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Recurrent BRCA- Associated Ovarian Carcinoma

MedGen UID:
1637849
Concept ID:
C4688332
Neoplastic Process
Synonym: Recurrent BRCA-Mutated Ovarian Carcinoma

Definition

The reemergence of BRCA-associated ovarian carcinoma after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent BRCA- Associated Ovarian Carcinoma

Professional guidelines

PubMed

Washington CR, Richardson DL, Moore KN
Future Oncol 2019 Oct;15(30):3435-3449. Epub 2019 Sep 3 doi: 10.2217/fon-2019-0271. PMID: 31478762
Matulonis UA
Clin Adv Hematol Oncol 2018 Jun;16(6):426-437. PMID: 30067614
Pignata S, C Cecere S, Du Bois A, Harter P, Heitz F
Ann Oncol 2017 Nov 1;28(suppl_8):viii51-viii56. doi: 10.1093/annonc/mdx441. PMID: 29232464

Recent clinical studies

Etiology

Tutt ANJ, Garber JE, Kaufman B, Viale G, Fumagalli D, Rastogi P, Gelber RD, de Azambuja E, Fielding A, Balmaña J, Domchek SM, Gelmon KA, Hollingsworth SJ, Korde LA, Linderholm B, Bandos H, Senkus E, Suga JM, Shao Z, Pippas AW, Nowecki Z, Huzarski T, Ganz PA, Lucas PC, Baker N, Loibl S, McConnell R, Piccart M, Schmutzler R, Steger GG, Costantino JP, Arahmani A, Wolmark N, McFadden E, Karantza V, Lakhani SR, Yothers G, Campbell C, Geyer CE Jr; OlympiA Clinical Trial Steering Committee and Investigators
N Engl J Med 2021 Jun 24;384(25):2394-2405. Epub 2021 Jun 3 doi: 10.1056/NEJMoa2105215. PMID: 34081848Free PMC Article
Stewart C, Ralyea C, Lockwood S
Semin Oncol Nurs 2019 Apr;35(2):151-156. Epub 2019 Mar 11 doi: 10.1016/j.soncn.2019.02.001. PMID: 30867104
Mittica G, Ghisoni E, Giannone G, Genta S, Aglietta M, Sapino A, Valabrega G
Recent Pat Anticancer Drug Discov 2018;13(4):392-410. doi: 10.2174/1574892813666180305165256. PMID: 29512470
Mirza MR, Monk BJ, Herrstedt J, Oza AM, Mahner S, Redondo A, Fabbro M, Ledermann JA, Lorusso D, Vergote I, Ben-Baruch NE, Marth C, Mądry R, Christensen RD, Berek JS, Dørum A, Tinker AV, du Bois A, González-Martín A, Follana P, Benigno B, Rosenberg P, Gilbert L, Rimel BJ, Buscema J, Balser JP, Agarwal S, Matulonis UA; ENGOT-OV16/NOVA Investigators
N Engl J Med 2016 Dec 1;375(22):2154-2164. Epub 2016 Oct 7 doi: 10.1056/NEJMoa1611310. PMID: 27717299
Narod SA, Salmena L
Discov Med 2011 Nov;12(66):445-53. PMID: 22127115

Diagnosis

González-Martín A, Pothuri B, Vergote I, DePont Christensen R, Graybill W, Mirza MR, McCormick C, Lorusso D, Hoskins P, Freyer G, Baumann K, Jardon K, Redondo A, Moore RG, Vulsteke C, O'Cearbhaill RE, Lund B, Backes F, Barretina-Ginesta P, Haggerty AF, Rubio-Pérez MJ, Shahin MS, Mangili G, Bradley WH, Bruchim I, Sun K, Malinowska IA, Li Y, Gupta D, Monk BJ; PRIMA/ENGOT-OV26/GOG-3012 Investigators
N Engl J Med 2019 Dec 19;381(25):2391-2402. Epub 2019 Sep 28 doi: 10.1056/NEJMoa1910962. PMID: 31562799
Stewart C, Ralyea C, Lockwood S
Semin Oncol Nurs 2019 Apr;35(2):151-156. Epub 2019 Mar 11 doi: 10.1016/j.soncn.2019.02.001. PMID: 30867104
Mittica G, Ghisoni E, Giannone G, Genta S, Aglietta M, Sapino A, Valabrega G
Recent Pat Anticancer Drug Discov 2018;13(4):392-410. doi: 10.2174/1574892813666180305165256. PMID: 29512470
Coleman RL, Oza AM, Lorusso D, Aghajanian C, Oaknin A, Dean A, Colombo N, Weberpals JI, Clamp A, Scambia G, Leary A, Holloway RW, Gancedo MA, Fong PC, Goh JC, O'Malley DM, Armstrong DK, Garcia-Donas J, Swisher EM, Floquet A, Konecny GE, McNeish IA, Scott CL, Cameron T, Maloney L, Isaacson J, Goble S, Grace C, Harding TC, Raponi M, Sun J, Lin KK, Giordano H, Ledermann JA; ARIEL3 investigators
Lancet 2017 Oct 28;390(10106):1949-1961. Epub 2017 Sep 12 doi: 10.1016/S0140-6736(17)32440-6. PMID: 28916367Free PMC Article
Mirza MR, Monk BJ, Herrstedt J, Oza AM, Mahner S, Redondo A, Fabbro M, Ledermann JA, Lorusso D, Vergote I, Ben-Baruch NE, Marth C, Mądry R, Christensen RD, Berek JS, Dørum A, Tinker AV, du Bois A, González-Martín A, Follana P, Benigno B, Rosenberg P, Gilbert L, Rimel BJ, Buscema J, Balser JP, Agarwal S, Matulonis UA; ENGOT-OV16/NOVA Investigators
N Engl J Med 2016 Dec 1;375(22):2154-2164. Epub 2016 Oct 7 doi: 10.1056/NEJMoa1611310. PMID: 27717299

Therapy

Tutt ANJ, Garber JE, Kaufman B, Viale G, Fumagalli D, Rastogi P, Gelber RD, de Azambuja E, Fielding A, Balmaña J, Domchek SM, Gelmon KA, Hollingsworth SJ, Korde LA, Linderholm B, Bandos H, Senkus E, Suga JM, Shao Z, Pippas AW, Nowecki Z, Huzarski T, Ganz PA, Lucas PC, Baker N, Loibl S, McConnell R, Piccart M, Schmutzler R, Steger GG, Costantino JP, Arahmani A, Wolmark N, McFadden E, Karantza V, Lakhani SR, Yothers G, Campbell C, Geyer CE Jr; OlympiA Clinical Trial Steering Committee and Investigators
N Engl J Med 2021 Jun 24;384(25):2394-2405. Epub 2021 Jun 3 doi: 10.1056/NEJMoa2105215. PMID: 34081848Free PMC Article
González-Martín A, Pothuri B, Vergote I, DePont Christensen R, Graybill W, Mirza MR, McCormick C, Lorusso D, Hoskins P, Freyer G, Baumann K, Jardon K, Redondo A, Moore RG, Vulsteke C, O'Cearbhaill RE, Lund B, Backes F, Barretina-Ginesta P, Haggerty AF, Rubio-Pérez MJ, Shahin MS, Mangili G, Bradley WH, Bruchim I, Sun K, Malinowska IA, Li Y, Gupta D, Monk BJ; PRIMA/ENGOT-OV26/GOG-3012 Investigators
N Engl J Med 2019 Dec 19;381(25):2391-2402. Epub 2019 Sep 28 doi: 10.1056/NEJMoa1910962. PMID: 31562799
Mittica G, Ghisoni E, Giannone G, Genta S, Aglietta M, Sapino A, Valabrega G
Recent Pat Anticancer Drug Discov 2018;13(4):392-410. doi: 10.2174/1574892813666180305165256. PMID: 29512470
Coleman RL, Oza AM, Lorusso D, Aghajanian C, Oaknin A, Dean A, Colombo N, Weberpals JI, Clamp A, Scambia G, Leary A, Holloway RW, Gancedo MA, Fong PC, Goh JC, O'Malley DM, Armstrong DK, Garcia-Donas J, Swisher EM, Floquet A, Konecny GE, McNeish IA, Scott CL, Cameron T, Maloney L, Isaacson J, Goble S, Grace C, Harding TC, Raponi M, Sun J, Lin KK, Giordano H, Ledermann JA; ARIEL3 investigators
Lancet 2017 Oct 28;390(10106):1949-1961. Epub 2017 Sep 12 doi: 10.1016/S0140-6736(17)32440-6. PMID: 28916367Free PMC Article
Mirza MR, Monk BJ, Herrstedt J, Oza AM, Mahner S, Redondo A, Fabbro M, Ledermann JA, Lorusso D, Vergote I, Ben-Baruch NE, Marth C, Mądry R, Christensen RD, Berek JS, Dørum A, Tinker AV, du Bois A, González-Martín A, Follana P, Benigno B, Rosenberg P, Gilbert L, Rimel BJ, Buscema J, Balser JP, Agarwal S, Matulonis UA; ENGOT-OV16/NOVA Investigators
N Engl J Med 2016 Dec 1;375(22):2154-2164. Epub 2016 Oct 7 doi: 10.1056/NEJMoa1611310. PMID: 27717299

Prognosis

Shah JB, Pueschl D, Wubbenhorst B, Fan M, Pluta J, D'Andrea K, Hubert AP, Shilan JS, Zhou W, Kraya AA, Llop Guevara A, Ruan C, Serra V, Balmaña J, Feldman M, Morin PJ, Nayak A, Maxwell KN, Domchek SM, Nathanson KL
Nat Commun 2022 Nov 7;13(1):6728. doi: 10.1038/s41467-022-34523-y. PMID: 36344544Free PMC Article
Wang YA, Jian JW, Hung CF, Peng HP, Yang CF, Cheng HS, Yang AS
BMC Cancer 2018 Mar 22;18(1):315. doi: 10.1186/s12885-018-4229-5. PMID: 29566657Free PMC Article
Mittica G, Ghisoni E, Giannone G, Genta S, Aglietta M, Sapino A, Valabrega G
Recent Pat Anticancer Drug Discov 2018;13(4):392-410. doi: 10.2174/1574892813666180305165256. PMID: 29512470
Ray-Coquard I
Future Oncol 2017 Oct;13(23s):17-21. Epub 2017 Oct 11 doi: 10.2217/fon-2017-0318. PMID: 29020822
Coleman RL, Oza AM, Lorusso D, Aghajanian C, Oaknin A, Dean A, Colombo N, Weberpals JI, Clamp A, Scambia G, Leary A, Holloway RW, Gancedo MA, Fong PC, Goh JC, O'Malley DM, Armstrong DK, Garcia-Donas J, Swisher EM, Floquet A, Konecny GE, McNeish IA, Scott CL, Cameron T, Maloney L, Isaacson J, Goble S, Grace C, Harding TC, Raponi M, Sun J, Lin KK, Giordano H, Ledermann JA; ARIEL3 investigators
Lancet 2017 Oct 28;390(10106):1949-1961. Epub 2017 Sep 12 doi: 10.1016/S0140-6736(17)32440-6. PMID: 28916367Free PMC Article

Clinical prediction guides

Giudice E, Huang TT, Nair JR, Zurcher G, McCoy A, Nousome D, Radke MR, Swisher EM, Lipkowitz S, Ibanez K, Donohue D, Malys T, Lee MJ, Redd B, Levy E, Rastogi S, Sato N, Trepel JB, Lee JM
Nat Commun 2024 Mar 30;15(1):2805. doi: 10.1038/s41467-024-47215-6. PMID: 38555285Free PMC Article
Shah JB, Pueschl D, Wubbenhorst B, Fan M, Pluta J, D'Andrea K, Hubert AP, Shilan JS, Zhou W, Kraya AA, Llop Guevara A, Ruan C, Serra V, Balmaña J, Feldman M, Morin PJ, Nayak A, Maxwell KN, Domchek SM, Nathanson KL
Nat Commun 2022 Nov 7;13(1):6728. doi: 10.1038/s41467-022-34523-y. PMID: 36344544Free PMC Article
Layman RM, Lin H, Gutierrez Barrera AM, Karuturi MS, Yam C, Arun BK
Cancer Med 2022 Mar;11(6):1474-1483. Epub 2022 Feb 6 doi: 10.1002/cam4.4566. PMID: 35128817Free PMC Article
Mittica G, Ghisoni E, Giannone G, Genta S, Aglietta M, Sapino A, Valabrega G
Recent Pat Anticancer Drug Discov 2018;13(4):392-410. doi: 10.2174/1574892813666180305165256. PMID: 29512470
Ray-Coquard I
Future Oncol 2017 Oct;13(23s):17-21. Epub 2017 Oct 11 doi: 10.2217/fon-2017-0318. PMID: 29020822

Recent systematic reviews

Adrianto N, Mangkuliguna G, Tandiono EJ, Sibarani CNR
Taiwan J Obstet Gynecol 2024 Sep;63(5):601-609. doi: 10.1016/j.tjog.2024.05.020. PMID: 39266137
Lin Q, Liu W, Xu S, Shang H, Li J, Guo Y, Tong J
BJOG 2021 Feb;128(3):485-493. Epub 2020 Aug 2 doi: 10.1111/1471-0528.16411. PMID: 32654312
Huber D, Seitz S, Kast K, Emons G, Ortmann O
Arch Gynecol Obstet 2020 Sep;302(3):715-720. Epub 2020 Jul 27 doi: 10.1007/s00404-020-05690-4. PMID: 32719921Free PMC Article
Ruscito I, Bellati F, Ray-Coquard I, Mirza MR, du Bois A, Gasparri ML, Costanzi F, De Marco MP, Nuti M, Caserta D, Pignata S, Dorigo O, Sehouli J, Braicu EI
Cancer Treat Rev 2020 Jul;87:102040. Epub 2020 May 26 doi: 10.1016/j.ctrv.2020.102040. PMID: 32485510
Co M, Liu T, Leung J, Li CH, Tse T, Wong M, Kwong A
Clin Breast Cancer 2020 Jun;20(3):e244-e250. Epub 2019 Aug 22 doi: 10.1016/j.clbc.2019.07.014. PMID: 32144082

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