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Refractory Pancreatic Neuroendocrine Carcinoma

MedGen UID:
1617685
•Concept ID:
C4527255
•
Neoplastic Process

Definition

Pancreatic neuroendocrine carcinoma that does not respond to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Pancreatic Neuroendocrine Carcinoma

Professional guidelines

PubMed

Clinicopathological data and treatment modalities for pancreatic vipomas: a systematic review.
Schizas D, Mastoraki A, Bagias G, Patras R, Moris D, Lazaridis II, Arkadopoulos N, Felekouras E
J BUON 2019 Mar-Apr;24(2):415-423. PMID: 31127985
Radioembolization in the treatment of unresectable liver tumors: experience across a range of primary cancers.
Coldwell D, Sangro B, Salem R, Wasan H, Kennedy A
Am J Clin Oncol 2012 Apr;35(2):167-77. doi: 10.1097/COC.0b013e3181f47923. PMID: 21127414
Diagnosis and treatment of gastrinoma in the era of proton pump inhibitors.
Banasch M, Schmitz F
Wien Klin Wochenschr 2007;119(19-20):573-8. doi: 10.1007/s00508-007-0884-2. PMID: 17985090

Recent clinical studies

Etiology

Narrative Review of Immunotherapy in Gastroentero-Pancreatic Neuroendocrine Neoplasms.
Kaur J, Vijayvergia N
Curr Oncol 2023 Sep 21;30(9):8653-8664. doi: 10.3390/curroncol30090627. PMID: 37754542Free PMC Article
A Phase II Trial of Everolimus in Patients with Advanced Pancreatic Neuroendocrine Carcinoma Refractory or Intolerant to Platinum-Containing Chemotherapy (NECTOR Trial).
Okuyama H, Ikeda M, Okusaka T, Furukawa M, Ohkawa S, Hosokawa A, Kojima Y, Hara H, Murohisa G, Shioji K, Asagi A, Mizuno N, Kojima M, Yamanaka T, Furuse J
Neuroendocrinology 2020;110(11-12):988-993. Epub 2020 Jan 2 doi: 10.1159/000505550. PMID: 31986515
Everolimus.
Hasskarl J
Recent Results Cancer Res 2018;211:101-123. doi: 10.1007/978-3-319-91442-8_8. PMID: 30069763
Chemotherapy for advanced poorly differentiated pancreatic neuroendocrine carcinoma.
Ikeda M, Okuyama H, Takahashi H, Ohno I, Shimizu S, Mitsunaga S, Kondo S, Morizane C, Ueno H, Okusaka T
J Hepatobiliary Pancreat Sci 2015 Aug;22(8):623-7. Epub 2015 Mar 5 doi: 10.1002/jhbp.228. PMID: 25755102
Liver transplantation and neuroendocrine tumors: lessons from a single centre experience and from the literature review.
Bonaccorsi-Riani E, Apestegui C, Jouret-Mourin A, Sempoux C, Goffette P, Ciccarelli O, Borbath I, Hubert C, Gigot JF, Hassoun Z, Lerut J
Transpl Int 2010 Jul;23(7):668-78. Epub 2010 May 5 doi: 10.1111/j.1432-2277.2010.01086.x. PMID: 20478000

Diagnosis

Clinicopathological data and treatment modalities for pancreatic vipomas: a systematic review.
Schizas D, Mastoraki A, Bagias G, Patras R, Moris D, Lazaridis II, Arkadopoulos N, Felekouras E
J BUON 2019 Mar-Apr;24(2):415-423. PMID: 31127985
Pancreatic acinar cell carcinoma: A review on molecular profiling of patient tumors.
Al-Hader A, Al-Rohil RN, Han H, Von Hoff D
World J Gastroenterol 2017 Dec 7;23(45):7945-7951. doi: 10.3748/wjg.v23.i45.7945. PMID: 29259370Free PMC Article
Chemotherapy for advanced poorly differentiated pancreatic neuroendocrine carcinoma.
Ikeda M, Okuyama H, Takahashi H, Ohno I, Shimizu S, Mitsunaga S, Kondo S, Morizane C, Ueno H, Okusaka T
J Hepatobiliary Pancreat Sci 2015 Aug;22(8):623-7. Epub 2015 Mar 5 doi: 10.1002/jhbp.228. PMID: 25755102
Zollinger-Ellison syndrome: classical considerations and current controversies.
Epelboym I, Mazeh H
Oncologist 2014 Jan;19(1):44-50. Epub 2013 Dec 6 doi: 10.1634/theoncologist.2013-0369. PMID: 24319020Free PMC Article
Radioembolization of liver tumors with yttrium-90 microspheres.
Ahmadzadehfar H, Biersack HJ, Ezziddin S
Semin Nucl Med 2010 Mar;40(2):105-21. doi: 10.1053/j.semnuclmed.2009.11.001. PMID: 20113679

Therapy

Emerging therapies for advanced insulinomas and glucagonomas.
Alexandraki KI, Kaltsas GA, Grozinsky-Glasberg S
Endocr Relat Cancer 2023 Sep 1;30(9) Epub 2023 Aug 7 doi: 10.1530/ERC-23-0020. PMID: 37343152
Pancreatic acinar cell carcinoma: A review on molecular profiling of patient tumors.
Al-Hader A, Al-Rohil RN, Han H, Von Hoff D
World J Gastroenterol 2017 Dec 7;23(45):7945-7951. doi: 10.3748/wjg.v23.i45.7945. PMID: 29259370Free PMC Article
Chemotherapy for advanced poorly differentiated pancreatic neuroendocrine carcinoma.
Ikeda M, Okuyama H, Takahashi H, Ohno I, Shimizu S, Mitsunaga S, Kondo S, Morizane C, Ueno H, Okusaka T
J Hepatobiliary Pancreat Sci 2015 Aug;22(8):623-7. Epub 2015 Mar 5 doi: 10.1002/jhbp.228. PMID: 25755102
Pharmacokinetics, distribution, and metabolism of [14C]sunitinib in rats, monkeys, and humans.
Speed B, Bu HZ, Pool WF, Peng GW, Wu EY, Patyna S, Bello C, Kang P
Drug Metab Dispos 2012 Mar;40(3):539-55. Epub 2011 Dec 16 doi: 10.1124/dmd.111.042853. PMID: 22180047
Radioembolization in the treatment of unresectable liver tumors: experience across a range of primary cancers.
Coldwell D, Sangro B, Salem R, Wasan H, Kennedy A
Am J Clin Oncol 2012 Apr;35(2):167-77. doi: 10.1097/COC.0b013e3181f47923. PMID: 21127414

Prognosis

Narrative Review of Immunotherapy in Gastroentero-Pancreatic Neuroendocrine Neoplasms.
Kaur J, Vijayvergia N
Curr Oncol 2023 Sep 21;30(9):8653-8664. doi: 10.3390/curroncol30090627. PMID: 37754542Free PMC Article
Pancreatic acinar cell carcinoma: A review on molecular profiling of patient tumors.
Al-Hader A, Al-Rohil RN, Han H, Von Hoff D
World J Gastroenterol 2017 Dec 7;23(45):7945-7951. doi: 10.3748/wjg.v23.i45.7945. PMID: 29259370Free PMC Article
Benefits from pharmacological and pharmacokinetic properties of sunitinib for clinical development.
Sablin MP, Dreyer C, Colichi C, Bouattour M, Delbaldo C, Faivre S, Raymond E
Expert Opin Drug Metab Toxicol 2010 Aug;6(8):1005-15. doi: 10.1517/17425255.2010.506872. PMID: 20636223
Liver transplantation and neuroendocrine tumors: lessons from a single centre experience and from the literature review.
Bonaccorsi-Riani E, Apestegui C, Jouret-Mourin A, Sempoux C, Goffette P, Ciccarelli O, Borbath I, Hubert C, Gigot JF, Hassoun Z, Lerut J
Transpl Int 2010 Jul;23(7):668-78. Epub 2010 May 5 doi: 10.1111/j.1432-2277.2010.01086.x. PMID: 20478000
Radioembolization of liver tumors with yttrium-90 microspheres.
Ahmadzadehfar H, Biersack HJ, Ezziddin S
Semin Nucl Med 2010 Mar;40(2):105-21. doi: 10.1053/j.semnuclmed.2009.11.001. PMID: 20113679

Clinical prediction guides

Narrative Review of Immunotherapy in Gastroentero-Pancreatic Neuroendocrine Neoplasms.
Kaur J, Vijayvergia N
Curr Oncol 2023 Sep 21;30(9):8653-8664. doi: 10.3390/curroncol30090627. PMID: 37754542Free PMC Article
A Phase II Trial of Everolimus in Patients with Advanced Pancreatic Neuroendocrine Carcinoma Refractory or Intolerant to Platinum-Containing Chemotherapy (NECTOR Trial).
Okuyama H, Ikeda M, Okusaka T, Furukawa M, Ohkawa S, Hosokawa A, Kojima Y, Hara H, Murohisa G, Shioji K, Asagi A, Mizuno N, Kojima M, Yamanaka T, Furuse J
Neuroendocrinology 2020;110(11-12):988-993. Epub 2020 Jan 2 doi: 10.1159/000505550. PMID: 31986515
Expression of liver X receptors in normal and refractory carcinoma tissues of the human lung and pancreas.
Kashiwagi K, Yanagida M, Matsui D, Tanaka M, Sugimoto K, Chen H, Ichikawa-Tomikawa N, Marubashi S, Suzuki H, Chiba H
Histol Histopathol 2018 May;33(5):497-505. Epub 2017 Nov 28 doi: 10.14670/HH-11-949. PMID: 29181837
Radioembolization of liver tumors with yttrium-90 microspheres.
Ahmadzadehfar H, Biersack HJ, Ezziddin S
Semin Nucl Med 2010 Mar;40(2):105-21. doi: 10.1053/j.semnuclmed.2009.11.001. PMID: 20113679
Islet cell tumors of the pancreas: the medical oncologist's perspective.
Brentjens R, Saltz L
Surg Clin North Am 2001 Jun;81(3):527-42. doi: 10.1016/s0039-6109(05)70141-9. PMID: 11459269

Recent systematic reviews

Clinicopathological data and treatment modalities for pancreatic vipomas: a systematic review.
Schizas D, Mastoraki A, Bagias G, Patras R, Moris D, Lazaridis II, Arkadopoulos N, Felekouras E
J BUON 2019 Mar-Apr;24(2):415-423. PMID: 31127985

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