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Cavernous hemangioma of retina

MedGen UID:
152678
•Concept ID:
C0730304
•
Neoplastic Process
Synonym: Retinal cavernous hemangioma
SNOMED CT: Cavernous hemangioma of retina (312937006)
 
HPO: HP:0011513
Monarch Initiative: MONDO:0021281

Definition

A benign tumor of the retina that appears as a grouping of blood-filled saccules within the inner retinal layers or on the surface of the optic disc. Retinal cavernous angioma are described as having a 'cluster of grapes' appearance. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCavernous hemangioma of retina
Follow this link to review classifications for Cavernous hemangioma of retina in Orphanet.

Professional guidelines

PubMed

Classification and management of hereditary retinal angiomas.
Augsburger JJ, Shields JA, Goldberg RE
Int Ophthalmol 1981 Aug;4(1-2):93-106. doi: 10.1007/BF00139583. PMID: 7298262
32P test in the differential diagnosis of ocular malignancy. Discussion.
Cox MS Jr
Trans Sect Ophthalmol Am Acad Ophthalmol Otolaryngol 1975 Mar-Apr;79(2):OP307-9. PMID: 1145954
Fluorescein angiography. An aid in the differential diagnosis of intraocular tumors.
Gass JD
Int Ophthalmol Clin 1972 Spring;12(1):85-120. doi: 10.1097/00004397-197203000-00007. PMID: 4566519

Recent clinical studies

Etiology

Endoscopic endonasal orbital cavernous hemangioma resection: global experience in techniques and outcomes.
Bleier BS, Castelnuovo P, Battaglia P, Turri-Zanoni M, Dallan I, Metson R, Sedaghat AR, Stefko ST, Gardner PA, Snyderman CH, Nogueira JF, Ramakrishnan VR, Muscatello L, Lenzi R, Freitag S
Int Forum Allergy Rhinol 2016 Feb;6(2):156-61. Epub 2015 Dec 1 doi: 10.1002/alr.21645. PMID: 26623968
Retinal cavernous hemangioma: fifty-two years of clinical follow-up with clinicopathologic correlation.
Shields JA, Eagle RC Jr, Ewing MQ, Lally SE, Shields CL
Retina 2014 Jun;34(6):1253-7. doi: 10.1097/IAE.0000000000000232. PMID: 24849703
Vertebral and spinal cavernous angiomas associated with familial cerebral cavernous malformation.
Toldo I, Drigo P, Mammi I, Marini V, Carollo C
Surg Neurol 2009 Feb;71(2):167-71. Epub 2008 Jan 22 doi: 10.1016/j.surneu.2007.07.067. PMID: 18207546
Hemangioma of the ciliary body: a case report and review of the literature.
Isola VM
Ophthalmologica 1996;210(4):239-43. doi: 10.1159/000310716. PMID: 8841073
Cavernous hemangioma of the retina. Genetic and central nervous system involvement.
Pancurak J, Goldberg MF, Frenkel M, Crowell RM
Retina 1985 Fall-Winter;5(4):215-20. PMID: 3835615

Diagnosis

Hamartomas of the Retina and Optic Disc.
Mirzayev I, Gündüz AK
Turk J Ophthalmol 2022 Dec 28;52(6):421-431. doi: 10.4274/tjo.galenos.2022.25979. PMID: 36578224Free PMC Article
Familial Cavernous Hemangioma.
Torres G, Kini AT, Al Othman B, Lee AG
J Neuroophthalmol 2020 Jun;40(2):262-264. doi: 10.1097/WNO.0000000000000778. PMID: 30893269
CAVERNOUS HEMANGIOMA OF THE RETINA: A Comprehensive Review of the Literature (1934-2015).
Wang W, Chen L
Retina 2017 Apr;37(4):611-621. doi: 10.1097/IAE.0000000000001374. PMID: 27820777
Retinal arterial macroaneurysms.
Rabb MF, Gagliano DA, Teske MP
Surv Ophthalmol 1988 Sep-Oct;33(2):73-96. doi: 10.1016/0039-6257(88)90160-9. PMID: 3055391
Amelanotic choroidal nevi.
Brown GC, Shields JA, Augsburger JJ
Ophthalmology 1981 Nov;88(11):1116-21. doi: 10.1016/s0161-6420(81)34896-9. PMID: 7335317

Therapy

RETINAL CAVERNOUS HEMANGIOMA WITH INTRALESIONAL PHLEBOLITHS.
Yu MD, Dalvin LA, Shields CL
Retin Cases Brief Rep 2020 Fall;14(4):301-304. doi: 10.1097/ICB.0000000000000724. PMID: 29505489
Optic Disc Deformation and Orbital Bone Erosion Secondary to a Huge Neglected Orbital Cavernous Hemangioma.
Bagheri A, Shahraki K, Tavakoli M
J Craniofac Surg 2018 Nov;29(8):e790-e792. doi: 10.1097/SCS.0000000000004777. PMID: 30277940
Therapeutic surprise! Photodynamic therapy for cavernous haemangioma of the disc.
Shanmugam MP, Ramanjulu R, Dwivedi S, Barigali A, Havanje A
Indian J Ophthalmol 2017 Aug;65(8):754-757. doi: 10.4103/ijo.IJO_41_16. PMID: 28820168Free PMC Article
A case of branch retinal artery occlusion following orbital cavernous hemangioma excision.
Sacconi R, Giordano Resti A, Lattanzio R, Pierro L, D'angelo A, Baccelli N, Bandello F
Eur J Ophthalmol 2014 Nov-Dec;24(6):972-5. Epub 2014 Jun 12 doi: 10.5301/ejo.5000501. PMID: 24966029
Retinal arterial macroaneurysms.
Rabb MF, Gagliano DA, Teske MP
Surv Ophthalmol 1988 Sep-Oct;33(2):73-96. doi: 10.1016/0039-6257(88)90160-9. PMID: 3055391

Prognosis

CAVERNOUS HEMANGIOMA OF THE RETINA: A Comprehensive Review of the Literature (1934-2015).
Wang W, Chen L
Retina 2017 Apr;37(4):611-621. doi: 10.1097/IAE.0000000000001374. PMID: 27820777
Endoscopic endonasal orbital cavernous hemangioma resection: global experience in techniques and outcomes.
Bleier BS, Castelnuovo P, Battaglia P, Turri-Zanoni M, Dallan I, Metson R, Sedaghat AR, Stefko ST, Gardner PA, Snyderman CH, Nogueira JF, Ramakrishnan VR, Muscatello L, Lenzi R, Freitag S
Int Forum Allergy Rhinol 2016 Feb;6(2):156-61. Epub 2015 Dec 1 doi: 10.1002/alr.21645. PMID: 26623968
Retinal cavernous hemangioma: fifty-two years of clinical follow-up with clinicopathologic correlation.
Shields JA, Eagle RC Jr, Ewing MQ, Lally SE, Shields CL
Retina 2014 Jun;34(6):1253-7. doi: 10.1097/IAE.0000000000000232. PMID: 24849703
Hemangioma of the ciliary body: a case report and review of the literature.
Isola VM
Ophthalmologica 1996;210(4):239-43. doi: 10.1159/000310716. PMID: 8841073
Cavernous hemangioma of the retina.
Alexander LJ, Moates KN
J Am Optom Assoc 1988 Jul;59(7):539-48. PMID: 3403902

Clinical prediction guides

Optical coherence tomography angiography findings in retinal cavernous hemangioma: New cases and review of the literature.
Nhari M, Bailleul H, Bricout M, Loria O, Nguyen AM, Kodjikian L, Mathis T
J Fr Ophtalmol 2023 Dec;46(10):1222-1226. Epub 2023 Oct 21 doi: 10.1016/j.jfo.2023.06.012. PMID: 37872067
Hamartomas of the Retina and Optic Disc.
Mirzayev I, Gündüz AK
Turk J Ophthalmol 2022 Dec 28;52(6):421-431. doi: 10.4274/tjo.galenos.2022.25979. PMID: 36578224Free PMC Article
Macular Cavernous Hemangioma Associated With Peripheral Vascular Anomalies and Nonperfusion.
Rao P, Abbey AM, Yonekawa Y, Shah AR, Capone A, Trese MT, Drenser KA
Ophthalmic Surg Lasers Imaging Retina 2015 Jul-Aug;46(7):764-7. doi: 10.3928/23258160-20150730-13. PMID: 26247459
Identification of a c.601C>G mutation in the CCM1 gene in a kindred with multiple skin, spinal and cerebral cavernous malformations.
Haghighi A, Fathi D, Shahbazi M, Motahari MM, Friedman B
J Neurol Sci 2013 Nov 15;334(1-2):97-101. Epub 2013 Aug 7 doi: 10.1016/j.jns.2013.07.2518. PMID: 24007869
Amelanotic choroidal nevi.
Brown GC, Shields JA, Augsburger JJ
Ophthalmology 1981 Nov;88(11):1116-21. doi: 10.1016/s0161-6420(81)34896-9. PMID: 7335317

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