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Metastatic Liposarcoma

MedGen UID:
163509
•Concept ID:
C0855059
•
Neoplastic Process
Synonym: Liposarcoma Metastatic

Definition

A liposarcoma that has metastasized to a secondary site. [from NCI]

Professional guidelines

PubMed

Eribulin therapy for the treatment of patients with advanced soft tissue sarcoma.
Seetharam M, Kolla KR, Chawla SP
Future Oncol 2018 Jul;14(16):1531-1545. Epub 2018 Feb 7 doi: 10.2217/fon-2017-0461. PMID: 29411654
Efficacy of trabectedin for the treatment of liposarcoma.
Zijoo R, von Mehren M
Expert Opin Pharmacother 2016 Oct;17(14):1953-62. Epub 2016 Sep 15 doi: 10.1080/14656566.2016.1229304. PMID: 27615729

Recent clinical studies

Etiology

Pharmacotherapy for liposarcoma: current state of the art and emerging systemic treatments.
Suarez-Kelly LP, Baldi GG, Gronchi A
Expert Opin Pharmacother 2019 Aug;20(12):1503-1515. Epub 2019 May 28 doi: 10.1080/14656566.2019.1618271. PMID: 31136210
FDA Approval Summary: Trabectedin for Unresectable or Metastatic Liposarcoma or Leiomyosarcoma Following an Anthracycline-Containing Regimen.
Barone A, Chi DC, Theoret MR, Chen H, He K, Kufrin D, Helms WS, Subramaniam S, Zhao H, Patel A, Goldberg KB, Keegan P, Pazdur R
Clin Cancer Res 2017 Dec 15;23(24):7448-7453. Epub 2017 Aug 3 doi: 10.1158/1078-0432.CCR-17-0898. PMID: 28774898
Efficacy and Safety of Trabectedin or Dacarbazine for Metastatic Liposarcoma or Leiomyosarcoma After Failure of Conventional Chemotherapy: Results of a Phase III Randomized Multicenter Clinical Trial.
Demetri GD, von Mehren M, Jones RL, Hensley ML, Schuetze SM, Staddon A, Milhem M, Elias A, Ganjoo K, Tawbi H, Van Tine BA, Spira A, Dean A, Khokhar NZ, Park YC, Knoblauch RE, Parekh TV, Maki RG, Patel SR
J Clin Oncol 2016 Mar 10;34(8):786-93. Epub 2015 Sep 14 doi: 10.1200/JCO.2015.62.4734. PMID: 26371143Free PMC Article
Long-lasting clinical benefit of sunitinib malate in the treatment of a case of heavily pre-treated metastatic liposarcoma.
Porzio R, Bella MA, Rossi G, Ardizzoni A
Anticancer Res 2013 Mar;33(3):1061-3. PMID: 23482782
Fat-containing lesions of the liver: radiologic-pathologic correlation.
Prasad SR, Wang H, Rosas H, Menias CO, Narra VR, Middleton WD, Heiken JP
Radiographics 2005 Mar-Apr;25(2):321-31. doi: 10.1148/rg.252045083. PMID: 15798052

Diagnosis

Long-term eribulin treatment in patients with a single kidney and retroperitoneal liposarcoma.
Tober N, Gentile M, Iodice G
Future Oncol 2020 Jan;16(1s):5-8. Epub 2019 Dec 24 doi: 10.2217/fon-2019-0595. PMID: 31872769
Pulmonary vein thrombosis after metastatic liposarcoma.
Tamizifar B, Zadeh MR, Foroghi E
Med Arh 2012;66(1):68-9. doi: 10.5455/medarh.2012.66.68-69. PMID: 22482350
Fat-containing lesions of the liver: radiologic-pathologic correlation.
Prasad SR, Wang H, Rosas H, Menias CO, Narra VR, Middleton WD, Heiken JP
Radiographics 2005 Mar-Apr;25(2):321-31. doi: 10.1148/rg.252045083. PMID: 15798052
Metastatic liposarcoma of the thyroid gland.
Azar AR, Weynand B, Daumerie C, Coche E
Br J Radiol 2003 Oct;76(910):750-2. doi: 10.1259/bjr/29206613. PMID: 14512338
Metastatic liposarcoma of the brain.
Kumar S, Teasdale E
Clin Radiol 2000 May;55(5):406-8. doi: 10.1053/crad.2000.0096. PMID: 10816410

Therapy

Complete Resection of a Cavoatrial Metastatic Liposarcoma under Hypothermic Circulatory Arrest.
Matsumoto R, Fujiyoshi T, Kamiya K, Matsubayashi J, Fukuda S, Nishibe T, Ogino H
Ann Thorac Cardiovasc Surg 2023 Aug 20;29(4):206-209. Epub 2022 Jan 29 doi: 10.5761/atcs.cr.21-00226. PMID: 35095053Free PMC Article
Multifarious targets beyond microtubules-role of eribulin in cancer therapy.
Seshadri P, Deb B, Kumar P
Front Biosci (Schol Ed) 2021 Dec 3;13(2):157-172. doi: 10.52586/S559. PMID: 34879468
Eribulin therapy for the treatment of patients with advanced soft tissue sarcoma.
Seetharam M, Kolla KR, Chawla SP
Future Oncol 2018 Jul;14(16):1531-1545. Epub 2018 Feb 7 doi: 10.2217/fon-2017-0461. PMID: 29411654
Efficacy of trabectedin for the treatment of liposarcoma.
Zijoo R, von Mehren M
Expert Opin Pharmacother 2016 Oct;17(14):1953-62. Epub 2016 Sep 15 doi: 10.1080/14656566.2016.1229304. PMID: 27615729
Efficacy and Safety of Trabectedin or Dacarbazine for Metastatic Liposarcoma or Leiomyosarcoma After Failure of Conventional Chemotherapy: Results of a Phase III Randomized Multicenter Clinical Trial.
Demetri GD, von Mehren M, Jones RL, Hensley ML, Schuetze SM, Staddon A, Milhem M, Elias A, Ganjoo K, Tawbi H, Van Tine BA, Spira A, Dean A, Khokhar NZ, Park YC, Knoblauch RE, Parekh TV, Maki RG, Patel SR
J Clin Oncol 2016 Mar 10;34(8):786-93. Epub 2015 Sep 14 doi: 10.1200/JCO.2015.62.4734. PMID: 26371143Free PMC Article

Prognosis

Complete Resection of a Cavoatrial Metastatic Liposarcoma under Hypothermic Circulatory Arrest.
Matsumoto R, Fujiyoshi T, Kamiya K, Matsubayashi J, Fukuda S, Nishibe T, Ogino H
Ann Thorac Cardiovasc Surg 2023 Aug 20;29(4):206-209. Epub 2022 Jan 29 doi: 10.5761/atcs.cr.21-00226. PMID: 35095053Free PMC Article
Combination of eribulin plus AKT inhibitor evokes synergistic cytotoxicity in soft tissue sarcoma cells.
Hayasaka N, Takada K, Nakamura H, Arihara Y, Kawano Y, Osuga T, Murase K, Kikuchi S, Iyama S, Emori M, Sugita S, Hasegawa T, Takasawa A, Miyanishi K, Kobune M, Kato J
Sci Rep 2019 Apr 8;9(1):5759. doi: 10.1038/s41598-019-42300-z. PMID: 30962488Free PMC Article
Efficacy and Safety of Trabectedin or Dacarbazine for Metastatic Liposarcoma or Leiomyosarcoma After Failure of Conventional Chemotherapy: Results of a Phase III Randomized Multicenter Clinical Trial.
Demetri GD, von Mehren M, Jones RL, Hensley ML, Schuetze SM, Staddon A, Milhem M, Elias A, Ganjoo K, Tawbi H, Van Tine BA, Spira A, Dean A, Khokhar NZ, Park YC, Knoblauch RE, Parekh TV, Maki RG, Patel SR
J Clin Oncol 2016 Mar 10;34(8):786-93. Epub 2015 Sep 14 doi: 10.1200/JCO.2015.62.4734. PMID: 26371143Free PMC Article
A case of stroke due to tumor emboli associated with metastatic cardiac liposarcoma.
Mitomi M, Kimura K, Iguchi Y, Hayashida A, Nishimura H, Irei I, Okawaki M, Ikeda H
Intern Med 2011;50(14):1489-91. Epub 2011 Jul 15 doi: 10.2169/internalmedicine.50.5071. PMID: 21757835
Cardiac metastatic liposarcoma.
Sugiyama K, Okubo T, Kamigaki Y, Kin H
Jpn J Thorac Cardiovasc Surg 2000 Oct;48(10):663-5. doi: 10.1007/BF03218225. PMID: 11080957

Clinical prediction guides

Surgical management of spinal liposarcoma: a case series of 7 patients and literature review.
Zhao C, Han Z, Xiao H, Yang C, Zhao Y, Fan T, Sun Z, Liu T, Xiao J
Eur Spine J 2016 Dec;25(12):4088-4093. Epub 2016 Jan 18 doi: 10.1007/s00586-015-4374-3. PMID: 26781842
Efficacy and Safety of Trabectedin or Dacarbazine for Metastatic Liposarcoma or Leiomyosarcoma After Failure of Conventional Chemotherapy: Results of a Phase III Randomized Multicenter Clinical Trial.
Demetri GD, von Mehren M, Jones RL, Hensley ML, Schuetze SM, Staddon A, Milhem M, Elias A, Ganjoo K, Tawbi H, Van Tine BA, Spira A, Dean A, Khokhar NZ, Park YC, Knoblauch RE, Parekh TV, Maki RG, Patel SR
J Clin Oncol 2016 Mar 10;34(8):786-93. Epub 2015 Sep 14 doi: 10.1200/JCO.2015.62.4734. PMID: 26371143Free PMC Article
Cardiac metastatic liposarcoma.
Sugiyama K, Okubo T, Kamigaki Y, Kin H
Jpn J Thorac Cardiovasc Surg 2000 Oct;48(10):663-5. doi: 10.1007/BF03218225. PMID: 11080957
Skeletal metastases in liposarcoma detectable only by magnetic resonance imaging.
Khurana JS, Rosenthal DI, Rosenberg AE, Mankin HJ
Clin Orthop Relat Res 1989 Jun;(243):204-7. PMID: 2721066
Metastatic liposarcoma of the right ventricle with outflow tract obstruction: restrictive pathophysiology predicts poor surgical outcome.
Bartels P, O'Callaghan WG, Peyton R, Sethi G, Maley T
Am Heart J 1988 Mar;115(3):696-8. doi: 10.1016/0002-8703(88)90828-9. PMID: 3344669

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