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DNA damage

MedGen UID:
3880
Concept ID:
C0012860
Cell or Molecular Dysfunction
Synonyms: DNA Damage; DNA Injuries; DNA Injury; DNA Lesion; DNA Lesions; Injury, DNA
SNOMED CT: DNA damage (68349007); DNA injury (68349007); Deoxyribonucleic acid damage (68349007)

Definition

Drug-, radiation-induced, or spontaneous injuries to DNA that introduce deviations from its normal double-helical conformation. These changes include structural distortions that interfere with replication and transcription, as well as point mutations that disrupt base pairs and exert damaging effects on future generations through changes in DNA sequence. If the damage is minor, it can often be repaired (DNA repair); extensive damage can induce apoptosis. [from NCI]

Professional guidelines

PubMed

Carusillo A, Mussolino C
Cells 2020 Jul 10;9(7) doi: 10.3390/cells9071665. PMID: 32664329Free PMC Article
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CA Cancer J Clin 2019 Jul;69(4):280-304. Epub 2019 May 17 doi: 10.3322/caac.21559. PMID: 31099893

Recent clinical studies

Etiology

Auschwitz E, Almeda J, Andl CD
Cells 2023 Oct 31;12(21) doi: 10.3390/cells12212552. PMID: 37947630Free PMC Article
Yousefzadeh M, Henpita C, Vyas R, Soto-Palma C, Robbins P, Niedernhofer L
Elife 2021 Jan 29;10 doi: 10.7554/eLife.62852. PMID: 33512317Free PMC Article
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Srinivas US, Tan BWQ, Vellayappan BA, Jeyasekharan AD
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Basu AK
Int J Mol Sci 2018 Mar 23;19(4) doi: 10.3390/ijms19040970. PMID: 29570697Free PMC Article

Diagnosis

Carante MP, Ramos RL, Ballarini F
Int J Mol Sci 2024 Jun 8;25(12) doi: 10.3390/ijms25126368. PMID: 38928074Free PMC Article
McKeague M
Int J Mol Sci 2017 Oct 22;18(10) doi: 10.3390/ijms18102212. PMID: 29065503Free PMC Article
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Goldstein M, Kastan MB
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Mah LJ, El-Osta A, Karagiannis TC
Leukemia 2010 Apr;24(4):679-86. Epub 2010 Feb 4 doi: 10.1038/leu.2010.6. PMID: 20130602

Therapy

Ettrich TJ, Seufferlein T
Curr Treat Options Oncol 2021 Oct 19;22(11):106. doi: 10.1007/s11864-021-00895-4. PMID: 34665339Free PMC Article
Coryell PR, Diekman BO, Loeser RF
Nat Rev Rheumatol 2021 Jan;17(1):47-57. Epub 2020 Nov 18 doi: 10.1038/s41584-020-00533-7. PMID: 33208917Free PMC Article
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Neuro Oncol 2020 Aug 17;22(8):1073-1113. doi: 10.1093/neuonc/noaa106. PMID: 32328653Free PMC Article
Lord CJ, Ashworth A
Science 2017 Mar 17;355(6330):1152-1158. Epub 2017 Mar 16 doi: 10.1126/science.aam7344. PMID: 28302823Free PMC Article
Wu Q, Liu L, Miron A, Klímová B, Wan D, Kuča K
Arch Toxicol 2016 Aug;90(8):1817-40. Epub 2016 Jun 3 doi: 10.1007/s00204-016-1744-5. PMID: 27259333

Prognosis

Schmitt M, Ceteci F, Gupta J, Pesic M, Böttger TW, Nicolas AM, Kennel KB, Engel E, Schewe M, Callak Kirisözü A, Petrocelli V, Dabiri Y, Varga J, Ramakrishnan M, Karimova M, Ablasser A, Sato T, Arkan MC, de Sauvage FJ, Greten FR
Nature 2022 Dec;612(7939):347-353. Epub 2022 Nov 16 doi: 10.1038/s41586-022-05426-1. PMID: 36385525Free PMC Article
Zhu Y, Mo M, Wei Y, Wu J, Pan J, Freedland SJ, Zheng Y, Ye D
Nat Rev Urol 2021 May;18(5):282-301. Epub 2021 Mar 10 doi: 10.1038/s41585-021-00442-8. PMID: 33692499
Mizrahi JD, Surana R, Valle JW, Shroff RT
Lancet 2020 Jun 27;395(10242):2008-2020. doi: 10.1016/S0140-6736(20)30974-0. PMID: 32593337
Biffi A, Montini E, Lorioli L, Cesani M, Fumagalli F, Plati T, Baldoli C, Martino S, Calabria A, Canale S, Benedicenti F, Vallanti G, Biasco L, Leo S, Kabbara N, Zanetti G, Rizzo WB, Mehta NA, Cicalese MP, Casiraghi M, Boelens JJ, Del Carro U, Dow DJ, Schmidt M, Assanelli A, Neduva V, Di Serio C, Stupka E, Gardner J, von Kalle C, Bordignon C, Ciceri F, Rovelli A, Roncarolo MG, Aiuti A, Sessa M, Naldini L
Science 2013 Aug 23;341(6148):1233158. Epub 2013 Jul 11 doi: 10.1126/science.1233158. PMID: 23845948
Narayanan DL, Saladi RN, Fox JL
Int J Dermatol 2010 Sep;49(9):978-86. doi: 10.1111/j.1365-4632.2010.04474.x. PMID: 20883261

Clinical prediction guides

Hong W, Zhang Y, Wang S, Zheng D, Hsu S, Zhou J, Fan J, Zeng Z, Wang N, Ding Z, Yu M, Gao Q, Du S
Cancer Lett 2024 Feb 1;582:216594. Epub 2023 Dec 20 doi: 10.1016/j.canlet.2023.216594. PMID: 38135208
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Front Immunol 2023;14:1297180. Epub 2023 Oct 31 doi: 10.3389/fimmu.2023.1297180. PMID: 38022619Free PMC Article
Paluch-Shimon S, Evron E
Breast 2019 Oct;47:33-42. Epub 2019 Jul 1 doi: 10.1016/j.breast.2019.06.007. PMID: 31344602
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Curr Opin Urol 2019 May;29(3):220-226. doi: 10.1097/MOU.0000000000000600. PMID: 30855376
Doak SH, Dusinska M
Mutagenesis 2017 Jan;32(1):1-4. doi: 10.1093/mutage/gew066. PMID: 28011747

Recent systematic reviews

Anemoulis M, Vlastos A, Kachtsidis V, Karras SN
Nutrients 2023 Jan 19;15(3) doi: 10.3390/nu15030532. PMID: 36771239Free PMC Article
Llavanera M, Delgado-Bermúdez A, Ribas-Maynou J, Salas-Huetos A, Yeste M
Fertil Steril 2022 Aug;118(2):291-313. Epub 2022 Jun 17 doi: 10.1016/j.fertnstert.2022.04.028. PMID: 35718545
Bravo-Gutiérrez OA, Falfán-Valencia R, Ramírez-Venegas A, Sansores RH, Ponciano-Rodríguez G, Pérez-Rubio G
Int J Environ Res Public Health 2021 Apr 13;18(8) doi: 10.3390/ijerph18084079. PMID: 33924379Free PMC Article
Semet M, Paci M, Saïas-Magnan J, Metzler-Guillemain C, Boissier R, Lejeune H, Perrin J
Andrology 2017 Jul;5(4):640-663. Epub 2017 Jun 16 doi: 10.1111/andr.12366. PMID: 28622464
Salas-Huetos A, Bulló M, Salas-Salvadó J
Hum Reprod Update 2017 Jul 1;23(4):371-389. doi: 10.1093/humupd/dmx006. PMID: 28333357

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