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DNA damage

MedGen UID:
3880
Concept ID:
C0012860
Cell or Molecular Dysfunction
Synonyms: Damage, DNA; Damages, DNA; DNA Damage; DNA Damages; DNA Injuries; DNA Injury; Injuries, DNA; Injury, DNA
SNOMED CT: DNA damage (68349007); DNA injury (68349007); Deoxyribonucleic acid damage (68349007)

Definition

Drug-, radiation-induced, or spontaneous injuries to DNA that introduce deviations from its normal double-helical conformation. These changes include structural distortions that interfere with replication and transcription, as well as point mutations that disrupt base pairs and exert damaging effects on future generations through changes in DNA sequence. If the damage is minor, it can often be repaired (DNA repair); extensive damage can induce apoptosis. [from NCI]

Professional guidelines

PubMed

Carusillo A, Mussolino C
Cells 2020 Jul 10;9(7) doi: 10.3390/cells9071665. PMID: 32664329Free PMC Article
Slade D
Genes Dev 2020 Mar 1;34(5-6):360-394. Epub 2020 Feb 6 doi: 10.1101/gad.334516.119. PMID: 32029455Free PMC Article
Lheureux S, Braunstein M, Oza AM
CA Cancer J Clin 2019 Jul;69(4):280-304. Epub 2019 May 17 doi: 10.3322/caac.21559. PMID: 31099893

Recent clinical studies

Etiology

Chen ACH, Peng Q, Fong SW, Lee KC, Yeung WSB, Lee YL
Genes (Basel) 2021 Sep 29;12(10) doi: 10.3390/genes12101548. PMID: 34680943Free PMC Article
Yousefzadeh M, Henpita C, Vyas R, Soto-Palma C, Robbins P, Niedernhofer L
Elife 2021 Jan 29;10 doi: 10.7554/eLife.62852. PMID: 33512317Free PMC Article
Patel J, Baptiste BA, Kim E, Hussain M, Croteau DL, Bohr VA
Carcinogenesis 2020 Dec 31;41(12):1625-1634. doi: 10.1093/carcin/bgaa114. PMID: 33146705Free PMC Article
Wang Y, Luo W, Wang Y
DNA Repair (Amst) 2019 Sep;81:102651. Epub 2019 Jul 8 doi: 10.1016/j.dnarep.2019.102651. PMID: 31302005Free PMC Article
Srinivas US, Tan BWQ, Vellayappan BA, Jeyasekharan AD
Redox Biol 2019 Jul;25:101084. Epub 2018 Dec 21 doi: 10.1016/j.redox.2018.101084. PMID: 30612957Free PMC Article

Diagnosis

Zhang Y, Zhang W, Wu X, Liu G, Dai Y, Jiang H, Zhang X
Andrologia 2022 Feb;54(1):e14275. Epub 2021 Oct 17 doi: 10.1111/and.14275. PMID: 34658054
Mancini M, Magnani E, Macchi F, Bonapace IM
Nucleic Acids Res 2021 Jun 21;49(11):6053-6068. doi: 10.1093/nar/gkab293. PMID: 33939809Free PMC Article
Sunada S, Saito H, Zhang D, Xu Z, Miki Y
Biochem Biophys Res Commun 2021 Apr 23;550:56-61. Epub 2021 Mar 5 doi: 10.1016/j.bbrc.2021.02.117. PMID: 33684621
Goldstein M, Kastan MB
Annu Rev Med 2015;66:129-43. Epub 2014 Nov 24 doi: 10.1146/annurev-med-081313-121208. PMID: 25423595
Sharma A, Singh K, Almasan A
Methods Mol Biol 2012;920:613-26. doi: 10.1007/978-1-61779-998-3_40. PMID: 22941631

Therapy

Ettrich TJ, Seufferlein T
Curr Treat Options Oncol 2021 Oct 19;22(11):106. doi: 10.1007/s11864-021-00895-4. PMID: 34665339Free PMC Article
Coryell PR, Diekman BO, Loeser RF
Nat Rev Rheumatol 2021 Jan;17(1):47-57. Epub 2020 Nov 18 doi: 10.1038/s41584-020-00533-7. PMID: 33208917Free PMC Article
Wen PY, Weller M, Lee EQ, Alexander BM, Barnholtz-Sloan JS, Barthel FP, Batchelor TT, Bindra RS, Chang SM, Chiocca EA, Cloughesy TF, DeGroot JF, Galanis E, Gilbert MR, Hegi ME, Horbinski C, Huang RY, Lassman AB, Le Rhun E, Lim M, Mehta MP, Mellinghoff IK, Minniti G, Nathanson D, Platten M, Preusser M, Roth P, Sanson M, Schiff D, Short SC, Taphoorn MJB, Tonn JC, Tsang J, Verhaak RGW, von Deimling A, Wick W, Zadeh G, Reardon DA, Aldape KD, van den Bent MJ
Neuro Oncol 2020 Aug 17;22(8):1073-1113. doi: 10.1093/neuonc/noaa106. PMID: 32328653Free PMC Article
Lord CJ, Ashworth A
Science 2017 Mar 17;355(6330):1152-1158. Epub 2017 Mar 16 doi: 10.1126/science.aam7344. PMID: 28302823Free PMC Article
Dreher ML, Davenport AJ
Crit Rev Food Sci Nutr 2013;53(7):738-50. doi: 10.1080/10408398.2011.556759. PMID: 23638933Free PMC Article

Prognosis

Schmitt M, Ceteci F, Gupta J, Pesic M, Böttger TW, Nicolas AM, Kennel KB, Engel E, Schewe M, Callak Kirisözü A, Petrocelli V, Dabiri Y, Varga J, Ramakrishnan M, Karimova M, Ablasser A, Sato T, Arkan MC, de Sauvage FJ, Greten FR
Nature 2022 Dec;612(7939):347-353. Epub 2022 Nov 16 doi: 10.1038/s41586-022-05426-1. PMID: 36385525Free PMC Article
Rossi A, Orecchioni S, Falvo P, Tabanelli V, Baiardi E, Agostinelli C, Melle F, Motta G, Calleri A, Fiori S, Corsini C, Casadei B, Mazzara S, Vitolo U, Bertolini F, Zinzani PL, Alcalay M, Pelicci PG, Pileri S, Tarella C, Derenzini E
Leukemia 2022 Jan;36(1):197-209. Epub 2021 Jul 24 doi: 10.1038/s41375-021-01347-6. PMID: 34304248Free PMC Article
Zhu Y, Mo M, Wei Y, Wu J, Pan J, Freedland SJ, Zheng Y, Ye D
Nat Rev Urol 2021 May;18(5):282-301. Epub 2021 Mar 10 doi: 10.1038/s41585-021-00442-8. PMID: 33692499
Huan L, Guo T, Wu Y, Xu L, Huang S, Xu Y, Liang L, He X
Mol Cancer 2020 Jan 21;19(1):11. doi: 10.1186/s12943-019-1122-z. PMID: 31964396Free PMC Article
Narayanan DL, Saladi RN, Fox JL
Int J Dermatol 2010 Sep;49(9):978-86. doi: 10.1111/j.1365-4632.2010.04474.x. PMID: 20883261

Clinical prediction guides

Tian Y, Xiao H, Yang Y, Zhang P, Yuan J, Zhang W, Chen L, Fan Y, Zhang J, Cheng H, Deng T, Yang L, Wang W, Chen G, Wang P, Gong P, Niu X, Zhang X
Mol Cancer 2023 Jan 10;22(1):5. doi: 10.1186/s12943-022-01706-6. PMID: 36627693Free PMC Article
Yu Y, Liu T, Yu G, Wang H, Du Z, Chen Y, Yang N, Cao K, Liu C, Wan Z, Shen H, Gao F, Yang Y, Zhang W
Cell Death Dis 2022 Nov 19;13(11):978. doi: 10.1038/s41419-022-05402-7. PMID: 36402747Free PMC Article
Chen M, Huang B, Zhu L, Wang Q, Pang Y, Cheng M, Lian H, Liu M, Zhao K, Xu S, Zhang J, Zhong C
Front Immunol 2022;13:875648. Epub 2022 May 26 doi: 10.3389/fimmu.2022.875648. PMID: 35720326Free PMC Article
Dancsok AR, Gao D, Lee AF, Steigen SE, Blay JY, Thomas DM, Maki RG, Nielsen TO, Demicco EG
Oncoimmunology 2020;9(1):1747340. Epub 2020 Apr 12 doi: 10.1080/2162402X.2020.1747340. PMID: 32313727Free PMC Article
Paschalis A, Sheehan B, Riisnaes R, Rodrigues DN, Gurel B, Bertan C, Ferreira A, Lambros MBK, Seed G, Yuan W, Dolling D, Welti JC, Neeb A, Sumanasuriya S, Rescigno P, Bianchini D, Tunariu N, Carreira S, Sharp A, Oyen W, de Bono JS
Eur Urol 2019 Oct;76(4):469-478. Epub 2019 Jul 22 doi: 10.1016/j.eururo.2019.06.030. PMID: 31345636Free PMC Article

Recent systematic reviews

Zhang Y, Zhang W, Wu X, Liu G, Dai Y, Jiang H, Zhang X
Andrologia 2022 Feb;54(1):e14275. Epub 2021 Oct 17 doi: 10.1111/and.14275. PMID: 34658054
Bravo-Gutiérrez OA, Falfán-Valencia R, Ramírez-Venegas A, Sansores RH, Ponciano-Rodríguez G, Pérez-Rubio G
Int J Environ Res Public Health 2021 Apr 13;18(8) doi: 10.3390/ijerph18084079. PMID: 33924379Free PMC Article
Beyfuss K, Hood DA
Redox Rep 2018 Dec;23(1):100-117. Epub 2018 Jan 3 doi: 10.1080/13510002.2017.1416773. PMID: 29298131Free PMC Article
Ricci E, Viganò P, Cipriani S, Somigliana E, Chiaffarino F, Bulfoni A, Parazzini F
Nutr J 2017 Jun 24;16(1):37. doi: 10.1186/s12937-017-0257-2. PMID: 28646871Free PMC Article
Semet M, Paci M, Saïas-Magnan J, Metzler-Guillemain C, Boissier R, Lejeune H, Perrin J
Andrology 2017 Jul;5(4):640-663. Epub 2017 Jun 16 doi: 10.1111/andr.12366. PMID: 28622464

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