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Lymphocyte Predominant Type Hodgkin Disease

MedGen UID:
276509
•Concept ID:
C1518064
•
Neoplastic Process
Synonym: Lymphocyte Predominant Type Hodgkin's Disease

Definition

An antiquated term that refers either to nodular lymphocyte predominant Hodgkin lymphoma or to lymphocyte-rich classical Hodgkin lymphoma. [from NCI]

Professional guidelines

PubMed

Nodular lymphocyte-predominant Hodgkin lymphoma characteristics, management of primary and relapsed/refractory disease and outcome analysis: the first comprehensive report from the Middle East.
Akhtar S, Rauf MS, Khafaga Y, Al-Kofide A, Elhassan TAM, Elshenawy MA, Nadri J, Mushtaq AH, Bakshi N, Shamayel M, Al-Sweedan S, Sarwar S, Maghfoor I
BMC Cancer 2021 Apr 1;21(1):351. doi: 10.1186/s12885-021-08074-2. PMID: 33794818Free PMC Article
Clinical characteristics and treatment response of Hodgkin's lymphoma in Taiwan.
Wu SJ, Chen CY, Su IJ, Tang JL, Chou WC, Ko BS, Huang SY, Yao M, Tsay W, Chen YC, Wang CH, Tien HF
J Formos Med Assoc 2008 Jan;107(1):4-12. doi: 10.1016/S0929-6646(08)60002-9. PMID: 18218572
Hodgkin's disease: classification and differential diagnosis.
Harris NL
Mod Pathol 1999 Feb;12(2):159-75. PMID: 10071341

Recent clinical studies

Etiology

Lymphocyte predominant Hodgkin's disease.
Ekstrand BC, Horning SJ
Curr Oncol Rep 2002 Sep;4(5):424-33. doi: 10.1007/s11912-002-0037-8. PMID: 12162918
Pulmonary lymphomas and other pulmonary lymphoid lesions. A clinicopathologic and immunologic study of 64 patients.
Kennedy JL, Nathwani BN, Burke JS, Hill LR, Rappaport H
Cancer 1985 Aug 1;56(3):539-52. doi: 10.1002/1097-0142(19850801)56:3<539::aid-cncr2820560322>3.0.co;2-d. PMID: 3839161
Results of a uniform histopathologic review system of lymphoma cases. A ten-year study from the Southeastern Cancer Study Group.
Vélez-García E, Durant J, Gams R, Bartolucci A
Cancer 1983 Aug 15;52(4):675-9. doi: 10.1002/1097-0142(19830815)52:4<675::aid-cncr2820520419>3.0.co;2-b. PMID: 6861104
Non-Hodgkin's lymphomas in leukemic phase: clinicopathologic correlations.
Come SE, Jaffe ES, Andersen JC, Mann RB, Johnson BL, DeVita VT Jr, Young RC
Am J Med 1980 Nov;69(5):667-74. doi: 10.1016/0002-9343(80)90416-7. PMID: 7001897
Hodgkin disease: an analysis of 128 cases.
Dawar R, Mangalik A
Am J Hematol 1978;4(3):209-15. doi: 10.1002/ajh.2830040302. PMID: 717385

Diagnosis

Variant histology of pediatric nodular lymphocyte-predominant Hodgkin lymphoma with IgD and CD30 expression.
Ali N, Moussa E, Khorshed E, Zaghloul MS, Elnashar A, Abdalla A
Pediatr Blood Cancer 2023 Nov;70(11):e30647. Epub 2023 Aug 28 doi: 10.1002/pbc.30647. PMID: 37638819
Primary Lung Small B-Cell Lymphoma versus Lymphoid Hyperplasia: Evaluation of Diagnostic Criteria in 26 Cases.
Bégueret H, Vergier B, Parrens M, Lehours P, Laurent F, Vernejoux JM, Dubus P, Velly JF, Mégraud F, Taytard A, Merlio JP, de Mascarel A
Am J Surg Pathol 2002 Jan;26(1):76-81. doi: 10.1097/00000478-200201000-00009. PMID: 11756772
Hodgkin's disease: classification and differential diagnosis.
Harris NL
Mod Pathol 1999 Feb;12(2):159-75. PMID: 10071341
Waldeyer's ring (WR) involvement in Hodgkin's disease.
Cionini L, Bastiani P, Biti GP, Mungai V, Ponticelli P, Di Lollo S
Radiother Oncol 1985 Jun;3(4):299-302. doi: 10.1016/s0167-8140(85)80042-6. PMID: 4011951
Primary mediastinal lymphoma in adults.
Lichtenstein AK, Levine A, Taylor CR, Boswell W, Rossman S, Feinstein DI, Lukes RJ
Am J Med 1980 Apr;68(4):509-14. doi: 10.1016/0002-9343(80)90294-6. PMID: 6892753

Therapy

Variant histology of pediatric nodular lymphocyte-predominant Hodgkin lymphoma with IgD and CD30 expression.
Ali N, Moussa E, Khorshed E, Zaghloul MS, Elnashar A, Abdalla A
Pediatr Blood Cancer 2023 Nov;70(11):e30647. Epub 2023 Aug 28 doi: 10.1002/pbc.30647. PMID: 37638819
Long-term follow-up of patients with nodular lymphocyte predominant Hodgkin lymphoma: A report from the Spanish Lymphoma Oncology Group.
Núñez-García B, Rodríguez-Pertierra M, Sequero S, Carvajal LG, Ruano-Ravina A, Aguiar D, Gumá J, Blanco CQ, García Arroyo FR, Garitaonaindia Y, Provencio Z, Calvo V, González-San Segundo C, Provencio M
Hematol Oncol 2021 Oct;39(4):506-512. Epub 2021 Feb 2 doi: 10.1002/hon.2835. PMID: 33528063
NK-cell intravascular lymphomatosis--a mini-review.
Nakamichi N, Fukuhara S, Aozasa K, Morii E
Eur J Haematol 2008 Jul;81(1):1-7. Epub 2008 May 6 doi: 10.1111/j.1600-0609.2008.01089.x. PMID: 18462254
Nodular type of lymphocyte predominant Hodgkin's disease. A clinical study of 50 cases.
Pappa VI, Norton AJ, Gupta RK, Wilson AM, Rohatiner AZ, Lister TA
Ann Oncol 1995 Jul;6(6):559-65. doi: 10.1093/oxfordjournals.annonc.a059244. PMID: 8573534
Pulmonary lymphomas and other pulmonary lymphoid lesions. A clinicopathologic and immunologic study of 64 patients.
Kennedy JL, Nathwani BN, Burke JS, Hill LR, Rappaport H
Cancer 1985 Aug 1;56(3):539-52. doi: 10.1002/1097-0142(19850801)56:3<539::aid-cncr2820560322>3.0.co;2-d. PMID: 3839161

Prognosis

Lymphocyte predominant Hodgkin's disease.
Ekstrand BC, Horning SJ
Curr Oncol Rep 2002 Sep;4(5):424-33. doi: 10.1007/s11912-002-0037-8. PMID: 12162918
Pulmonary lymphomas and other pulmonary lymphoid lesions. A clinicopathologic and immunologic study of 64 patients.
Kennedy JL, Nathwani BN, Burke JS, Hill LR, Rappaport H
Cancer 1985 Aug 1;56(3):539-52. doi: 10.1002/1097-0142(19850801)56:3<539::aid-cncr2820560322>3.0.co;2-d. PMID: 3839161
Hodgkin disease of bone: radiographic correlation with the histological classification.
Braunstein EM
Radiology 1980 Dec;137(3):643-6. doi: 10.1148/radiology.137.3.7444049. PMID: 7444049
Non-Hodgkin's lymphomas in leukemic phase: clinicopathologic correlations.
Come SE, Jaffe ES, Andersen JC, Mann RB, Johnson BL, DeVita VT Jr, Young RC
Am J Med 1980 Nov;69(5):667-74. doi: 10.1016/0002-9343(80)90416-7. PMID: 7001897
Hodgkin disease: an analysis of 128 cases.
Dawar R, Mangalik A
Am J Hematol 1978;4(3):209-15. doi: 10.1002/ajh.2830040302. PMID: 717385

Clinical prediction guides

Nodular lymphocyte-predominant Hodgkin lymphoma characteristics, management of primary and relapsed/refractory disease and outcome analysis: the first comprehensive report from the Middle East.
Akhtar S, Rauf MS, Khafaga Y, Al-Kofide A, Elhassan TAM, Elshenawy MA, Nadri J, Mushtaq AH, Bakshi N, Shamayel M, Al-Sweedan S, Sarwar S, Maghfoor I
BMC Cancer 2021 Apr 1;21(1):351. doi: 10.1186/s12885-021-08074-2. PMID: 33794818Free PMC Article
Does "in situ lymphoma" occur as a distinct step in the development of nodular lymphocyte-predominant Hodgkin lymphoma?
Carbone A
Cancer 2012 Jan 1;118(1):15-6. Epub 2011 Jul 5 doi: 10.1002/cncr.26228. PMID: 21732334
Primary Lung Small B-Cell Lymphoma versus Lymphoid Hyperplasia: Evaluation of Diagnostic Criteria in 26 Cases.
Bégueret H, Vergier B, Parrens M, Lehours P, Laurent F, Vernejoux JM, Dubus P, Velly JF, Mégraud F, Taytard A, Merlio JP, de Mascarel A
Am J Surg Pathol 2002 Jan;26(1):76-81. doi: 10.1097/00000478-200201000-00009. PMID: 11756772
Nodular type of lymphocyte predominant Hodgkin's disease. A clinical study of 50 cases.
Pappa VI, Norton AJ, Gupta RK, Wilson AM, Rohatiner AZ, Lister TA
Ann Oncol 1995 Jul;6(6):559-65. doi: 10.1093/oxfordjournals.annonc.a059244. PMID: 8573534
Gastrointestinal lymphoid neoplasms.
Kahn LB, Mir R
Semin Diagn Pathol 1985 Aug;2(3):197-209. PMID: 3916555

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