Luminal B Prostate Carcinoma

MedGen UID:: 1621837
•Concept ID:: C4527416
•: Neoplastic Process

Synonym:

Luminal B Prostate Cancer

Definition

Prostate carcinoma associated with increased androgen receptor expression and signaling (androgen activity pathway), increased luminal markers, and a higher proliferation score than the luminal A prostate carcinoma. Patients with luminal B prostate carcinoma have the poorest prognosis but respond better to postoperative androgen deprivation therapy compared to patients with non-luminal B prostate carcinoma. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVLuminal B Prostate Carcinoma

Epithelial neoplasm
- Carcinoma
  - Genitourinary System Carcinoma
    - Male Reproductive System Carcinoma
      - Prostate carcinoma
        Prostate Carcinoma by Gene Expression Profile
        Luminal B Prostate Carcinoma

Professional guidelines

PubMed

Use of Drugs in Clinical Practice and the Associated Cost of Cancer Treatment in Adult Patients with Solid Tumors: A 10-Year Retrospective Cohort Study.

Carreras MJ, Tomás-Guillén E, Farriols A, Renedo-Miró B, Valdivia C, Vidal J, Saura C, Carles J, Felip E, Gorgas MQ, Tabernero J, Monterde J
Curr Oncol 2023 Aug 30;30(9):7984-8004. doi: 10.3390/curroncol30090580. PMID: 37754495 Free PMC Article

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Recent clinical studies

Etiology

Use of Drugs in Clinical Practice and the Associated Cost of Cancer Treatment in Adult Patients with Solid Tumors: A 10-Year Retrospective Cohort Study.

Biomarkers of aggressiveness in genitourinary tumors with emphasis on kidney, bladder, and prostate cancer.

Cimadamore A, Gasparrini S, Santoni M, Cheng L, Lopez-Beltran A, Battelli N, Massari F, Giunchi F, Fiorentino M, Scarpelli M, Montironi R
Expert Rev Mol Diagn 2018 Jul;18(7):645-655. Epub 2018 Jun 29 doi: 10.1080/14737159.2018.1490179. PMID: 29912582

Luminal Water Imaging: A New MR Imaging T2 Mapping Technique for Prostate Cancer Diagnosis.

Sabouri S, Chang SD, Savdie R, Zhang J, Jones EC, Goldenberg SL, Black PC, Kozlowski P
Radiology 2017 Aug;284(2):451-459. Epub 2017 Apr 10 doi: 10.1148/radiol.2017161687. PMID: 28394754 Free PMC Article

Epithelial-restricted gene profile of primary cultures from human prostate tumors: a molecular approach to predict clinical behavior of prostate cancer.

Nanni S, Priolo C, Grasselli A, D'Eletto M, Merola R, Moretti F, Gallucci M, De Carli P, Sentinelli S, Cianciulli AM, Mottolese M, Carlini P, Arcelli D, Helmer-Citterich M, Gaetano C, Loda M, Pontecorvi A, Bacchetti S, Sacchi A, Farsetti A
Mol Cancer Res 2006 Feb;4(2):79-92. doi: 10.1158/1541-7786.MCR-05-0098. PMID: 16513839

Expression of osteoprotegerin (OPG), TNF related apoptosis inducing ligand (TRAIL), and receptor activator of nuclear factor kappaB ligand (RANKL) in human breast tumours.

Van Poznak C, Cross SS, Saggese M, Hudis C, Panageas KS, Norton L, Coleman RE, Holen I
J Clin Pathol 2006 Jan;59(1):56-63. doi: 10.1136/jcp.2005.026534. PMID: 16394281 Free PMC Article

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Diagnosis

Use of Drugs in Clinical Practice and the Associated Cost of Cancer Treatment in Adult Patients with Solid Tumors: A 10-Year Retrospective Cohort Study.

Alpha-methylacyl-CoA racemase (AMACR) protein is upregulated in early proliferative lesions of the breast irrespective of apocrine differentiation.

Gatalica Z, Stafford P, Vranic S
Hum Pathol 2022 Nov;129:40-46. Epub 2022 Aug 21 doi: 10.1016/j.humpath.2022.08.002. PMID: 35998819

Clinical and Genomic Implications of Luminal and Basal Subtypes Across Carcinomas.

Zhao SG, Chen WS, Das R, Chang SL, Tomlins SA, Chou J, Quigley DA, Dang HX, Barnard TJ, Mahal BA, Gibb EA, Liu Y, Davicioni E, Duska LR, Posadas EM, Jolly S, Spratt DE, Nguyen PL, Maher CA, Small EJ, Feng FY
Clin Cancer Res 2019 Apr 15;25(8):2450-2457. Epub 2018 Dec 20 doi: 10.1158/1078-0432.CCR-18-3121. PMID: 30573691

Luminal Water Imaging: A New MR Imaging T2 Mapping Technique for Prostate Cancer Diagnosis.

Differentially methylated genes and androgen receptor re-expression in small cell prostate carcinomas.

Kleb B, Estécio MR, Zhang J, Tzelepi V, Chung W, Jelinek J, Navone NM, Tahir S, Marquez VE, Issa JP, Maity S, Aparicio A
Epigenetics 2016 Mar 3;11(3):184-93. Epub 2016 Feb 18 doi: 10.1080/15592294.2016.1146851. PMID: 26890396 Free PMC Article

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Therapy

Clinical and Genomic Implications of Luminal and Basal Subtypes Across Carcinomas.

Differentially methylated genes and androgen receptor re-expression in small cell prostate carcinomas.

See all (2)

Prognosis

Temporal evolution of cellular heterogeneity during the progression to advanced AR-negative prostate cancer.

Brady NJ, Bagadion AM, Singh R, Conteduca V, Van Emmenis L, Arceci E, Pakula H, Carelli R, Khani F, Bakht M, Sigouros M, Bareja R, Sboner A, Elemento O, Tagawa S, Nanus DM, Loda M, Beltran H, Robinson B, Rickman DS
Nat Commun 2021 Jun 7;12(1):3372. doi: 10.1038/s41467-021-23780-y. PMID: 34099734 Free PMC Article

Clinical and Genomic Implications of Luminal and Basal Subtypes Across Carcinomas.

Biomarkers of aggressiveness in genitourinary tumors with emphasis on kidney, bladder, and prostate cancer.

Differentially methylated genes and androgen receptor re-expression in small cell prostate carcinomas.

Correlation of microvessel density with nuclear pleomorphism, mitotic count and vascular invasion in breast and prostate cancers at preclinical and clinical levels.

Muhammadnejad S, Muhammadnejad A, Haddadi M, Oghabian MA, Mohagheghi MA, Tirgari F, Sadeghi-Fazel F, Amanpour S
Asian Pac J Cancer Prev 2013;14(1):63-8. doi: 10.7314/apjcp.2013.14.1.63. PMID: 23534805

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