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Head and neck cancer

MedGen UID:
78920
Concept ID:
C0278996
Neoplastic Process
Synonyms: Cancer of Head and Neck; Cancer of the Head and Neck; Head and Neck Cancer
SNOMED CT: Malignant tumor of head and/or neck (255056009); Malignant tumor of head and neck (255056009)
 
Monarch Initiative: MONDO:0005627

Definition

A primary or metastatic malignant neoplasm affecting the head and neck. Representative examples include oral cavity squamous cell carcinoma, laryngeal squamous cell carcinoma, and salivary gland carcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Head and neck cancer

Professional guidelines

PubMed

Kuan EC, Wang EW, Adappa ND, Beswick DM, London NR Jr, Su SY, Wang MB, Abuzeid WM, Alexiev B, Alt JA, Antognoni P, Alonso-Basanta M, Batra PS, Bhayani M, Bell D, Bernal-Sprekelsen M, Betz CS, Blay JY, Bleier BS, Bonilla-Velez J, Callejas C, Carrau RL, Casiano RR, Castelnuovo P, Chandra RK, Chatzinakis V, Chen SB, Chiu AG, Choby G, Chowdhury NI, Citardi MJ, Cohen MA, Dagan R, Dalfino G, Dallan I, Dassi CS, de Almeida J, Dei Tos AP, DelGaudio JM, Ebert CS, El-Sayed IH, Eloy JA, Evans JJ, Fang CH, Farrell NF, Ferrari M, Fischbein N, Folbe A, Fokkens WJ, Fox MG, Lund VJ, Gallia GL, Gardner PA, Geltzeiler M, Georgalas C, Getz AE, Govindaraj S, Gray ST, Grayson JW, Gross BA, Grube JG, Guo R, Ha PK, Halderman AA, Hanna EY, Harvey RJ, Hernandez SC, Holtzman AL, Hopkins C, Huang Z, Huang Z, Humphreys IM, Hwang PH, Iloreta AM, Ishii M, Ivan ME, Jafari A, Kennedy DW, Khan M, Kimple AJ, Kingdom TT, Knisely A, Kuo YJ, Lal D, Lamarre ED, Lan MY, Le H, Lechner M, Lee NY, Lee JK, Lee VH, Levine CG, Lin JC, Lin DT, Lobo BC, Locke T, Luong AU, Magliocca KR, Markovic SN, Matnjani G, McKean EL, Meço C, Mendenhall WM, Michel L, Na'ara S, Nicolai P, Nuss DW, Nyquist GG, Oakley GM, Omura K, Orlandi RR, Otori N, Papagiannopoulos P, Patel ZM, Pfister DG, Phan J, Psaltis AJ, Rabinowitz MR, Ramanathan M Jr, Rimmer R, Rosen MR, Sanusi O, Sargi ZB, Schafhausen P, Schlosser RJ, Sedaghat AR, Senior BA, Shrivastava R, Sindwani R, Smith TL, Smith KA, Snyderman CH, Solares CA, Sreenath SB, Stamm A, Stölzel K, Sumer B, Surda P, Tajudeen BA, Thompson LDR, Thorp BD, Tong CCL, Tsang RK, Turner JH, Turri-Zanoni M, Udager AM, van Zele T, VanKoevering K, Welch KC, Wise SK, Witterick IJ, Won TB, Wong SN, Woodworth BA, Wormald PJ, Yao WC, Yeh CF, Zhou B, Palmer JN
Int Forum Allergy Rhinol 2024 Feb;14(2):149-608. Epub 2024 Jan 2 doi: 10.1002/alr.23262. PMID: 37658764
Capella DL, Gonçalves JM, Abrantes AAA, Grando LJ, Daniel FI
Braz J Otorhinolaryngol 2017 Sep-Oct;83(5):585-593. Epub 2017 Jan 24 doi: 10.1016/j.bjorl.2016.12.005. PMID: 28209441Free PMC Article
Marur S, Forastiere AA
Mayo Clin Proc 2016 Mar;91(3):386-96. doi: 10.1016/j.mayocp.2015.12.017. PMID: 26944243

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Head and Neck Cancers, 2024

UK NICE Guideline NG12, Suspected cancer: recognition and referral, 2023

Recent clinical studies

Etiology

Gui L, He X, Tang L, Yao J, Pi J
BMC Med Genomics 2023 Aug 24;16(1):200. doi: 10.1186/s12920-023-01634-4. PMID: 37620971Free PMC Article
Yu VX, Long S, Tassler A
JAMA Otolaryngol Head Neck Surg 2023 May 1;149(5):470. doi: 10.1001/jamaoto.2023.0195. PMID: 36995722
Juszczak HM, Rosenfeld RM
Otolaryngol Clin North Am 2022 Oct;55(5):909-927. Epub 2022 Sep 7 doi: 10.1016/j.otc.2022.06.001. PMID: 36088162
Porcheri C, Mitsiadis TA
Adv Exp Med Biol 2021;1287:81-103. doi: 10.1007/978-3-030-55031-8_7. PMID: 33034028
Rahman QB, Iocca O, Kufta K, Shanti RM
Oral Maxillofac Surg Clin North Am 2020 Aug;32(3):367-375. Epub 2020 May 29 doi: 10.1016/j.coms.2020.04.002. PMID: 32482563

Diagnosis

Gui L, He X, Tang L, Yao J, Pi J
BMC Med Genomics 2023 Aug 24;16(1):200. doi: 10.1186/s12920-023-01634-4. PMID: 37620971Free PMC Article
Vallianou NG, Evangelopoulos A, Kounatidis D, Panagopoulos F, Geladari E, Karampela I, Stratigou T, Dalamaga M
Curr Oncol Rep 2023 Aug;25(8):897-912. Epub 2023 May 22 doi: 10.1007/s11912-023-01425-1. PMID: 37213060
Müller Bark J, Kulasinghe A, Amenábar JM, Punyadeera C
Adv Clin Chem 2021;101:1-40. Epub 2020 Aug 18 doi: 10.1016/bs.acc.2020.06.006. PMID: 33706886
Yan K, Agrawal N, Gooi Z
Med Clin North Am 2018 Nov;102(6):1013-1025. Epub 2018 Sep 20 doi: 10.1016/j.mcna.2018.06.012. PMID: 30342605
Huang SH, O'Sullivan B
Curr Treat Options Oncol 2017 Jul;18(7):40. doi: 10.1007/s11864-017-0484-y. PMID: 28555375

Therapy

Lacas B, Carmel A, Landais C, Wong SJ, Licitra L, Tobias JS, Burtness B, Ghi MG, Cohen EEW, Grau C, Wolf G, Hitt R, Corvò R, Budach V, Kumar S, Laskar SG, Mazeron JJ, Zhong LP, Dobrowsky W, Ghadjar P, Fallai C, Zakotnik B, Sharma A, Bensadoun RJ, Ruo Redda MG, Racadot S, Fountzilas G, Brizel D, Rovea P, Argiris A, Nagy ZT, Lee JW, Fortpied C, Harris J, Bourhis J, Aupérin A, Blanchard P, Pignon JP; MACH-NC Collaborative Group
Radiother Oncol 2021 Mar;156:281-293. Epub 2021 Jan 27 doi: 10.1016/j.radonc.2021.01.013. PMID: 33515668Free PMC Article
Machiels JP, Tao Y, Burtness B, Tahara M, Licitra L, Rischin D, Waldron J, Simon C, Gregoire V, Harrington K, Alves GV, Figueiredo Lima IP, Pointreau Y, M Hughes BG, Aksoy S, Hetnal M, Ge JY, Brown H, Cheng J, Bidadi B, Siu LL
Future Oncol 2020 Jun;16(18):1235-1243. Epub 2020 Jun 3 doi: 10.2217/fon-2020-0184. PMID: 32490686
Ng WT, Wong ECY, Lee VHF, Chan JYW, Lee AWM
Jpn J Clin Oncol 2018 Jan 1;48(1):13-21. doi: 10.1093/jjco/hyx151. PMID: 29145620
Fukuhara H, Ino Y, Todo T
Cancer Sci 2016 Oct;107(10):1373-1379. Epub 2016 Sep 9 doi: 10.1111/cas.13027. PMID: 27486853Free PMC Article
Rivera F, García-Castaño A, Vega N, Vega-Villegas ME, Gutiérrez-Sanz L
Expert Rev Anticancer Ther 2009 Oct;9(10):1421-8. doi: 10.1586/era.09.113. PMID: 19828002

Prognosis

Lopez J, Tufaro AP
Oral Maxillofac Surg Clin North Am 2024 Aug;36(3):369-377. Epub 2024 May 22 doi: 10.1016/j.coms.2024.04.001. PMID: 38777728
Aragón N, Ordoñez D, Urrea MF, Holguín J, Collazos P, García LS, Osorio MC, Barreto JM, Bravo LE
Community Dent Oral Epidemiol 2022 Aug;50(4):292-299. Epub 2021 Jun 8 doi: 10.1111/cdoe.12671. PMID: 34105170Free PMC Article
Frowen J
Curr Opin Otolaryngol Head Neck Surg 2019 Jun;27(3):162-167. doi: 10.1097/MOO.0000000000000541. PMID: 30946062
Zanoni DK, Montero PH, Migliacci JC, Shah JP, Wong RJ, Ganly I, Patel SG
Oral Oncol 2019 Mar;90:115-121. Epub 2019 Feb 15 doi: 10.1016/j.oraloncology.2019.02.001. PMID: 30846169Free PMC Article
De Felice F, de Vincentiis M, Valentini V, Musio D, Mezi S, Lo Mele L, Terenzi V, D'Aguanno V, Cassoni A, Di Brino M, Tenore G, Bulzonetti N, Battisti A, Greco A, Pompa G, Minni A, Romeo U, Cortesi E, Polimeni A, Tombolini V
Crit Rev Oncol Hematol 2017 May;113:151-155. Epub 2017 Mar 14 doi: 10.1016/j.critrevonc.2017.03.012. PMID: 28427504

Clinical prediction guides

Moloney EC, Brunner M, Alexander AJ, Clark J
Head Neck 2015 Aug;37(8):1225-31. Epub 2014 Jul 11 doi: 10.1002/hed.23722. PMID: 24797251
Nelke KH, Pawlak W, Gerber H, Leszczyszyn J
Adv Clin Exp Med 2014 Nov-Dec;23(6):1019-27. doi: 10.17219/acem/37361. PMID: 25618131
Vigneswaran N, Williams MD
Oral Maxillofac Surg Clin North Am 2014 May;26(2):123-41. doi: 10.1016/j.coms.2014.01.001. PMID: 24794262Free PMC Article
Begg AC
Semin Radiat Oncol 2012 Apr;22(2):108-18. doi: 10.1016/j.semradonc.2011.12.002. PMID: 22385918
Rivera F, García-Castaño A, Vega N, Vega-Villegas ME, Gutiérrez-Sanz L
Expert Rev Anticancer Ther 2009 Oct;9(10):1421-8. doi: 10.1586/era.09.113. PMID: 19828002

Recent systematic reviews

Bossola M, Antocicco M, Pepe G
JPEN J Parenter Enteral Nutr 2022 Aug;46(6):1258-1269. Epub 2022 May 22 doi: 10.1002/jpen.2360. PMID: 35244947
Mäkitie AA, Alabi RO, Orell H, Youssef O, Almangush A, Homma A, Takes RP, López F, de Bree R, Rodrigo JP, Ferlito A
Adv Ther 2022 Apr;39(4):1502-1523. Epub 2022 Feb 27 doi: 10.1007/s12325-022-02074-9. PMID: 35224702Free PMC Article
Banda KJ, Chu H, Kao CC, Voss J, Chiu HL, Chang PC, Chen R, Chou KR
Int J Nurs Stud 2021 Feb;114:103827. Epub 2020 Nov 11 doi: 10.1016/j.ijnurstu.2020.103827. PMID: 33352439
Dort JC, Farwell DG, Findlay M, Huber GF, Kerr P, Shea-Budgell MA, Simon C, Uppington J, Zygun D, Ljungqvist O, Harris J
JAMA Otolaryngol Head Neck Surg 2017 Mar 1;143(3):292-303. doi: 10.1001/jamaoto.2016.2981. PMID: 27737447
Cohen EE, LaMonte SJ, Erb NL, Beckman KL, Sadeghi N, Hutcheson KA, Stubblefield MD, Abbott DM, Fisher PS, Stein KD, Lyman GH, Pratt-Chapman ML
CA Cancer J Clin 2016 May;66(3):203-39. Epub 2016 Mar 22 doi: 10.3322/caac.21343. PMID: 27002678

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2024
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Head and Neck Cancers, 2024
    • NICE, 2023
      UK NICE Guideline NG12, Suspected cancer: recognition and referral, 2023

    Consumer resources

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