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Erythroleukemia

MedGen UID:
1614281
•Concept ID:
C4520840
•
Neoplastic Process
Synonyms: erythroleukemia; Erythroleukemia (Erythroid/Myeloid); Erythroleukemia, Erythroid/Myeloid
 
Monarch Initiative: MONDO:0859598

Definition

Acute erythroid leukemia characterised by the presence of at least 50% erythroid precursors and at least 20% myeloblasts in the bone marrow. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVErythroleukemia

Professional guidelines

PubMed

Erythroleukemia-historical perspectives and recent advances in diagnosis and management.
Boddu P, Benton CB, Wang W, Borthakur G, Khoury JD, Pemmaraju N
Blood Rev 2018 Mar;32(2):96-105. Epub 2017 Sep 18 doi: 10.1016/j.blre.2017.09.002. PMID: 28965757Free PMC Article
Acute erythroleukemia: diagnosis and management.
Santos FP, Bueso-Ramos CE, Ravandi F
Expert Rev Hematol 2010 Dec;3(6):705-18. doi: 10.1586/ehm.10.62. PMID: 21091147
Review: erythroleukemia: clinical course and management.
Masood A, Holkova B, Chanan-Khan A
Clin Adv Hematol Oncol 2010 Apr;8(4):288-90. PMID: 20505652

Recent clinical studies

Therapy

Sunitinib selectively targets leukemogenic signaling of mutant SHP2 in juvenile myelomonocytic leukemia.
He C, Peng Z, Zhang D, Guo Y, Liang T, Zhao Y, Yu L, Zhang Q, Chang Z, Xiao Y, Li N, Xue H, Wu S, Zhao ZJ, Zhang C, Chen Y
Biochem Pharmacol 2023 Jul;213:115588. Epub 2023 May 13 doi: 10.1016/j.bcp.2023.115588. PMID: 37187274
Erythroid/megakaryocytic differentiation confers BCL-XL dependency and venetoclax resistance in acute myeloid leukemia.
Kuusanmäki H, Dufva O, Vähä-Koskela M, Leppä AM, Huuhtanen J, Vänttinen I, Nygren P, Klievink J, Bouhlal J, Pölönen P, Zhang Q, Adnan-Awad S, Mancebo-Pérez C, Saad J, Miettinen J, Javarappa KK, Aakko S, Ruokoranta T, Eldfors S, Heinäniemi M, Theilgaard-Mönch K, Wartiovaara-Kautto U, Keränen M, Porkka K, Konopleva M, Wennerberg K, Kontro M, Heckman CA, Mustjoki S
Blood 2023 Mar 30;141(13):1610-1625. doi: 10.1182/blood.2021011094. PMID: 36508699Free PMC Article
Development of a curative treatment within the AML-BFM studies.
Creutzig U, Zimmermann M, Dworzak MN, Ritter J, Schellong G, Reinhardt D
Klin Padiatr 2013 May;225 Suppl 1:S79-86. Epub 2013 May 22 doi: 10.1055/s-0033-1337968. PMID: 23700063
Discovery and development of SAHA as an anticancer agent.
Marks PA
Oncogene 2007 Feb 26;26(9):1351-6. doi: 10.1038/sj.onc.1210204. PMID: 17322921
From discovery to the coming generation of histone deacetylase inhibitors.
Yoshida M, Matsuyama A, Komatsu Y, Nishino N
Curr Med Chem 2003 Nov;10(22):2351-8. doi: 10.2174/0929867033456602. PMID: 14529478

Prognosis

Erythroid/megakaryocytic differentiation confers BCL-XL dependency and venetoclax resistance in acute myeloid leukemia.
Kuusanmäki H, Dufva O, Vähä-Koskela M, Leppä AM, Huuhtanen J, Vänttinen I, Nygren P, Klievink J, Bouhlal J, Pölönen P, Zhang Q, Adnan-Awad S, Mancebo-Pérez C, Saad J, Miettinen J, Javarappa KK, Aakko S, Ruokoranta T, Eldfors S, Heinäniemi M, Theilgaard-Mönch K, Wartiovaara-Kautto U, Keränen M, Porkka K, Konopleva M, Wennerberg K, Kontro M, Heckman CA, Mustjoki S
Blood 2023 Mar 30;141(13):1610-1625. doi: 10.1182/blood.2021011094. PMID: 36508699Free PMC Article
Erythroleukemia: an Update.
Weinberg OK, Arber DA
Curr Oncol Rep 2021 Apr 20;23(6):69. doi: 10.1007/s11912-021-01060-8. PMID: 33876292
Erythroleukemia-historical perspectives and recent advances in diagnosis and management.
Boddu P, Benton CB, Wang W, Borthakur G, Khoury JD, Pemmaraju N
Blood Rev 2018 Mar;32(2):96-105. Epub 2017 Sep 18 doi: 10.1016/j.blre.2017.09.002. PMID: 28965757Free PMC Article
Revisiting erythroleukemia.
Arber DA
Curr Opin Hematol 2017 Mar;24(2):146-151. doi: 10.1097/MOH.0000000000000314. PMID: 27875373
Acute erythroid leukemia.
Zuo Z, Polski JM, Kasyan A, Medeiros LJ
Arch Pathol Lab Med 2010 Sep;134(9):1261-70. doi: 10.5858/2009-0350-RA.1. PMID: 20807044

Clinical prediction guides

GAPDH is involved in the heme-maturation of myoglobin and hemoglobin.
Tupta B, Stuehr E, Sumi MP, Sweeny EA, Smith B, Stuehr DJ, Ghosh A
FASEB J 2022 Feb;36(2):e22099. doi: 10.1096/fj.202101237RR. PMID: 34972240Free PMC Article
Anticancer Activity and In Silico ADMET Properties of 2,4,5-Trisubstitutedthiazole Derivatives.
Al-Jaidi BA, Telfah ST, Bardaweel SK, Deb PK, Borah P, Venugopala KN, Bataineh YA, Al Khames Aga QA
Curr Drug Metab 2021;22(7):532-536. doi: 10.2174/1389200221666201217094602. PMID: 33334285
Confirming the recessive inheritance of PERP-related erythrokeratoderma.
Patel N, Alkeraye S, Alobeid E, Alshidi T, Helaby R, Abdulwahab F, Shamseldin HE, Alkuraya FS
Clin Genet 2020 Apr;97(4):661-665. Epub 2020 Jan 12 doi: 10.1111/cge.13699. PMID: 31898316
Acute Myeloid Leukemia With Myelodysplasia-Related Changes.
Vardiman J, Reichard K
Am J Clin Pathol 2015 Jul;144(1):29-43. doi: 10.1309/AJCP58RSMFRHLHHH. PMID: 26071460
Transcription factor GATA-1 and erythroid development.
Simon MC
Proc Soc Exp Biol Med 1993 Feb;202(2):115-21. doi: 10.3181/00379727-202-43519a. PMID: 8424101

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