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B Lymphoblastic Lymphoma

MedGen UID:
163608
•Concept ID:
C0855146
•
Neoplastic Process
Synonyms: B-Lymphoblastic Lymphoma; Precursor B-cell lymphoblastic lymphoma; Precursor B-Lymphoblastic Lymphoma
SNOMED CT: Precursor B-cell lymphoblastic lymphoma (128807009)

Definition

An uncommon type of lymphoma. It constitutes approximately 10% of cases of lymphoblastic lymphoma. Approximately 75% of cases reported in a literature review involved patients who were less than 18 years of age. The most commonly affected sites are the skin, bone, soft tissue, and lymph nodes. It has a high remission rate with a median survival of approximately 60 months. (WHO, 2001) [from NCI]

Professional guidelines

PubMed

Diagnosis and management of lymphoblastic lymphoma in children, adolescents and young adults.
Temple WC, Mueller S, Hermiston ML, Burkhardt B
Best Pract Res Clin Haematol 2023 Mar;36(1):101449. Epub 2023 Feb 16 doi: 10.1016/j.beha.2023.101449. PMID: 36907639
Clinical features and treatment outcomes of adult B- and T-lymphoblastic lymphoma: results of multicentre analysis in Korea.
Chang MH, Kim SJ, Kim K, Oh SY, Lee DH, Huh J, Ko YH, Choi CW, Yang DH, Won JH, Kim WS, Suh C
Leuk Lymphoma 2009 Jul;50(7):1119-25. doi: 10.1080/10428190902926999. PMID: 19557632
Characteristic clinicopathologic features of adult B-cell lymphoblastic lymphoma with special emphasis on differential diagnosis with an atypical form probably of blastic lymphocytic lymphoma of intermediate differentiation origin.
Cheng AL, Su IJ, Tien HF, Wang CC, Chen YC, Wang CH
Cancer 1994 Feb 1;73(3):706-10. doi: 10.1002/1097-0142(19940201)73:3<706::aid-cncr2820730334>3.0.co;2-u. PMID: 7507799

Recent clinical studies

Etiology

International Consensus Classification of acute lymphoblastic leukemia/lymphoma.
Duffield AS, Mullighan CG, Borowitz MJ
Virchows Arch 2023 Jan;482(1):11-26. Epub 2022 Nov 24 doi: 10.1007/s00428-022-03448-8. PMID: 36422706Free PMC Article
Humanized CD19-Targeted Chimeric Antigen Receptor (CAR) T Cells in CAR-Naive and CAR-Exposed Children and Young Adults With Relapsed or Refractory Acute Lymphoblastic Leukemia.
Myers RM, Li Y, Barz Leahy A, Barrett DM, Teachey DT, Callahan C, Fasano CC, Rheingold SR, DiNofia A, Wray L, Aplenc R, Baniewicz D, Liu H, Shaw PA, Pequignot E, Getz KD, Brogdon JL, Fesnak AD, Siegel DL, Davis MM, Bartoszek C, Lacey SF, Hexner EO, Chew A, Wertheim GB, Levine BL, June CH, Grupp SA, Maude SL
J Clin Oncol 2021 Sep 20;39(27):3044-3055. Epub 2021 Jun 22 doi: 10.1200/JCO.20.03458. PMID: 34156874Free PMC Article
Analysis of clinicopathological and cytogenetic differences between B-lymphoblastic lymphoma and B-lymphoblastic leukemia in childhood.
Knez V, Bao L, Carstens B, Liang X
Leuk Lymphoma 2020 Sep;61(9):2129-2135. Epub 2020 May 19 doi: 10.1080/10428194.2020.1761970. PMID: 32427530
Aggressive B-cell lymphomas: how many categories do we need?
Said JW
Mod Pathol 2013 Jan;26 Suppl 1(0 1):S42-56. Epub 2012 Nov 16 doi: 10.1038/modpathol.2012.178. PMID: 23154748Free PMC Article
Predicting transformation in follicular lymphoma.
de Jong D, de Boer JP
Leuk Lymphoma 2009 Sep;50(9):1406-11. doi: 10.1080/10428190903093815. PMID: 19606378

Diagnosis

Diagnosis and management of lymphoblastic lymphoma in children, adolescents and young adults.
Temple WC, Mueller S, Hermiston ML, Burkhardt B
Best Pract Res Clin Haematol 2023 Mar;36(1):101449. Epub 2023 Feb 16 doi: 10.1016/j.beha.2023.101449. PMID: 36907639
International Consensus Classification of acute lymphoblastic leukemia/lymphoma.
Duffield AS, Mullighan CG, Borowitz MJ
Virchows Arch 2023 Jan;482(1):11-26. Epub 2022 Nov 24 doi: 10.1007/s00428-022-03448-8. PMID: 36422706Free PMC Article
Simultaneous Discordant B-Lymphoblastic Lymphoma and Follicular Lymphoma.
Fujimoto A, Ikejiri F, Arakawa F, Ito S, Okada Y, Takahashi F, Matsuda S, Okada T, Inoue M, Takahashi T, Miyake T, Maruyama R, Ohshima K, Suzumiya J, Suzuki R
Am J Clin Pathol 2021 Feb 4;155(2):308-317. doi: 10.1093/ajcp/aqaa126. PMID: 32915189
Extramedullary CD20-positive B-lymphoblastic lymphoma in a 5-year-old child: A diagnostic challenge.
Abdul Jalil D, Raja Sabudin RZA, Tang YL, Masir N
Malays J Pathol 2020 Aug;42(2):273-276. PMID: 32860381
Prognostic Factors and Outcomes of Adult Lymphoblastic Lymphoma in the United States.
El-Fattah MA
Clin Lymphoma Myeloma Leuk 2017 Aug;17(8):498-505.e6. Epub 2017 Jun 6 doi: 10.1016/j.clml.2017.05.016. PMID: 28647403

Therapy

Humanized CD19-Targeted Chimeric Antigen Receptor (CAR) T Cells in CAR-Naive and CAR-Exposed Children and Young Adults With Relapsed or Refractory Acute Lymphoblastic Leukemia.
Myers RM, Li Y, Barz Leahy A, Barrett DM, Teachey DT, Callahan C, Fasano CC, Rheingold SR, DiNofia A, Wray L, Aplenc R, Baniewicz D, Liu H, Shaw PA, Pequignot E, Getz KD, Brogdon JL, Fesnak AD, Siegel DL, Davis MM, Bartoszek C, Lacey SF, Hexner EO, Chew A, Wertheim GB, Levine BL, June CH, Grupp SA, Maude SL
J Clin Oncol 2021 Sep 20;39(27):3044-3055. Epub 2021 Jun 22 doi: 10.1200/JCO.20.03458. PMID: 34156874Free PMC Article
Philadelphia chromosome-positive B-lymphoblastic lymphoma successfully treated with chemotherapy regimen containing imatinib: A rare case report and literature review.
Li X, Cao W, Zhang S, Li L, Li Y, Jiang Z, Wan D, Yu J
Medicine (Baltimore) 2021 Jun 11;100(23):e26323. doi: 10.1097/MD.0000000000026323. PMID: 34115047Free PMC Article
BCR/ABL1-positive B-lymphoblastic Lymphoma Successfully Treated with Dasatinib-combined Chemotherapy.
Yamada C, Shimomura Y, Kamijyo K, Kanda-Kato M, Yoshioka S, Yamashita D, Ishikawa T
Intern Med 2021 Oct 1;60(19):3149-3153. Epub 2021 Apr 5 doi: 10.2169/internalmedicine.7066-21. PMID: 33814500Free PMC Article
A Case of Renal Involvement in B Lymphoblastic Lymphoma Leukemia.
Zhang L, Feng Y, Cheng N, Zou Q, Lai W, Liu JJ
Clin Lab 2019 Jan 1;65(1) doi: 10.7754/Clin.Lab.2018.180726. PMID: 30775881
Efficacy of the GMALL-B-ALL/NHL2002 protocol in Burkitt leukemia/lymphoma and aggressive non-Hodgkin-lymphomas with or without CNS involvement.
Sakarou M, Eisele L, Dührsen U, Hüttmann A
Eur J Haematol 2019 Mar;102(3):241-250. Epub 2019 Jan 20 doi: 10.1111/ejh.13199. PMID: 30471148

Prognosis

How I approach B-lymphoblastic lymphoma in children.
Devine KJ, Fries C, Hermiston M, Wistinghausen B
Pediatr Blood Cancer 2023 Aug;70(8):e30401. Epub 2023 May 9 doi: 10.1002/pbc.30401. PMID: 37158503
Diagnosis and management of lymphoblastic lymphoma in children, adolescents and young adults.
Temple WC, Mueller S, Hermiston ML, Burkhardt B
Best Pract Res Clin Haematol 2023 Mar;36(1):101449. Epub 2023 Feb 16 doi: 10.1016/j.beha.2023.101449. PMID: 36907639
Extramedullary CD20-positive B-lymphoblastic lymphoma in a 5-year-old child: A diagnostic challenge.
Abdul Jalil D, Raja Sabudin RZA, Tang YL, Masir N
Malays J Pathol 2020 Aug;42(2):273-276. PMID: 32860381
Genomic characterization of pediatric B-lymphoblastic lymphoma and B-lymphoblastic leukemia using formalin-fixed tissues.
Meyer JA, Zhou D, Mason CC, Downie JM, Rodic V, Abromowitch M, Wistinghausen B, Termuhlen AM, Angiolillo AL, Perkins SL, Lones MA, Barnette P, Schiffman JD, Miles RR
Pediatr Blood Cancer 2017 Jul;64(7) Epub 2016 Dec 13 doi: 10.1002/pbc.26363. PMID: 27957801
Predicting transformation in follicular lymphoma.
de Jong D, de Boer JP
Leuk Lymphoma 2009 Sep;50(9):1406-11. doi: 10.1080/10428190903093815. PMID: 19606378

Clinical prediction guides

B-Lymphoblastic Lymphoma in Children: A Case Series From a Single Institution.
Devine KJ, Trivedi H, Reilly AF
J Pediatr Hematol Oncol 2024 Apr 1;46(3):e254-e258. Epub 2024 Feb 16 doi: 10.1097/MPH.0000000000002828. PMID: 38408123Free PMC Article
How I approach B-lymphoblastic lymphoma in children.
Devine KJ, Fries C, Hermiston M, Wistinghausen B
Pediatr Blood Cancer 2023 Aug;70(8):e30401. Epub 2023 May 9 doi: 10.1002/pbc.30401. PMID: 37158503
Analysis of clinicopathological and cytogenetic differences between B-lymphoblastic lymphoma and B-lymphoblastic leukemia in childhood.
Knez V, Bao L, Carstens B, Liang X
Leuk Lymphoma 2020 Sep;61(9):2129-2135. Epub 2020 May 19 doi: 10.1080/10428194.2020.1761970. PMID: 32427530
Genomic characterization of pediatric B-lymphoblastic lymphoma and B-lymphoblastic leukemia using formalin-fixed tissues.
Meyer JA, Zhou D, Mason CC, Downie JM, Rodic V, Abromowitch M, Wistinghausen B, Termuhlen AM, Angiolillo AL, Perkins SL, Lones MA, Barnette P, Schiffman JD, Miles RR
Pediatr Blood Cancer 2017 Jul;64(7) Epub 2016 Dec 13 doi: 10.1002/pbc.26363. PMID: 27957801
Predicting transformation in follicular lymphoma.
de Jong D, de Boer JP
Leuk Lymphoma 2009 Sep;50(9):1406-11. doi: 10.1080/10428190903093815. PMID: 19606378

Recent systematic reviews

Solitary manifestations of primary B-lymphoblastic lymphoma of the spine: Systematic literature review with case illustration.
Croci DM, Gamboa NT, Osman AEG, Maese L, Mazur M, Bisson EF, Dailey AT
Clin Neurol Neurosurg 2022 Jan;212:107064. Epub 2021 Nov 24 doi: 10.1016/j.clineuro.2021.107064. PMID: 34871993

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