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Sleep Arousal Disorders

MedGen UID:
156256
•Concept ID:
C0752294
•
Disease or Syndrome
Synonyms: Arousal Disorder, Sleep; Arousal Disorders, Sleep; Sleep Arousal Disorder

Definition

Sleep disorders characterized by impaired arousal from the deeper stages of sleep (generally stage III or IV sleep). [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSleep Arousal Disorders

Professional guidelines

PubMed

Management of sleep disorders in fibromyalgia.
Moldofsky H
Rheum Dis Clin North Am 2002 May;28(2):353-65. doi: 10.1016/s0889-857x(01)00012-6. PMID: 12122923

Recent clinical studies

Etiology

Behavioral and psychological treatments for NREM parasomnias: A systematic review.
Mundt JM, Schuiling MD, Warlick C, Dietch JR, Wescott AB, Hagenaars M, Furst A, Khorramdel K, Baron KG
Sleep Med 2023 Nov;111:36-53. Epub 2023 Sep 6 doi: 10.1016/j.sleep.2023.09.004. PMID: 37716336Free PMC Article
Sleep disorders in anti-NMDAR encephalitis.
Ariño H, Muñoz-Lopetegi A, Martinez-Hernandez E, Armangue T, Rosa-Justicia M, Escudero D, Matos N, Graus F, Sugranyes G, Castro-Fornieles J, Compte A, Dalmau J, Santamaria J
Neurology 2020 Aug 11;95(6):e671-e684. Epub 2020 Jun 23 doi: 10.1212/WNL.0000000000009987. PMID: 32576635
Clinical neurophysiology of NREM parasomnias.
Rodriguez CL, Foldvary-Schaefer N
Handb Clin Neurol 2019;161:397-410. doi: 10.1016/B978-0-444-64142-7.00063-1. PMID: 31307616
Treating insomnia improves depression, maladaptive thinking, and hyperarousal in postmenopausal women: comparing cognitive-behavioral therapy for insomnia (CBTI), sleep restriction therapy, and sleep hygiene education.
Kalmbach DA, Cheng P, Arnedt JT, Anderson JR, Roth T, Fellman-Couture C, Williams RA, Drake CL
Sleep Med 2019 Mar;55:124-134. Epub 2018 Dec 28 doi: 10.1016/j.sleep.2018.11.019. PMID: 30785053Free PMC Article
Parasomnias and movement disorders in children and adolescents.
Bloomfield ER, Shatkin JP
Child Adolesc Psychiatr Clin N Am 2009 Oct;18(4):947-65. doi: 10.1016/j.chc.2009.04.010. PMID: 19836698

Diagnosis

Somnambulism.
Cordani R, Lopez R, Barateau L, Chenini S, Nobili L, Dauvilliers Y
Sleep Med Clin 2024 Mar;19(1):43-54. Epub 2023 Nov 2 doi: 10.1016/j.jsmc.2023.10.001. PMID: 38368068
NonREM Disorders of Arousal and Related Parasomnias: an Updated Review.
Irfan M, Schenck CH, Howell MJ
Neurotherapeutics 2021 Jan;18(1):124-139. Epub 2021 Feb 1 doi: 10.1007/s13311-021-01011-y. PMID: 33527254Free PMC Article
Clinical neurophysiology of NREM parasomnias.
Rodriguez CL, Foldvary-Schaefer N
Handb Clin Neurol 2019;161:397-410. doi: 10.1016/B978-0-444-64142-7.00063-1. PMID: 31307616
Arousal disorders.
Provini F, Tinuper P, Bisulli F, Lugaresi E
Sleep Med 2011 Dec;12 Suppl 2:S22-6. doi: 10.1016/j.sleep.2011.10.007. PMID: 22136894
Violence in sleep.
Siclari F, Khatami R, Urbaniok F, Nobili L, Mahowald MW, Schenck CH, Cramer Bornemann MA, Bassetti CL
Brain 2010 Dec;133(Pt 12):3494-509. doi: 10.1093/brain/awq296. PMID: 21126993

Therapy

Big Data in sleep apnoea: Opportunities and challenges.
Pépin JL, Bailly S, Tamisier R
Respirology 2020 May;25(5):486-494. Epub 2019 Aug 14 doi: 10.1111/resp.13669. PMID: 31411796
Treating insomnia improves depression, maladaptive thinking, and hyperarousal in postmenopausal women: comparing cognitive-behavioral therapy for insomnia (CBTI), sleep restriction therapy, and sleep hygiene education.
Kalmbach DA, Cheng P, Arnedt JT, Anderson JR, Roth T, Fellman-Couture C, Williams RA, Drake CL
Sleep Med 2019 Mar;55:124-134. Epub 2018 Dec 28 doi: 10.1016/j.sleep.2018.11.019. PMID: 30785053Free PMC Article
Comorbid sleep disorders and suicide risk among children and adolescents with bipolar disorder.
Stanley IH, Hom MA, Luby JL, Joshi PT, Wagner KD, Emslie GJ, Walkup JT, Axelson DA, Joiner TE
J Psychiatr Res 2017 Dec;95:54-59. Epub 2017 Jul 29 doi: 10.1016/j.jpsychires.2017.07.027. PMID: 28777984Free PMC Article
Hyperarousal in insomnia and hypnotic dose escalation.
Roehrs TA, Roth T
Sleep Med 2016 Jul;23:16-20. Epub 2016 Jul 6 doi: 10.1016/j.sleep.2016.06.008. PMID: 27692272Free PMC Article
Enuresis nocturna and sleep quality.
Gozmen S, Keskin S, Akil I
Pediatr Nephrol 2008 Aug;23(8):1293-6. Epub 2008 May 28 doi: 10.1007/s00467-008-0817-y. PMID: 18506489

Prognosis

Trajectory of maternal depression and parasomnias.
Guttier MC, Halal CS, Matijasevich A, Del-Ponte B, Tovo-Rodrigues L, Barros F, Bassani DG, Santos IS
J Sleep Res 2024 Feb;33(1):e13870. Epub 2023 Mar 20 doi: 10.1111/jsr.13870. PMID: 36940922
Interobserver reliability of ICSD-3 diagnostic criteria for disorders of arousal in adults.
Loddo G, Vignatelli L, Zenesini C, Lusa F, Sambati L, Baldelli L, Favoni V, Pisani LR, Pierangeli G, Cevoli S, Provini F
Sleep Breath 2019 Dec;23(4):1309-1314. Epub 2019 Sep 14 doi: 10.1007/s11325-019-01937-w. PMID: 31522407
Treating insomnia improves depression, maladaptive thinking, and hyperarousal in postmenopausal women: comparing cognitive-behavioral therapy for insomnia (CBTI), sleep restriction therapy, and sleep hygiene education.
Kalmbach DA, Cheng P, Arnedt JT, Anderson JR, Roth T, Fellman-Couture C, Williams RA, Drake CL
Sleep Med 2019 Mar;55:124-134. Epub 2018 Dec 28 doi: 10.1016/j.sleep.2018.11.019. PMID: 30785053Free PMC Article
Obstructive sleep apnea exaggerates cognitive dysfunction in stroke patients.
Zhang Y, Wang W, Cai S, Sheng Q, Pan S, Shen F, Tang Q, Liu Y
Sleep Med 2017 May;33:183-190. Epub 2017 Feb 4 doi: 10.1016/j.sleep.2016.11.028. PMID: 28291701
Sleep-related cortical arousals in adult subjects with negative polysomnography.
Jaimchariyatam N, Rodriguez CL, Budur K
Sleep Breath 2015 Sep;19(3):989-96. Epub 2014 Dec 4 doi: 10.1007/s11325-014-1090-x. PMID: 25471634

Clinical prediction guides

Nocturnal agitation: From sleep state dissociation to sleep-related dissociative state.
Lopez R, Micoulaud-Franchi JA, Peter-Derex L, Dauvilliers Y
Rev Neurol (Paris) 2023 Oct;179(7):675-686. Epub 2023 Aug 23 doi: 10.1016/j.neurol.2023.07.003. PMID: 37625976
Disorders of arousal in 4 older men: evidence from clinical practice.
Loddo G, Fragiacomo F, Mainieri G, Mondini S, Buzzi G, Calandra-Buonaura G, Provini F
J Clin Sleep Med 2022 Jan 1;18(1):129-136. doi: 10.5664/jcsm.9516. PMID: 34180806Free PMC Article
Sleep disorders in anti-NMDAR encephalitis.
Ariño H, Muñoz-Lopetegi A, Martinez-Hernandez E, Armangue T, Rosa-Justicia M, Escudero D, Matos N, Graus F, Sugranyes G, Castro-Fornieles J, Compte A, Dalmau J, Santamaria J
Neurology 2020 Aug 11;95(6):e671-e684. Epub 2020 Jun 23 doi: 10.1212/WNL.0000000000009987. PMID: 32576635
Violence in sleep.
Siclari F, Khatami R, Urbaniok F, Nobili L, Mahowald MW, Schenck CH, Cramer Bornemann MA, Bassetti CL
Brain 2010 Dec;133(Pt 12):3494-509. doi: 10.1093/brain/awq296. PMID: 21126993
Sleep disturbances in Parkinsonism.
Askenasy JJ
J Neural Transm (Vienna) 2003 Feb;110(2):125-50. doi: 10.1007/s007020300001. PMID: 12589574

Recent systematic reviews

Behavioral and psychological treatments for NREM parasomnias: A systematic review.
Mundt JM, Schuiling MD, Warlick C, Dietch JR, Wescott AB, Hagenaars M, Furst A, Khorramdel K, Baron KG
Sleep Med 2023 Nov;111:36-53. Epub 2023 Sep 6 doi: 10.1016/j.sleep.2023.09.004. PMID: 37716336Free PMC Article

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