature teratoma.
Furtado SV, Ghosal N, Rokade VB, Hegde AS
J Clin Neurosci 2011 Feb;18(2):296-8. Epub 2010 Oct 27 doi: 10.1016/j.jocn.2010.03.061. PMID: 21030259

Diagnosis

Prognostic factors for pure ovarian immature teratoma and the role of adjuvant chemotherapy in stage I diseases.
Li S, Zhang X, Zhang T, Yin M, Cao D, Xiang Y, Yang J
Ann Med 2023;55(2):2273984. Epub 2023 Nov 1 doi: 10.1080/07853890.2023.2273984. PMID: 37909181Free PMC Article
Primary immature teratoma of the thigh: a review.
Mavrogenis AF, Agrogiannis G, Toutouzas KG
Eur J Orthop Surg Traumatol 2023 May;33(4):773-778. Epub 2022 Mar 31 doi: 10.1007/s00590-022-03256-5. PMID: 35377080
Adjuvant and post-surgical treatment in non-epithelial ovarian cancer.
El Helali A, Kwok GST, Tse KY
Best Pract Res Clin Obstet Gynaecol 2022 Jan;78:74-85. Epub 2021 Aug 4 doi: 10.1016/j.bpobgyn.2021.06.001. PMID: 34493450
Mediastinal Germ Cell Tumors: A Review and Update on Pathologic, Clinical, and Molecular Features.
El-Zaatari ZM, Ro JY
Adv Anat Pathol 2021 Sep 1;28(5):335-350. doi: 10.1097/PAP.0000000000000304. PMID: 34029275
Germ Cell Tumors of the Female Genital Tract.
Euscher ED
Surg Pathol Clin 2019 Jun;12(2):621-649. doi: 10.1016/j.path.2019.01.005. PMID: 31097117

Therapy

Balancing efficacy with long-term side-effects: can we safely de-escalate therapy for germ cell tumors?
Shamash J, Ng K
Expert Rev Anticancer Ther 2023 Feb;23(2):127-134. Epub 2023 Jan 17 doi: 10.1080/14737140.2023.2162042. PMID: 36648077
Growing Teratoma Syndrome After Chemotherapy For Ovarian Immature Teratoma.
Imran H, Siddiqui AH, Wilson F, Pashankar F
J Pediatr Hematol Oncol 2020 Oct;42(7):e630-e633. doi: 10.1097/MPH.0000000000001525. PMID: 31205224
Recent advances in molecular biology and treatment strategies for intracranial germ cell tumors.
Huang X, Zhang R, Mao Y, Zhou LF, Zhang C
World J Pediatr 2016 Aug;12(3):275-282. Epub 2016 Jun 29 doi: 10.1007/s12519-016-0021-2. PMID: 27351562
Management of Ovarian Cancer In Younger Women.
Uma Devi K, Purushotham N, Jayashree N
Rev Recent Clin Trials 2015;10(4):263-9. doi: 10.2174/1574887110666150923112047. PMID: 26411956
Immature teratoma of ovary--outcome following primary and secondary surgery: study of a single institution cohort.
Reddihalli PV, Subbian A, Umadevi K, Rathod PS, Krishnappa S, Nanaiah SP, Bafna UD
Eur J Obstet Gynecol Reprod Biol 2015 Sep;192:17-21. Epub 2015 Jun 25 doi: 10.1016/j.ejogrb.2015.06.017. PMID: 26142911

Prognosis

Prognostic factors for pure ovarian immature teratoma and the role of adjuvant chemotherapy in stage I diseases.
Li S, Zhang X, Zhang T, Yin M, Cao D, Xiang Y, Yang J
Ann Med 2023;55(2):2273984. Epub 2023 Nov 1 doi: 10.1080/07853890.2023.2273984. PMID: 37909181Free PMC Article
Characterization of immature ovarian teratomas through single-cell transcriptome.
Cao M, Deng Y, Deng Y, Wu J, Yang C, Wang Z, Hou Q, Fu H, Ren Z, Xia X, Li Y, Wang W, Xu H, Liao X, Shu Y
Front Immunol 2023;14:1131814. Epub 2023 Mar 3 doi: 10.3389/fimmu.2023.1131814. PMID: 36936909Free PMC Article
Primary immature teratoma of the thigh: a review.
Mavrogenis AF, Agrogiannis G, Toutouzas KG
Eur J Orthop Surg Traumatol 2023 May;33(4):773-778. Epub 2022 Mar 31 doi: 10.1007/s00590-022-03256-5. PMID: 35377080
Pediatric ovarian immature teratoma: Histological grading and clinical characteristics.
Shinkai T, Masumoto K, Chiba F, Shirane K, Tanaka Y, Aiyoshi T, Sasaki T, Ono K, Gotoh C, Urita Y, Takayasu H, Suzuki R, Sakashita S
J Pediatr Surg 2020 Apr;55(4):707-710. Epub 2019 May 11 doi: 10.1016/j.jpedsurg.2019.04.037. PMID: 31130350
Persistent grunting respirations after birth.
Rocha GM, Flor-De-Lima FS, Guimaraes HA
Minerva Pediatr 2018 Jun;70(3):217-224. Epub 2016 Sep 8 doi: 10.23736/S0026-4946.16.04490-X. PMID: 27607482

Clinical prediction guides

Assessment of Molecular Markers in Pediatric Ovarian Tumors: Romanian Single-Center Experience.
Bîcă O, Ciongradi CI, Benchia D, Sârbu I, Alecsa M, Cristofor AE, Bîcă DE, Lozneanu L
Int J Mol Sci 2024 Jun 19;25(12) doi: 10.3390/ijms25126752. PMID: 38928458Free PMC Article
Primary and Recurrent Growing Teratoma Syndrome in Central Nervous System Nongerminomatous Germ Cell Tumors: Case Series and Review of the Literature.
Tsuyuguchi S, Sugiyama K, Kinoshita Y, Kolakshyapati M, Takayasu T, Usui S, Takano M, Yonezawa U, Taguchi A, Amatya VJ, Takeshima Y, Kurisu K, Yamasaki F
World Neurosurg 2020 Feb;134:e360-e371. Epub 2019 Nov 18 doi: 10.1016/j.wneu.2019.10.074. PMID: 31751614
Ovarian tumors: a survey of selected advances of note during the life of this journal.
Young RH
Hum Pathol 2020 Jan;95:169-206. Epub 2019 Oct 22 doi: 10.1016/j.humpath.2019.09.002. PMID: 31654691
Persistent grunting respirations after birth.
Rocha GM, Flor-De-Lima FS, Guimaraes HA
Minerva Pediatr 2018 Jun;70(3):217-224. Epub 2016 Sep 8 doi: 10.23736/S0026-4946.16.04490-X. PMID: 27607482
Characteristics, treatment and outcomes of women with immature ovarian teratoma, 1998-2012.
Jorge S, Jones NL, Chen L, Hou JY, Tergas AI, Burke WM, Ananth CV, Neugut AI, Herhshman DL, Wright JD
Gynecol Oncol 2016 Aug;142(2):261-6. Epub 2016 Jun 1 doi: 10.1016/j.ygyno.2016.05.024. PMID: 27222024Free PMC Article

Recent systematic reviews

Extragonadal teratomas in women and adolescent girls: A systematic review.
Kanneganti A, Bhadiraju P, Tong PSY
Eur J Obstet Gynecol Reprod Biol 2021 Jul;262:134-141. Epub 2021 May 7 doi: 10.1016/j.ejogrb.2021.05.005. PMID: 34022590
Fetal intracranial immature teratoma: presentation of a case and a systematic review of the literature.
Robles Fradejas M, Gonzalo García I, De Las Casas Quispe AC, Martin García A, García Higuera MI, Rodriguez Minguélez M, Martínez-Guisasola J
J Matern Fetal Neonatal Med 2017 May;30(10):1139-1146. Epub 2016 Jul 11 doi: 10.1080/14767058.2016.1205029. PMID: 27334556

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