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Retinal cavernous angioma

MedGen UID:
152678
•Concept ID:
C0730304
•
Neoplastic Process
Synonyms: Cavernous Angioma of Retina; cavernous angioma of retina; Cavernous Angioma of the Retina; cavernous angioma of the retina; Cavernous hemangioma of retina; Cavernous Hemangioma of Retina; cavernous hemangioma of retina; Cavernous Hemangioma of the Retina; cavernous hemangioma of the retina; Retina Cavernous Angioma; retina cavernous angioma; Retina Cavernous Hemangioma; retina cavernous hemangioma; Retinal Cavernous Angioma; retinal cavernous angioma; Retinal Cavernous Hemangioma; retinal cavernous hemangioma
SNOMED CT: Cavernous hemangioma of retina (312937006)
 
HPO: HP:0011513
Monarch Initiative: MONDO:0021281

Definition

A benign tumor of the retina that appears as a grouping of blood-filled saccules within the inner retinal layers or on the surface of the optic disc. Retinal cavernous angioma are described as having a 'cluster of grapes' appearance. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRetinal cavernous angioma
Follow this link to review classifications for Retinal cavernous angioma in Orphanet.

Professional guidelines

PubMed

Classification and management of hereditary retinal angiomas.
Augsburger JJ, Shields JA, Goldberg RE
Int Ophthalmol 1981 Aug;4(1-2):93-106. doi: 10.1007/BF00139583. PMID: 7298262
32P test in the differential diagnosis of ocular malignancy. Discussion.
Cox MS Jr
Trans Sect Ophthalmol Am Acad Ophthalmol Otolaryngol 1975 Mar-Apr;79(2):OP307-9. PMID: 1145954
Fluorescein angiography. An aid in the differential diagnosis of intraocular tumors.
Gass JD
Int Ophthalmol Clin 1972 Spring;12(1):85-120. doi: 10.1097/00004397-197203000-00007. PMID: 4566519

Recent clinical studies

Etiology

Indocyanine Green-Assisted Endoscopic Transorbital Excision of Lateral Orbital Apex Cavernous Hemangioma.
Fong Ng BC, Kwan Mak CH, Chan NL, Lam CW, Yuen HK, Poon TL
World Neurosurg 2022 Feb;158:167. Epub 2021 Nov 20 doi: 10.1016/j.wneu.2021.11.060. PMID: 34808413
Stereotactic radiosurgery for orbital cavernous venous malformation: a single center's experience for 15 years.
Lee WJ, Cho KR, Choi JW, Kong DS, Seol HJ, Nam DH, Kim YD, Woo KI, Lee JI
Acta Neurochir (Wien) 2021 Feb;163(2):357-364. Epub 2020 Sep 15 doi: 10.1007/s00701-020-04575-4. PMID: 32929542
Retinal cavernous hemangioma: fifty-two years of clinical follow-up with clinicopathologic correlation.
Shields JA, Eagle RC Jr, Ewing MQ, Lally SE, Shields CL
Retina 2014 Jun;34(6):1253-7. doi: 10.1097/IAE.0000000000000232. PMID: 24849703
Vertebral and spinal cavernous angiomas associated with familial cerebral cavernous malformation.
Toldo I, Drigo P, Mammi I, Marini V, Carollo C
Surg Neurol 2009 Feb;71(2):167-71. Epub 2008 Jan 22 doi: 10.1016/j.surneu.2007.07.067. PMID: 18207546
Hemangioma of the ciliary body: a case report and review of the literature.
Isola VM
Ophthalmologica 1996;210(4):239-43. doi: 10.1159/000310716. PMID: 8841073

Diagnosis

Hamartomas of the Retina and Optic Disc.
Mirzayev I, Gündüz AK
Turk J Ophthalmol 2022 Dec 28;52(6):421-431. doi: 10.4274/tjo.galenos.2022.25979. PMID: 36578224Free PMC Article
Familial Cavernous Hemangioma.
Torres G, Kini AT, Al Othman B, Lee AG
J Neuroophthalmol 2020 Jun;40(2):262-264. doi: 10.1097/WNO.0000000000000778. PMID: 30893269
Imaging of retinal and choroidal vascular tumours.
Heimann H, Jmor F, Damato B
Eye (Lond) 2013 Feb;27(2):208-16. Epub 2012 Nov 30 doi: 10.1038/eye.2012.251. PMID: 23196648Free PMC Article
Retinal vascular tumors.
Singh AD, Rundle PA, Rennie I
Ophthalmol Clin North Am 2005 Mar;18(1):167-76, x. doi: 10.1016/j.ohc.2004.07.005. PMID: 15763202
Retinal arterial macroaneurysms.
Rabb MF, Gagliano DA, Teske MP
Surv Ophthalmol 1988 Sep-Oct;33(2):73-96. doi: 10.1016/0039-6257(88)90160-9. PMID: 3055391

Therapy

RETINAL CAVERNOUS HEMANGIOMA WITH INTRALESIONAL PHLEBOLITHS.
Yu MD, Dalvin LA, Shields CL
Retin Cases Brief Rep 2020 Fall;14(4):301-304. doi: 10.1097/ICB.0000000000000724. PMID: 29505489
Therapeutic surprise! Photodynamic therapy for cavernous haemangioma of the disc.
Shanmugam MP, Ramanjulu R, Dwivedi S, Barigali A, Havanje A
Indian J Ophthalmol 2017 Aug;65(8):754-757. doi: 10.4103/ijo.IJO_41_16. PMID: 28820168Free PMC Article
Is systemic infliximab therapy effective for retinal cavernous hemangioma?
Alsulaiman SM, Abouammoh MA, Al-Dahmash SA, Abu El-Asrar AM
Saudi Med J 2014 Sep;35(9):1127-30. PMID: 25228188Free PMC Article
A case of branch retinal artery occlusion following orbital cavernous hemangioma excision.
Sacconi R, Giordano Resti A, Lattanzio R, Pierro L, D'angelo A, Baccelli N, Bandello F
Eur J Ophthalmol 2014 Nov-Dec;24(6):972-5. Epub 2014 Jun 12 doi: 10.5301/ejo.5000501. PMID: 24966029
Retinal arterial macroaneurysms.
Rabb MF, Gagliano DA, Teske MP
Surv Ophthalmol 1988 Sep-Oct;33(2):73-96. doi: 10.1016/0039-6257(88)90160-9. PMID: 3055391

Prognosis

CAVERNOUS HEMANGIOMA OF THE RETINA: A Comprehensive Review of the Literature (1934-2015).
Wang W, Chen L
Retina 2017 Apr;37(4):611-621. doi: 10.1097/IAE.0000000000001374. PMID: 27820777
Retinal cavernous hemangioma: fifty-two years of clinical follow-up with clinicopathologic correlation.
Shields JA, Eagle RC Jr, Ewing MQ, Lally SE, Shields CL
Retina 2014 Jun;34(6):1253-7. doi: 10.1097/IAE.0000000000000232. PMID: 24849703
Novel KRIT1/CCM1 mutation in a patient with retinal cavernous hemangioma and cerebral cavernous malformation.
Reddy S, Gorin MB, McCannel TA, Tsui I, Straatsma BR
Graefes Arch Clin Exp Ophthalmol 2010 Sep;248(9):1359-61. Epub 2010 Mar 20 doi: 10.1007/s00417-010-1329-6. PMID: 20306072Free PMC Article
Retinal vascular tumors.
Singh AD, Rundle PA, Rennie I
Ophthalmol Clin North Am 2005 Mar;18(1):167-76, x. doi: 10.1016/j.ohc.2004.07.005. PMID: 15763202
Hemangioma of the ciliary body: a case report and review of the literature.
Isola VM
Ophthalmologica 1996;210(4):239-43. doi: 10.1159/000310716. PMID: 8841073

Clinical prediction guides

Optical coherence tomography angiography findings in retinal cavernous hemangioma: New cases and review of the literature.
Nhari M, Bailleul H, Bricout M, Loria O, Nguyen AM, Kodjikian L, Mathis T
J Fr Ophtalmol 2023 Dec;46(10):1222-1226. Epub 2023 Oct 21 doi: 10.1016/j.jfo.2023.06.012. PMID: 37872067
Hamartomas of the Retina and Optic Disc.
Mirzayev I, Gündüz AK
Turk J Ophthalmol 2022 Dec 28;52(6):421-431. doi: 10.4274/tjo.galenos.2022.25979. PMID: 36578224Free PMC Article
Stereotactic radiosurgery for orbital cavernous venous malformation: a single center's experience for 15 years.
Lee WJ, Cho KR, Choi JW, Kong DS, Seol HJ, Nam DH, Kim YD, Woo KI, Lee JI
Acta Neurochir (Wien) 2021 Feb;163(2):357-364. Epub 2020 Sep 15 doi: 10.1007/s00701-020-04575-4. PMID: 32929542
Familial cerebral, hepatic, and retinal cavernous angiomas: a new syndrome.
Drigo P, Mammi I, Battistella PA, Ricchieri G, Carollo C
Childs Nerv Syst 1994 May;10(4):205-9. doi: 10.1007/BF00301155. PMID: 7923228
Amelanotic choroidal nevi.
Brown GC, Shields JA, Augsburger JJ
Ophthalmology 1981 Nov;88(11):1116-21. doi: 10.1016/s0161-6420(81)34896-9. PMID: 7335317

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