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Stage IV Hodgkin Disease Lymphocyte Predominance Type

MedGen UID:
163191
•Concept ID:
C0855077
•
Neoplastic Process
Synonym: Stage IV Hodgkin's Disease Lymphocyte Predominance Type

Definition

Stage IV adult Hodgkin disease means there is disseminated (multifocal) involvement of one or more extralymphatic organs, with or without associated lymph node involvement, or isolated extralymphatic organ involvement with distant (nonregional) nodal involvement. (from PDQ) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVStage IV Hodgkin Disease Lymphocyte Predominance Type

Professional guidelines

PubMed

Nodular lymphocyte-predominant Hodgkin lymphoma characteristics, management of primary and relapsed/refractory disease and outcome analysis: the first comprehensive report from the Middle East.
Akhtar S, Rauf MS, Khafaga Y, Al-Kofide A, Elhassan TAM, Elshenawy MA, Nadri J, Mushtaq AH, Bakshi N, Shamayel M, Al-Sweedan S, Sarwar S, Maghfoor I
BMC Cancer 2021 Apr 1;21(1):351. doi: 10.1186/s12885-021-08074-2. PMID: 33794818Free PMC Article
The treatment of childhood Hodgkin lymphoma: improved survival in a developing country.
Büyükpamukçu M, Varan A, Akyüz C, Atahan L, Ozyar E, Kale G, Köksal Y, Kutluk T
Acta Oncol 2009;48(1):44-51. doi: 10.1080/02841860802310991. PMID: 18777215
T-cell/histiocyte-rich large B-cell lymphoma is a disseminated aggressive neoplasm: differential diagnosis from Hodgkin's lymphoma.
Fraga M, Sánchez-Verde L, Forteza J, García-Rivero A, Piris MA
Histopathology 2002 Sep;41(3):216-29. doi: 10.1046/j.1365-2559.2002.01466.x. PMID: 12207783

Recent clinical studies

Etiology

Nodular lymphocyte-predominant Hodgkin lymphoma characteristics, management of primary and relapsed/refractory disease and outcome analysis: the first comprehensive report from the Middle East.
Akhtar S, Rauf MS, Khafaga Y, Al-Kofide A, Elhassan TAM, Elshenawy MA, Nadri J, Mushtaq AH, Bakshi N, Shamayel M, Al-Sweedan S, Sarwar S, Maghfoor I
BMC Cancer 2021 Apr 1;21(1):351. doi: 10.1186/s12885-021-08074-2. PMID: 33794818Free PMC Article
Long-term follow-up of patients with nodular lymphocyte predominant Hodgkin lymphoma: A report from the Spanish Lymphoma Oncology Group.
Núñez-García B, Rodríguez-Pertierra M, Sequero S, Carvajal LG, Ruano-Ravina A, Aguiar D, Gumá J, Blanco CQ, García Arroyo FR, Garitaonaindia Y, Provencio Z, Calvo V, González-San Segundo C, Provencio M
Hematol Oncol 2021 Oct;39(4):506-512. Epub 2021 Feb 2 doi: 10.1002/hon.2835. PMID: 33528063
Hodgkin's lymphoma in Pakistan: a clinico-epidemiological study of 658 cases at a cancer center in Lahore.
Siddiqui N, Ayub B, Badar F, Zaidi A
Asian Pac J Cancer Prev 2006 Oct-Dec;7(4):651-5. PMID: 17250446
Pediatric Hodgkin's disease.
Oliapuram Jose B, Koerner P, Bertolone S, Patel CC, Spanos WJ Jr, Paris KJ, Silverman CL, Yashar CM
J Ky Med Assoc 2004 Mar;102(3):104-6. PMID: 15067795
Clinical features of nodular paragranuloma (Hodgkin's disease, lymphocyte predominance type, nodular).
Hansmann ML, Zwingers T, Böske A, Löffler H, Lennert K
J Cancer Res Clin Oncol 1984;108(3):321-30. doi: 10.1007/BF00390466. PMID: 6511805

Diagnosis

Nodular lymphocyte-predominant Hodgkin lymphoma characteristics, management of primary and relapsed/refractory disease and outcome analysis: the first comprehensive report from the Middle East.
Akhtar S, Rauf MS, Khafaga Y, Al-Kofide A, Elhassan TAM, Elshenawy MA, Nadri J, Mushtaq AH, Bakshi N, Shamayel M, Al-Sweedan S, Sarwar S, Maghfoor I
BMC Cancer 2021 Apr 1;21(1):351. doi: 10.1186/s12885-021-08074-2. PMID: 33794818Free PMC Article
Long-term follow-up of patients with nodular lymphocyte predominant Hodgkin lymphoma: A report from the Spanish Lymphoma Oncology Group.
Núñez-García B, Rodríguez-Pertierra M, Sequero S, Carvajal LG, Ruano-Ravina A, Aguiar D, Gumá J, Blanco CQ, García Arroyo FR, Garitaonaindia Y, Provencio Z, Calvo V, González-San Segundo C, Provencio M
Hematol Oncol 2021 Oct;39(4):506-512. Epub 2021 Feb 2 doi: 10.1002/hon.2835. PMID: 33528063
Management of Hodgkin's lymphoma with midbrain involvement: A case report and review of literature.
Maka VV, Chitrapur R, Kilara N, Prabhu VM, Krishnamoorthy N
Hematology 2015 Jun;20(5):272-5. Epub 2014 Aug 18 doi: 10.1179/1607845414Y.0000000190. PMID: 25133862
Interfollicular small lymphocytic lymphoma: the diagnostic significance of pseudofollicles.
Ellison DJ, Nathwani BN, Cho SY, Martin SE
Hum Pathol 1989 Nov;20(11):1108-18. doi: 10.1016/0046-8177(89)90231-1. PMID: 2680893
Clinical features of nodular paragranuloma (Hodgkin's disease, lymphocyte predominance type, nodular).
Hansmann ML, Zwingers T, Böske A, Löffler H, Lennert K
J Cancer Res Clin Oncol 1984;108(3):321-30. doi: 10.1007/BF00390466. PMID: 6511805

Therapy

Long-term follow-up of patients with nodular lymphocyte predominant Hodgkin lymphoma: A report from the Spanish Lymphoma Oncology Group.
Núñez-García B, Rodríguez-Pertierra M, Sequero S, Carvajal LG, Ruano-Ravina A, Aguiar D, Gumá J, Blanco CQ, García Arroyo FR, Garitaonaindia Y, Provencio Z, Calvo V, González-San Segundo C, Provencio M
Hematol Oncol 2021 Oct;39(4):506-512. Epub 2021 Feb 2 doi: 10.1002/hon.2835. PMID: 33528063
Management of Hodgkin's lymphoma with midbrain involvement: A case report and review of literature.
Maka VV, Chitrapur R, Kilara N, Prabhu VM, Krishnamoorthy N
Hematology 2015 Jun;20(5):272-5. Epub 2014 Aug 18 doi: 10.1179/1607845414Y.0000000190. PMID: 25133862
Pediatric Hodgkin's disease.
Oliapuram Jose B, Koerner P, Bertolone S, Patel CC, Spanos WJ Jr, Paris KJ, Silverman CL, Yashar CM
J Ky Med Assoc 2004 Mar;102(3):104-6. PMID: 15067795
The importance of staging laparotomy in pediatric Hodgkin's disease.
Breuer CK, Tarbell NJ, Mauch PM, Weinstein HJ, Morrissey M, Neuberg D, Shamberger RC
J Pediatr Surg 1994 Aug;29(8):1085-9. doi: 10.1016/0022-3468(94)90284-4. PMID: 7965511
Clinical features of nodular paragranuloma (Hodgkin's disease, lymphocyte predominance type, nodular).
Hansmann ML, Zwingers T, Böske A, Löffler H, Lennert K
J Cancer Res Clin Oncol 1984;108(3):321-30. doi: 10.1007/BF00390466. PMID: 6511805

Prognosis

Long-term follow-up of patients with nodular lymphocyte predominant Hodgkin lymphoma: A report from the Spanish Lymphoma Oncology Group.
Núñez-García B, Rodríguez-Pertierra M, Sequero S, Carvajal LG, Ruano-Ravina A, Aguiar D, Gumá J, Blanco CQ, García Arroyo FR, Garitaonaindia Y, Provencio Z, Calvo V, González-San Segundo C, Provencio M
Hematol Oncol 2021 Oct;39(4):506-512. Epub 2021 Feb 2 doi: 10.1002/hon.2835. PMID: 33528063
Management of Hodgkin's lymphoma with midbrain involvement: A case report and review of literature.
Maka VV, Chitrapur R, Kilara N, Prabhu VM, Krishnamoorthy N
Hematology 2015 Jun;20(5):272-5. Epub 2014 Aug 18 doi: 10.1179/1607845414Y.0000000190. PMID: 25133862
The treatment of childhood Hodgkin lymphoma: improved survival in a developing country.
Büyükpamukçu M, Varan A, Akyüz C, Atahan L, Ozyar E, Kale G, Köksal Y, Kutluk T
Acta Oncol 2009;48(1):44-51. doi: 10.1080/02841860802310991. PMID: 18777215
Clinical features of nodular paragranuloma (Hodgkin's disease, lymphocyte predominance type, nodular).
Hansmann ML, Zwingers T, Böske A, Löffler H, Lennert K
J Cancer Res Clin Oncol 1984;108(3):321-30. doi: 10.1007/BF00390466. PMID: 6511805
Lung involvement in Hodgkin's disease.
MacDonald JB
Thorax 1977 Dec;32(6):664-7. doi: 10.1136/thx.32.6.664. PMID: 601727Free PMC Article

Clinical prediction guides

Nodular lymphocyte-predominant Hodgkin lymphoma characteristics, management of primary and relapsed/refractory disease and outcome analysis: the first comprehensive report from the Middle East.
Akhtar S, Rauf MS, Khafaga Y, Al-Kofide A, Elhassan TAM, Elshenawy MA, Nadri J, Mushtaq AH, Bakshi N, Shamayel M, Al-Sweedan S, Sarwar S, Maghfoor I
BMC Cancer 2021 Apr 1;21(1):351. doi: 10.1186/s12885-021-08074-2. PMID: 33794818Free PMC Article
Long-term follow-up of patients with nodular lymphocyte predominant Hodgkin lymphoma: A report from the Spanish Lymphoma Oncology Group.
Núñez-García B, Rodríguez-Pertierra M, Sequero S, Carvajal LG, Ruano-Ravina A, Aguiar D, Gumá J, Blanco CQ, García Arroyo FR, Garitaonaindia Y, Provencio Z, Calvo V, González-San Segundo C, Provencio M
Hematol Oncol 2021 Oct;39(4):506-512. Epub 2021 Feb 2 doi: 10.1002/hon.2835. PMID: 33528063
Epstein-Barr virus-positive diffuse large B-cell lymphoma in children: a disease reminiscent of Epstein-Barr virus-positive diffuse large B-cell lymphoma of the elderly.
Uccini S, Al-Jadiry MF, Scarpino S, Ferraro D, Alsaadawi AR, Al-Darraji AF, Moleti ML, Testi AM, Al-Hadad SA, Ruco L
Hum Pathol 2015 May;46(5):716-24. Epub 2015 Feb 3 doi: 10.1016/j.humpath.2015.01.011. PMID: 25704629
Hodgkin's lymphoma in Pakistan: a clinico-epidemiological study of 658 cases at a cancer center in Lahore.
Siddiqui N, Ayub B, Badar F, Zaidi A
Asian Pac J Cancer Prev 2006 Oct-Dec;7(4):651-5. PMID: 17250446
Clinical features of nodular paragranuloma (Hodgkin's disease, lymphocyte predominance type, nodular).
Hansmann ML, Zwingers T, Böske A, Löffler H, Lennert K
J Cancer Res Clin Oncol 1984;108(3):321-30. doi: 10.1007/BF00390466. PMID: 6511805

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