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ALK Gene Translocation

MedGen UID:
1391314
•Concept ID:
C4329227
•
Cell or Molecular Dysfunction
Synonyms: ALK Translocation; Anaplastic Lymphoma Kinase Gene Translocation; Anaplastic Lymphoma Receptor Tyrosine Kinase Gene Translocation; CD246 Gene Translocation

Definition

A cytogenetic abnormality that refers to any translocation involving the ALK gene. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVALK Gene Translocation

Professional guidelines

PubMed

Driver Fusions and Their Implications in the Development and Treatment of Human Cancers.
Gao Q, Liang WW, Foltz SM, Mutharasu G, Jayasinghe RG, Cao S, Liao WW, Reynolds SM, Wyczalkowski MA, Yao L, Yu L, Sun SQ; Fusion Analysis Working Group; Cancer Genome Atlas Research Network, Chen K, Lazar AJ, Fields RC, Wendl MC, Van Tine BA, Vij R, Chen F, Nykter M, Shmulevich I, Ding L
Cell Rep 2018 Apr 3;23(1):227-238.e3. doi: 10.1016/j.celrep.2018.03.050. PMID: 29617662Free PMC Article
Management of NSCLC: focus on crizotinib.
Landi L, Cappuzzo F
Expert Opin Pharmacother 2014 Dec;15(17):2587-97. Epub 2014 Oct 10 doi: 10.1517/14656566.2014.970174. PMID: 25301075
The biology and treatment of EML4-ALK non-small cell lung cancer.
Sasaki T, Rodig SJ, Chirieac LR, Jänne PA
Eur J Cancer 2010 Jul;46(10):1773-80. Epub 2010 Apr 24 doi: 10.1016/j.ejca.2010.04.002. PMID: 20418096Free PMC Article

Recent clinical studies

Etiology

ALCL by any other name: the many facets of anaplastic large cell lymphoma.
Irshaid L, Xu ML
Pathology 2020 Jan;52(1):100-110. Epub 2019 Nov 6 doi: 10.1016/j.pathol.2019.09.007. PMID: 31706671
Recurrent Cytogenetic Abnormalities in Non-Hodgkin's Lymphoma and Chronic Lymphocytic Leukemia.
Ma ES
Methods Mol Biol 2017;1541:279-293. doi: 10.1007/978-1-4939-6703-2_22. PMID: 27910030
Clinical Features of Lung Cancer in Japanese Patients Aged Under 50.
Igata F, Uchino J, Fujita M, Iwasaki A, Watanabe K
Asian Pac J Cancer Prev 2016;17(7):3377-80. PMID: 27509978
ALK gene copy number gain and its clinical significance in hepatocellular carcinoma.
Jia SW, Fu S, Wang F, Shao Q, Huang HB, Shao JY
World J Gastroenterol 2014 Jan 7;20(1):183-92. doi: 10.3748/wjg.v20.i1.183. PMID: 24415871Free PMC Article
Pathobiology and molecular profiling of peripheral T-cell lymphomas.
de Leval L, Gaulard P
Hematology Am Soc Hematol Educ Program 2008:272-9. doi: 10.1182/asheducation-2008.1.272. PMID: 19074096

Diagnosis

ALK-positive histiocytosis with disseminated disease responded to alectinib: a case report.
Tian Y, Li J, Liu B, Xie H, Zheng M, Yao W
Ann Palliat Med 2021 Sep;10(9):10095-10101. doi: 10.21037/apm-21-2117. PMID: 34628929
ALCL by any other name: the many facets of anaplastic large cell lymphoma.
Irshaid L, Xu ML
Pathology 2020 Jan;52(1):100-110. Epub 2019 Nov 6 doi: 10.1016/j.pathol.2019.09.007. PMID: 31706671
Recurrent Cytogenetic Abnormalities in Non-Hodgkin's Lymphoma and Chronic Lymphocytic Leukemia.
Ma ES
Methods Mol Biol 2017;1541:279-293. doi: 10.1007/978-1-4939-6703-2_22. PMID: 27910030
Clinical Features of Lung Cancer in Japanese Patients Aged Under 50.
Igata F, Uchino J, Fujita M, Iwasaki A, Watanabe K
Asian Pac J Cancer Prev 2016;17(7):3377-80. PMID: 27509978
Newly available antibodies with practical applications in surgical pathology.
Chan JK
Int J Surg Pathol 2013 Dec;21(6):553-72. doi: 10.1177/1066896913507601. PMID: 24225578

Therapy

ALK-positive histiocytosis with disseminated disease responded to alectinib: a case report.
Tian Y, Li J, Liu B, Xie H, Zheng M, Yao W
Ann Palliat Med 2021 Sep;10(9):10095-10101. doi: 10.21037/apm-21-2117. PMID: 34628929
Combined Cellular and Biochemical Profiling to Identify Predictive Drug Response Biomarkers for Kinase Inhibitors Approved for Clinical Use between 2013 and 2017.
Uitdehaag JCM, Kooijman JJ, de Roos JADM, Prinsen MBW, Dylus J, Willemsen-Seegers N, Kawase Y, Sawa M, de Man J, van Gerwen SJC, Buijsman RC, Zaman GJR
Mol Cancer Ther 2019 Feb;18(2):470-481. Epub 2018 Oct 31 doi: 10.1158/1535-7163.MCT-18-0877. PMID: 30381447
Developments for Personalized Medicine of Lung Cancer Subtypes: Mass Spectrometry-Based Clinical Proteogenomic Analysis of Oncogenic Mutations.
Nishimura T, Nakamura H
Adv Exp Med Biol 2016;926:115-137. doi: 10.1007/978-3-319-42316-6_8. PMID: 27686809
Metastatic EML4-ALK fusion detected by circulating DNA genotyping in an EGFR-mutated NSCLC patient and successful management by adding ALK inhibitors: a case report.
Liang W, He Q, Chen Y, Chuai S, Yin W, Wang W, Peng G, Zhou C, He J
BMC Cancer 2016 Feb 5;16:62. doi: 10.1186/s12885-016-2088-5. PMID: 26850068Free PMC Article
Targeted agents in non-small cell lung cancer (NSCLC): clinical developments and rationale for the combination with thoracic radiotherapy.
Koh PK, Faivre-Finn C, Blackhall FH, De Ruysscher D
Cancer Treat Rev 2012 Oct;38(6):626-40. Epub 2011 Dec 22 doi: 10.1016/j.ctrv.2011.11.003. PMID: 22196919

Prognosis

ALCL by any other name: the many facets of anaplastic large cell lymphoma.
Irshaid L, Xu ML
Pathology 2020 Jan;52(1):100-110. Epub 2019 Nov 6 doi: 10.1016/j.pathol.2019.09.007. PMID: 31706671
Recurrent Cytogenetic Abnormalities in Non-Hodgkin's Lymphoma and Chronic Lymphocytic Leukemia.
Ma ES
Methods Mol Biol 2017;1541:279-293. doi: 10.1007/978-1-4939-6703-2_22. PMID: 27910030
Clinical Features of Lung Cancer in Japanese Patients Aged Under 50.
Igata F, Uchino J, Fujita M, Iwasaki A, Watanabe K
Asian Pac J Cancer Prev 2016;17(7):3377-80. PMID: 27509978
ALK gene copy number gain and its clinical significance in hepatocellular carcinoma.
Jia SW, Fu S, Wang F, Shao Q, Huang HB, Shao JY
World J Gastroenterol 2014 Jan 7;20(1):183-92. doi: 10.3748/wjg.v20.i1.183. PMID: 24415871Free PMC Article
Newly available antibodies with practical applications in surgical pathology.
Chan JK
Int J Surg Pathol 2013 Dec;21(6):553-72. doi: 10.1177/1066896913507601. PMID: 24225578

Clinical prediction guides

Combined Cellular and Biochemical Profiling to Identify Predictive Drug Response Biomarkers for Kinase Inhibitors Approved for Clinical Use between 2013 and 2017.
Uitdehaag JCM, Kooijman JJ, de Roos JADM, Prinsen MBW, Dylus J, Willemsen-Seegers N, Kawase Y, Sawa M, de Man J, van Gerwen SJC, Buijsman RC, Zaman GJR
Mol Cancer Ther 2019 Feb;18(2):470-481. Epub 2018 Oct 31 doi: 10.1158/1535-7163.MCT-18-0877. PMID: 30381447
Recurrent Cytogenetic Abnormalities in Non-Hodgkin's Lymphoma and Chronic Lymphocytic Leukemia.
Ma ES
Methods Mol Biol 2017;1541:279-293. doi: 10.1007/978-1-4939-6703-2_22. PMID: 27910030
Clinical Features of Lung Cancer in Japanese Patients Aged Under 50.
Igata F, Uchino J, Fujita M, Iwasaki A, Watanabe K
Asian Pac J Cancer Prev 2016;17(7):3377-80. PMID: 27509978
ALK gene copy number gain and its clinical significance in hepatocellular carcinoma.
Jia SW, Fu S, Wang F, Shao Q, Huang HB, Shao JY
World J Gastroenterol 2014 Jan 7;20(1):183-92. doi: 10.3748/wjg.v20.i1.183. PMID: 24415871Free PMC Article
Newly available antibodies with practical applications in surgical pathology.
Chan JK
Int J Surg Pathol 2013 Dec;21(6):553-72. doi: 10.1177/1066896913507601. PMID: 24225578

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