U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Head and neck cancer

MedGen UID:
78920
Concept ID:
C0278996
Neoplastic Process
Synonyms: Cancer of Head and Neck; Cancer of the Head and Neck; Head and Neck Cancer
SNOMED CT: Malignant tumor of head and/or neck (255056009); Malignant tumor of head and neck (255056009)
 
Monarch Initiative: MONDO:0005627

Definition

A primary or metastatic malignant neoplasm affecting the head and neck. Representative examples include oral cavity squamous cell carcinoma, laryngeal squamous cell carcinoma, and salivary gland carcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Head and neck cancer

Professional guidelines

PubMed

Kuan EC, Wang EW, Adappa ND, Beswick DM, London NR Jr, Su SY, Wang MB, Abuzeid WM, Alexiev B, Alt JA, Antognoni P, Alonso-Basanta M, Batra PS, Bhayani M, Bell D, Bernal-Sprekelsen M, Betz CS, Blay JY, Bleier BS, Bonilla-Velez J, Callejas C, Carrau RL, Casiano RR, Castelnuovo P, Chandra RK, Chatzinakis V, Chen SB, Chiu AG, Choby G, Chowdhury NI, Citardi MJ, Cohen MA, Dagan R, Dalfino G, Dallan I, Dassi CS, de Almeida J, Dei Tos AP, DelGaudio JM, Ebert CS, El-Sayed IH, Eloy JA, Evans JJ, Fang CH, Farrell NF, Ferrari M, Fischbein N, Folbe A, Fokkens WJ, Fox MG, Lund VJ, Gallia GL, Gardner PA, Geltzeiler M, Georgalas C, Getz AE, Govindaraj S, Gray ST, Grayson JW, Gross BA, Grube JG, Guo R, Ha PK, Halderman AA, Hanna EY, Harvey RJ, Hernandez SC, Holtzman AL, Hopkins C, Huang Z, Huang Z, Humphreys IM, Hwang PH, Iloreta AM, Ishii M, Ivan ME, Jafari A, Kennedy DW, Khan M, Kimple AJ, Kingdom TT, Knisely A, Kuo YJ, Lal D, Lamarre ED, Lan MY, Le H, Lechner M, Lee NY, Lee JK, Lee VH, Levine CG, Lin JC, Lin DT, Lobo BC, Locke T, Luong AU, Magliocca KR, Markovic SN, Matnjani G, McKean EL, Meço C, Mendenhall WM, Michel L, Na'ara S, Nicolai P, Nuss DW, Nyquist GG, Oakley GM, Omura K, Orlandi RR, Otori N, Papagiannopoulos P, Patel ZM, Pfister DG, Phan J, Psaltis AJ, Rabinowitz MR, Ramanathan M Jr, Rimmer R, Rosen MR, Sanusi O, Sargi ZB, Schafhausen P, Schlosser RJ, Sedaghat AR, Senior BA, Shrivastava R, Sindwani R, Smith TL, Smith KA, Snyderman CH, Solares CA, Sreenath SB, Stamm A, Stölzel K, Sumer B, Surda P, Tajudeen BA, Thompson LDR, Thorp BD, Tong CCL, Tsang RK, Turner JH, Turri-Zanoni M, Udager AM, van Zele T, VanKoevering K, Welch KC, Wise SK, Witterick IJ, Won TB, Wong SN, Woodworth BA, Wormald PJ, Yao WC, Yeh CF, Zhou B, Palmer JN
Int Forum Allergy Rhinol 2024 Feb;14(2):149-608. Epub 2024 Jan 2 doi: 10.1002/alr.23262. PMID: 37658764
Nakao-Kato M, Rathore FA
J Pak Med Assoc 2023 Aug;73(8):1749-1752. doi: 10.47391/JPMA.23-61. PMID: 37697781
Marur S, Forastiere AA
Mayo Clin Proc 2016 Mar;91(3):386-96. doi: 10.1016/j.mayocp.2015.12.017. PMID: 26944243

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Head and Neck Cancers, 2024

UK NICE Guideline NG12, Suspected cancer: recognition and referral, 2023

Recent clinical studies

Etiology

De Pasquale G, Mancin S, Matteucci S, Cattani D, Pastore M, Franzese C, Scorsetti M, Mazzoleni B
Clin Nutr ESPEN 2023 Dec;58:326-334. Epub 2023 Oct 31 doi: 10.1016/j.clnesp.2023.10.033. PMID: 38057023
Porcheri C, Mitsiadis TA
Adv Exp Med Biol 2021;1287:81-103. doi: 10.1007/978-3-030-55031-8_7. PMID: 33034028
Rahman QB, Iocca O, Kufta K, Shanti RM
Oral Maxillofac Surg Clin North Am 2020 Aug;32(3):367-375. Epub 2020 May 29 doi: 10.1016/j.coms.2020.04.002. PMID: 32482563
Cervenka BP, Rao S, Bewley AF
Otolaryngol Clin North Am 2018 Aug;51(4):741-751. Epub 2018 May 23 doi: 10.1016/j.otc.2018.03.004. PMID: 29801920
Gogarty DS, Shuman A, O'Sullivan EM, Sheahan P, Kinsella J, Timon C, O'Neill JP
J Laryngol Otol 2016 Jan;130(1):8-14. Epub 2015 Nov 20 doi: 10.1017/S0022215115003084. PMID: 26585180

Diagnosis

De Pasquale G, Mancin S, Matteucci S, Cattani D, Pastore M, Franzese C, Scorsetti M, Mazzoleni B
Clin Nutr ESPEN 2023 Dec;58:326-334. Epub 2023 Oct 31 doi: 10.1016/j.clnesp.2023.10.033. PMID: 38057023
Müller Bark J, Kulasinghe A, Amenábar JM, Punyadeera C
Adv Clin Chem 2021;101:1-40. Epub 2020 Aug 18 doi: 10.1016/bs.acc.2020.06.006. PMID: 33706886
Rahman QB, Iocca O, Kufta K, Shanti RM
Oral Maxillofac Surg Clin North Am 2020 Aug;32(3):367-375. Epub 2020 May 29 doi: 10.1016/j.coms.2020.04.002. PMID: 32482563
Yan K, Agrawal N, Gooi Z
Med Clin North Am 2018 Nov;102(6):1013-1025. Epub 2018 Sep 20 doi: 10.1016/j.mcna.2018.06.012. PMID: 30342605
Huang SH, O'Sullivan B
Curr Treat Options Oncol 2017 Jul;18(7):40. doi: 10.1007/s11864-017-0484-y. PMID: 28555375

Therapy

Lacas B, Carmel A, Landais C, Wong SJ, Licitra L, Tobias JS, Burtness B, Ghi MG, Cohen EEW, Grau C, Wolf G, Hitt R, Corvò R, Budach V, Kumar S, Laskar SG, Mazeron JJ, Zhong LP, Dobrowsky W, Ghadjar P, Fallai C, Zakotnik B, Sharma A, Bensadoun RJ, Ruo Redda MG, Racadot S, Fountzilas G, Brizel D, Rovea P, Argiris A, Nagy ZT, Lee JW, Fortpied C, Harris J, Bourhis J, Aupérin A, Blanchard P, Pignon JP; MACH-NC Collaborative Group
Radiother Oncol 2021 Mar;156:281-293. Epub 2021 Jan 27 doi: 10.1016/j.radonc.2021.01.013. PMID: 33515668Free PMC Article
Wang C, Dickie J, Sutavani RV, Pointer C, Thomas GJ, Savelyeva N
Front Immunol 2018;9:830. Epub 2018 Apr 23 doi: 10.3389/fimmu.2018.00830. PMID: 29740440Free PMC Article
Ng WT, Wong ECY, Lee VHF, Chan JYW, Lee AWM
Jpn J Clin Oncol 2018 Jan 1;48(1):13-21. doi: 10.1093/jjco/hyx151. PMID: 29145620
Fukuhara H, Ino Y, Todo T
Cancer Sci 2016 Oct;107(10):1373-1379. Epub 2016 Sep 9 doi: 10.1111/cas.13027. PMID: 27486853Free PMC Article
Rivera F, García-Castaño A, Vega N, Vega-Villegas ME, Gutiérrez-Sanz L
Expert Rev Anticancer Ther 2009 Oct;9(10):1421-8. doi: 10.1586/era.09.113. PMID: 19828002

Prognosis

Frowen J
Curr Opin Otolaryngol Head Neck Surg 2019 Jun;27(3):162-167. doi: 10.1097/MOO.0000000000000541. PMID: 30946062
Zanoni DK, Montero PH, Migliacci JC, Shah JP, Wong RJ, Ganly I, Patel SG
Oral Oncol 2019 Mar;90:115-121. Epub 2019 Feb 15 doi: 10.1016/j.oraloncology.2019.02.001. PMID: 30846169Free PMC Article
De Felice F, de Vincentiis M, Valentini V, Musio D, Mezi S, Lo Mele L, Terenzi V, D'Aguanno V, Cassoni A, Di Brino M, Tenore G, Bulzonetti N, Battisti A, Greco A, Pompa G, Minni A, Romeo U, Cortesi E, Polimeni A, Tombolini V
Crit Rev Oncol Hematol 2017 May;113:151-155. Epub 2017 Mar 14 doi: 10.1016/j.critrevonc.2017.03.012. PMID: 28427504
Miller MC, Shuman AG; American Head and Neck Society’s Committee on Survivorship
JAMA Otolaryngol Head Neck Surg 2016 Oct 1;142(10):1002-1008. doi: 10.1001/jamaoto.2016.1615. PMID: 27414519
Yoshida EJ, García J, Eisele DW, Chen AM
Int J Pediatr Otorhinolaryngol 2014 Feb;78(2):174-8. Epub 2013 Nov 19 doi: 10.1016/j.ijporl.2013.11.001. PMID: 24332197

Clinical prediction guides

Moloney EC, Brunner M, Alexander AJ, Clark J
Head Neck 2015 Aug;37(8):1225-31. Epub 2014 Jul 11 doi: 10.1002/hed.23722. PMID: 24797251
Nelke KH, Pawlak W, Gerber H, Leszczyszyn J
Adv Clin Exp Med 2014 Nov-Dec;23(6):1019-27. doi: 10.17219/acem/37361. PMID: 25618131
Vigneswaran N, Williams MD
Oral Maxillofac Surg Clin North Am 2014 May;26(2):123-41. doi: 10.1016/j.coms.2014.01.001. PMID: 24794262Free PMC Article
Worsham MJ, Stephen JK, Chen KM, Havard S, Shah V, Gardner G, Schweitzer VG
Cancer Lett 2014 Jan 28;342(2):178-84. Epub 2012 Mar 1 doi: 10.1016/j.canlet.2012.02.018. PMID: 22388100Free PMC Article
Rivera F, García-Castaño A, Vega N, Vega-Villegas ME, Gutiérrez-Sanz L
Expert Rev Anticancer Ther 2009 Oct;9(10):1421-8. doi: 10.1586/era.09.113. PMID: 19828002

Recent systematic reviews

Kuhn MA, Gillespie MB, Ishman SL, Ishii LE, Brody R, Cohen E, Dhar SI, Hutcheson K, Jefferson G, Johnson F, Rameau A, Sher D, Starmer H, Strohl M, Ulmer K, Vaitaitis V, Begum S, Batjargal M, Dhepyasuwan N
Otolaryngol Head Neck Surg 2023 Apr;168(4):571-592. doi: 10.1002/ohn.302. PMID: 36965195
Bossola M, Antocicco M, Pepe G
JPEN J Parenter Enteral Nutr 2022 Aug;46(6):1258-1269. Epub 2022 May 22 doi: 10.1002/jpen.2360. PMID: 35244947
Mäkitie AA, Alabi RO, Orell H, Youssef O, Almangush A, Homma A, Takes RP, López F, de Bree R, Rodrigo JP, Ferlito A
Adv Ther 2022 Apr;39(4):1502-1523. Epub 2022 Feb 27 doi: 10.1007/s12325-022-02074-9. PMID: 35224702Free PMC Article
Dort JC, Farwell DG, Findlay M, Huber GF, Kerr P, Shea-Budgell MA, Simon C, Uppington J, Zygun D, Ljungqvist O, Harris J
JAMA Otolaryngol Head Neck Surg 2017 Mar 1;143(3):292-303. doi: 10.1001/jamaoto.2016.2981. PMID: 27737447
Cohen EE, LaMonte SJ, Erb NL, Beckman KL, Sadeghi N, Hutcheson KA, Stubblefield MD, Abbott DM, Fisher PS, Stein KD, Lyman GH, Pratt-Chapman ML
CA Cancer J Clin 2016 May;66(3):203-39. Epub 2016 Mar 22 doi: 10.3322/caac.21343. PMID: 27002678

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2024
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Head and Neck Cancers, 2024
    • NICE, 2023
      UK NICE Guideline NG12, Suspected cancer: recognition and referral, 2023

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...