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DNA Fragmentation

MedGen UID:
138244
Concept ID:
C0376669
Molecular Function
Synonym: Fragmentation, DNA

Definition

A process that results in the breaking of macromolecular DNA into small pieces. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDNA Fragmentation

Professional guidelines

PubMed

Andrabi SW, Ara A, Saharan A, Jaffar M, Gugnani N, Esteves SC
JBRA Assist Reprod 2024 Jun 1;28(2):306-319. doi: 10.5935/1518-0557.20230076. PMID: 38289201Free PMC Article
Leisegang K, Sengupta P, Agarwal A, Henkel R
Andrologia 2021 Feb;53(1):e13617. Epub 2020 May 12 doi: 10.1111/and.13617. PMID: 32399992
Coughlan C, Ledger W, Wang Q, Liu F, Demirol A, Gurgan T, Cutting R, Ong K, Sallam H, Li TC
Reprod Biomed Online 2014 Jan;28(1):14-38. Epub 2013 Sep 14 doi: 10.1016/j.rbmo.2013.08.011. PMID: 24269084

Recent clinical studies

Etiology

Szabó A, Váncsa S, Hegyi P, Váradi A, Forintos A, Filipov T, Ács J, Ács N, Szarvas T, Nyirády P, Kopa Z
Reprod Biol Endocrinol 2023 Jan 18;21(1):5. doi: 10.1186/s12958-023-01054-0. PMID: 36653793Free PMC Article
Aitken RJ, Lewis SEM
Andrology 2023 Nov;11(8):1545-1557. Epub 2023 Jan 16 doi: 10.1111/andr.13375. PMID: 36604857
Alshiraihi I, Kato TA
Methods Mol Biol 2023;2519:53-63. doi: 10.1007/978-1-0716-2433-3_6. PMID: 36066709
Esteves SC, Zini A, Coward RM, Evenson DP, Gosálvez J, Lewis SEM, Sharma R, Humaidan P
Andrologia 2021 Mar;53(2):e13874. Epub 2020 Oct 27 doi: 10.1111/and.13874. PMID: 33108829Free PMC Article
Agarwal A, Cho CL, Esteves SC
Curr Opin Obstet Gynecol 2016 Jun;28(3):164-71. doi: 10.1097/GCO.0000000000000271. PMID: 27054510

Diagnosis

Moore CL, Savenka AV, Basnakian AG
Int J Mol Sci 2021 Jan 2;22(1) doi: 10.3390/ijms22010412. PMID: 33401733Free PMC Article
Esteves SC, Zini A, Coward RM, Evenson DP, Gosálvez J, Lewis SEM, Sharma R, Humaidan P
Andrologia 2021 Mar;53(2):e13874. Epub 2020 Oct 27 doi: 10.1111/and.13874. PMID: 33108829Free PMC Article
Sharma R, Iovine C, Agarwal A, Henkel R
Andrologia 2021 Mar;53(2):e13738. Epub 2020 Jul 24 doi: 10.1111/and.13738. PMID: 32706440
Softness KA, Trussler JT, Carrasquillo RJ
Curr Opin Urol 2020 May;30(3):290-295. doi: 10.1097/MOU.0000000000000761. PMID: 32235275
Cannarella R, Condorelli RA, Mongioì LM, La Vignera S, Calogero AE
Int J Mol Sci 2020 Mar 3;21(5) doi: 10.3390/ijms21051728. PMID: 32138324Free PMC Article

Therapy

An Y, Zhao X, Zhang Z, Xia Z, Yang M, Ma L, Zhao Y, Xu G, Du S, Wu X, Zhang S, Hong X, Jin X, Sun K
Nat Commun 2023 Jan 18;14(1):287. doi: 10.1038/s41467-023-35959-6. PMID: 36653380Free PMC Article
Banks N, Sun F, Krawetz SA, Coward RM, Masson P, Smith JF, Trussell JC, Santoro N, Zhang H, Steiner AZ
Fertil Steril 2021 Oct;116(4):973-979. Epub 2021 Jul 18 doi: 10.1016/j.fertnstert.2021.06.035. PMID: 34289935Free PMC Article
Steiner AZ, Hansen KR, Barnhart KT, Cedars MI, Legro RS, Diamond MP, Krawetz SA, Usadi R, Baker VL, Coward RM, Huang H, Wild R, Masson P, Smith JF, Santoro N, Eisenberg E, Zhang H; Reproductive Medicine Network
Fertil Steril 2020 Mar;113(3):552-560.e3. Epub 2020 Feb 25 doi: 10.1016/j.fertnstert.2019.11.008. PMID: 32111479Free PMC Article
Schisterman EF, Sjaarda LA, Clemons T, Carrell DT, Perkins NJ, Johnstone E, Lamb D, Chaney K, Van Voorhis BJ, Ryan G, Summers K, Hotaling J, Robins J, Mills JL, Mendola P, Chen Z, DeVilbiss EA, Peterson CM, Mumford SL
JAMA 2020 Jan 7;323(1):35-48. doi: 10.1001/jama.2019.18714. PMID: 31910279Free PMC Article
Sanford M, Lyseng-Williamson KA
Drugs 2008;68(4):439-47. doi: 10.2165/00003495-200868040-00004. PMID: 18318562

Prognosis

Schlegel PN
Fertil Steril 2023 Oct;120(4):707-708. Epub 2023 Aug 11 doi: 10.1016/j.fertnstert.2023.08.007. PMID: 37573998
Szabó A, Váncsa S, Hegyi P, Váradi A, Forintos A, Filipov T, Ács J, Ács N, Szarvas T, Nyirády P, Kopa Z
Reprod Biol Endocrinol 2023 Jan 18;21(1):5. doi: 10.1186/s12958-023-01054-0. PMID: 36653793Free PMC Article
Esfahani MS, Hamilton EG, Mehrmohamadi M, Nabet BY, Alig SK, King DA, Steen CB, Macaulay CW, Schultz A, Nesselbush MC, Soo J, Schroers-Martin JG, Chen B, Binkley MS, Stehr H, Chabon JJ, Sworder BJ, Hui AB, Frank MJ, Moding EJ, Liu CL, Newman AM, Isbell JM, Rudin CM, Li BT, Kurtz DM, Diehn M, Alizadeh AA
Nat Biotechnol 2022 Apr;40(4):585-597. Epub 2022 Mar 31 doi: 10.1038/s41587-022-01222-4. PMID: 35361996Free PMC Article
Lewis SE
Adv Exp Med Biol 2014;791:103-16. doi: 10.1007/978-1-4614-7783-9_7. PMID: 23955675
Shafik A, Shafik AA, Shafik I, El Sibai O
Arch Androl 2006 May-Jun;52(3):197-208. doi: 10.1080/01485010500503561. PMID: 16574602

Clinical prediction guides

Zhu D, Wang H, Wu W, Geng S, Zhong G, Li Y, Guo H, Long G, Ren Q, Luan Y, Duan C, Wei B, Ma J, Li S, Zhou J, Mao M
BMC Biol 2023 Nov 13;21(1):253. doi: 10.1186/s12915-023-01752-6. PMID: 37953260Free PMC Article
Schlegel PN
Fertil Steril 2023 Oct;120(4):707-708. Epub 2023 Aug 11 doi: 10.1016/j.fertnstert.2023.08.007. PMID: 37573998
Noy L, Barnea I, Mirsky SK, Kamber D, Levi M, Shaked NT
Cytometry A 2023 Jun;103(6):470-478. Epub 2022 Nov 23 doi: 10.1002/cyto.a.24703. PMID: 36333835
Karavolos S
Semin Reprod Med 2021 Nov;39(5-06):194-199. Epub 2021 Oct 18 doi: 10.1055/s-0041-1736261. PMID: 34662912
Oehninger S, Ombelet W
Fertil Steril 2019 May;111(5):835-841. Epub 2019 Apr 8 doi: 10.1016/j.fertnstert.2019.03.005. PMID: 30975387

Recent systematic reviews

Szabó A, Váncsa S, Hegyi P, Váradi A, Forintos A, Filipov T, Ács J, Ács N, Szarvas T, Nyirády P, Kopa Z
Reprod Biol Endocrinol 2023 Jan 18;21(1):5. doi: 10.1186/s12958-023-01054-0. PMID: 36653793Free PMC Article
Farahani L, Tharakan T, Yap T, Ramsay JW, Jayasena CN, Minhas S
Andrology 2021 Jan;9(1):115-144. Epub 2020 Oct 7 doi: 10.1111/andr.12886. PMID: 32794312
Simon L, Emery B, Carrell DT
Adv Exp Med Biol 2019;1166:87-105. doi: 10.1007/978-3-030-21664-1_6. PMID: 31301048
Beyfuss K, Hood DA
Redox Rep 2018 Dec;23(1):100-117. Epub 2018 Jan 3 doi: 10.1080/13510002.2017.1416773. PMID: 29298131Free PMC Article
Lafuente R, García-Blàquez N, Jacquemin B, Checa MA
Fertil Steril 2016 Sep 15;106(4):880-96. Epub 2016 Aug 24 doi: 10.1016/j.fertnstert.2016.08.022. PMID: 27565259

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