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Mucosal Melanoma of the Head and Neck

MedGen UID:
1612951
•Concept ID:
C4524458
•
Neoplastic Process

Definition

A melanoma that arises in the mucosa of the nasal cavity, paranasal sinuses, oral cavity, oropharynx, nasopharynx, larynx, and hypopharynx. [from NCI]

Professional guidelines

PubMed

Epidemiology, staging and management of mucosal melanoma of the head and neck: a narrative review.
Jeong YJ, Thompson JF, Ch'ng S
Chin Clin Oncol 2023 Jun;12(3):28. doi: 10.21037/cco-23-16. PMID: 37417292
Management of mucosal melanomas of the head and neck: did we make any progress?
Moreno MA, Hanna EY
Curr Opin Otolaryngol Head Neck Surg 2010 Apr;18(2):101-6. doi: 10.1097/MOO.0b013e3283374d31. PMID: 20234212
Current management of mucosal melanoma of the head and neck.
Medina JE, Ferlito A, Pellitteri PK, Shaha AR, Khafif A, Devaney KO, Fisher SR, O'Brien CJ, Byers RM, Robbins KT, Pitman KT, Rinaldo A
J Surg Oncol 2003 Jun;83(2):116-22. doi: 10.1002/jso.10247. PMID: 12772206

Recent clinical studies

Etiology

PRAME Expression in Mucosal Melanoma of the Head and Neck Region.
Ricci C, Altavilla MV, Corti B, Pasquini E, Presutti L, Baietti AM, Amorosa L, Balbi T, Baldovini C, Ambrosi F, Grillini M, D'Errico A, Fiorentino M, Foschini MP
Am J Surg Pathol 2023 May 1;47(5):599-610. Epub 2023 Mar 13 doi: 10.1097/PAS.0000000000002032. PMID: 36912431Free PMC Article
Mucosal melanoma of the head and neck.
Ascierto PA, Accorona R, Botti G, Farina D, Fossati P, Gatta G, Gogas H, Lombardi D, Maroldi R, Nicolai P, Ravanelli M, Vanella V
Crit Rev Oncol Hematol 2017 Apr;112:136-152. Epub 2017 Feb 13 doi: 10.1016/j.critrevonc.2017.01.019. PMID: 28325255
Outcomes of mucosal melanoma of the head and neck.
Frakes JM, Strom TJ, Naghavi AO, Trotti A, Rao NG, McCaffrey JC, Otto KJ, Padhya T, Caudell JJ
J Med Imaging Radiat Oncol 2016 Apr;60(2):268-73. Epub 2015 Nov 23 doi: 10.1111/1754-9485.12404. PMID: 26597431
Mucosal melanoma of the head and neck: recurrence characteristics and survival outcomes.
Bakkal FK, Başman A, Kızıl Y, Ekinci Ö, Gümüşok M, Ekrem Zorlu M, Aydil U
Oral Surg Oral Med Oral Pathol Oral Radiol 2015 Nov;120(5):575-80. Epub 2015 Jul 6 doi: 10.1016/j.oooo.2015.06.038. PMID: 26260765
Management of mucosal melanomas of the head and neck: did we make any progress?
Moreno MA, Hanna EY
Curr Opin Otolaryngol Head Neck Surg 2010 Apr;18(2):101-6. doi: 10.1097/MOO.0b013e3283374d31. PMID: 20234212

Diagnosis

PRAME Expression in Mucosal Melanoma of the Head and Neck Region.
Ricci C, Altavilla MV, Corti B, Pasquini E, Presutti L, Baietti AM, Amorosa L, Balbi T, Baldovini C, Ambrosi F, Grillini M, D'Errico A, Fiorentino M, Foschini MP
Am J Surg Pathol 2023 May 1;47(5):599-610. Epub 2023 Mar 13 doi: 10.1097/PAS.0000000000002032. PMID: 36912431Free PMC Article
Mucosal melanoma of the head and neck: recurrence characteristics and survival outcomes.
Bakkal FK, Başman A, Kızıl Y, Ekinci Ö, Gümüşok M, Ekrem Zorlu M, Aydil U
Oral Surg Oral Med Oral Pathol Oral Radiol 2015 Nov;120(5):575-80. Epub 2015 Jul 6 doi: 10.1016/j.oooo.2015.06.038. PMID: 26260765
Mucosal melanoma of the head and neck: a systematic review of the literature.
Lazarev S, Gupta V, Hu K, Harrison LB, Bakst R
Int J Radiat Oncol Biol Phys 2014 Dec 1;90(5):1108-18. doi: 10.1016/j.ijrobp.2014.03.042. PMID: 25539369
Rare presentations of primary melanoma and special populations: a systematic review.
Kottschade LA, Grotz TE, Dronca RS, Salomao DR, Pulido JS, Wasif N, Jakub JW, Bagaria SP, Kumar R, Kaur JS, Morita SY, Moran SL, Nguyen JT, Nguyen EC, Hand JL, Erickson LA, Brewer JD, Baum CL, Miller RC, Swanson DL, Lowe V, Markovic SN
Am J Clin Oncol 2014 Dec;37(6):635-41. doi: 10.1097/COC.0b013e3182868e82. PMID: 23563206Free PMC Article
Management of mucosal melanomas of the head and neck: did we make any progress?
Moreno MA, Hanna EY
Curr Opin Otolaryngol Head Neck Surg 2010 Apr;18(2):101-6. doi: 10.1097/MOO.0b013e3283374d31. PMID: 20234212

Therapy

Importance of Margins, Radiotherapy, and Systemic Therapy in Mucosal Melanoma of the Head and Neck.
Sahovaler A, Ziai H, Cardemil F, Huang SH, Su J, Goldstein DP, Gilbert R, Hosni A, Hope A, Waldron J, Spreafico A, Monteiro E, Witterick I, Irish J, Gullane P, Xu W, O'Sullivan B, de Almeida JR
Laryngoscope 2021 Oct;131(10):2269-2276. Epub 2021 Apr 15 doi: 10.1002/lary.29555. PMID: 33856051
Proton beam therapy as a nonsurgical approach to mucosal melanoma of the head and neck: a pilot study.
Zenda S, Kawashima M, Nishio T, Kohno R, Nihei K, Onozawa M, Arahira S, Ogino T
Int J Radiat Oncol Biol Phys 2011 Sep 1;81(1):135-9. Epub 2010 Oct 13 doi: 10.1016/j.ijrobp.2010.04.071. PMID: 20950948
Biochemotherapy in patients with advanced head and neck mucosal melanoma.
Bartell HL, Bedikian AY, Papadopoulos NE, Dett TK, Ballo MT, Myers JN, Hwu P, Kim KB
Head Neck 2008 Dec;30(12):1592-8. doi: 10.1002/hed.20910. PMID: 18798304
Primary malignant mucosal melanoma of the head and neck.
Bradley PJ
Curr Opin Otolaryngol Head Neck Surg 2006 Apr;14(2):100-4. doi: 10.1097/01.moo.0000193176.54450.c4. PMID: 16552267
Melanoma of the head and neck.
Day TA, Hornig JD, Sharma AK, Brescia F, Gillespie MB, Lathers D
Curr Treat Options Oncol 2005 Jan;6(1):19-30. doi: 10.1007/s11864-005-0010-5. PMID: 15610712

Prognosis

Mucosal melanoma of the head and neck.
Ascierto PA, Accorona R, Botti G, Farina D, Fossati P, Gatta G, Gogas H, Lombardi D, Maroldi R, Nicolai P, Ravanelli M, Vanella V
Crit Rev Oncol Hematol 2017 Apr;112:136-152. Epub 2017 Feb 13 doi: 10.1016/j.critrevonc.2017.01.019. PMID: 28325255
Mucosal melanoma of the head and neck: a systematic review of the literature.
Lazarev S, Gupta V, Hu K, Harrison LB, Bakst R
Int J Radiat Oncol Biol Phys 2014 Dec 1;90(5):1108-18. doi: 10.1016/j.ijrobp.2014.03.042. PMID: 25539369
Mucosal melanoma of the head and neck: predictors of prognosis.
Shuman AG, Light E, Olsen SH, Pynnonen MA, Taylor JM, Johnson TM, Bradford CR
Arch Otolaryngol Head Neck Surg 2011 Apr;137(4):331-7. doi: 10.1001/archoto.2011.46. PMID: 21502471
Management of mucosal melanomas of the head and neck: did we make any progress?
Moreno MA, Hanna EY
Curr Opin Otolaryngol Head Neck Surg 2010 Apr;18(2):101-6. doi: 10.1097/MOO.0b013e3283374d31. PMID: 20234212
Melanoma of the head and neck.
Day TA, Hornig JD, Sharma AK, Brescia F, Gillespie MB, Lathers D
Curr Treat Options Oncol 2005 Jan;6(1):19-30. doi: 10.1007/s11864-005-0010-5. PMID: 15610712

Clinical prediction guides

PRAME Expression in Mucosal Melanoma of the Head and Neck Region.
Ricci C, Altavilla MV, Corti B, Pasquini E, Presutti L, Baietti AM, Amorosa L, Balbi T, Baldovini C, Ambrosi F, Grillini M, D'Errico A, Fiorentino M, Foschini MP
Am J Surg Pathol 2023 May 1;47(5):599-610. Epub 2023 Mar 13 doi: 10.1097/PAS.0000000000002032. PMID: 36912431Free PMC Article
Predictors of survival in head and neck mucosal melanoma.
Schmidt MQ, David J, Yoshida EJ, Scher K, Mita A, Shiao SL, Ho AS, Zumsteg ZS
Oral Oncol 2017 Oct;73:36-42. Epub 2017 Aug 10 doi: 10.1016/j.oraloncology.2017.08.002. PMID: 28939074
Checkpoint inhibition for advanced mucosal melanoma.
Thierauf J, Veit JA, Hess J, Treiber N, Lisson C, Weissinger SE, Bommer M, Hoffmann TK
Eur J Dermatol 2017 Apr 1;27(2):160-165. doi: 10.1684/ejd.2016.2949. PMID: 28174141
Primary malignant mucosal melanoma of the head and neck.
Bradley PJ
Curr Opin Otolaryngol Head Neck Surg 2006 Apr;14(2):100-4. doi: 10.1097/01.moo.0000193176.54450.c4. PMID: 16552267
Current management of mucosal melanoma of the head and neck.
Medina JE, Ferlito A, Pellitteri PK, Shaha AR, Khafif A, Devaney KO, Fisher SR, O'Brien CJ, Byers RM, Robbins KT, Pitman KT, Rinaldo A
J Surg Oncol 2003 Jun;83(2):116-22. doi: 10.1002/jso.10247. PMID: 12772206

Recent systematic reviews

Immunotherapy as a treatment modality for mucosal melanoma of the head and neck: A systematic review.
Wehbe J, Jaikaransingh D, Walker A
Medicine (Baltimore) 2022 Aug 5;101(31):e29979. doi: 10.1097/MD.0000000000029979. PMID: 35945708Free PMC Article
Mucosal melanoma of the head and neck: a systematic review of the literature.
Lazarev S, Gupta V, Hu K, Harrison LB, Bakst R
Int J Radiat Oncol Biol Phys 2014 Dec 1;90(5):1108-18. doi: 10.1016/j.ijrobp.2014.03.042. PMID: 25539369
Rare presentations of primary melanoma and special populations: a systematic review.
Kottschade LA, Grotz TE, Dronca RS, Salomao DR, Pulido JS, Wasif N, Jakub JW, Bagaria SP, Kumar R, Kaur JS, Morita SY, Moran SL, Nguyen JT, Nguyen EC, Hand JL, Erickson LA, Brewer JD, Baum CL, Miller RC, Swanson DL, Lowe V, Markovic SN
Am J Clin Oncol 2014 Dec;37(6):635-41. doi: 10.1097/COC.0b013e3182868e82. PMID: 23563206Free PMC Article

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