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Primary Malignant Neoplasm

MedGen UID:
227011
•Concept ID:
C1306459
•
Neoplastic Process
Synonym: Primary malignant neoplasm
SNOMED CT: Primary malignant neoplasm (372087000)

Definition

A malignant tumor at the original site of growth. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPrimary Malignant Neoplasm

Professional guidelines

PubMed

Profiling of novel circulating microRNAs as a non-invasive biomarker in diagnosis and follow-up of high and low-grade gliomas.
Tabibkhooei A, Izadpanahi M, Arab A, Zare-Mirzaei A, Minaeian S, Rostami A, Mohsenian A
Clin Neurol Neurosurg 2020 Mar;190:105652. Epub 2019 Dec 27 doi: 10.1016/j.clineuro.2019.105652. PMID: 31896490
Prospect of rindopepimut in the treatment of glioblastoma.
Elsamadicy AA, Chongsathidkiet P, Desai R, Woroniecka K, Farber SH, Fecci PE, Sampson JH
Expert Opin Biol Ther 2017 Apr;17(4):507-513. Epub 2017 Mar 5 doi: 10.1080/14712598.2017.1299705. PMID: 28274144Free PMC Article
Current and future management strategies for relapsed or progressive hepatoblastoma.
Venkatramani R, Furman WL, Fuchs J, Warmann SW, Malogolowkin MH
Paediatr Drugs 2012 Aug 1;14(4):221-32. doi: 10.2165/11597740-000000000-00000. PMID: 22702740

Recent clinical studies

Etiology

Clinical characteristics and prognostic analysis of multiple primary malignant neoplasms in patients with lung cancer.
Wang H, Hou J, Zhang G, Zhang M, Li P, Yan X, Ma Z
Cancer Gene Ther 2019 Nov;26(11-12):419-426. Epub 2019 Jan 31 doi: 10.1038/s41417-019-0084-z. PMID: 30700800
Incidence of second primary malignant neoplasm in Malwa region of central India.
Naik A, Bhandari V, Saadvik RY, Gupta KL, Kausar M, Batra M
J Cancer Res Ther 2018 Jul-Sep;14(5):999-1004. doi: 10.4103/0973-1482.183560. PMID: 30197338
Second Primary Malignant Neoplasms and Survival in Adolescent and Young Adult Cancer Survivors.
Keegan THM, Bleyer A, Rosenberg AS, Li Q, Goldfarb M
JAMA Oncol 2017 Nov 1;3(11):1554-1557. doi: 10.1001/jamaoncol.2017.0465. PMID: 28426850Free PMC Article
Prospect of rindopepimut in the treatment of glioblastoma.
Elsamadicy AA, Chongsathidkiet P, Desai R, Woroniecka K, Farber SH, Fecci PE, Sampson JH
Expert Opin Biol Ther 2017 Apr;17(4):507-513. Epub 2017 Mar 5 doi: 10.1080/14712598.2017.1299705. PMID: 28274144Free PMC Article
BRAF and Epithelial-Mesenchymal Transition: Lessons From Papillary Thyroid Carcinoma and Primary Cutaneous Melanoma.
Mitchell B, Dhingra JK, Mahalingam M
Adv Anat Pathol 2016 Jul;23(4):244-71. doi: 10.1097/PAP.0000000000000113. PMID: 27145091

Diagnosis

GammaTile(®): Surgically targeted radiation therapy for glioblastomas.
Gessler DJ, Ferreira C, Dusenbery K, Chen CC
Future Oncol 2020 Oct;16(30):2445-2455. Epub 2020 Jul 3 doi: 10.2217/fon-2020-0558. PMID: 32618209
Second Primary Malignant Neoplasms and Survival in Adolescent and Young Adult Cancer Survivors.
Keegan THM, Bleyer A, Rosenberg AS, Li Q, Goldfarb M
JAMA Oncol 2017 Nov 1;3(11):1554-1557. doi: 10.1001/jamaoncol.2017.0465. PMID: 28426850Free PMC Article
Prospect of rindopepimut in the treatment of glioblastoma.
Elsamadicy AA, Chongsathidkiet P, Desai R, Woroniecka K, Farber SH, Fecci PE, Sampson JH
Expert Opin Biol Ther 2017 Apr;17(4):507-513. Epub 2017 Mar 5 doi: 10.1080/14712598.2017.1299705. PMID: 28274144Free PMC Article
BRAF and Epithelial-Mesenchymal Transition: Lessons From Papillary Thyroid Carcinoma and Primary Cutaneous Melanoma.
Mitchell B, Dhingra JK, Mahalingam M
Adv Anat Pathol 2016 Jul;23(4):244-71. doi: 10.1097/PAP.0000000000000113. PMID: 27145091
Spinal hemangiomas.
Healy M, Herz DA, Pearl L
Neurosurgery 1983 Dec;13(6):689-91. doi: 10.1227/00006123-198312000-00013. PMID: 6657023

Therapy

Use of multikinase inhibitors/lenvatinib in patients with synchronous/metachronous cancers coinciding with radioactive-resistant differentiated thyroid cancer.
Sambo M
Cancer Med 2022 Oct;11 Suppl 1(Suppl 1):26-32. doi: 10.1002/cam4.5107. PMID: 36202607Free PMC Article
Association Between Androgen Deprivation Therapy and Mortality Among Patients With Prostate Cancer and COVID-19.
Schmidt AL, Tucker MD, Bakouny Z, Labaki C, Hsu CY, Shyr Y, Armstrong AJ, Beer TM, Bijjula RR, Bilen MA, Connell CF, Dawsey SJ, Faller B, Gao X, Gartrell BA, Gill D, Gulati S, Halabi S, Hwang C, Joshi M, Khaki AR, Menon H, Morris MJ, Puc M, Russell KB, Shah NJ, Sharifi N, Shaya J, Schweizer MT, Steinharter J, Wulff-Burchfield EM, Xu W, Zhu J, Mishra S, Grivas P, Rini BI, Warner JL, Zhang T, Choueiri TK, Gupta S, McKay RR
JAMA Netw Open 2021 Nov 1;4(11):e2134330. doi: 10.1001/jamanetworkopen.2021.34330. PMID: 34767021Free PMC Article
GammaTile(®): Surgically targeted radiation therapy for glioblastomas.
Gessler DJ, Ferreira C, Dusenbery K, Chen CC
Future Oncol 2020 Oct;16(30):2445-2455. Epub 2020 Jul 3 doi: 10.2217/fon-2020-0558. PMID: 32618209
Incidence of second primary malignant neoplasm in Malwa region of central India.
Naik A, Bhandari V, Saadvik RY, Gupta KL, Kausar M, Batra M
J Cancer Res Ther 2018 Jul-Sep;14(5):999-1004. doi: 10.4103/0973-1482.183560. PMID: 30197338
Prospect of rindopepimut in the treatment of glioblastoma.
Elsamadicy AA, Chongsathidkiet P, Desai R, Woroniecka K, Farber SH, Fecci PE, Sampson JH
Expert Opin Biol Ther 2017 Apr;17(4):507-513. Epub 2017 Mar 5 doi: 10.1080/14712598.2017.1299705. PMID: 28274144Free PMC Article

Prognosis

GammaTile(®): Surgically targeted radiation therapy for glioblastomas.
Gessler DJ, Ferreira C, Dusenbery K, Chen CC
Future Oncol 2020 Oct;16(30):2445-2455. Epub 2020 Jul 3 doi: 10.2217/fon-2020-0558. PMID: 32618209
Clinical characteristics and prognostic analysis of multiple primary malignant neoplasms in patients with lung cancer.
Wang H, Hou J, Zhang G, Zhang M, Li P, Yan X, Ma Z
Cancer Gene Ther 2019 Nov;26(11-12):419-426. Epub 2019 Jan 31 doi: 10.1038/s41417-019-0084-z. PMID: 30700800
Incidence and Risk of Second Primary Malignant Neoplasm After a First Head and Neck Squamous Cell Carcinoma.
Adjei Boakye E, Buchanan P, Hinyard L, Osazuwa-Peters N, Schootman M, Piccirillo JF
JAMA Otolaryngol Head Neck Surg 2018 Aug 1;144(8):727-737. doi: 10.1001/jamaoto.2018.0993. PMID: 30027284Free PMC Article
Second Primary Malignant Neoplasms and Survival in Adolescent and Young Adult Cancer Survivors.
Keegan THM, Bleyer A, Rosenberg AS, Li Q, Goldfarb M
JAMA Oncol 2017 Nov 1;3(11):1554-1557. doi: 10.1001/jamaoncol.2017.0465. PMID: 28426850Free PMC Article
Malignant neoplasms of the sinonasal tract: report of 71 patients and literature review and analysis.
Khademi B, Moradi A, Hoseini S, Mohammadianpanah M
Oral Maxillofac Surg 2009 Dec;13(4):191-9. doi: 10.1007/s10006-009-0170-8. PMID: 19795137

Clinical prediction guides

3D-printed hemipelvic prosthesis combined with a dual mobility bearing in patients with primary malignant neoplasm involving the acetabulum: clinical outcomes and finite element analysis.
Wang M, Liu T, Xu C, Liu C, Li B, Lian Q, Chen T, Qiao S, Wang Z
BMC Surg 2022 Oct 6;22(1):357. doi: 10.1186/s12893-022-01804-8. PMID: 36203147Free PMC Article
High-throughput microRNA profile in adult and pediatric primary glioblastomas: the role of miR-10b-5p and miR-630 in the tumor aggressiveness.
Junior LGD, Baroni M, Lira RCP, Teixeira S, Fedatto PF, Silveira VS, Suazo VK, Veronez LC, Panepucci RA, Antônio DSM, Yunes JA, Brandalise SR, Dos Santos Aguiar S, Neder L, de Oliveira RS, Machado HR, Carlotti CG Jr, Tone LG, Valera ET, Scrideli CA
Mol Biol Rep 2020 Sep;47(9):6949-6959. Epub 2020 Sep 4 doi: 10.1007/s11033-020-05754-3. PMID: 32888124
Incidence of second primary malignant neoplasm in Malwa region of central India.
Naik A, Bhandari V, Saadvik RY, Gupta KL, Kausar M, Batra M
J Cancer Res Ther 2018 Jul-Sep;14(5):999-1004. doi: 10.4103/0973-1482.183560. PMID: 30197338
Incidence and Risk of Second Primary Malignant Neoplasm After a First Head and Neck Squamous Cell Carcinoma.
Adjei Boakye E, Buchanan P, Hinyard L, Osazuwa-Peters N, Schootman M, Piccirillo JF
JAMA Otolaryngol Head Neck Surg 2018 Aug 1;144(8):727-737. doi: 10.1001/jamaoto.2018.0993. PMID: 30027284Free PMC Article
Cyclin D1 and p53 overexpression predicts multiple primary malignant neoplasms of the hypopharynx and esophagus.
Kohmura T, Hasegawa Y, Ogawa T, Matsuura H, Takahashi M, Yanagita N, Nakashima T
Arch Otolaryngol Head Neck Surg 1999 Dec;125(12):1351-4. doi: 10.1001/archotol.125.12.1351. PMID: 10604413

Recent systematic reviews

Palliative surgery for malignant bowel obstruction from carcinomatosis: a systematic review.
Paul Olson TJ, Pinkerton C, Brasel KJ, Schwarze ML
JAMA Surg 2014 Apr;149(4):383-92. doi: 10.1001/jamasurg.2013.4059. PMID: 24477929Free PMC Article

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