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Recurrent Esophageal Squamous Cell Carcinoma

MedGen UID:
163455
•Concept ID:
C0854769
•
Neoplastic Process
Synonyms: Recurrent Squamous Cell Carcinoma of Esophagus; Recurrent Squamous Cell Carcinoma of the Esophagus

Definition

An esophageal squamous cell carcinoma which has reappeared after a period of remission or after presumed treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Esophageal Squamous Cell Carcinoma

Professional guidelines

PubMed

External beam radiotherapy with or without californium-252 neutron brachytherapy for treatment of recurrence after definitive chemoradiotherapy.
Wu WA, Yang YP, Liang J, Zhao J, Wang JS, Zhang J
Sci Rep 2020 Dec 1;10(1):20902. doi: 10.1038/s41598-020-78074-y. PMID: 33262384Free PMC Article
Pembrolizumab for the treatment of esophageal cancer.
Yamamoto S, Kato K
Expert Opin Biol Ther 2020 Oct;20(10):1143-1150. Epub 2020 Jul 14 doi: 10.1080/14712598.2020.1792881. PMID: 32620063
How does presurgical chemotherapy influence the efficiency of treatment for esophageal cancer recurrence after curative esophagectomy?
Taniyama Y, Sakurai T, Hikage M, Okamoto H, Sato C, Takaya K, Unno M, Kamei T
Thorac Cancer 2019 Apr;10(4):769-774. Epub 2019 Feb 12 doi: 10.1111/1759-7714.12996. PMID: 30756477Free PMC Article

Recent clinical studies

Etiology

Inflammatory prognostic factors in advanced or recurrent esophageal squamous cell carcinoma treated with nivolumab.
Ikoma T, Shimokawa M, Matsumoto T, Boku S, Yasuda T, Shibata N, Kurioka Y, Takatani M, Nobuhisa T, Namikawa T, Kitagawa H, Hanazaki K, Doi K, Shimada T, Tsumura T, Marusawa H, Kanaya S, Morita S, Inokuma T, Nagai H, Yasui H, Satake H
Cancer Immunol Immunother 2023 Feb;72(2):427-435. Epub 2022 Aug 4 doi: 10.1007/s00262-022-03265-7. PMID: 35927359Free PMC Article
A re-irradiation dose of 55-60 Gy improves the survival rate of patients with local recurrent esophageal squamous cell carcinoma after radiotherapy.
Wu X, Hu X, Chen J, He L
Radiat Oncol 2021 Jun 8;16(1):100. doi: 10.1186/s13014-021-01828-z. PMID: 34103059Free PMC Article
Evaluating the optimal re-irradiation dose for locally recurrent esophageal squamous cell carcinoma after definitive radiotherapy.
Xu X, Wang Z, Jiang S, Shang Y, Wu Y
Radiat Oncol 2019 Nov 4;14(1):191. doi: 10.1186/s13014-019-1402-1. PMID: 31684983Free PMC Article
Prognostic Significance of the Prognostic Nutritional Index in Patients with Recurrent Esophageal Squamous Cell Carcinoma.
Nakatani M, Migita K, Matsumoto S, Wakatsuki K, Ito M, Nakade H, Kunishige T, Kitano M, Sho M
Nutr Cancer 2018 Apr;70(3):467-473. Epub 2018 Mar 12 doi: 10.1080/01635581.2018.1445771. PMID: 29528703
Systematic review and meta-analysis on the significance of salvage esophagectomy for persistent or recurrent esophageal squamous cell carcinoma after definitive chemoradiotherapy.
Kumagai K, Mariosa D, Tsai JA, Nilsson M, Ye W, Lundell L, Rouvelas I
Dis Esophagus 2016 Oct;29(7):734-739. Epub 2015 Aug 28 doi: 10.1111/dote.12399. PMID: 26316181

Diagnosis

Long-term survival after definitive proton beam therapy for oligorecurrent esophageal squamous cell carcinoma: a case report.
Ishikawa Y, Suzuki M, Yamaguchi H, Seto I, Machida M, Takagawa Y, Jingu K, Kikuchi Y, Murakami M
J Med Case Rep 2022 Feb 14;16(1):68. doi: 10.1186/s13256-022-03275-0. PMID: 35152904Free PMC Article
Pembrolizumab for the treatment of esophageal cancer.
Yamamoto S, Kato K
Expert Opin Biol Ther 2020 Oct;20(10):1143-1150. Epub 2020 Jul 14 doi: 10.1080/14712598.2020.1792881. PMID: 32620063
Mediastinoscopic salvage esophagectomy for recurrent esophageal squamous cell carcinoma after definitive chemoradiotherapy in a previously pneumonectomized patient.
Okumura T, Seto Y, Aikou S, Moriyama M, Sekine S, Hashimoto I, Shibuya K, Hojo S, Yoshioka I, Nagata T, Fujii T
Asian J Endosc Surg 2019 Oct;12(4):452-456. Epub 2018 Nov 8 doi: 10.1111/ases.12658. PMID: 30411514
Evaluation of combined docetaxel and nedaplatin chemotherapy for recurrent esophageal cancer compared with conventional chemotherapy using cisplatin and 5-fluorouracil: a retrospective study.
Fujita Y, Hiramatsu M, Kawai M, Sumiyoshi K, Nishimura H, Tanigawa N
Dis Esophagus 2008;21(6):496-501. doi: 10.1111/j.1442-2050.2007.00806.x. PMID: 18840134
Salvage chemotherapy with mitomycin C, ifosfamide, and cisplatin (MIC) for previously treated metastatic or recurrent esophageal squamous cell carcinoma.
Park BB, Im YH, Hwang IG, Lee SC, Ahn JS, Ahn MJ, Lim HY, Kang WK, Park K
Invest New Drugs 2008 Aug;26(4):387-92. Epub 2008 Mar 27 doi: 10.1007/s10637-008-9126-3. PMID: 18368291

Therapy

Inflammatory prognostic factors in advanced or recurrent esophageal squamous cell carcinoma treated with nivolumab.
Ikoma T, Shimokawa M, Matsumoto T, Boku S, Yasuda T, Shibata N, Kurioka Y, Takatani M, Nobuhisa T, Namikawa T, Kitagawa H, Hanazaki K, Doi K, Shimada T, Tsumura T, Marusawa H, Kanaya S, Morita S, Inokuma T, Nagai H, Yasui H, Satake H
Cancer Immunol Immunother 2023 Feb;72(2):427-435. Epub 2022 Aug 4 doi: 10.1007/s00262-022-03265-7. PMID: 35927359Free PMC Article
Combination of photodynamic therapy and endoscopic mucosal resection for recurrent esophageal squamous cell carcinoma after chemoradiotherapy.
Sato H, Hikichi T, Kato T, Nakamura J, Hashimoto M, Kobashi R, Yanagita T, Takasumi M, Kobayakawa M, Ohira H
Clin J Gastroenterol 2022 Dec;15(6):1035-1040. Epub 2022 Sep 5 doi: 10.1007/s12328-022-01695-5. PMID: 36064946
Pembrolizumab for the treatment of esophageal cancer.
Yamamoto S, Kato K
Expert Opin Biol Ther 2020 Oct;20(10):1143-1150. Epub 2020 Jul 14 doi: 10.1080/14712598.2020.1792881. PMID: 32620063
Prognostic Significance of the Prognostic Nutritional Index in Patients with Recurrent Esophageal Squamous Cell Carcinoma.
Nakatani M, Migita K, Matsumoto S, Wakatsuki K, Ito M, Nakade H, Kunishige T, Kitano M, Sho M
Nutr Cancer 2018 Apr;70(3):467-473. Epub 2018 Mar 12 doi: 10.1080/01635581.2018.1445771. PMID: 29528703
Prognostic factors of metastatic or recurrent esophageal squamous cell carcinoma in patients receiving three-drug combination chemotherapy.
Chen WW, Lin CC, Huang TC, Cheng AL, Yeh KH, Hsu CH
Anticancer Res 2013 Sep;33(9):4123-8. PMID: 24023359

Prognosis

Inflammatory prognostic factors in advanced or recurrent esophageal squamous cell carcinoma treated with nivolumab.
Ikoma T, Shimokawa M, Matsumoto T, Boku S, Yasuda T, Shibata N, Kurioka Y, Takatani M, Nobuhisa T, Namikawa T, Kitagawa H, Hanazaki K, Doi K, Shimada T, Tsumura T, Marusawa H, Kanaya S, Morita S, Inokuma T, Nagai H, Yasui H, Satake H
Cancer Immunol Immunother 2023 Feb;72(2):427-435. Epub 2022 Aug 4 doi: 10.1007/s00262-022-03265-7. PMID: 35927359Free PMC Article
A re-irradiation dose of 55-60 Gy improves the survival rate of patients with local recurrent esophageal squamous cell carcinoma after radiotherapy.
Wu X, Hu X, Chen J, He L
Radiat Oncol 2021 Jun 8;16(1):100. doi: 10.1186/s13014-021-01828-z. PMID: 34103059Free PMC Article
Pembrolizumab for the treatment of esophageal cancer.
Yamamoto S, Kato K
Expert Opin Biol Ther 2020 Oct;20(10):1143-1150. Epub 2020 Jul 14 doi: 10.1080/14712598.2020.1792881. PMID: 32620063
Evaluating the optimal re-irradiation dose for locally recurrent esophageal squamous cell carcinoma after definitive radiotherapy.
Xu X, Wang Z, Jiang S, Shang Y, Wu Y
Radiat Oncol 2019 Nov 4;14(1):191. doi: 10.1186/s13014-019-1402-1. PMID: 31684983Free PMC Article
Prognostic Significance of the Prognostic Nutritional Index in Patients with Recurrent Esophageal Squamous Cell Carcinoma.
Nakatani M, Migita K, Matsumoto S, Wakatsuki K, Ito M, Nakade H, Kunishige T, Kitano M, Sho M
Nutr Cancer 2018 Apr;70(3):467-473. Epub 2018 Mar 12 doi: 10.1080/01635581.2018.1445771. PMID: 29528703

Clinical prediction guides

Inflammatory prognostic factors in advanced or recurrent esophageal squamous cell carcinoma treated with nivolumab.
Ikoma T, Shimokawa M, Matsumoto T, Boku S, Yasuda T, Shibata N, Kurioka Y, Takatani M, Nobuhisa T, Namikawa T, Kitagawa H, Hanazaki K, Doi K, Shimada T, Tsumura T, Marusawa H, Kanaya S, Morita S, Inokuma T, Nagai H, Yasui H, Satake H
Cancer Immunol Immunother 2023 Feb;72(2):427-435. Epub 2022 Aug 4 doi: 10.1007/s00262-022-03265-7. PMID: 35927359Free PMC Article
Pembrolizumab for the treatment of esophageal cancer.
Yamamoto S, Kato K
Expert Opin Biol Ther 2020 Oct;20(10):1143-1150. Epub 2020 Jul 14 doi: 10.1080/14712598.2020.1792881. PMID: 32620063
Nimotuzumab, an EGFR‑targeted antibody, promotes radiosensitivity of recurrent esophageal squamous cell carcinoma.
Yu Y, Guan H, Jiang L, Li X, Xing L, Sun X
Int J Oncol 2020 Apr;56(4):945-956. Epub 2020 Feb 12 doi: 10.3892/ijo.2020.4981. PMID: 32319582
Evaluating the optimal re-irradiation dose for locally recurrent esophageal squamous cell carcinoma after definitive radiotherapy.
Xu X, Wang Z, Jiang S, Shang Y, Wu Y
Radiat Oncol 2019 Nov 4;14(1):191. doi: 10.1186/s13014-019-1402-1. PMID: 31684983Free PMC Article
Prognostic Significance of the Prognostic Nutritional Index in Patients with Recurrent Esophageal Squamous Cell Carcinoma.
Nakatani M, Migita K, Matsumoto S, Wakatsuki K, Ito M, Nakade H, Kunishige T, Kitano M, Sho M
Nutr Cancer 2018 Apr;70(3):467-473. Epub 2018 Mar 12 doi: 10.1080/01635581.2018.1445771. PMID: 29528703

Recent systematic reviews

Systematic review and meta-analysis on the significance of salvage esophagectomy for persistent or recurrent esophageal squamous cell carcinoma after definitive chemoradiotherapy.
Kumagai K, Mariosa D, Tsai JA, Nilsson M, Ye W, Lundell L, Rouvelas I
Dis Esophagus 2016 Oct;29(7):734-739. Epub 2015 Aug 28 doi: 10.1111/dote.12399. PMID: 26316181

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