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Second Primary Malignant Neoplasm

MedGen UID:
155897
•Concept ID:
C0751623
•
Neoplastic Process
Synonyms: Cancer, Second; Cancer, Second Primary; Cancers, Second; Cancers, Second Primary; Second Cancer; Second Cancers; Second Primary Cancer; Second Primary Cancers
SNOMED CT: Second primary cancer (878806005)

Definition

A primary malignant neoplasm in a patient who has been already diagnosed with a primary malignant neoplasm in another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSecond Primary Malignant Neoplasm

Professional guidelines

PubMed

European consensus-based interdisciplinary guideline for melanoma. Part 2: Treatment - Update 2022.
Garbe C, Amaral T, Peris K, Hauschild A, Arenberger P, Basset-Seguin N, Bastholt L, Bataille V, Del Marmol V, Dréno B, Fargnoli MC, Forsea AM, Grob JJ, Hoeller C, Kaufmann R, Kelleners-Smeets N, Lallas A, Lebbé C, Lytvynenko B, Malvehy J, Moreno-Ramirez D, Nathan P, Pellacani G, Saiag P, Stratigos AJ, Van Akkooi ACJ, Vieira R, Zalaudek I, Lorigan P; European Dermatology Forum (EDF), the European Association of Dermato-Oncology (EADO), and the European Organization for Research and Treatment of Cancer (EORTC)
Eur J Cancer 2022 Jul;170:256-284. Epub 2022 May 24 doi: 10.1016/j.ejca.2022.04.018. PMID: 35623961
Radiomics Improves Cancer Screening and Early Detection.
Gillies RJ, Schabath MB
Cancer Epidemiol Biomarkers Prev 2020 Dec;29(12):2556-2567. Epub 2020 Sep 11 doi: 10.1158/1055-9965.EPI-20-0075. PMID: 32917666
Testicular Cancer: Diagnosis and Treatment.
Baird DC, Meyers GJ, Hu JS
Am Fam Physician 2018 Feb 15;97(4):261-268. PMID: 29671528

Recent clinical studies

Etiology

Cell-free DNA fragmentomics and second malignant neoplasm risk in patients with PTEN hamartoma tumor syndrome.
Liu D, Yehia L, Dhawan A, Ni Y, Eng C
Cell Rep Med 2024 Feb 20;5(2):101384. Epub 2024 Jan 18 doi: 10.1016/j.xcrm.2023.101384. PMID: 38242121Free PMC Article
Risk of subsequent malignant neoplasms after an index potentially-human papillomavirus (HPV)-associated cancers.
Wang M, Sharma A, Osazuwa-Peters N, Simpson MC, Schootman M, Piccirillo JF, Huh WK, Adjei Boakye E
Cancer Epidemiol 2020 Feb;64:101649. Epub 2019 Dec 6 doi: 10.1016/j.canep.2019.101649. PMID: 31816512Free PMC Article
Incidence of second primary malignant neoplasm in Malwa region of central India.
Naik A, Bhandari V, Saadvik RY, Gupta KL, Kausar M, Batra M
J Cancer Res Ther 2018 Jul-Sep;14(5):999-1004. doi: 10.4103/0973-1482.183560. PMID: 30197338
Incidence and Risk of Second Primary Malignant Neoplasm After a First Head and Neck Squamous Cell Carcinoma.
Adjei Boakye E, Buchanan P, Hinyard L, Osazuwa-Peters N, Schootman M, Piccirillo JF
JAMA Otolaryngol Head Neck Surg 2018 Aug 1;144(8):727-737. doi: 10.1001/jamaoto.2018.0993. PMID: 30027284Free PMC Article
BRAF and Epithelial-Mesenchymal Transition: Lessons From Papillary Thyroid Carcinoma and Primary Cutaneous Melanoma.
Mitchell B, Dhingra JK, Mahalingam M
Adv Anat Pathol 2016 Jul;23(4):244-71. doi: 10.1097/PAP.0000000000000113. PMID: 27145091

Diagnosis

Cell-free DNA fragmentomics and second malignant neoplasm risk in patients with PTEN hamartoma tumor syndrome.
Liu D, Yehia L, Dhawan A, Ni Y, Eng C
Cell Rep Med 2024 Feb 20;5(2):101384. Epub 2024 Jan 18 doi: 10.1016/j.xcrm.2023.101384. PMID: 38242121Free PMC Article
Risk of subsequent malignant neoplasms after an index potentially-human papillomavirus (HPV)-associated cancers.
Wang M, Sharma A, Osazuwa-Peters N, Simpson MC, Schootman M, Piccirillo JF, Huh WK, Adjei Boakye E
Cancer Epidemiol 2020 Feb;64:101649. Epub 2019 Dec 6 doi: 10.1016/j.canep.2019.101649. PMID: 31816512Free PMC Article
Incidence of second primary malignant neoplasm in Malwa region of central India.
Naik A, Bhandari V, Saadvik RY, Gupta KL, Kausar M, Batra M
J Cancer Res Ther 2018 Jul-Sep;14(5):999-1004. doi: 10.4103/0973-1482.183560. PMID: 30197338
Incidence and Risk of Second Primary Malignant Neoplasm After a First Head and Neck Squamous Cell Carcinoma.
Adjei Boakye E, Buchanan P, Hinyard L, Osazuwa-Peters N, Schootman M, Piccirillo JF
JAMA Otolaryngol Head Neck Surg 2018 Aug 1;144(8):727-737. doi: 10.1001/jamaoto.2018.0993. PMID: 30027284Free PMC Article
BRAF and Epithelial-Mesenchymal Transition: Lessons From Papillary Thyroid Carcinoma and Primary Cutaneous Melanoma.
Mitchell B, Dhingra JK, Mahalingam M
Adv Anat Pathol 2016 Jul;23(4):244-71. doi: 10.1097/PAP.0000000000000113. PMID: 27145091

Therapy

Intensive treatment strategies in advanced-stage Hodgkin's lymphoma (HD9 and HD12): analysis of long-term survival in two randomised trials.
von Tresckow B, Kreissl S, Goergen H, Bröckelmann PJ, Pabst T, Fridrik M, Rummel M, Jung W, Thiemer J, Sasse S, Bürkle C, Baues C, Diehl V, Engert A, Borchmann P; German Hodgkin Study Group
Lancet Haematol 2018 Oct;5(10):e462-e473. doi: 10.1016/S2352-3026(18)30140-6. PMID: 30290903
Incidence of second primary malignant neoplasm in Malwa region of central India.
Naik A, Bhandari V, Saadvik RY, Gupta KL, Kausar M, Batra M
J Cancer Res Ther 2018 Jul-Sep;14(5):999-1004. doi: 10.4103/0973-1482.183560. PMID: 30197338
The development of two different malignancies in a patient with large congenital melanocytic nevus.
Ambros T, Furian R, Riccardi F
Pediatr Dermatol 2011 Nov-Dec;28(6):729-731. Epub 2011 Sep 25 doi: 10.1111/j.1525-1470.2011.01398.x. PMID: 21950562

Prognosis

Cell-free DNA fragmentomics and second malignant neoplasm risk in patients with PTEN hamartoma tumor syndrome.
Liu D, Yehia L, Dhawan A, Ni Y, Eng C
Cell Rep Med 2024 Feb 20;5(2):101384. Epub 2024 Jan 18 doi: 10.1016/j.xcrm.2023.101384. PMID: 38242121Free PMC Article
Risk of subsequent malignant neoplasms after an index potentially-human papillomavirus (HPV)-associated cancers.
Wang M, Sharma A, Osazuwa-Peters N, Simpson MC, Schootman M, Piccirillo JF, Huh WK, Adjei Boakye E
Cancer Epidemiol 2020 Feb;64:101649. Epub 2019 Dec 6 doi: 10.1016/j.canep.2019.101649. PMID: 31816512Free PMC Article
Intensive treatment strategies in advanced-stage Hodgkin's lymphoma (HD9 and HD12): analysis of long-term survival in two randomised trials.
von Tresckow B, Kreissl S, Goergen H, Bröckelmann PJ, Pabst T, Fridrik M, Rummel M, Jung W, Thiemer J, Sasse S, Bürkle C, Baues C, Diehl V, Engert A, Borchmann P; German Hodgkin Study Group
Lancet Haematol 2018 Oct;5(10):e462-e473. doi: 10.1016/S2352-3026(18)30140-6. PMID: 30290903
Incidence and Risk of Second Primary Malignant Neoplasm After a First Head and Neck Squamous Cell Carcinoma.
Adjei Boakye E, Buchanan P, Hinyard L, Osazuwa-Peters N, Schootman M, Piccirillo JF
JAMA Otolaryngol Head Neck Surg 2018 Aug 1;144(8):727-737. doi: 10.1001/jamaoto.2018.0993. PMID: 30027284Free PMC Article
Increased melanoma risk in individuals with papillary thyroid carcinoma.
Oakley GM, Curtin K, Layfield L, Jarboe E, Buchmann LO, Hunt JP
JAMA Otolaryngol Head Neck Surg 2014 May;140(5):423-7. doi: 10.1001/jamaoto.2014.78. PMID: 24626334

Clinical prediction guides

Cell-free DNA fragmentomics and second malignant neoplasm risk in patients with PTEN hamartoma tumor syndrome.
Liu D, Yehia L, Dhawan A, Ni Y, Eng C
Cell Rep Med 2024 Feb 20;5(2):101384. Epub 2024 Jan 18 doi: 10.1016/j.xcrm.2023.101384. PMID: 38242121Free PMC Article
Risk of subsequent malignant neoplasms after an index potentially-human papillomavirus (HPV)-associated cancers.
Wang M, Sharma A, Osazuwa-Peters N, Simpson MC, Schootman M, Piccirillo JF, Huh WK, Adjei Boakye E
Cancer Epidemiol 2020 Feb;64:101649. Epub 2019 Dec 6 doi: 10.1016/j.canep.2019.101649. PMID: 31816512Free PMC Article
Intensive treatment strategies in advanced-stage Hodgkin's lymphoma (HD9 and HD12): analysis of long-term survival in two randomised trials.
von Tresckow B, Kreissl S, Goergen H, Bröckelmann PJ, Pabst T, Fridrik M, Rummel M, Jung W, Thiemer J, Sasse S, Bürkle C, Baues C, Diehl V, Engert A, Borchmann P; German Hodgkin Study Group
Lancet Haematol 2018 Oct;5(10):e462-e473. doi: 10.1016/S2352-3026(18)30140-6. PMID: 30290903
Incidence of second primary malignant neoplasm in Malwa region of central India.
Naik A, Bhandari V, Saadvik RY, Gupta KL, Kausar M, Batra M
J Cancer Res Ther 2018 Jul-Sep;14(5):999-1004. doi: 10.4103/0973-1482.183560. PMID: 30197338
Incidence and Risk of Second Primary Malignant Neoplasm After a First Head and Neck Squamous Cell Carcinoma.
Adjei Boakye E, Buchanan P, Hinyard L, Osazuwa-Peters N, Schootman M, Piccirillo JF
JAMA Otolaryngol Head Neck Surg 2018 Aug 1;144(8):727-737. doi: 10.1001/jamaoto.2018.0993. PMID: 30027284Free PMC Article

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