U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Trichoepithelioma

MedGen UID:
138112
Concept ID:
C0349658
Neoplastic Process
Synonym: Trichoblastoma
SNOMED CT: Trichoblastoma (878881002); Brooke's tumor (274898000); Epithelioma adenoides cysticum (274898000); Trichoepithelioma (274898000); Trichoblastoma (277942005); Trichoepithelioma (59186007); Brooke's tumor (59186007); Epithelioma adenoides cysticum (59186007)
 
HPO: HP:0025367
Monarch Initiative: MONDO:0020593

Definition

A benign hair follicle tumor whose tumor cells form rudimentary hair follicles but not actual hair shafts. A trichoepithelioma is usually less than one centimeter, firm, round, and shihy with yellow, pink, brown, or bluish color. They may occur multiply, usually on the face, and may gradually increase in number with age. [from HPO]

Conditions with this feature

Follicular atrophoderma and basal cell epitheliomata
MedGen UID:
87539
Concept ID:
C0346104
Neoplastic Process
Bazex-Dupre-Christol syndrome (BDCS) is an X-linked dominant disorder characterized by a triad of congenital hypotrichosis, follicular atrophoderma affecting the dorsa of the hands and feet, the face, and extensor surfaces of the elbows or knees, and the development of basal cell neoplasms, including basal cell nevi and basal cell carcinomas from the second decade onward (Yung and Newton-Bishop, 2005). Rombo syndrome (180730) has similar features, but shows autosomal dominant inheritance.

Professional guidelines

PubMed

Lobo Y, Blake T, Wheller L
Australas J Dermatol 2021 May;62(2):e192-e200. Epub 2021 Jan 5 doi: 10.1111/ajd.13537. PMID: 33403677
Kneitz H, Fetzer S, Goebeler M, Bröcker EB
J Dtsch Dermatol Ges 2018 Jun;16(6):719-728. doi: 10.1111/ddg.13547. PMID: 29873924
Nagy N, Farkas K, Kemény L, Széll M
Eur J Med Genet 2015 May;58(5):271-8. Epub 2015 Mar 14 doi: 10.1016/j.ejmg.2015.02.010. PMID: 25782638

Recent clinical studies

Etiology

Mohanty SK, Sardana R, McFall M, Pradhan D, Usmani A, Jha S, Mishra SK, Sampat NY, Lobo A, Wu JM, Balzer BL, Frishberg DP
Appl Immunohistochem Mol Morphol 2022 Apr 1;30(4):273-277. doi: 10.1097/PAI.0000000000001002. PMID: 35384877
Díaz-Flores L, Gutiérrez R, García MP, González-Gómez M, Rodríguez-Rodriguez R, Hernández-León N, Díaz-Flores L Jr, Carrasco JL
Int J Mol Sci 2021 Jul 8;22(14) doi: 10.3390/ijms22147342. PMID: 34298962Free PMC Article
Aslam A
Curr Treat Options Oncol 2017 Aug;18(8):49. doi: 10.1007/s11864-017-0491-z. PMID: 28681209
Mamelak AJ, Goldberg LH, Katz TM, Graves JJ, Arnon O, Kimyai-Asadi A
J Am Acad Dermatol 2010 Jan;62(1):102-106. doi: 10.1016/j.jaad.2009.06.066. PMID: 20082889
Inalöz HS, Chowdhury MM, Knight AG
J Eur Acad Dermatol Venereol 2001 Sep;15(5):481-3. doi: 10.1046/j.1468-3083.2001.00302.x. PMID: 11763398

Diagnosis

Fiegen AP, Tjarks BJ, Jassim AD
S D Med 2018 Apr;71(4):164-166. PMID: 29996033
Karimzadeh I, Namazi MR, Karimzadeh A
Acta Dermatovenerol Croat 2018 Jun;26(2):162-165. PMID: 29989874
Stanoszek LM, Wang GY, Harms PW
Arch Pathol Lab Med 2017 Nov;141(11):1490-1502. doi: 10.5858/arpa.2017-0222-RA. PMID: 29072946
Gordon S, Fischer C, Martin A, Rosman IS, Council ML
Dermatol Surg 2017 Aug;43(8):1012-1016. doi: 10.1097/DSS.0000000000001142. PMID: 28654578
Johnson H, Robles M, Kamino H, Walters RF, Lee A, Sanchez M
Dermatol Online J 2008 Oct 15;14(10):5. PMID: 19061604

Therapy

Lan X, Guo G, Wang X, Yan Q, Xue R, Li Y, Zhu J, Dong Z, Wang F, Li G, Wang X, Xu J, Jiang Y
Skin Res Technol 2024 Jan;30(1):e13571. doi: 10.1111/srt.13571. PMID: 38196164Free PMC Article
Lobo Y, Blake T, Wheller L
Australas J Dermatol 2021 May;62(2):e192-e200. Epub 2021 Jan 5 doi: 10.1111/ajd.13537. PMID: 33403677
Xian J, Huang X, Li Q, Peng X, Peng X
BMC Infect Dis 2019 Aug 9;19(1):707. doi: 10.1186/s12879-019-4351-2. PMID: 31399065Free PMC Article
Layegh P, Sharifi-Sistani N, Abadian M, Moghiman T
Indian J Dermatol Venereol Leprol 2008 Nov-Dec;74(6):632-4. doi: 10.4103/0378-6323.45109. PMID: 19171990
Matt D, Xin H, Vortmeyer AO, Zhuang Z, Burg G, Böni R
Arch Dermatol 2000 May;136(5):657-60. doi: 10.1001/archderm.136.5.657. PMID: 10815860

Prognosis

Mehta A, Davey J, Wiedemeyer K, Brenn T
Histopathology 2021 Jun;78(7):970-975. Epub 2021 Apr 6 doi: 10.1111/his.14325. PMID: 33393120
Kang KJ, Seo BF, Shin J, Kwon H, Byeon JH, Jung SN
J Craniofac Surg 2019 May/Jun;30(3):e197-e199. doi: 10.1097/SCS.0000000000005089. PMID: 30394977
Aslam A
Curr Treat Options Oncol 2017 Aug;18(8):49. doi: 10.1007/s11864-017-0491-z. PMID: 28681209
Gordon S, Fischer C, Martin A, Rosman IS, Council ML
Dermatol Surg 2017 Aug;43(8):1012-1016. doi: 10.1097/DSS.0000000000001142. PMID: 28654578
Carter JJ, Kaur MR, Hargitai B, Brown R, Slator R, Abdullah A
Clin Exp Dermatol 2007 Sep;32(5):522-4. Epub 2007 Apr 24 doi: 10.1111/j.1365-2230.2007.02431.x. PMID: 17459070

Clinical prediction guides

Mohanty SK, Sardana R, McFall M, Pradhan D, Usmani A, Jha S, Mishra SK, Sampat NY, Lobo A, Wu JM, Balzer BL, Frishberg DP
Appl Immunohistochem Mol Morphol 2022 Apr 1;30(4):273-277. doi: 10.1097/PAI.0000000000001002. PMID: 35384877
Baykal C, Atcı T, Yılmaz Z, Büyükbabani N
J Cutan Pathol 2021 Jul;48(7):884-895. Epub 2021 Mar 9 doi: 10.1111/cup.13979. PMID: 33569789
Kang KJ, Seo BF, Shin J, Kwon H, Byeon JH, Jung SN
J Craniofac Surg 2019 May/Jun;30(3):e197-e199. doi: 10.1097/SCS.0000000000005089. PMID: 30394977
Nagy N, Farkas K, Kemény L, Széll M
Eur J Med Genet 2015 May;58(5):271-8. Epub 2015 Mar 14 doi: 10.1016/j.ejmg.2015.02.010. PMID: 25782638
Jemec B, Løvgreen Nielsen P, Jemec GB, Balsev E
Dermatol Online J 1999 May;5(1):1. PMID: 10673444

Recent systematic reviews

Lobo Y, Blake T, Wheller L
Australas J Dermatol 2021 May;62(2):e192-e200. Epub 2021 Jan 5 doi: 10.1111/ajd.13537. PMID: 33403677

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...