U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Luminal B Prostate Carcinoma

MedGen UID:
1621837
Concept ID:
C4527416
Neoplastic Process
Synonym: Luminal B Prostate Cancer

Definition

Prostate carcinoma associated with increased androgen receptor expression and signaling (androgen activity pathway), increased luminal markers, and a higher proliferation score than the luminal A prostate carcinoma. Patients with luminal B prostate carcinoma have the poorest prognosis but respond better to postoperative androgen deprivation therapy compared to patients with non-luminal B prostate carcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLuminal B Prostate Carcinoma

Professional guidelines

PubMed

Carreras MJ, Tomás-Guillén E, Farriols A, Renedo-Miró B, Valdivia C, Vidal J, Saura C, Carles J, Felip E, Gorgas MQ, Tabernero J, Monterde J
Curr Oncol 2023 Aug 30;30(9):7984-8004. doi: 10.3390/curroncol30090580. PMID: 37754495Free PMC Article

Recent clinical studies

Etiology

Carreras MJ, Tomás-Guillén E, Farriols A, Renedo-Miró B, Valdivia C, Vidal J, Saura C, Carles J, Felip E, Gorgas MQ, Tabernero J, Monterde J
Curr Oncol 2023 Aug 30;30(9):7984-8004. doi: 10.3390/curroncol30090580. PMID: 37754495Free PMC Article
Cimadamore A, Gasparrini S, Santoni M, Cheng L, Lopez-Beltran A, Battelli N, Massari F, Giunchi F, Fiorentino M, Scarpelli M, Montironi R
Expert Rev Mol Diagn 2018 Jul;18(7):645-655. Epub 2018 Jun 29 doi: 10.1080/14737159.2018.1490179. PMID: 29912582
Sabouri S, Chang SD, Savdie R, Zhang J, Jones EC, Goldenberg SL, Black PC, Kozlowski P
Radiology 2017 Aug;284(2):451-459. Epub 2017 Apr 10 doi: 10.1148/radiol.2017161687. PMID: 28394754Free PMC Article
Nanni S, Priolo C, Grasselli A, D'Eletto M, Merola R, Moretti F, Gallucci M, De Carli P, Sentinelli S, Cianciulli AM, Mottolese M, Carlini P, Arcelli D, Helmer-Citterich M, Gaetano C, Loda M, Pontecorvi A, Bacchetti S, Sacchi A, Farsetti A
Mol Cancer Res 2006 Feb;4(2):79-92. doi: 10.1158/1541-7786.MCR-05-0098. PMID: 16513839
Montironi R, Mazzucchelli R, Stramazzotti D, Pomante R, Thompson D, Bartels PH
Mol Pathol 2000 Jun;53(3):122-8. doi: 10.1136/mp.53.3.122. PMID: 10897330Free PMC Article

Diagnosis

Gatalica Z, Stafford P, Vranic S
Hum Pathol 2022 Nov;129:40-46. Epub 2022 Aug 21 doi: 10.1016/j.humpath.2022.08.002. PMID: 35998819
Zhao SG, Chen WS, Das R, Chang SL, Tomlins SA, Chou J, Quigley DA, Dang HX, Barnard TJ, Mahal BA, Gibb EA, Liu Y, Davicioni E, Duska LR, Posadas EM, Jolly S, Spratt DE, Nguyen PL, Maher CA, Small EJ, Feng FY
Clin Cancer Res 2019 Apr 15;25(8):2450-2457. Epub 2018 Dec 20 doi: 10.1158/1078-0432.CCR-18-3121. PMID: 30573691
Sabouri S, Chang SD, Savdie R, Zhang J, Jones EC, Goldenberg SL, Black PC, Kozlowski P
Radiology 2017 Aug;284(2):451-459. Epub 2017 Apr 10 doi: 10.1148/radiol.2017161687. PMID: 28394754Free PMC Article
Kleb B, Estécio MR, Zhang J, Tzelepi V, Chung W, Jelinek J, Navone NM, Tahir S, Marquez VE, Issa JP, Maity S, Aparicio A
Epigenetics 2016 Mar 3;11(3):184-93. Epub 2016 Feb 18 doi: 10.1080/15592294.2016.1146851. PMID: 26890396Free PMC Article
Webber MM, Waghray A, Bello D
Clin Cancer Res 1995 Oct;1(10):1089-94. PMID: 9815898

Therapy

Zhao SG, Chen WS, Das R, Chang SL, Tomlins SA, Chou J, Quigley DA, Dang HX, Barnard TJ, Mahal BA, Gibb EA, Liu Y, Davicioni E, Duska LR, Posadas EM, Jolly S, Spratt DE, Nguyen PL, Maher CA, Small EJ, Feng FY
Clin Cancer Res 2019 Apr 15;25(8):2450-2457. Epub 2018 Dec 20 doi: 10.1158/1078-0432.CCR-18-3121. PMID: 30573691
Kleb B, Estécio MR, Zhang J, Tzelepi V, Chung W, Jelinek J, Navone NM, Tahir S, Marquez VE, Issa JP, Maity S, Aparicio A
Epigenetics 2016 Mar 3;11(3):184-93. Epub 2016 Feb 18 doi: 10.1080/15592294.2016.1146851. PMID: 26890396Free PMC Article

Prognosis

Brady NJ, Bagadion AM, Singh R, Conteduca V, Van Emmenis L, Arceci E, Pakula H, Carelli R, Khani F, Bakht M, Sigouros M, Bareja R, Sboner A, Elemento O, Tagawa S, Nanus DM, Loda M, Beltran H, Robinson B, Rickman DS
Nat Commun 2021 Jun 7;12(1):3372. doi: 10.1038/s41467-021-23780-y. PMID: 34099734Free PMC Article
Zhao SG, Chen WS, Das R, Chang SL, Tomlins SA, Chou J, Quigley DA, Dang HX, Barnard TJ, Mahal BA, Gibb EA, Liu Y, Davicioni E, Duska LR, Posadas EM, Jolly S, Spratt DE, Nguyen PL, Maher CA, Small EJ, Feng FY
Clin Cancer Res 2019 Apr 15;25(8):2450-2457. Epub 2018 Dec 20 doi: 10.1158/1078-0432.CCR-18-3121. PMID: 30573691
Cimadamore A, Gasparrini S, Santoni M, Cheng L, Lopez-Beltran A, Battelli N, Massari F, Giunchi F, Fiorentino M, Scarpelli M, Montironi R
Expert Rev Mol Diagn 2018 Jul;18(7):645-655. Epub 2018 Jun 29 doi: 10.1080/14737159.2018.1490179. PMID: 29912582
Kleb B, Estécio MR, Zhang J, Tzelepi V, Chung W, Jelinek J, Navone NM, Tahir S, Marquez VE, Issa JP, Maity S, Aparicio A
Epigenetics 2016 Mar 3;11(3):184-93. Epub 2016 Feb 18 doi: 10.1080/15592294.2016.1146851. PMID: 26890396Free PMC Article
Muhammadnejad S, Muhammadnejad A, Haddadi M, Oghabian MA, Mohagheghi MA, Tirgari F, Sadeghi-Fazel F, Amanpour S
Asian Pac J Cancer Prev 2013;14(1):63-8. doi: 10.7314/apjcp.2013.14.1.63. PMID: 23534805

Clinical prediction guides

Gatalica Z, Stafford P, Vranic S
Hum Pathol 2022 Nov;129:40-46. Epub 2022 Aug 21 doi: 10.1016/j.humpath.2022.08.002. PMID: 35998819
Cimadamore A, Gasparrini S, Santoni M, Cheng L, Lopez-Beltran A, Battelli N, Massari F, Giunchi F, Fiorentino M, Scarpelli M, Montironi R
Expert Rev Mol Diagn 2018 Jul;18(7):645-655. Epub 2018 Jun 29 doi: 10.1080/14737159.2018.1490179. PMID: 29912582
Sabouri S, Chang SD, Savdie R, Zhang J, Jones EC, Goldenberg SL, Black PC, Kozlowski P
Radiology 2017 Aug;284(2):451-459. Epub 2017 Apr 10 doi: 10.1148/radiol.2017161687. PMID: 28394754Free PMC Article
Muhammadnejad S, Muhammadnejad A, Haddadi M, Oghabian MA, Mohagheghi MA, Tirgari F, Sadeghi-Fazel F, Amanpour S
Asian Pac J Cancer Prev 2013;14(1):63-8. doi: 10.7314/apjcp.2013.14.1.63. PMID: 23534805
Sinha AA, Gleason DF, Staley NA, Wilson MJ, Sameni M, Sloane BF
Anat Rec 1995 Mar;241(3):353-62. doi: 10.1002/ar.1092410309. PMID: 7538734

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...