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BRCA-Associated Ovarian Carcinoma

MedGen UID:
1635506
•Concept ID:
C4688331
•
Neoplastic Process
Synonym: BRCA-Mutated Ovarian Carcinoma

Definition

Ovarian carcinoma caused by deleterious germline mutation in a gene of the BRCA family. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBRCA-Associated Ovarian Carcinoma

Professional guidelines

PubMed

Olaparib in the treatment of ovarian cancer.
Washington CR, Richardson DL, Moore KN
Future Oncol 2019 Oct;15(30):3435-3449. Epub 2019 Sep 3 doi: 10.2217/fon-2019-0271. PMID: 31478762
BRCA-associated Cancers: Role of Imaging in Screening, Diagnosis, and Management.
Lee MV, Katabathina VS, Bowerson ML, Mityul MI, Shetty AS, Elsayes KM, Balachandran A, Bhosale PR, McCullough AE, Menias CO
Radiographics 2017 Jul-Aug;37(4):1005-1023. Epub 2017 May 26 doi: 10.1148/rg.2017160144. PMID: 28548905
Veliparib for the treatment of ovarian cancer.
Bogliolo S, Cassani C, Dominoni M, Musacchi V, Venturini PL, Spinillo A, Ferrero S, Gardella B
Expert Opin Investig Drugs 2016;25(3):367-74. Epub 2016 Feb 16 doi: 10.1517/13543784.2016.1146677. PMID: 26807493

Recent clinical studies

Etiology

BRCA1/2 reversion mutations in a pan-cancer cohort.
Nakamura K, Hayashi H, Kawano R, Ishikawa M, Aimono E, Mizuno T, Kuroda H, Kojima Y, Niikura N, Kawanishi A, Takeshita K, Suzuki S, Ueno S, Okuwaki K, Sasaki J, Yamaguchi M, Masuda K, Chiyoda T, Yamagami W, Okada C, Nohara S, Tanishima S, Nishihara H
Cancer Sci 2024 Feb;115(2):635-647. Epub 2023 Dec 1 doi: 10.1111/cas.16033. PMID: 38041241Free PMC Article
Molecular basis and therapeutic targets in prostate cancer: A comprehensive review.
Militaru FC, Militaru V, Crisan N, Bocsan IC, Udrea AA, Catana A, Kutasi E, Militaru MS
Biomol Biomed 2023 Sep 4;23(5):760-771. doi: 10.17305/bb.2023.8782. PMID: 37021836Free PMC Article
Hereditary Breast and Ovarian Cancer: An Updated Primer for OB/GYNs.
Bellcross CA
Obstet Gynecol Clin North Am 2022 Mar;49(1):117-147. doi: 10.1016/j.ogc.2021.11.005. PMID: 35168766
BRCA-associated Cancers: Role of Imaging in Screening, Diagnosis, and Management.
Lee MV, Katabathina VS, Bowerson ML, Mityul MI, Shetty AS, Elsayes KM, Balachandran A, Bhosale PR, McCullough AE, Menias CO
Radiographics 2017 Jul-Aug;37(4):1005-1023. Epub 2017 May 26 doi: 10.1148/rg.2017160144. PMID: 28548905
BRCA1 and BRCA2 mutations and breast cancer.
Narod SA, Salmena L
Discov Med 2011 Nov;12(66):445-53. PMID: 22127115

Diagnosis

Molecular basis and therapeutic targets in prostate cancer: A comprehensive review.
Militaru FC, Militaru V, Crisan N, Bocsan IC, Udrea AA, Catana A, Kutasi E, Militaru MS
Biomol Biomed 2023 Sep 4;23(5):760-771. doi: 10.17305/bb.2023.8782. PMID: 37021836Free PMC Article
Hereditary Breast and Ovarian Cancer: An Updated Primer for OB/GYNs.
Bellcross CA
Obstet Gynecol Clin North Am 2022 Mar;49(1):117-147. doi: 10.1016/j.ogc.2021.11.005. PMID: 35168766
Olaparib in the treatment of ovarian cancer.
Washington CR, Richardson DL, Moore KN
Future Oncol 2019 Oct;15(30):3435-3449. Epub 2019 Sep 3 doi: 10.2217/fon-2019-0271. PMID: 31478762
BRCA-associated Cancers: Role of Imaging in Screening, Diagnosis, and Management.
Lee MV, Katabathina VS, Bowerson ML, Mityul MI, Shetty AS, Elsayes KM, Balachandran A, Bhosale PR, McCullough AE, Menias CO
Radiographics 2017 Jul-Aug;37(4):1005-1023. Epub 2017 May 26 doi: 10.1148/rg.2017160144. PMID: 28548905
Olaparib.
Goulooze SC, Cohen AF, Rissmann R
Br J Clin Pharmacol 2016 Jan;81(1):171-3. Epub 2015 Oct 24 doi: 10.1111/bcp.12761. PMID: 26344419Free PMC Article

Therapy

Theranostic biomarkers and PARP-inhibitors effectiveness in patients with non-BRCA associated homologous recombination deficient tumors: Still looking through a dirty glass window?
Incorvaia L, Perez A, Marchetti C, Brando C, Gristina V, Cancelliere D, Pivetti A, Contino S, Di Giovanni E, Barraco N, Bono M, Giurintano A, Bazan Russo TD, Gottardo A, Cutaia S, Pedone E, Peri M, Corsini LR, Fanale D, Galvano A, Scambia G, Badalamenti G, Russo A, Bazan V
Cancer Treat Rev 2023 Dec;121:102650. Epub 2023 Oct 31 doi: 10.1016/j.ctrv.2023.102650. PMID: 37939446
Molecular basis and therapeutic targets in prostate cancer: A comprehensive review.
Militaru FC, Militaru V, Crisan N, Bocsan IC, Udrea AA, Catana A, Kutasi E, Militaru MS
Biomol Biomed 2023 Sep 4;23(5):760-771. doi: 10.17305/bb.2023.8782. PMID: 37021836Free PMC Article
Olaparib in the treatment of ovarian cancer.
Washington CR, Richardson DL, Moore KN
Future Oncol 2019 Oct;15(30):3435-3449. Epub 2019 Sep 3 doi: 10.2217/fon-2019-0271. PMID: 31478762
Olaparib.
Goulooze SC, Cohen AF, Rissmann R
Br J Clin Pharmacol 2016 Jan;81(1):171-3. Epub 2015 Oct 24 doi: 10.1111/bcp.12761. PMID: 26344419Free PMC Article
Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers.
Fong PC, Boss DS, Yap TA, Tutt A, Wu P, Mergui-Roelvink M, Mortimer P, Swaisland H, Lau A, O'Connor MJ, Ashworth A, Carmichael J, Kaye SB, Schellens JH, de Bono JS
N Engl J Med 2009 Jul 9;361(2):123-34. Epub 2009 Jun 24 doi: 10.1056/NEJMoa0900212. PMID: 19553641

Prognosis

BRCA1/2 reversion mutations in a pan-cancer cohort.
Nakamura K, Hayashi H, Kawano R, Ishikawa M, Aimono E, Mizuno T, Kuroda H, Kojima Y, Niikura N, Kawanishi A, Takeshita K, Suzuki S, Ueno S, Okuwaki K, Sasaki J, Yamaguchi M, Masuda K, Chiyoda T, Yamagami W, Okada C, Nohara S, Tanishima S, Nishihara H
Cancer Sci 2024 Feb;115(2):635-647. Epub 2023 Dec 1 doi: 10.1111/cas.16033. PMID: 38041241Free PMC Article
Theranostic biomarkers and PARP-inhibitors effectiveness in patients with non-BRCA associated homologous recombination deficient tumors: Still looking through a dirty glass window?
Incorvaia L, Perez A, Marchetti C, Brando C, Gristina V, Cancelliere D, Pivetti A, Contino S, Di Giovanni E, Barraco N, Bono M, Giurintano A, Bazan Russo TD, Gottardo A, Cutaia S, Pedone E, Peri M, Corsini LR, Fanale D, Galvano A, Scambia G, Badalamenti G, Russo A, Bazan V
Cancer Treat Rev 2023 Dec;121:102650. Epub 2023 Oct 31 doi: 10.1016/j.ctrv.2023.102650. PMID: 37939446
Molecular basis and therapeutic targets in prostate cancer: A comprehensive review.
Militaru FC, Militaru V, Crisan N, Bocsan IC, Udrea AA, Catana A, Kutasi E, Militaru MS
Biomol Biomed 2023 Sep 4;23(5):760-771. doi: 10.17305/bb.2023.8782. PMID: 37021836Free PMC Article
Hereditary Breast and Ovarian Cancer: An Updated Primer for OB/GYNs.
Bellcross CA
Obstet Gynecol Clin North Am 2022 Mar;49(1):117-147. doi: 10.1016/j.ogc.2021.11.005. PMID: 35168766
BRCA-associated Cancers: Role of Imaging in Screening, Diagnosis, and Management.
Lee MV, Katabathina VS, Bowerson ML, Mityul MI, Shetty AS, Elsayes KM, Balachandran A, Bhosale PR, McCullough AE, Menias CO
Radiographics 2017 Jul-Aug;37(4):1005-1023. Epub 2017 May 26 doi: 10.1148/rg.2017160144. PMID: 28548905

Clinical prediction guides

BRCA1/2 reversion mutations in a pan-cancer cohort.
Nakamura K, Hayashi H, Kawano R, Ishikawa M, Aimono E, Mizuno T, Kuroda H, Kojima Y, Niikura N, Kawanishi A, Takeshita K, Suzuki S, Ueno S, Okuwaki K, Sasaki J, Yamaguchi M, Masuda K, Chiyoda T, Yamagami W, Okada C, Nohara S, Tanishima S, Nishihara H
Cancer Sci 2024 Feb;115(2):635-647. Epub 2023 Dec 1 doi: 10.1111/cas.16033. PMID: 38041241Free PMC Article
Theranostic biomarkers and PARP-inhibitors effectiveness in patients with non-BRCA associated homologous recombination deficient tumors: Still looking through a dirty glass window?
Incorvaia L, Perez A, Marchetti C, Brando C, Gristina V, Cancelliere D, Pivetti A, Contino S, Di Giovanni E, Barraco N, Bono M, Giurintano A, Bazan Russo TD, Gottardo A, Cutaia S, Pedone E, Peri M, Corsini LR, Fanale D, Galvano A, Scambia G, Badalamenti G, Russo A, Bazan V
Cancer Treat Rev 2023 Dec;121:102650. Epub 2023 Oct 31 doi: 10.1016/j.ctrv.2023.102650. PMID: 37939446
Hereditary Breast and Ovarian Cancer: An Updated Primer for OB/GYNs.
Bellcross CA
Obstet Gynecol Clin North Am 2022 Mar;49(1):117-147. doi: 10.1016/j.ogc.2021.11.005. PMID: 35168766
BRCA-associated ovarian cancer: from molecular genetics to risk management.
Girolimetti G, Perrone AM, Santini D, Barbieri E, Guerra F, Ferrari S, Zamagni C, De Iaco P, Gasparre G, Turchetti D
Biomed Res Int 2014;2014:787143. Epub 2014 Jul 22 doi: 10.1155/2014/787143. PMID: 25136623Free PMC Article
Genomic instability in breast and ovarian cancers: translation into clinical predictive biomarkers.
Vollebergh MA, Jonkers J, Linn SC
Cell Mol Life Sci 2012 Jan;69(2):223-45. Epub 2011 Sep 16 doi: 10.1007/s00018-011-0809-0. PMID: 21922196

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