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Medial rectus muscle overaction

MedGen UID:
1633121
•Concept ID:
C4703523
•
Pathologic Function
HPO: HP:0031754

Definition

Excessive action of the medial rectus muscle caused by increased innervation typically as a consequence of palsy or limitation to the ipsilateral antagonist or contralateral synergist. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMedial rectus muscle overaction

Professional guidelines

PubMed

Long-term follow-up of bilateral botulinum toxin injections versus bilateral recessions of the medial rectus muscles for treatment of infantile esotropia.
Gursoy H, Basmak H, Sahin A, Yildirim N, Aydin Y, Colak E
J AAPOS 2012 Jun;16(3):269-73. doi: 10.1016/j.jaapos.2012.01.010. PMID: 22681945
Treatment for "A" and "V" exotropia by slanting muscle insertions.
Ohba M, Nakagawa T
Jpn J Ophthalmol 2000 Jul-Aug;44(4):433-8. doi: 10.1016/s0021-5155(00)00182-9. PMID: 10974302
Botulinum toxin management of essential infantile esotropia in children.
McNeer KW, Tucker MG, Spencer RF
Arch Ophthalmol 1997 Nov;115(11):1411-8. doi: 10.1001/archopht.1997.01100160581010. PMID: 9366672

Recent clinical studies

Etiology

Long-term Motor and Sensory Outcomes After Unilateral Medial Rectus Recession-Lateral Rectus Resection for Infantile Esotropia.
Mohan K, Sharma SK
J Pediatr Ophthalmol Strabismus 2024 Mar-Apr;61(2):106-113. Epub 2023 Aug 24 doi: 10.3928/01913913-20230721-01. PMID: 37615418
What to expect from primary inferior oblique overaction after esotropia surgery : Primary inferior oblique overaction in esotropia.
Freitas-da-Costa P, Alves H, Santos-Silva R, Falcão-Reis F, Breda J, Magalhães A
BMC Ophthalmol 2023 Dec 15;23(1):512. doi: 10.1186/s12886-023-03256-x. PMID: 38102543Free PMC Article
Conventional surgery versus botulinum toxin injections for partially accommodative esotropia.
AlShammari S, Alaam M, Alfreihi S
J AAPOS 2022 Feb;26(1):16.e1-16.e6. Epub 2022 Jan 10 doi: 10.1016/j.jaapos.2021.08.308. PMID: 35017084
Risk factors for consecutive exotropia after esotropia surgery.
Han SY, Han J, Rhiu S, Lee JB, Han SH
Jpn J Ophthalmol 2016 Jul;60(4):333-40. Epub 2016 May 27 doi: 10.1007/s10384-016-0443-3. PMID: 27230032
Results of surgery for congenital esotropia.
Castro PD, Pedroso A, Hernández L, Naranjo RM, Méndez TJ, Arias A
MEDICC Rev 2011 Jan;13(1):18-22. doi: 10.37757/MR2011V13.N1.6. PMID: 21351685

Diagnosis

Clinical significance of CTGF and Cry61 protein in extraocular muscles of strabismic patients.
Yu X, Shi S, Cui Y, Shentu X, Sun Z
Graefes Arch Clin Exp Ophthalmol 2023 Oct;261(10):2845-2851. Epub 2023 May 10 doi: 10.1007/s00417-023-06096-z. PMID: 37162563
Slipped Medial Rectus Muscle With Stretched Scar After Pterygium Surgery.
Sen P, Kumar A, Jain E, Mohan A
J Pediatr Ophthalmol Strabismus 2019 Apr 29;56:e34-e37. doi: 10.3928/01913913-20190326-02. PMID: 31034087
New strabismus surgical techniques.
Ludwig IH, Clark RA, Stager DR Sr
J AAPOS 2013 Feb;17(1):79-88. doi: 10.1016/j.jaapos.2012.09.019. PMID: 23415038
Heterotopic muscle pulleys or oblique muscle dysfunction?
Clark RA, Miller JM, Rosenbaum AL, Demer JL
J AAPOS 1998 Feb;2(1):17-25. doi: 10.1016/s1091-8531(98)90105-7. PMID: 10532362
Congenital esotropia.
Nelson LB, Wagner RS, Simon JW, Harley RD
Surv Ophthalmol 1987 May-Jun;31(6):363-83. doi: 10.1016/0039-6257(87)90030-0. PMID: 3303394

Therapy

Slipped Medial Rectus Muscle With Stretched Scar After Pterygium Surgery.
Sen P, Kumar A, Jain E, Mohan A
J Pediatr Ophthalmol Strabismus 2019 Apr 29;56:e34-e37. doi: 10.3928/01913913-20190326-02. PMID: 31034087
Risk factors for consecutive exotropia after esotropia surgery.
Han SY, Han J, Rhiu S, Lee JB, Han SH
Jpn J Ophthalmol 2016 Jul;60(4):333-40. Epub 2016 May 27 doi: 10.1007/s10384-016-0443-3. PMID: 27230032
Anterior and nasal transposition of the inferior oblique muscle for dissociated vertical deviation associated with inferior oblique muscle overaction.
Fard MA
J AAPOS 2010 Feb;14(1):35-8. doi: 10.1016/j.jaapos.2009.11.011. PMID: 20227620
Thyroid disease and vertical rectus muscle overaction after retrobulbar anesthesia.
Han SK, Hwang JM
J Cataract Refract Surg 2003 Jan;29(1):78-84. doi: 10.1016/s0886-3350(02)01437-2. PMID: 12551671
Congenital esotropia.
Nelson LB, Wagner RS, Simon JW, Harley RD
Surv Ophthalmol 1987 May-Jun;31(6):363-83. doi: 10.1016/0039-6257(87)90030-0. PMID: 3303394

Prognosis

Long-term Motor and Sensory Outcomes After Unilateral Medial Rectus Recession-Lateral Rectus Resection for Infantile Esotropia.
Mohan K, Sharma SK
J Pediatr Ophthalmol Strabismus 2024 Mar-Apr;61(2):106-113. Epub 2023 Aug 24 doi: 10.3928/01913913-20230721-01. PMID: 37615418
Conventional surgery versus botulinum toxin injections for partially accommodative esotropia.
AlShammari S, Alaam M, Alfreihi S
J AAPOS 2022 Feb;26(1):16.e1-16.e6. Epub 2022 Jan 10 doi: 10.1016/j.jaapos.2021.08.308. PMID: 35017084
Risk factors for consecutive exotropia after esotropia surgery.
Han SY, Han J, Rhiu S, Lee JB, Han SH
Jpn J Ophthalmol 2016 Jul;60(4):333-40. Epub 2016 May 27 doi: 10.1007/s10384-016-0443-3. PMID: 27230032
Three horizontal muscle surgery for large-angle infantile or presumed infantile esotropia: long-term motor outcomes.
Chatzistefanou KI, Ladas ID, Droutsas KD, Koutsandrea C, Chimonidou E
JAMA Ophthalmol 2013 Aug;131(8):1041-8. doi: 10.1001/jamaophthalmol.2013.704. PMID: 23699727
Activated satellite cells in medial rectus muscles of patients with strabismus.
Antunes-Foschini RS, Miyashita D, Bicas HE, McLoon LK
Invest Ophthalmol Vis Sci 2008 Jan;49(1):215-20. doi: 10.1167/iovs.07-0507. PMID: 18172095Free PMC Article

Clinical prediction guides

Long-term Motor and Sensory Outcomes After Unilateral Medial Rectus Recession-Lateral Rectus Resection for Infantile Esotropia.
Mohan K, Sharma SK
J Pediatr Ophthalmol Strabismus 2024 Mar-Apr;61(2):106-113. Epub 2023 Aug 24 doi: 10.3928/01913913-20230721-01. PMID: 37615418
Unilateral Surgery in Bilateral Asymmetrical Dissociated Vertical Deviation With Strong Preferential Fixation.
Lembo A, Serafino M, Villani E, Nucci P
J Pediatr Ophthalmol Strabismus 2022 Jan-Feb;59(1):60-64. Epub 2021 Sep 30 doi: 10.3928/01913913-20210708-06. PMID: 34592873
Spontaneous Regression of Over-elevation in Adduction Following Esotropia Surgery.
Göncü T, Akal A, Adibelli FM, Çakmak S, Düsünür M
J Pediatr Ophthalmol Strabismus 2016 Jan-Feb;53(1):35-9. doi: 10.3928/01913913-20160113-04. PMID: 26836001
Activated satellite cells in medial rectus muscles of patients with strabismus.
Antunes-Foschini RS, Miyashita D, Bicas HE, McLoon LK
Invest Ophthalmol Vis Sci 2008 Jan;49(1):215-20. doi: 10.1167/iovs.07-0507. PMID: 18172095Free PMC Article
Inferior oblique overaction in infantile esotropia: fundus extorsion as a predictive sign.
Eustis HS, Nussdorf JD
J Pediatr Ophthalmol Strabismus 1996 Mar-Apr;33(2):85-8. doi: 10.3928/0191-3913-19960301-05. PMID: 8965244

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