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Cutaneous Squamous Cell Carcinoma of the Head and Neck

MedGen UID:: 1614715
•Concept ID:: C4524517
•: Neoplastic Process

Definition

A squamous cell carcinoma that arises from the skin of the head and neck. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVCutaneous Squamous Cell Carcinoma of the Head and Neck

Disease
- Neoplasm
  - Epithelial neoplasm
    - Carcinoma
      - Head and neck carcinoma
        Squamous cell carcinoma of the head and neck
        Cutaneous Squamous Cell Carcinoma of the Head and Neck
        Cutaneous Squamous Cell Carcinoma of the Head and Neck by AJCC v8 Stage
        Stage 0 Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8
        Stage I Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8
        Stage II Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8
        Stage III Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8
        Stage IV Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8
        External ear squamous cell carcinoma
        Metastatic Cutaneous Squamous Cell Carcinoma of the Head and Neck
        Advanced Cutaneous Squamous Cell Carcinoma of the Head and Neck
        Locally Advanced Cutaneous Squamous Cell Carcinoma of the Head and Neck
        Recurrent Cutaneous Squamous Cell Carcinoma of the Head and Neck
        Refractory Cutaneous Squamous Cell Carcinoma of the Head and Neck
        Resectable Cutaneous Squamous Cell Carcinoma of the Head and Neck

Professional guidelines

PubMed

Surgical management of recurrent cutaneous squamous cell carcinoma of the head and neck after definitive surgery and radiotherapy.

Toppi J, Tham YS, Webb A, Henderson MA, Rischin D, Magarey MJR
ANZ J Surg 2020 Jul;90(7-8):1391-1395. Epub 2020 Jul 5 doi: 10.1111/ans.16095. PMID: 32627359

Head and Neck Cancer International Group (HNCIG) Consensus Guidelines for the Delivery of Postoperative Radiation Therapy in Complex Cutaneous Squamous Cell Carcinoma of the Head and Neck (cSCCHN).

Porceddu SV, Daniels C, Yom SS, Liu H, Waldron J, Gregoire V, Moore A, Veness M, Yao M, Johansen J, Mehanna H, Rischin D, Le QT
Int J Radiat Oncol Biol Phys 2020 Jul 15;107(4):641-651. Epub 2020 Apr 11 doi: 10.1016/j.ijrobp.2020.03.024. PMID: 32289475

Management of the neck in metastatic cutaneous squamous cell carcinoma of the head and neck.

D'Souza J, Clark J
Curr Opin Otolaryngol Head Neck Surg 2011 Apr;19(2):99-105. doi: 10.1097/MOO.0b013e328343e811. PMID: 21297477

See all (14)

Recent clinical studies

Etiology

Aggressive Cutaneous Squamous Cell Carcinoma of the Head and Neck: A Review.

Desai N, Divatia MK, Jadhav A, Wagh A
Curr Oncol 2023 Jul 11;30(7):6634-6647. doi: 10.3390/curroncol30070487. PMID: 37504347 Free PMC Article

High-Risk Cutaneous Squamous Cell Carcinoma of the Head and Neck: A Clinical Review.

Yan F, Tillman BN, Nijhawan RI, Srivastava D, Sher DJ, Avkshtol V, Homsi J, Bishop JA, Wynings EM, Lee R, Myers LL, Day AT
Ann Surg Oncol 2021 Dec;28(13):9009-9030. Epub 2021 Jun 30 doi: 10.1245/s10434-021-10108-9. PMID: 34195900

Head and Neck Cancer International Group (HNCIG) Consensus Guidelines for the Delivery of Postoperative Radiation Therapy in Complex Cutaneous Squamous Cell Carcinoma of the Head and Neck (cSCCHN).

Cutaneous Squamous Cell Carcinoma in Immunosuppressed Patients.

Tam S, Gross ND
Curr Oncol Rep 2019 Jul 29;21(9):82. doi: 10.1007/s11912-019-0831-1. PMID: 31359288

Management of the neck in metastatic cutaneous squamous cell carcinoma of the head and neck.

D'Souza J, Clark J
Curr Opin Otolaryngol Head Neck Surg 2011 Apr;19(2):99-105. doi: 10.1097/MOO.0b013e328343e811. PMID: 21297477

See all (97)

Diagnosis

Aggressive Cutaneous Squamous Cell Carcinoma of the Head and Neck: A Review.

Desai N, Divatia MK, Jadhav A, Wagh A
Curr Oncol 2023 Jul 11;30(7):6634-6647. doi: 10.3390/curroncol30070487. PMID: 37504347 Free PMC Article

High-Risk Cutaneous Squamous Cell Carcinoma of the Head and Neck: A Clinical Review.

Pilot Phase II Trial of Neoadjuvant Immunotherapy in Locoregionally Advanced, Resectable Cutaneous Squamous Cell Carcinoma of the Head and Neck.

Ferrarotto R, Amit M, Nagarajan P, Rubin ML, Yuan Y, Bell D, El-Naggar AK, Johnson JM, Morrison WH, Rosenthal DI, Glisson BS, Johnson FM, Lu C, Mott FE, Esmaeli B, Diaz EM Jr, Gidley PW, Goepfert RP, Lewis CM, Weber RS, Wargo JA, Basu S, Duan F, Yadav SS, Sharma P, Allison JP, Myers JN, Gross ND
Clin Cancer Res 2021 Aug 15;27(16):4557-4565. Epub 2021 Jun 29 doi: 10.1158/1078-0432.CCR-21-0585. PMID: 34187851 Free PMC Article

Survival after parotid gland metastases of cutaneous squamous cell carcinoma of the head and neck.

Meyer MF, Wolber P, Arolt C, Wessel M, Quaas A, Lang S, Klussmann JP, Semrau R, Beutner D
Oral Maxillofac Surg 2021 Sep;25(3):383-388. Epub 2021 Jan 5 doi: 10.1007/s10006-020-00934-8. PMID: 33400041 Free PMC Article

Insight into the epidemiology of cutaneous squamous cell carcinoma with perineural spread.

Warren TA, Whiteman DC, Porceddu SV, Panizza BJ
Head Neck 2016 Sep;38(9):1416-20. Epub 2016 Apr 4 doi: 10.1002/hed.24453. PMID: 27043827

See all (31)

Therapy

High-Risk Cutaneous Squamous Cell Carcinoma of the Head and Neck: A Clinical Review.

Pilot Phase II Trial of Neoadjuvant Immunotherapy in Locoregionally Advanced, Resectable Cutaneous Squamous Cell Carcinoma of the Head and Neck.

Cutaneous Squamous Cell Carcinoma in Immunosuppressed Patients.

Tam S, Gross ND
Curr Oncol Rep 2019 Jul 29;21(9):82. doi: 10.1007/s11912-019-0831-1. PMID: 31359288

Postoperative Concurrent Chemoradiotherapy Versus Postoperative Radiotherapy in High-Risk Cutaneous Squamous Cell Carcinoma of the Head and Neck: The Randomized Phase III TROG 05.01 Trial.

Porceddu SV, Bressel M, Poulsen MG, Stoneley A, Veness MJ, Kenny LM, Wratten C, Corry J, Cooper S, Fogarty GB, Collins M, Collins MK, Macann AMJ, Milross CG, Penniment MG, Liu HY, King MT, Panizza BJ, Rischin D
J Clin Oncol 2018 May 1;36(13):1275-1283. Epub 2018 Mar 14 doi: 10.1200/JCO.2017.77.0941. PMID: 29537906

Prospective study of sentinel node biopsy for high-risk cutaneous squamous cell carcinoma of the head and neck.

Gore SM, Shaw D, Martin RC, Kelder W, Roth K, Uren R, Gao K, Davies S, Ashford BG, Ngo Q, Shannon K, Clark JR
Head Neck 2016 Apr;38 Suppl 1:E884-9. Epub 2015 Jul 15 doi: 10.1002/hed.24120. PMID: 25965008

See all (17)

Prognosis

Aggressive Cutaneous Squamous Cell Carcinoma of the Head and Neck: A Review.

Desai N, Divatia MK, Jadhav A, Wagh A
Curr Oncol 2023 Jul 11;30(7):6634-6647. doi: 10.3390/curroncol30070487. PMID: 37504347 Free PMC Article

High-Risk Cutaneous Squamous Cell Carcinoma of the Head and Neck: A Clinical Review.

Palliative Radiotherapy for Cutaneous Squamous Cell Carcinoma of the Head-and-Neck Region.

Staackmann C, Schild SE, Rades D
In Vivo 2021 Jul-Aug;35(4):2283-2288. doi: 10.21873/invivo.12501. PMID: 34182507 Free PMC Article

Cutaneous Squamous Cell Carcinoma in Immunosuppressed Patients.

Tam S, Gross ND
Curr Oncol Rep 2019 Jul 29;21(9):82. doi: 10.1007/s11912-019-0831-1. PMID: 31359288

Management of the neck in metastatic cutaneous squamous cell carcinoma of the head and neck.

D'Souza J, Clark J
Curr Opin Otolaryngol Head Neck Surg 2011 Apr;19(2):99-105. doi: 10.1097/MOO.0b013e328343e811. PMID: 21297477

See all (91)

Clinical prediction guides

High-Risk Cutaneous Squamous Cell Carcinoma of the Head and Neck: A Clinical Review.

Palliative Radiotherapy for Cutaneous Squamous Cell Carcinoma of the Head-and-Neck Region.

Staackmann C, Schild SE, Rades D
In Vivo 2021 Jul-Aug;35(4):2283-2288. doi: 10.21873/invivo.12501. PMID: 34182507 Free PMC Article

The role of parotidectomy for advanced cutaneous squamous cell carcinoma of the head and neck.

Kampel L, Dorman A, Horovitz G, Warshavsky A, Gutfeld O, Muhanna N
Eur Arch Otorhinolaryngol 2021 Oct;278(10):3955-3963. Epub 2021 Jan 6 doi: 10.1007/s00405-020-06574-8. PMID: 33404750

Postoperative Concurrent Chemoradiotherapy Versus Postoperative Radiotherapy in High-Risk Cutaneous Squamous Cell Carcinoma of the Head and Neck: The Randomized Phase III TROG 05.01 Trial.

Management of the neck in metastatic cutaneous squamous cell carcinoma of the head and neck.

D'Souza J, Clark J
Curr Opin Otolaryngol Head Neck Surg 2011 Apr;19(2):99-105. doi: 10.1097/MOO.0b013e328343e811. PMID: 21297477

See all (55)

Recent systematic reviews

Sentinel lymph node biopsy in high-risk cutaneous squamous cell carcinoma of the head and neck: Systematic review and meta-analysis.

Costantino A, Canali L, Festa BM, Spriano G, Mercante G, De Virgilio A
Head Neck 2022 Oct;44(10):2288-2300. Epub 2022 Jun 17 doi: 10.1002/hed.27121. PMID: 35713173

Outcomes of Cutaneous Squamous Cell Carcinoma in the Head and Neck Region With Regional Lymph Node Metastasis: A Systematic Review and Meta-analysis.

Sahovaler A, Krishnan RJ, Yeh DH, Zhou Q, Palma D, Fung K, Yoo J, Nichols A, MacNeil SD
JAMA Otolaryngol Head Neck Surg 2019 Apr 1;145(4):352-360. doi: 10.1001/jamaoto.2018.4515. PMID: 30844021 Free PMC Article

Immunosuppression Impact on Head and Neck Cutaneous Squamous Cell Carcinoma: A Systematic Review with Meta-analysis.

Elghouche AN, Pflum ZE, Schmalbach CE
Otolaryngol Head Neck Surg 2019 Mar;160(3):439-446. Epub 2018 Oct 23 doi: 10.1177/0194599818808511. PMID: 30348055

See all (3)

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Cutaneous Squamous Cell Carcinoma of the Head and Neck

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Practice guidelines

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