U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Superficial Fibromatosis

MedGen UID:
140804
•Concept ID:
C0406571
•
Disease or Syndrome
Synonyms: Superficial fibromatosis; superficial Fibromatosis
SNOMED CT: Superficial fibromatosis (238853007)
 
Monarch Initiative: MONDO:0016037
Orphanet: ORPHA199257

Definition

A poorly circumscribed, intermediate fibrocytic neoplasm arising from the superficial soft tissues. It is characterized by the presence of spindle-shaped fibroblasts, and an infiltrative growth pattern. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSuperficial Fibromatosis
Follow this link to review classifications for Superficial Fibromatosis in Orphanet.

Professional guidelines

PubMed

Superficial fibromatosis: MRI radiomics and T2 mapping correlate with treatment response.
Ramachandran A, Fox T, Wolfson A, Banks J, Subhawong TK
Magn Reson Imaging 2021 Sep;81:53-59. Epub 2021 Jun 9 doi: 10.1016/j.mri.2021.06.003. PMID: 34116132
Differential diagnostic considerations of desmoid-type fibromatosis.
Goldstein JA, Cates JM
Adv Anat Pathol 2015 Jul;22(4):260-6. doi: 10.1097/PAP.0000000000000077. PMID: 26050263

Recent clinical studies

Etiology

Superficial fibromatosis: MRI radiomics and T2 mapping correlate with treatment response.
Ramachandran A, Fox T, Wolfson A, Banks J, Subhawong TK
Magn Reson Imaging 2021 Sep;81:53-59. Epub 2021 Jun 9 doi: 10.1016/j.mri.2021.06.003. PMID: 34116132
Cutaneous desmoid-type fibromatosis: A rare case with molecular profiling.
Aghighi M, Cloutier JM, Hoover WD Jr, Roy K, Lo AA, Brown RA
J Cutan Pathol 2021 Sep;48(9):1185-1188. Epub 2021 Jun 30 doi: 10.1111/cup.14058. PMID: 33978242
Peyronie disease: a clinicopathologic study of 71 cases with emphasis on histopathologic patterns and prevalent metaplastic ossification.
Hatfield BS, King CR, Udager AM, Williamson SR, Gandhi JS, Amin MB, Spruill L, Lindsey KG, Pillappa R, Roseman JT 2nd, Mochel MC, Smith SC
Hum Pathol 2020 Oct;104:9-17. Epub 2020 Jul 15 doi: 10.1016/j.humpath.2020.07.013. PMID: 32681945
T2 signal intensity as an imaging biomarker for patients with superficial Fibromatoses of the hands (Dupuytren's disease) and feet (Ledderhose disease) undergoing definitive electron beam irradiation.
Banks JS, Wolfson AH, Subhawong TK
Skeletal Radiol 2018 Feb;47(2):243-251. Epub 2017 Oct 30 doi: 10.1007/s00256-017-2792-5. PMID: 29085992
The role of cytogenetics in the classification of soft tissue tumours.
Dei Tos AP, Dal Cin P
Virchows Arch 1997 Aug;431(2):83-94. doi: 10.1007/s004280050073. PMID: 9293889

Diagnosis

Pachydermodactyly: the role of ultrasonography, superb microvascular imaging, and elastography in diagnosis.
Novais CM, Soares-de-Almeida L, Garcia J, Madruga Dias J
Skeletal Radiol 2022 Feb;51(2):435-439. Epub 2021 Aug 11 doi: 10.1007/s00256-021-03887-5. PMID: 34379173
Nuclear β-catenin immunoexpression in scars.
Goto K, Ishikawa M, Aizawa D, Muramatsu K, Naka M, Sugino T
J Cutan Pathol 2021 Jan;48(1):18-23. Epub 2020 Aug 6 doi: 10.1111/cup.13806. PMID: 32652763
Comparison of β-Catenin and LEF1 Immunohistochemical Stains in Desmoid-type Fibromatosis and its Selected Mimickers, With Unexpected Finding of LEF1 Positivity in Scars.
Zou Y, Zhang Y, Church J, Liu X
Appl Immunohistochem Mol Morphol 2018 Oct;26(9):648-653. doi: 10.1097/PAI.0000000000000487. PMID: 28027119
Differential diagnostic considerations of desmoid-type fibromatosis.
Goldstein JA, Cates JM
Adv Anat Pathol 2015 Jul;22(4):260-6. doi: 10.1097/PAP.0000000000000077. PMID: 26050263
The role of cytogenetics in the classification of soft tissue tumours.
Dei Tos AP, Dal Cin P
Virchows Arch 1997 Aug;431(2):83-94. doi: 10.1007/s004280050073. PMID: 9293889

Therapy

Comparison of β-Catenin and LEF1 Immunohistochemical Stains in Desmoid-type Fibromatosis and its Selected Mimickers, With Unexpected Finding of LEF1 Positivity in Scars.
Zou Y, Zhang Y, Church J, Liu X
Appl Immunohistochem Mol Morphol 2018 Oct;26(9):648-653. doi: 10.1097/PAI.0000000000000487. PMID: 28027119

Prognosis

Superficial fibromatosis: MRI radiomics and T2 mapping correlate with treatment response.
Ramachandran A, Fox T, Wolfson A, Banks J, Subhawong TK
Magn Reson Imaging 2021 Sep;81:53-59. Epub 2021 Jun 9 doi: 10.1016/j.mri.2021.06.003. PMID: 34116132
T2 signal intensity as an imaging biomarker for patients with superficial Fibromatoses of the hands (Dupuytren's disease) and feet (Ledderhose disease) undergoing definitive electron beam irradiation.
Banks JS, Wolfson AH, Subhawong TK
Skeletal Radiol 2018 Feb;47(2):243-251. Epub 2017 Oct 30 doi: 10.1007/s00256-017-2792-5. PMID: 29085992
Detection of beta-catenin mutations in paraffin-embedded sporadic desmoid-type fibromatosis by mutation-specific restriction enzyme digestion (MSRED): an ancillary diagnostic tool.
Amary MF, Pauwels P, Meulemans E, Roemen GM, Islam L, Idowu B, Bousdras K, Diss TC, O'Donnell P, Flanagan AM
Am J Surg Pathol 2007 Sep;31(9):1299-309. doi: 10.1097/PAS.0b013e31802f581a. PMID: 17721184

Clinical prediction guides

Superficial fibromatosis: MRI radiomics and T2 mapping correlate with treatment response.
Ramachandran A, Fox T, Wolfson A, Banks J, Subhawong TK
Magn Reson Imaging 2021 Sep;81:53-59. Epub 2021 Jun 9 doi: 10.1016/j.mri.2021.06.003. PMID: 34116132
T2 signal intensity as an imaging biomarker for patients with superficial Fibromatoses of the hands (Dupuytren's disease) and feet (Ledderhose disease) undergoing definitive electron beam irradiation.
Banks JS, Wolfson AH, Subhawong TK
Skeletal Radiol 2018 Feb;47(2):243-251. Epub 2017 Oct 30 doi: 10.1007/s00256-017-2792-5. PMID: 29085992
Comparison of β-Catenin and LEF1 Immunohistochemical Stains in Desmoid-type Fibromatosis and its Selected Mimickers, With Unexpected Finding of LEF1 Positivity in Scars.
Zou Y, Zhang Y, Church J, Liu X
Appl Immunohistochem Mol Morphol 2018 Oct;26(9):648-653. doi: 10.1097/PAI.0000000000000487. PMID: 28027119
Detection of beta-catenin mutations in paraffin-embedded sporadic desmoid-type fibromatosis by mutation-specific restriction enzyme digestion (MSRED): an ancillary diagnostic tool.
Amary MF, Pauwels P, Meulemans E, Roemen GM, Islam L, Idowu B, Bousdras K, Diss TC, O'Donnell P, Flanagan AM
Am J Surg Pathol 2007 Sep;31(9):1299-309. doi: 10.1097/PAS.0b013e31802f581a. PMID: 17721184
The role of cytogenetics in the classification of soft tissue tumours.
Dei Tos AP, Dal Cin P
Virchows Arch 1997 Aug;431(2):83-94. doi: 10.1007/s004280050073. PMID: 9293889

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Reviews

    Related information

    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...