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Metastatic Myxoid Liposarcoma

MedGen UID:
1656934
•Concept ID:
C4087469
•
Neoplastic Process
Synonym: Metastatic Myxoid/Round Cell Liposarcoma

Definition

Myxoid liposarcoma that has spread to other anatomic sites. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Myxoid Liposarcoma

Professional guidelines

PubMed

Kinome profiling of myxoid liposarcoma reveals NF-kappaB-pathway kinase activity and casein kinase II inhibition as a potential treatment option.
Willems SM, Schrage YM, Bruijn IH, Szuhai K, Hogendoorn PC, Bovée JV
Mol Cancer 2010 Sep 23;9:257. doi: 10.1186/1476-4598-9-257. PMID: 20863376Free PMC Article

Recent clinical studies

Etiology

Prognostic factors of metastatic myxoid liposarcoma.
Shinoda Y, Kobayashi E, Kobayashi H, Mori T, Asano N, Nakayama R, Morioka H, Iwata S, Yonemoto T, Ishii T, Hiruma T, Kawai A, Kawano H
BMC Cancer 2020 Sep 14;20(1):883. doi: 10.1186/s12885-020-07384-1. PMID: 32928160Free PMC Article
Sustained clinico-radiologic response to anti-cytotoxic T lymphocyte antigen 4 antibody therapy in metastatic myxoid liposarcoma.
Dasanu CA
J Oncol Pharm Pract 2017 Oct;23(7):549-551. Epub 2016 Aug 10 doi: 10.1177/1078155216664202. PMID: 27511215
The first case report of a metastatic myxoid liposarcoma invading the left atrial cavity and pulmonary vein.
Dogan U, Zamani A, Gormus N, Paksoy Y, Avunduk MC, Demirbas S
Heart Surg Forum 2011 Aug;14(4):E261-3. doi: 10.1532/HSF98.20111021. PMID: 21859649
Metastatic myxoid liposarcomas: imaging and histopathologic findings.
Sheah K, Ouellette HA, Torriani M, Nielsen GP, Kattapuram S, Bredella MA
Skeletal Radiol 2008 Mar;37(3):251-8. Epub 2007 Dec 21 doi: 10.1007/s00256-007-0424-1. PMID: 18097662
Metastatic myxoid liposarcoma in the mesentery: what is debated? Case report and a review of the literature.
Tomita H, Yamaguchi K, Matsuo M, Ohno T, Nishimoto Y, Hirose Y
Am Surg 2006 Jan;72(1):68-70. PMID: 16494187

Diagnosis

Rare case of metastatic liposarcoma to the thyroid gland and a review of the literature of metastatic sarcomas to the thyroid.
Xing MH, Mundi N, Govindan A, Khorsandi A, Brandwein-Weber M, Matloob A, Liaw B, Urken ML
Head Neck 2021 Mar;43(3):E20-E26. Epub 2020 Nov 21 doi: 10.1002/hed.26552. PMID: 33220159
Prognostic factors of metastatic myxoid liposarcoma.
Shinoda Y, Kobayashi E, Kobayashi H, Mori T, Asano N, Nakayama R, Morioka H, Iwata S, Yonemoto T, Ishii T, Hiruma T, Kawai A, Kawano H
BMC Cancer 2020 Sep 14;20(1):883. doi: 10.1186/s12885-020-07384-1. PMID: 32928160Free PMC Article
Solitary metastasis of myxoid liposarcoma from the thigh to intraperitoneum: a case report.
Kim DW, Jee YS
World J Surg Oncol 2019 Oct 28;17(1):172. doi: 10.1186/s12957-019-1724-3. PMID: 31660994Free PMC Article
Cytogenetic evidence of metastatic myxoid liposarcoma and therapy-related myelodysplastic syndrome in a bone marrow biopsy.
Rossi S, Canal F, Licci S, Zanatta L, Laurino L, Gottardi M, Gherlinzoni F, Dei Tos AP
Hum Pathol 2009 Jul;40(7):1040-4. Epub 2009 May 12 doi: 10.1016/j.humpath.2008.12.020. PMID: 19439345
Metastatic myxoid liposarcomas: imaging and histopathologic findings.
Sheah K, Ouellette HA, Torriani M, Nielsen GP, Kattapuram S, Bredella MA
Skeletal Radiol 2008 Mar;37(3):251-8. Epub 2007 Dec 21 doi: 10.1007/s00256-007-0424-1. PMID: 18097662

Therapy

Sustained clinico-radiologic response to anti-cytotoxic T lymphocyte antigen 4 antibody therapy in metastatic myxoid liposarcoma.
Dasanu CA
J Oncol Pharm Pract 2017 Oct;23(7):549-551. Epub 2016 Aug 10 doi: 10.1177/1078155216664202. PMID: 27511215
Phase II study of amrubicin (SM-5887), a synthetic 9-aminoanthracycline, as first line treatment in patients with metastatic or unresectable soft tissue sarcoma: durable response in myxoid liposarcoma with TLS-CHOP translocation.
Gupta S, Gouw L, Wright J, Chawla S, Pitt D, Wade M, Boucher K, Sharma S
Invest New Drugs 2016 Apr;34(2):243-52. Epub 2016 Feb 20 doi: 10.1007/s10637-016-0333-z. PMID: 26897615
The first case report of a metastatic myxoid liposarcoma invading the left atrial cavity and pulmonary vein.
Dogan U, Zamani A, Gormus N, Paksoy Y, Avunduk MC, Demirbas S
Heart Surg Forum 2011 Aug;14(4):E261-3. doi: 10.1532/HSF98.20111021. PMID: 21859649
Kinome profiling of myxoid liposarcoma reveals NF-kappaB-pathway kinase activity and casein kinase II inhibition as a potential treatment option.
Willems SM, Schrage YM, Bruijn IH, Szuhai K, Hogendoorn PC, Bovée JV
Mol Cancer 2010 Sep 23;9:257. doi: 10.1186/1476-4598-9-257. PMID: 20863376Free PMC Article
Cytogenetic evidence of metastatic myxoid liposarcoma and therapy-related myelodysplastic syndrome in a bone marrow biopsy.
Rossi S, Canal F, Licci S, Zanatta L, Laurino L, Gottardi M, Gherlinzoni F, Dei Tos AP
Hum Pathol 2009 Jul;40(7):1040-4. Epub 2009 May 12 doi: 10.1016/j.humpath.2008.12.020. PMID: 19439345

Prognosis

Prognostic factors of metastatic myxoid liposarcoma.
Shinoda Y, Kobayashi E, Kobayashi H, Mori T, Asano N, Nakayama R, Morioka H, Iwata S, Yonemoto T, Ishii T, Hiruma T, Kawai A, Kawano H
BMC Cancer 2020 Sep 14;20(1):883. doi: 10.1186/s12885-020-07384-1. PMID: 32928160Free PMC Article
Feasibility of whole-body MRI for detecting metastatic myxoid liposarcoma: a case series.
Seo SW, Kwon JW, Jang SW, Jang SP, Park YS
Orthopedics 2011 Nov 9;34(11):e748-54. doi: 10.3928/01477447-20110922-15. PMID: 22049957
Excellent local control rates and distinctive patterns of failure in myxoid liposarcoma treated with conservation surgery and radiotherapy.
Guadagnolo BA, Zagars GK, Ballo MT, Patel SR, Lewis VO, Benjamin RS, Pollock RE
Int J Radiat Oncol Biol Phys 2008 Mar 1;70(3):760-5. Epub 2007 Sep 24 doi: 10.1016/j.ijrobp.2007.07.2337. PMID: 17892916
Metastatic myxoid liposarcoma in the mesentery: what is debated? Case report and a review of the literature.
Tomita H, Yamaguchi K, Matsuo M, Ohno T, Nishimoto Y, Hirose Y
Am Surg 2006 Jan;72(1):68-70. PMID: 16494187
Cardiac encasement by metastatic myxoid liposarcoma.
Lee DS, Barnard M, Freeman MR, Hutchison SJ, Graham AF, Chiu B
Cardiovasc Pathol 2002 Nov-Dec;11(6):322-5. doi: 10.1016/s1054-8807(02)00131-x. PMID: 12459432

Clinical prediction guides

Prognostic factors of metastatic myxoid liposarcoma.
Shinoda Y, Kobayashi E, Kobayashi H, Mori T, Asano N, Nakayama R, Morioka H, Iwata S, Yonemoto T, Ishii T, Hiruma T, Kawai A, Kawano H
BMC Cancer 2020 Sep 14;20(1):883. doi: 10.1186/s12885-020-07384-1. PMID: 32928160Free PMC Article
Feasibility of whole-body MRI for detecting metastatic myxoid liposarcoma: a case series.
Seo SW, Kwon JW, Jang SW, Jang SP, Park YS
Orthopedics 2011 Nov 9;34(11):e748-54. doi: 10.3928/01477447-20110922-15. PMID: 22049957

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