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Absent hippocampal commissure

MedGen UID:
1380796
•Concept ID:
C4479643
•
Finding
Synonym: Agenesis of the hippocampal commissure
 
HPO: HP:0033646

Definition

Absence of the fibers that connect the contralateral hippocampi via the crura of the fornix and run beneath the posterior portion of the corpus callosum. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbsent hippocampal commissure

Conditions with this feature

Gaze palsy, familial horizontal, with progressive scoliosis, 2
MedGen UID:
1393733
•Concept ID:
C4479640
•
Disease or Syndrome
See: Condition Record
Gaze palsy, familial horizontal, with progressive scoliosis, 2

Recent clinical studies

Etiology

Opposing effects of thyroid hormones on hypothalamic subunits and limbic structures in hyperthyroidism patients: A comprehensive volumetric study.
Genç B, Aslan K, Avcı U, İncesu L, Günbey HP
J Neuroendocrinol 2024 Mar;36(3):e13369. Epub 2024 Feb 7 doi: 10.1111/jne.13369. PMID: 38326952
Characterization of white matter alterations using diffusion kurtosis imaging in patients with amyotrophic lateral sclerosis.
Anand T, Ishaque A, Ta D, Khan MU, Bharti K, Wu A, Krebs D, Beaulieu C, Seres P, Kalra S
Brain Behav 2023 Jul;13(7):e3102. Epub 2023 Jun 6 doi: 10.1002/brb3.3102. PMID: 37279166Free PMC Article
Age specificity in fornix-to-hippocampus association.
Gazes Y, Li P, Sun E, Razlighi Q, Tsapanou A
Brain Imaging Behav 2019 Oct;13(5):1444-1452. doi: 10.1007/s11682-018-9958-1. PMID: 30187206Free PMC Article
Pupillary responses and memory-guided visual search reveal age-related and Alzheimer's-related memory decline.
Dragan MC, Leonard TK, Lozano AM, McAndrews MP, Ng K, Ryan JD, Tang-Wai DF, Wynn JS, Hoffman KL
Behav Brain Res 2017 Mar 30;322(Pt B):351-361. Epub 2016 Sep 9 doi: 10.1016/j.bbr.2016.09.014. PMID: 27616343
The hippocampal commissure: a new finding at prenatal 3D ultrasound in fetuses with isolated complete agenesis of the corpus callosum.
Contro E, Nanni M, Bellussi F, Salsi G, Grisolia G, Sanz-Cortès M, Righini A, Rizzo N, Pilu G, Ghi T
Prenat Diagn 2015 Sep;35(9):919-22. Epub 2015 Jul 16 doi: 10.1002/pd.4645. PMID: 26126648

Diagnosis

Opposing effects of thyroid hormones on hypothalamic subunits and limbic structures in hyperthyroidism patients: A comprehensive volumetric study.
Genç B, Aslan K, Avcı U, İncesu L, Günbey HP
J Neuroendocrinol 2024 Mar;36(3):e13369. Epub 2024 Feb 7 doi: 10.1111/jne.13369. PMID: 38326952
Characterization of Vps13b-mutant mice reveals neuroanatomical and behavioral phenotypes with females less affected.
Montillot C, Skutunova E, Ayushma, Dubied M, Lahmar A, Nguyen S, Peerally B, Prin F, Duffourd Y, Thauvin-Robinet C, Duplomb L, Wang H, Ansar M, Faivre L, Navarro N, Minocha S, Collins SC, Yalcin B
Neurobiol Dis 2023 Sep;185:106259. Epub 2023 Aug 12 doi: 10.1016/j.nbd.2023.106259. PMID: 37573958
White-matter commissures: a clinically focused anatomical review.
Lavrador JP, Ferreira V, Lourenço M, Alexandre I, Rocha M, Oliveira E, Kailaya-Vasan A, Neto L
Surg Radiol Anat 2019 Jun;41(6):613-624. Epub 2019 May 22 doi: 10.1007/s00276-019-02218-7. PMID: 31119409
Age specificity in fornix-to-hippocampus association.
Gazes Y, Li P, Sun E, Razlighi Q, Tsapanou A
Brain Imaging Behav 2019 Oct;13(5):1444-1452. doi: 10.1007/s11682-018-9958-1. PMID: 30187206Free PMC Article
Pupillary responses and memory-guided visual search reveal age-related and Alzheimer's-related memory decline.
Dragan MC, Leonard TK, Lozano AM, McAndrews MP, Ng K, Ryan JD, Tang-Wai DF, Wynn JS, Hoffman KL
Behav Brain Res 2017 Mar 30;322(Pt B):351-361. Epub 2016 Sep 9 doi: 10.1016/j.bbr.2016.09.014. PMID: 27616343

Therapy

Semilobar holoprosencephaly with midline 'seam': a topologic and morphogenetic model based upon MRI analysis.
Takahashi T, Kinsman S, Makris N, Grant E, Haselgrove C, McInerney S, Kennedy DN, Takahashi T, Fredrickson K, Mori S, Caviness VS
Cereb Cortex 2003 Dec;13(12):1299-312. doi: 10.1093/cercor/bhg077. PMID: 14615296

Prognosis

Age specificity in fornix-to-hippocampus association.
Gazes Y, Li P, Sun E, Razlighi Q, Tsapanou A
Brain Imaging Behav 2019 Oct;13(5):1444-1452. doi: 10.1007/s11682-018-9958-1. PMID: 30187206Free PMC Article
The hippocampal commissure: a new finding at prenatal 3D ultrasound in fetuses with isolated complete agenesis of the corpus callosum.
Contro E, Nanni M, Bellussi F, Salsi G, Grisolia G, Sanz-Cortès M, Righini A, Rizzo N, Pilu G, Ghi T
Prenat Diagn 2015 Sep;35(9):919-22. Epub 2015 Jul 16 doi: 10.1002/pd.4645. PMID: 26126648

Clinical prediction guides

Opposing effects of thyroid hormones on hypothalamic subunits and limbic structures in hyperthyroidism patients: A comprehensive volumetric study.
Genç B, Aslan K, Avcı U, İncesu L, Günbey HP
J Neuroendocrinol 2024 Mar;36(3):e13369. Epub 2024 Feb 7 doi: 10.1111/jne.13369. PMID: 38326952
Age specificity in fornix-to-hippocampus association.
Gazes Y, Li P, Sun E, Razlighi Q, Tsapanou A
Brain Imaging Behav 2019 Oct;13(5):1444-1452. doi: 10.1007/s11682-018-9958-1. PMID: 30187206Free PMC Article
Pupillary responses and memory-guided visual search reveal age-related and Alzheimer's-related memory decline.
Dragan MC, Leonard TK, Lozano AM, McAndrews MP, Ng K, Ryan JD, Tang-Wai DF, Wynn JS, Hoffman KL
Behav Brain Res 2017 Mar 30;322(Pt B):351-361. Epub 2016 Sep 9 doi: 10.1016/j.bbr.2016.09.014. PMID: 27616343
The hippocampal commissure: a new finding at prenatal 3D ultrasound in fetuses with isolated complete agenesis of the corpus callosum.
Contro E, Nanni M, Bellussi F, Salsi G, Grisolia G, Sanz-Cortès M, Righini A, Rizzo N, Pilu G, Ghi T
Prenat Diagn 2015 Sep;35(9):919-22. Epub 2015 Jul 16 doi: 10.1002/pd.4645. PMID: 26126648
Complex sensory cross integration deficits in a case of corpus callosum agenesis with bilateral language representation: positron-emission-tomography and neuropsychological findings.
Kessler J, Huber M, Pawlik G, Heiss WD, Markowitsch HJ
Int J Neurosci 1991 Jun;58(3-4):275-82. doi: 10.3109/00207459108985443. PMID: 1365050

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