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t(2;5)(p23;q35)

MedGen UID:
273749
•Concept ID:
C1515757
•
Cell or Molecular Dysfunction

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVt(2;5)(p23;q35)

Professional guidelines

PubMed

Molecular Screening in Anaplastic Lymphoma Kinase-Positive Anaplastic Large Cell Lymphoma: Anaplastic Lymphoma Kinase Analysis, Next-Generation Sequencing Fusion Gene Detection, and T-Cell Receptor Immunoprofiling.
Kalinova M, Mrhalova M, Kabickova E, Svaton M, Skotnicova A, Prouzova Z, Krenova Z, Kolenova A, Divoka M, Fronkova E, Kodet R
Mod Pathol 2024 Mar;37(3):100428. Epub 2024 Jan 23 doi: 10.1016/j.modpat.2024.100428. PMID: 38266918
Clinicopathologic features and treatment outcome of children with large-cell lymphoma and the t(2;5)(p23;q35).
Sandlund JT, Pui CH, Roberts WM, Santana VM, Morris SW, Berard CW, Hutchison RE, Ribeiro RC, Mahmoud H, Crist WM
Blood 1994 Oct 15;84(8):2467-71. PMID: 7919366
Cytogenetic analysis of 434 consecutively ascertained specimens of non-Hodgkin's lymphoma: correlations between recurrent aberrations, histology, and exposure to cytotoxic treatment.
Offit K, Jhanwar SC, Ladanyi M, Filippa DA, Chaganti RS
Genes Chromosomes Cancer 1991 May;3(3):189-201. doi: 10.1002/gcc.2870030304. PMID: 1868033

Recent clinical studies

Etiology

Recurrent Cytogenetic Abnormalities in Non-Hodgkin's Lymphoma and Chronic Lymphocytic Leukemia.
Ma ES
Methods Mol Biol 2017;1541:279-293. doi: 10.1007/978-1-4939-6703-2_22. PMID: 27910030
ALK-positive anaplastic large cell lymphoma: an evolving story.
Bonzheim I, Steinhilber J, Fend F, Lamant L, Quintanilla-Martinez L
Front Biosci (Schol Ed) 2015 Jun 1;7(2):248-59. doi: 10.2741/S438. PMID: 25961700
Mass spectrometry-based proteomic studies of human anaplastic large cell lymphoma.
Lim MS, Elenitoba-Johnson KS
Mol Cell Proteomics 2006 Oct;5(10):1787-98. Epub 2006 Jun 19 doi: 10.1074/mcp.R600005-MCP200. PMID: 16785248
Assessment of t(2;5)(p23;q35) translocation and variants in pediatric ALK+ anaplastic large cell lymphoma.
Liang X, Meech SJ, Odom LF, Bitter MA, Ryder JW, Hunger SP, Lovell MA, Meltesen L, Wei Q, Williams SA, Hutchinson RN, McGavran L
Am J Clin Pathol 2004 Apr;121(4):496-506. doi: 10.1309/TLE8-FN6E-YF0N-JGP7. PMID: 15080301
Translocations involving anaplastic lymphoma kinase (ALK).
Duyster J, Bai RY, Morris SW
Oncogene 2001 Sep 10;20(40):5623-37. doi: 10.1038/sj.onc.1204594. PMID: 11607814

Diagnosis

Recurrent Cytogenetic Abnormalities in Non-Hodgkin's Lymphoma and Chronic Lymphocytic Leukemia.
Ma ES
Methods Mol Biol 2017;1541:279-293. doi: 10.1007/978-1-4939-6703-2_22. PMID: 27910030
ALK-positive anaplastic large cell lymphoma: an evolving story.
Bonzheim I, Steinhilber J, Fend F, Lamant L, Quintanilla-Martinez L
Front Biosci (Schol Ed) 2015 Jun 1;7(2):248-59. doi: 10.2741/S438. PMID: 25961700
Anaplastic large cell lymphoma arising in bone: report of a case of the monomorphic variant with the t(2;5)(p23;q35) translocation.
Lones MA, Sanger W, Perkins SL, Medeiros LJ
Arch Pathol Lab Med 2000 Sep;124(9):1339-43. doi: 10.5858/2000-124-1339-ALCLAI. PMID: 10975933
Genomic DNA amplification and the detection of t(2;5)(p23;q35) in lymphoid neoplasms.
Sarris AH, Luthra R, Cabanillas F, Morris SW, Pugh WC
Leuk Lymphoma 1998 May;29(5-6):507-14. doi: 10.3109/10428199809050910. PMID: 9643564
Diagnosis of t(2;5)(p23;q35)-associated Ki-1 lymphoma with immunohistochemistry.
Shiota M, Fujimoto J, Takenaga M, Satoh H, Ichinohasama R, Abe M, Nakano M, Yamamoto T, Mori S
Blood 1994 Dec 1;84(11):3648-52. PMID: 7949120

Therapy

The oncogenic JUNB/CD30 axis contributes to cell cycle deregulation in ALK+ anaplastic large cell lymphoma.
Atsaves V, Lekakis L, Drakos E, Leventaki V, Ghaderi M, Baltatzis GE, Chioureas D, Jones D, Feretzaki M, Liakou C, Panayiotidis P, Gorgoulis V, Patsouris E, Medeiros LJ, Claret FX, Rassidakis GZ
Br J Haematol 2014 Nov;167(4):514-23. Epub 2014 Aug 22 doi: 10.1111/bjh.13079. PMID: 25145835
Potential therapies for anaplastic lymphoma kinase-driven tumors in children: progress to date.
Lowe EJ, Lim MS
Paediatr Drugs 2013 Jun;15(3):163-9. doi: 10.1007/s40272-013-0027-3. PMID: 23696342Free PMC Article
Detection of t(2;5) in anaplastic large cell lymphoma: comparison of immunohistochemical studies, FISH, and RT-PCR in paraffin-embedded tissue.
Cataldo KA, Jalal SM, Law ME, Ansell SM, Inwards DJ, Fine M, Arber DA, Pulford KA, Strickler JG
Am J Surg Pathol 1999 Nov;23(11):1386-92. doi: 10.1097/00000478-199911000-00009. PMID: 10555007
The use of fluorescent in situ hybridization for detection of the t(2;5)(p23;q35) translocation in anaplastic large-cell lymphoma.
Johnson PW, Leek J, Swinbank K, Angus B, Roberts P, Markham AF, Selby PJ, MacLennan KA
Ann Oncol 1997;8 Suppl 2:65-9. PMID: 9209644
Clinicopathologic features and treatment outcome of children with large-cell lymphoma and the t(2;5)(p23;q35).
Sandlund JT, Pui CH, Roberts WM, Santana VM, Morris SW, Berard CW, Hutchison RE, Ribeiro RC, Mahmoud H, Crist WM
Blood 1994 Oct 15;84(8):2467-71. PMID: 7919366

Prognosis

Recurrent Cytogenetic Abnormalities in Non-Hodgkin's Lymphoma and Chronic Lymphocytic Leukemia.
Ma ES
Methods Mol Biol 2017;1541:279-293. doi: 10.1007/978-1-4939-6703-2_22. PMID: 27910030
Oncogenic role of miR-155 in anaplastic large cell lymphoma lacking the t(2;5) translocation.
Merkel O, Hamacher F, Griessl R, Grabner L, Schiefer AI, Prutsch N, Baer C, Egger G, Schlederer M, Krenn PW, Hartmann TN, Simonitsch-Klupp I, Plass C, Staber PB, Moriggl R, Turner SD, Greil R, Kenner L
J Pathol 2015 Aug;236(4):445-56. Epub 2015 Apr 27 doi: 10.1002/path.4539. PMID: 25820993Free PMC Article
Cytogenetic analysis of pediatric anaplastic large cell lymphoma.
Mussolin L, Pillon M, Bonato P, Leszl A, Franceschetto G, Di Meglio A, d'Amore ES, Sainati L, Rosolen A
Pediatr Blood Cancer 2010 Sep;55(3):446-51. doi: 10.1002/pbc.22550. PMID: 20658615
Genomic DNA amplification and the detection of t(2;5)(p23;q35) in lymphoid neoplasms.
Sarris AH, Luthra R, Cabanillas F, Morris SW, Pugh WC
Leuk Lymphoma 1998 May;29(5-6):507-14. doi: 10.3109/10428199809050910. PMID: 9643564
Large-cell anaplastic lymphoma-specific translocation (t[2;5] [p23;q35]) in Hodgkin's disease: indication of a common pathogenesis?
Orscheschek K, Merz H, Hell J, Binder T, Bartels H, Feller AC
Lancet 1995 Jan 14;345(8942):87-90. doi: 10.1016/s0140-6736(95)90061-6. PMID: 7815887

Clinical prediction guides

Molecular Screening in Anaplastic Lymphoma Kinase-Positive Anaplastic Large Cell Lymphoma: Anaplastic Lymphoma Kinase Analysis, Next-Generation Sequencing Fusion Gene Detection, and T-Cell Receptor Immunoprofiling.
Kalinova M, Mrhalova M, Kabickova E, Svaton M, Skotnicova A, Prouzova Z, Krenova Z, Kolenova A, Divoka M, Fronkova E, Kodet R
Mod Pathol 2024 Mar;37(3):100428. Epub 2024 Jan 23 doi: 10.1016/j.modpat.2024.100428. PMID: 38266918
miR-497 suppresses cycle progression through an axis involving CDK6 in ALK-positive cells.
Hoareau-Aveilla C, Quelen C, Congras A, Caillet N, Labourdette D, Dozier C, Brousset P, Lamant L, Meggetto F
Haematologica 2019 Feb;104(2):347-359. Epub 2018 Sep 27 doi: 10.3324/haematol.2018.195131. PMID: 30262555Free PMC Article
The role of anaplastic lymphoma kinase in pediatric cancers.
Takita J
Cancer Sci 2017 Oct;108(10):1913-1920. Epub 2017 Aug 24 doi: 10.1111/cas.13333. PMID: 28756644Free PMC Article
Recurrent Cytogenetic Abnormalities in Non-Hodgkin's Lymphoma and Chronic Lymphocytic Leukemia.
Ma ES
Methods Mol Biol 2017;1541:279-293. doi: 10.1007/978-1-4939-6703-2_22. PMID: 27910030
ALK-positive anaplastic large cell lymphoma: an evolving story.
Bonzheim I, Steinhilber J, Fend F, Lamant L, Quintanilla-Martinez L
Front Biosci (Schol Ed) 2015 Jun 1;7(2):248-59. doi: 10.2741/S438. PMID: 25961700

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