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Depersonalization disorder

MedGen UID:
151919
•Concept ID:
C0683416
•
Mental or Behavioral Dysfunction
Synonyms: Depersonalization Disorder; Depersonalization Disorders; Disorder, Depersonalization; Disorders, Depersonalization
SNOMED CT: Depersonalization disorder (70764005); Depersonalization neurosis (70764005); Depersonalization syndrome (70764005)
 
Monarch Initiative: MONDO:0001186

Definition

A disorder characterized by persistent or recurrent episodes of feeling detached from one''s self (either one''s body or one''s mental processes), although the sufferer remains aware that this is only a feeling and does not represent reality. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDepersonalization disorder

Professional guidelines

PubMed

Adaptive immersive Virtual Environments as a treatment for depersonalization disorder.
Patrikelis P, Konstantakopoulos G, Messinis L, Alexoudi A, Stefanatou M, Nasios G, Gatzonis S
Psychiatriki 2021 Dec 20;32(4):317-327. Epub 2021 Aug 5 doi: 10.22365/jpsych.2021.032. PMID: 34390559
Dissociation in Borderline Personality Disorder: Recent Experimental, Neurobiological Studies, and Implications for Future Research and Treatment.
Krause-Utz A, Frost R, Chatzaki E, Winter D, Schmahl C, Elzinga BM
Curr Psychiatry Rep 2021 Apr 28;23(6):37. doi: 10.1007/s11920-021-01246-8. PMID: 33909198Free PMC Article
Lamotrigine in the treatment of depersonalization disorder.
Sierra M, Phillips ML, Lambert MV, Senior C, David AS, Krystal JH
J Clin Psychiatry 2001 Oct;62(10):826-7. doi: 10.4088/jcp.v62n1012b. PMID: 11816874

Recent clinical studies

Etiology

Depersonalization Disorder: Directed Forgetting as a Function of Emotionality.
Simeon D, Knutelska M
J Trauma Dissociation 2023 Mar-Apr;24(2):241-251. Epub 2022 Oct 22 doi: 10.1080/15299732.2022.2136328. PMID: 36271703
Attention and Memory in Depersonalization-Spectrum Dissociative Disorders: Impact of Selective-Divided Attentional Condition, Stimulus Emotionality, and Stress.
Simeon D, Knutelska M, Putnam FW, Schmeidler J, Smith LM
J Trauma Dissociation 2023 Jan-Feb;24(1):42-62. Epub 2022 May 26 doi: 10.1080/15299732.2022.2079798. PMID: 35616140
Depersonalization disorder and anxiety: a special relationship?
Sierra M, Medford N, Wyatt G, David AS
Psychiatry Res 2012 May 15;197(1-2):123-7. Epub 2012 Mar 12 doi: 10.1016/j.psychres.2011.12.017. PMID: 22414660
Dissociative disorders in DSM-5.
Spiegel D, Loewenstein RJ, Lewis-Fernández R, Sar V, Simeon D, Vermetten E, Cardeña E, Dell PF
Depress Anxiety 2011 Sep;28(9):824-52. doi: 10.1002/da.20874. PMID: 21910187
Depersonalization and personality in panic disorder.
Mendoza L, Navinés R, Crippa JA, Fagundo AB, Gutierrez F, Nardi AE, Bulbena A, Valdés M, Martín-Santos R
Compr Psychiatry 2011 Jul-Aug;52(4):413-9. Epub 2010 Nov 5 doi: 10.1016/j.comppsych.2010.09.002. PMID: 21683177

Diagnosis

Dissociative disorders in DSM-5.
Spiegel D, Lewis-Fernández R, Lanius R, Vermetten E, Simeon D, Friedman M
Annu Rev Clin Psychol 2013;9:299-326. Epub 2013 Feb 1 doi: 10.1146/annurev-clinpsy-050212-185531. PMID: 23394228
Dissociative disorders in DSM-5.
Spiegel D, Loewenstein RJ, Lewis-Fernández R, Sar V, Simeon D, Vermetten E, Cardeña E, Brown RJ, Dell PF
Depress Anxiety 2011 Dec 21;28(12):E17-45. doi: 10.1002/da.20923. PMID: 22134959
Depersonalization disorder.
Reutens S, Nielsen O, Sachdev P
Curr Opin Psychiatry 2010 May;23(3):278-83. doi: 10.1097/YCO.0b013e3283387ab4. PMID: 20308898
Cognitive-affective neuroscience of depersonalization.
Stein DJ, Simeon D
CNS Spectr 2009 Sep;14(9):467-71. doi: 10.1017/s109285290002352x. PMID: 19890227
Dissociative disorders.
Kihlstrom JF
Annu Rev Clin Psychol 2005;1:227-53. doi: 10.1146/annurev.clinpsy.1.102803.143925. PMID: 17716088

Therapy

Lamotrigine Uses in Psychiatric Practice.
Naguy A, Al-Enezi N
Am J Ther 2019 Jan/Feb;26(1):e96-e102. doi: 10.1097/MJT.0000000000000535. PMID: 30601211
Psychophysiological investigations in depersonalization disorder and effects of electrodermal biofeedback.
Schoenberg PL, Sierra M, David AS
J Trauma Dissociation 2012;13(3):311-29. doi: 10.1080/15299732.2011.606742. PMID: 22545565
Depersonalization disorder: pharmacological approaches.
Sierra M
Expert Rev Neurother 2008 Jan;8(1):19-26. doi: 10.1586/14737175.8.1.19. PMID: 18088198
Alcohol-induced depersonalization.
Raimo EB, Roemer RA, Moster M, Shan Y
Biol Psychiatry 1999 Jun 1;45(11):1523-6. doi: 10.1016/s0006-3223(98)00257-1. PMID: 10356638
Depersonalization disorder and self-injurious behavior.
Simeon D, Stein DJ, Hollander E
J Clin Psychiatry 1995;56 Suppl 4:36-9; discussion 40. PMID: 7713864

Prognosis

Depersonalization Disorder: Directed Forgetting as a Function of Emotionality.
Simeon D, Knutelska M
J Trauma Dissociation 2023 Mar-Apr;24(2):241-251. Epub 2022 Oct 22 doi: 10.1080/15299732.2022.2136328. PMID: 36271703
Depersonalization disorder and anxiety: a special relationship?
Sierra M, Medford N, Wyatt G, David AS
Psychiatry Res 2012 May 15;197(1-2):123-7. Epub 2012 Mar 12 doi: 10.1016/j.psychres.2011.12.017. PMID: 22414660
Cannabis-induced depersonalization disorder in adolescence.
Hürlimann F, Kupferschmid S, Simon AE
Neuropsychobiology 2012;65(3):141-6. Epub 2012 Feb 25 doi: 10.1159/000334605. PMID: 22378193
Depersonalization disorder.
Reutens S, Nielsen O, Sachdev P
Curr Opin Psychiatry 2010 May;23(3):278-83. doi: 10.1097/YCO.0b013e3283387ab4. PMID: 20308898
Alcohol-induced depersonalization.
Raimo EB, Roemer RA, Moster M, Shan Y
Biol Psychiatry 1999 Jun 1;45(11):1523-6. doi: 10.1016/s0006-3223(98)00257-1. PMID: 10356638

Clinical prediction guides

Depersonalization Disorder: Directed Forgetting as a Function of Emotionality.
Simeon D, Knutelska M
J Trauma Dissociation 2023 Mar-Apr;24(2):241-251. Epub 2022 Oct 22 doi: 10.1080/15299732.2022.2136328. PMID: 36271703
Attention and Memory in Depersonalization-Spectrum Dissociative Disorders: Impact of Selective-Divided Attentional Condition, Stimulus Emotionality, and Stress.
Simeon D, Knutelska M, Putnam FW, Schmeidler J, Smith LM
J Trauma Dissociation 2023 Jan-Feb;24(1):42-62. Epub 2022 May 26 doi: 10.1080/15299732.2022.2079798. PMID: 35616140
Dissociation in Borderline Personality Disorder: Recent Experimental, Neurobiological Studies, and Implications for Future Research and Treatment.
Krause-Utz A, Frost R, Chatzaki E, Winter D, Schmahl C, Elzinga BM
Curr Psychiatry Rep 2021 Apr 28;23(6):37. doi: 10.1007/s11920-021-01246-8. PMID: 33909198Free PMC Article
Dissociative symptoms and dissociative disorder comorbidity in patients with obsessive-compulsive disorder.
Belli H, Ural C, Vardar MK, Yesılyurt S, Oncu F
Compr Psychiatry 2012 Oct;53(7):975-80. Epub 2012 Mar 17 doi: 10.1016/j.comppsych.2012.02.004. PMID: 22425531
Depersonalization disorder and anxiety: a special relationship?
Sierra M, Medford N, Wyatt G, David AS
Psychiatry Res 2012 May 15;197(1-2):123-7. Epub 2012 Mar 12 doi: 10.1016/j.psychres.2011.12.017. PMID: 22414660

Recent systematic reviews

Emotional response in depersonalization: A systematic review of electrodermal activity studies.
Horn M, Fovet T, Vaiva G, Thomas P, Amad A, D'Hondt F
J Affect Disord 2020 Nov 1;276:877-882. Epub 2020 Jul 21 doi: 10.1016/j.jad.2020.07.064. PMID: 32739705

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