U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Metastatic Malignant Neoplasm in the Anus

MedGen UID:
151938
•Concept ID:
C0686106
•
Neoplastic Process
Synonyms: Metastatic malignant neoplasm of anus; Metastatic malignant neoplasm to anus; Metastatic Malignant Neoplasm to the Anus; Secondary malignant neoplasm of anus
SNOMED CT: Secondary malignant neoplasm of anus (94172001); Metastatic malignant neoplasm to anus (94172001); Metastatic malignant neoplasm of anus (94172001)

Definition

An epithelial or non-epithelial malignant neoplasm that has spread to the anus from another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Malignant Neoplasm in the Anus

Professional guidelines

PubMed

Anal Carcinoma, Version 2.2023, NCCN Clinical Practice Guidelines in Oncology.
Benson AB, Venook AP, Al-Hawary MM, Azad N, Chen YJ, Ciombor KK, Cohen S, Cooper HS, Deming D, Garrido-Laguna I, Grem JL, Hecht JR, Hoffe S, Hubbard J, Hunt S, Hussan H, Jeck W, Johung KL, Joseph N, Kirilcuk N, Krishnamurthi S, Maratt J, Messersmith WA, Meyerhardt J, Miller ED, Mulcahy MF, Nurkin S, Overman MJ, Parikh A, Patel H, Pedersen K, Saltz L, Schneider C, Shibata D, Skibber JM, Sofocleous CT, Stotsky-Himelfarb E, Tavakkoli A, Willett CG, Williams G, Algieri F, Gurski L, Stehman K
J Natl Compr Canc Netw 2023 Jun;21(6):653-677. doi: 10.6004/jnccn.2023.0030. PMID: 37308125
The Management and Prevention of Anal Squamous Cell Carcinoma.
Eng C, Messick C, Glynne-Jones R
Am Soc Clin Oncol Educ Book 2019 Jan;39:216-225. Epub 2019 May 17 doi: 10.1200/EDBK_237433. PMID: 31099616
The diagnosis and management of extramammary Paget's disease.
Ito T, Kaku-Ito Y, Furue M
Expert Rev Anticancer Ther 2018 Jun;18(6):543-553. Epub 2018 Mar 27 doi: 10.1080/14737140.2018.1457955. PMID: 29575944

Recent clinical studies

Etiology

Preoperative Treatment of Locally Advanced Rectal Cancer.
Schrag D, Shi Q, Weiser MR, Gollub MJ, Saltz LB, Musher BL, Goldberg J, Al Baghdadi T, Goodman KA, McWilliams RR, Farma JM, George TJ, Kennecke HF, Shergill A, Montemurro M, Nelson GD, Colgrove B, Gordon V, Venook AP, O'Reilly EM, Meyerhardt JA, Dueck AC, Basch E, Chang GJ, Mamon HJ
N Engl J Med 2023 Jul 27;389(4):322-334. Epub 2023 Jun 4 doi: 10.1056/NEJMoa2303269. PMID: 37272534Free PMC Article
Anal Cancer: The Past, Present and Future.
Gondal TA, Chaudhary N, Bajwa H, Rauf A, Le D, Ahmed S
Curr Oncol 2023 Mar 11;30(3):3232-3250. doi: 10.3390/curroncol30030246. PMID: 36975459Free PMC Article
Meta-analysis of neoadjuvant immunotherapy for non-metastatic colorectal cancer.
Zhou L, Yang XQ, Zhao GY, Wang FJ, Liu X
Front Immunol 2023;14:1044353. Epub 2023 Jan 27 doi: 10.3389/fimmu.2023.1044353. PMID: 36776899Free PMC Article
Locally Recurrent Disease Related to Anal Canal Cancers.
Sammour T, Rodriguez-Bigas MA, Skibber JM
Surg Oncol Clin N Am 2017 Jan;26(1):115-125. doi: 10.1016/j.soc.2016.07.006. PMID: 27889030
EUS-guided therapeutic paracentesis.
Varadarajulu S, Drelichman ER
Gastrointest Endosc 2008 Apr;67(4):758-9. Epub 2008 Feb 21 doi: 10.1016/j.gie.2007.08.025. PMID: 18178210

Diagnosis

Anal and Perianal Preneoplastic Lesions.
Loughrey MB, Shepherd NA
Gastroenterol Clin North Am 2024 Mar;53(1):201-220. Epub 2023 Oct 16 doi: 10.1016/j.gtc.2023.09.007. PMID: 38280748
Anal Cancer: The Past, Present and Future.
Gondal TA, Chaudhary N, Bajwa H, Rauf A, Le D, Ahmed S
Curr Oncol 2023 Mar 11;30(3):3232-3250. doi: 10.3390/curroncol30030246. PMID: 36975459Free PMC Article
Epidemiology of liver metastases.
Horn SR, Stoltzfus KC, Lehrer EJ, Dawson LA, Tchelebi L, Gusani NJ, Sharma NK, Chen H, Trifiletti DM, Zaorsky NG
Cancer Epidemiol 2020 Aug;67:101760. Epub 2020 Jun 17 doi: 10.1016/j.canep.2020.101760. PMID: 32562887
Extramammary Paget disease.
St Claire K, Hoover A, Ashack K, Khachemoune A
Dermatol Online J 2019 Apr 15;25(4) PMID: 31046904
Human papillomavirus and cervical cancer.
Crosbie EJ, Einstein MH, Franceschi S, Kitchener HC
Lancet 2013 Sep 7;382(9895):889-99. Epub 2013 Apr 23 doi: 10.1016/S0140-6736(13)60022-7. PMID: 23618600

Therapy

Preoperative Treatment of Locally Advanced Rectal Cancer.
Schrag D, Shi Q, Weiser MR, Gollub MJ, Saltz LB, Musher BL, Goldberg J, Al Baghdadi T, Goodman KA, McWilliams RR, Farma JM, George TJ, Kennecke HF, Shergill A, Montemurro M, Nelson GD, Colgrove B, Gordon V, Venook AP, O'Reilly EM, Meyerhardt JA, Dueck AC, Basch E, Chang GJ, Mamon HJ
N Engl J Med 2023 Jul 27;389(4):322-334. Epub 2023 Jun 4 doi: 10.1056/NEJMoa2303269. PMID: 37272534Free PMC Article
Anal Cancer: The Past, Present and Future.
Gondal TA, Chaudhary N, Bajwa H, Rauf A, Le D, Ahmed S
Curr Oncol 2023 Mar 11;30(3):3232-3250. doi: 10.3390/curroncol30030246. PMID: 36975459Free PMC Article
Meta-analysis of neoadjuvant immunotherapy for non-metastatic colorectal cancer.
Zhou L, Yang XQ, Zhao GY, Wang FJ, Liu X
Front Immunol 2023;14:1044353. Epub 2023 Jan 27 doi: 10.3389/fimmu.2023.1044353. PMID: 36776899Free PMC Article
Long-Term Outcomes of NRG Oncology/RTOG 0529: A Phase 2 Evaluation of Dose-Painted Intensity Modulated Radiation Therapy in Combination With 5-Fluorouracil and Mitomycin-C for the Reduction of Acute Morbidity in Anal Canal Cancer.
Kachnic LA, Winter KA, Myerson RJ, Goodyear MD, Abitbol AA, Streeter OE, Augspurger ME, Schefter TE, Katz AW, Fisher BJ, Henke LE, Narayan S, Crane CH
Int J Radiat Oncol Biol Phys 2022 Jan 1;112(1):146-157. Epub 2021 Aug 14 doi: 10.1016/j.ijrobp.2021.08.008. PMID: 34400269Free PMC Article
Human papillomavirus and cervical cancer.
Crosbie EJ, Einstein MH, Franceschi S, Kitchener HC
Lancet 2013 Sep 7;382(9895):889-99. Epub 2013 Apr 23 doi: 10.1016/S0140-6736(13)60022-7. PMID: 23618600

Prognosis

Epidemiology of liver metastases.
Horn SR, Stoltzfus KC, Lehrer EJ, Dawson LA, Tchelebi L, Gusani NJ, Sharma NK, Chen H, Trifiletti DM, Zaorsky NG
Cancer Epidemiol 2020 Aug;67:101760. Epub 2020 Jun 17 doi: 10.1016/j.canep.2020.101760. PMID: 32562887
Extramammary Paget disease.
St Claire K, Hoover A, Ashack K, Khachemoune A
Dermatol Online J 2019 Apr 15;25(4) PMID: 31046904
Nivolumab for previously treated unresectable metastatic anal cancer (NCI9673): a multicentre, single-arm, phase 2 study.
Morris VK, Salem ME, Nimeiri H, Iqbal S, Singh P, Ciombor K, Polite B, Deming D, Chan E, Wade JL, Xiao L, Bekaii-Saab T, Vence L, Blando J, Mahvash A, Foo WC, Ohaji C, Pasia M, Bland G, Ohinata A, Rogers J, Mehdizadeh A, Banks K, Lanman R, Wolff RA, Streicher H, Allison J, Sharma P, Eng C
Lancet Oncol 2017 Apr;18(4):446-453. Epub 2017 Feb 18 doi: 10.1016/S1470-2045(17)30104-3. PMID: 28223062Free PMC Article
EUS-guided therapeutic paracentesis.
Varadarajulu S, Drelichman ER
Gastrointest Endosc 2008 Apr;67(4):758-9. Epub 2008 Feb 21 doi: 10.1016/j.gie.2007.08.025. PMID: 18178210
Surgical management of metastatic inguinal lymphadenopathy.
Swan MC, Furniss D, Cassell OC
BMJ 2004 Nov 27;329(7477):1272-6. doi: 10.1136/bmj.329.7477.1272. PMID: 15564260Free PMC Article

Clinical prediction guides

The Role of Immunotherapy in the Treatment of Anal Cancer and Future Strategies.
Jácome AA, Morris VK, Eng C
Curr Treat Options Oncol 2022 Aug;23(8):1073-1085. Epub 2022 Jun 6 doi: 10.1007/s11864-022-00939-3. PMID: 35666353
Use of Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer: Initial Results From the Pembrolizumab Arm of a Phase 2 Randomized Clinical Trial.
Rahma OE, Yothers G, Hong TS, Russell MM, You YN, Parker W, Jacobs SA, Colangelo LH, Lucas PC, Gollub MJ, Hall WA, Kachnic LA, Vijayvergia N, O'Rourke MA, Faller BA, Valicenti RK, Schefter TE, George S, Kainthla R, Stella PJ, Sigurdson E, Wolmark N, George TJ
JAMA Oncol 2021 Aug 1;7(8):1225-1230. doi: 10.1001/jamaoncol.2021.1683. PMID: 34196693Free PMC Article
Extramammary Paget disease.
St Claire K, Hoover A, Ashack K, Khachemoune A
Dermatol Online J 2019 Apr 15;25(4) PMID: 31046904
Practising high-resolution anoscopy.
Palefsky JM
Sex Health 2012 Dec;9(6):580-6. doi: 10.1071/SH12045. PMID: 23380236
Treatment of relapsing anal carcinoma.
Tanum G
Acta Oncol 1993;32(1):33-5. doi: 10.3109/02841869309083882. PMID: 8466762

Recent systematic reviews

Immune-checkpoint inhibitors in anal squamous cell carcinoma: a systematic review and meta-analysis.
Pala L, De Pas T, Stucchi E, Catania C, Cocorocchio E, Zampino MG, Rossi G, Zattarin E, Di Muzio A, Laszlo D, Stucchi S, Conforti F
Semin Oncol 2023 Dec;50(6):140-143. Epub 2023 Nov 24 doi: 10.1053/j.seminoncol.2023.11.002. PMID: 38065801
[(18)F]-FDG PET in anal canal cancer: a systematic review and meta-analysis.
Mirshahvalad SA, Mesci A, Murad V, Kohan A, Ortega C, Veit-Haibach P, Metser U
Eur J Nucl Med Mol Imaging 2023 Dec;51(1):258-277. Epub 2023 Aug 18 doi: 10.1007/s00259-023-06393-z. PMID: 37592085
Meta-analysis of neoadjuvant immunotherapy for non-metastatic colorectal cancer.
Zhou L, Yang XQ, Zhao GY, Wang FJ, Liu X
Front Immunol 2023;14:1044353. Epub 2023 Jan 27 doi: 10.3389/fimmu.2023.1044353. PMID: 36776899Free PMC Article
A systematic review and meta-analysis of mortality in anal cancer patients by HIV status.
Sumner L, Kamitani E, Chase S, Wang Y
Cancer Epidemiol 2022 Feb;76:102069. Epub 2021 Dec 2 doi: 10.1016/j.canep.2021.102069. PMID: 34864578
Prognostic biomarkers in squamous cell carcinoma of the anus: a systematic review.
Lampejo T, Kavanagh D, Clark J, Goldin R, Osborn M, Ziprin P, Cleator S
Br J Cancer 2010 Dec 7;103(12):1858-69. Epub 2010 Nov 9 doi: 10.1038/sj.bjc.6605984. PMID: 21063399Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...