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Second Primary Malignant Neoplasm

MedGen UID:
155897
•Concept ID:
C0751623
•
Neoplastic Process
Synonyms: Cancer, Second; Cancer, Second Primary; Cancers, Second; Cancers, Second Primary; Second Cancer; Second Cancers; Second Primary Cancer; Second Primary Cancers
SNOMED CT: Second primary cancer (878806005)

Definition

A primary malignant neoplasm in a patient who has been already diagnosed with a primary malignant neoplasm in another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSecond Primary Malignant Neoplasm

Professional guidelines

PubMed

Excess Body Weight and the Risk of Second Primary Cancers Among Cancer Survivors.
Bodelon C, Sung H, Mitchell EL, Deubler EL, Newton CC, Jemal A, Teras LR, Patel AV
JAMA Netw Open 2024 Sep 3;7(9):e2433132. doi: 10.1001/jamanetworkopen.2024.33132. PMID: 39287946Free PMC Article

Recent clinical studies

Etiology

Excess Body Weight and the Risk of Second Primary Cancers Among Cancer Survivors.
Bodelon C, Sung H, Mitchell EL, Deubler EL, Newton CC, Jemal A, Teras LR, Patel AV
JAMA Netw Open 2024 Sep 3;7(9):e2433132. doi: 10.1001/jamanetworkopen.2024.33132. PMID: 39287946Free PMC Article
Cell-free DNA fragmentomics and second malignant neoplasm risk in patients with PTEN hamartoma tumor syndrome.
Liu D, Yehia L, Dhawan A, Ni Y, Eng C
Cell Rep Med 2024 Feb 20;5(2):101384. Epub 2024 Jan 18 doi: 10.1016/j.xcrm.2023.101384. PMID: 38242121Free PMC Article
Incidence of second primary malignant neoplasm in Malwa region of central India.
Naik A, Bhandari V, Saadvik RY, Gupta KL, Kausar M, Batra M
J Cancer Res Ther 2018 Jul-Sep;14(5):999-1004. doi: 10.4103/0973-1482.183560. PMID: 30197338
Incidence and Risk of Second Primary Malignant Neoplasm After a First Head and Neck Squamous Cell Carcinoma.
Adjei Boakye E, Buchanan P, Hinyard L, Osazuwa-Peters N, Schootman M, Piccirillo JF
JAMA Otolaryngol Head Neck Surg 2018 Aug 1;144(8):727-737. doi: 10.1001/jamaoto.2018.0993. PMID: 30027284Free PMC Article
BRAF and Epithelial-Mesenchymal Transition: Lessons From Papillary Thyroid Carcinoma and Primary Cutaneous Melanoma.
Mitchell B, Dhingra JK, Mahalingam M
Adv Anat Pathol 2016 Jul;23(4):244-71. doi: 10.1097/PAP.0000000000000113. PMID: 27145091

Diagnosis

Excess Body Weight and the Risk of Second Primary Cancers Among Cancer Survivors.
Bodelon C, Sung H, Mitchell EL, Deubler EL, Newton CC, Jemal A, Teras LR, Patel AV
JAMA Netw Open 2024 Sep 3;7(9):e2433132. doi: 10.1001/jamanetworkopen.2024.33132. PMID: 39287946Free PMC Article
Cell-free DNA fragmentomics and second malignant neoplasm risk in patients with PTEN hamartoma tumor syndrome.
Liu D, Yehia L, Dhawan A, Ni Y, Eng C
Cell Rep Med 2024 Feb 20;5(2):101384. Epub 2024 Jan 18 doi: 10.1016/j.xcrm.2023.101384. PMID: 38242121Free PMC Article
Incidence of second primary malignant neoplasm in Malwa region of central India.
Naik A, Bhandari V, Saadvik RY, Gupta KL, Kausar M, Batra M
J Cancer Res Ther 2018 Jul-Sep;14(5):999-1004. doi: 10.4103/0973-1482.183560. PMID: 30197338
Incidence and Risk of Second Primary Malignant Neoplasm After a First Head and Neck Squamous Cell Carcinoma.
Adjei Boakye E, Buchanan P, Hinyard L, Osazuwa-Peters N, Schootman M, Piccirillo JF
JAMA Otolaryngol Head Neck Surg 2018 Aug 1;144(8):727-737. doi: 10.1001/jamaoto.2018.0993. PMID: 30027284Free PMC Article
BRAF and Epithelial-Mesenchymal Transition: Lessons From Papillary Thyroid Carcinoma and Primary Cutaneous Melanoma.
Mitchell B, Dhingra JK, Mahalingam M
Adv Anat Pathol 2016 Jul;23(4):244-71. doi: 10.1097/PAP.0000000000000113. PMID: 27145091

Therapy

Intensive treatment strategies in advanced-stage Hodgkin's lymphoma (HD9 and HD12): analysis of long-term survival in two randomised trials.
von Tresckow B, Kreissl S, Goergen H, Bröckelmann PJ, Pabst T, Fridrik M, Rummel M, Jung W, Thiemer J, Sasse S, Bürkle C, Baues C, Diehl V, Engert A, Borchmann P; German Hodgkin Study Group
Lancet Haematol 2018 Oct;5(10):e462-e473. doi: 10.1016/S2352-3026(18)30140-6. PMID: 30290903
Incidence of second primary malignant neoplasm in Malwa region of central India.
Naik A, Bhandari V, Saadvik RY, Gupta KL, Kausar M, Batra M
J Cancer Res Ther 2018 Jul-Sep;14(5):999-1004. doi: 10.4103/0973-1482.183560. PMID: 30197338
The development of two different malignancies in a patient with large congenital melanocytic nevus.
Ambros T, Furian R, Riccardi F
Pediatr Dermatol 2011 Nov-Dec;28(6):729-731. Epub 2011 Sep 25 doi: 10.1111/j.1525-1470.2011.01398.x. PMID: 21950562

Prognosis

Cell-free DNA fragmentomics and second malignant neoplasm risk in patients with PTEN hamartoma tumor syndrome.
Liu D, Yehia L, Dhawan A, Ni Y, Eng C
Cell Rep Med 2024 Feb 20;5(2):101384. Epub 2024 Jan 18 doi: 10.1016/j.xcrm.2023.101384. PMID: 38242121Free PMC Article
Risk of subsequent malignant neoplasms after an index potentially-human papillomavirus (HPV)-associated cancers.
Wang M, Sharma A, Osazuwa-Peters N, Simpson MC, Schootman M, Piccirillo JF, Huh WK, Adjei Boakye E
Cancer Epidemiol 2020 Feb;64:101649. Epub 2019 Dec 6 doi: 10.1016/j.canep.2019.101649. PMID: 31816512Free PMC Article
Incidence and Risk of Second Primary Malignant Neoplasm After a First Head and Neck Squamous Cell Carcinoma.
Adjei Boakye E, Buchanan P, Hinyard L, Osazuwa-Peters N, Schootman M, Piccirillo JF
JAMA Otolaryngol Head Neck Surg 2018 Aug 1;144(8):727-737. doi: 10.1001/jamaoto.2018.0993. PMID: 30027284Free PMC Article
Increased melanoma risk in individuals with papillary thyroid carcinoma.
Oakley GM, Curtin K, Layfield L, Jarboe E, Buchmann LO, Hunt JP
JAMA Otolaryngol Head Neck Surg 2014 May;140(5):423-7. doi: 10.1001/jamaoto.2014.78. PMID: 24626334
Familial uveal melanoma. Clinical observations on 56 patients.
Singh AD, Shields CL, De Potter P, Shields JA, Trock B, Cater J, Pastore D
Arch Ophthalmol 1996 Apr;114(4):392-9. doi: 10.1001/archopht.1996.01100130388005. PMID: 8602775

Clinical prediction guides

Cell-free DNA fragmentomics and second malignant neoplasm risk in patients with PTEN hamartoma tumor syndrome.
Liu D, Yehia L, Dhawan A, Ni Y, Eng C
Cell Rep Med 2024 Feb 20;5(2):101384. Epub 2024 Jan 18 doi: 10.1016/j.xcrm.2023.101384. PMID: 38242121Free PMC Article
Risk of subsequent malignant neoplasms after an index potentially-human papillomavirus (HPV)-associated cancers.
Wang M, Sharma A, Osazuwa-Peters N, Simpson MC, Schootman M, Piccirillo JF, Huh WK, Adjei Boakye E
Cancer Epidemiol 2020 Feb;64:101649. Epub 2019 Dec 6 doi: 10.1016/j.canep.2019.101649. PMID: 31816512Free PMC Article
Incidence of second primary malignant neoplasm in Malwa region of central India.
Naik A, Bhandari V, Saadvik RY, Gupta KL, Kausar M, Batra M
J Cancer Res Ther 2018 Jul-Sep;14(5):999-1004. doi: 10.4103/0973-1482.183560. PMID: 30197338
Incidence and Risk of Second Primary Malignant Neoplasm After a First Head and Neck Squamous Cell Carcinoma.
Adjei Boakye E, Buchanan P, Hinyard L, Osazuwa-Peters N, Schootman M, Piccirillo JF
JAMA Otolaryngol Head Neck Surg 2018 Aug 1;144(8):727-737. doi: 10.1001/jamaoto.2018.0993. PMID: 30027284Free PMC Article
Familial uveal melanoma. Clinical observations on 56 patients.
Singh AD, Shields CL, De Potter P, Shields JA, Trock B, Cater J, Pastore D
Arch Ophthalmol 1996 Apr;114(4):392-9. doi: 10.1001/archopht.1996.01100130388005. PMID: 8602775

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