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Idiopathic inflammatory myopathy

MedGen UID:
148290
•Concept ID:
C0751356
•
Disease or Syndrome
Synonyms: Idiopathic Inflammatory Myopathies; Idiopathic Inflammatory Myopathy; Idiopathic Inflammatory Myositis; Inflammatory Myopathies, Idiopathic; Inflammatory Myopathy, Idiopathic; Myopathies, Idiopathic Inflammatory; Myopathy, Idiopathic Inflammatory
SNOMED CT: Idiopathic inflammatory myopathy (702380008); Idiopathic inflammatory myositis (702380008)
 
Monarch Initiative: MONDO:0600023

Definition

An umbrella term for diseases which have chronic muscle inflammation and weakness of unknown etiology. The types of idiopathic inflammatory myopathy are further defined by either clinicopathologic criteria or by the presence of certain autoantibodies. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIdiopathic inflammatory myopathy
Follow this link to review classifications for Idiopathic inflammatory myopathy in Orphanet.

Professional guidelines

PubMed

International Guideline for Idiopathic Inflammatory Myopathy-Associated Cancer Screening: an International Myositis Assessment and Clinical Studies Group (IMACS) initiative.
Oldroyd AGS, Callen JP, Chinoy H, Chung L, Fiorentino D, Gordon P, Machado PM, McHugh N, Selva-O'Callaghan A, Schmidt J, Tansley SL, Vleugels RA, Werth VP; International Myositis Assessment and Clinical Studies Group Cancer Screening Expert Group, Aggarwal R
Nat Rev Rheumatol 2023 Dec;19(12):805-817. Epub 2023 Nov 9 doi: 10.1038/s41584-023-01045-w. PMID: 37945774Free PMC Article
Juvenile Dermatomyositis: Advances in Pathogenesis, Assessment, and Management.
Leung AKC, Lam JM, Alobaida S, Leong KF, Wong AHC
Curr Pediatr Rev 2021;17(4):273-287. doi: 10.2174/1573396317666210426105045. PMID: 33902423
Clinical manifestations and treatment of antisynthetase syndrome.
Marco JL, Collins BF
Best Pract Res Clin Rheumatol 2020 Aug;34(4):101503. Epub 2020 Apr 11 doi: 10.1016/j.berh.2020.101503. PMID: 32284267

Recent clinical studies

Etiology

International Guideline for Idiopathic Inflammatory Myopathy-Associated Cancer Screening: an International Myositis Assessment and Clinical Studies Group (IMACS) initiative.
Oldroyd AGS, Callen JP, Chinoy H, Chung L, Fiorentino D, Gordon P, Machado PM, McHugh N, Selva-O'Callaghan A, Schmidt J, Tansley SL, Vleugels RA, Werth VP; International Myositis Assessment and Clinical Studies Group Cancer Screening Expert Group, Aggarwal R
Nat Rev Rheumatol 2023 Dec;19(12):805-817. Epub 2023 Nov 9 doi: 10.1038/s41584-023-01045-w. PMID: 37945774Free PMC Article
Juvenile dermatomyositis. Where are we now?
McCann LJ, Livermore P, Wilkinson MGL, Wedderburn LR
Clin Exp Rheumatol 2022 Feb;40(2):394-403. Epub 2022 Feb 7 doi: 10.55563/clinexprheumatol/56ilob. PMID: 35225221
Juvenile Dermatomyositis: Advances in Pathogenesis, Assessment, and Management.
Leung AKC, Lam JM, Alobaida S, Leong KF, Wong AHC
Curr Pediatr Rev 2021;17(4):273-287. doi: 10.2174/1573396317666210426105045. PMID: 33902423
Dermatomyositis: Clinical features and pathogenesis.
DeWane ME, Waldman R, Lu J
J Am Acad Dermatol 2020 Feb;82(2):267-281. Epub 2019 Jul 4 doi: 10.1016/j.jaad.2019.06.1309. PMID: 31279808
Diagnosis and classification of idiopathic inflammatory myopathies.
Lundberg IE, Miller FW, Tjärnlund A, Bottai M
J Intern Med 2016 Jul;280(1):39-51. doi: 10.1111/joim.12524. PMID: 27320359Free PMC Article

Diagnosis

Juvenile dermatomyositis. Where are we now?
McCann LJ, Livermore P, Wilkinson MGL, Wedderburn LR
Clin Exp Rheumatol 2022 Feb;40(2):394-403. Epub 2022 Feb 7 doi: 10.55563/clinexprheumatol/56ilob. PMID: 35225221
Idiopathic inflammatory myopathies: a review.
Ashton C, Paramalingam S, Stevenson B, Brusch A, Needham M
Intern Med J 2021 Jun;51(6):845-852. doi: 10.1111/imj.15358. PMID: 34155760
Clinical manifestations and treatment of antisynthetase syndrome.
Marco JL, Collins BF
Best Pract Res Clin Rheumatol 2020 Aug;34(4):101503. Epub 2020 Apr 11 doi: 10.1016/j.berh.2020.101503. PMID: 32284267
Dermatomyositis: Clinical features and pathogenesis.
DeWane ME, Waldman R, Lu J
J Am Acad Dermatol 2020 Feb;82(2):267-281. Epub 2019 Jul 4 doi: 10.1016/j.jaad.2019.06.1309. PMID: 31279808
Diagnosis and classification of idiopathic inflammatory myopathies.
Lundberg IE, Miller FW, Tjärnlund A, Bottai M
J Intern Med 2016 Jul;280(1):39-51. doi: 10.1111/joim.12524. PMID: 27320359Free PMC Article

Therapy

Rituximab as the first-line therapy in anti-synthetase syndrome-related interstitial lung disease.
Zekić T
Rheumatol Int 2023 Jun;43(6):1015-1021. Epub 2023 Mar 16 doi: 10.1007/s00296-023-05302-9. PMID: 36928934
Use of Janus kinase inhibitors in dermatomyositis: a systematic literature review.
Paik JJ, Lubin G, Gromatzky A, Mudd PN Jr, Ponda MP, Christopher-Stine L
Clin Exp Rheumatol 2023 Mar;41(2):348-358. Epub 2022 Jun 28 doi: 10.55563/clinexprheumatol/hxin6o. PMID: 35766013Free PMC Article
Juvenile Dermatomyositis: Advances in Pathogenesis, Assessment, and Management.
Leung AKC, Lam JM, Alobaida S, Leong KF, Wong AHC
Curr Pediatr Rev 2021;17(4):273-287. doi: 10.2174/1573396317666210426105045. PMID: 33902423
Antisynthetase syndrome - much more than just a myopathy.
Opinc AH, Makowska JS
Semin Arthritis Rheum 2021 Feb;51(1):72-83. Epub 2020 Dec 22 doi: 10.1016/j.semarthrit.2020.09.020. PMID: 33360231
Juvenile Idiopathic Inflammatory Myopathies.
Huber AM
Pediatr Clin North Am 2018 Aug;65(4):739-756. doi: 10.1016/j.pcl.2018.04.006. PMID: 30031496

Prognosis

Juvenile dermatomyositis. Where are we now?
McCann LJ, Livermore P, Wilkinson MGL, Wedderburn LR
Clin Exp Rheumatol 2022 Feb;40(2):394-403. Epub 2022 Feb 7 doi: 10.55563/clinexprheumatol/56ilob. PMID: 35225221
Clinical manifestations and treatment of antisynthetase syndrome.
Marco JL, Collins BF
Best Pract Res Clin Rheumatol 2020 Aug;34(4):101503. Epub 2020 Apr 11 doi: 10.1016/j.berh.2020.101503. PMID: 32284267
Dermatomyositis: Clinical features and pathogenesis.
DeWane ME, Waldman R, Lu J
J Am Acad Dermatol 2020 Feb;82(2):267-281. Epub 2019 Jul 4 doi: 10.1016/j.jaad.2019.06.1309. PMID: 31279808
A Comprehensive Overview on Myositis-Specific Antibodies: New and Old Biomarkers in Idiopathic Inflammatory Myopathy.
Satoh M, Tanaka S, Ceribelli A, Calise SJ, Chan EK
Clin Rev Allergy Immunol 2017 Feb;52(1):1-19. doi: 10.1007/s12016-015-8510-y. PMID: 26424665Free PMC Article
Diagnosis and classification of idiopathic inflammatory myopathies.
Lundberg IE, Miller FW, Tjärnlund A, Bottai M
J Intern Med 2016 Jul;280(1):39-51. doi: 10.1111/joim.12524. PMID: 27320359Free PMC Article

Clinical prediction guides

Immune-mediated necrotizing myopathy (IMNM): A myopathological challenge.
Merlonghi G, Antonini G, Garibaldi M
Autoimmun Rev 2022 Feb;21(2):102993. Epub 2021 Nov 16 doi: 10.1016/j.autrev.2021.102993. PMID: 34798316
Juvenile Dermatomyositis: Advances in Pathogenesis, Assessment, and Management.
Leung AKC, Lam JM, Alobaida S, Leong KF, Wong AHC
Curr Pediatr Rev 2021;17(4):273-287. doi: 10.2174/1573396317666210426105045. PMID: 33902423
Antisynthetase syndrome - much more than just a myopathy.
Opinc AH, Makowska JS
Semin Arthritis Rheum 2021 Feb;51(1):72-83. Epub 2020 Dec 22 doi: 10.1016/j.semarthrit.2020.09.020. PMID: 33360231
A Comprehensive Overview on Myositis-Specific Antibodies: New and Old Biomarkers in Idiopathic Inflammatory Myopathy.
Satoh M, Tanaka S, Ceribelli A, Calise SJ, Chan EK
Clin Rev Allergy Immunol 2017 Feb;52(1):1-19. doi: 10.1007/s12016-015-8510-y. PMID: 26424665Free PMC Article
Idiopathic inflammatory myositis.
Tieu J, Lundberg IE, Limaye V
Best Pract Res Clin Rheumatol 2016 Feb;30(1):149-68. Epub 2016 May 26 doi: 10.1016/j.berh.2016.04.007. PMID: 27421222

Recent systematic reviews

Lung involvement in juvenile idiopathic inflammatory myopathy: A systematic review.
Abu-Rumeileh S, Marrani E, Maniscalco V, Maccora I, Pagnini I, Mastrolia MV, Rouster-Stevens K, Simonini G
Autoimmun Rev 2023 Oct;22(10):103416. Epub 2023 Aug 22 doi: 10.1016/j.autrev.2023.103416. PMID: 37611886
Current status of clinical outcome measures in inclusion body myositis: a systematised review.
Roy B, Lucchini M, Lilleker JB, Goyal NA, Naddaf E, Adler B, Alfano LN, Malandraki GA, Focht Garand KL, Mochel D, Badrising U, Machado PM, Pagkatipunan R, Ramdharry G, Wang L, Funaro MC, Schmidt J, Kushlaf H, Schiopu E, Stipancic K, Goyal N, d'Alessandro M, Conticini E, Cruz-Coble B, Lloyd TE; International Myositis Assessment and Clinical Studies (IMACS) Inclusion Body Myositis Scientific Interest Group
Clin Exp Rheumatol 2023 Mar;41(2):370-378. Epub 2023 Feb 3 doi: 10.55563/clinexprheumatol/ifacv3. PMID: 36762744
A Systematic Review and Metaanalysis of Predictors of Mortality in Idiopathic Inflammatory Myopathy-Associated Interstitial Lung Disease.
Hannah JR, Law HE, Gordon T, Rooney M, Buazon A, Adas M, Nagra D, Stovin C, Galloway J, Gordon PA
J Rheumatol 2023 Mar;50(3):373-383. Epub 2022 Sep 1 doi: 10.3899/jrheum.220383. PMID: 36379584
Use of Janus kinase inhibitors in dermatomyositis: a systematic literature review.
Paik JJ, Lubin G, Gromatzky A, Mudd PN Jr, Ponda MP, Christopher-Stine L
Clin Exp Rheumatol 2023 Mar;41(2):348-358. Epub 2022 Jun 28 doi: 10.55563/clinexprheumatol/hxin6o. PMID: 35766013Free PMC Article
Efficacy and safety of intravenous and subcutaneous immunoglobulin therapy in idiopathic inflammatory myopathy: A systematic review and meta-analysis.
Goswami RP, Haldar SN, Chatterjee M, Vij P, van der Kooi AJ, Lim J, Raaphorst J, Bhadu D, Gelardi C, Danieli MG, Kumar U
Autoimmun Rev 2022 Feb;21(2):102997. Epub 2021 Nov 17 doi: 10.1016/j.autrev.2021.102997. PMID: 34800685

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