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Increased level of myristic acid in serum

MedGen UID:
1638969
•Concept ID:
C4703649
•
Finding
Synonym: Increased level of tetradecanoic acid in serum
 
HPO: HP:0410154

Definition

An increase in the level of myristic acid in the serum. [from HPO]

Professional guidelines

PubMed

Effects of nicotinic acid treatment on fatty acid composition of plasma lipids and adipose tissue in hyperlipidaemia.
Wahlberg G, Walldius G
Scand J Clin Lab Invest 1992 Oct;52(6):547-53. doi: 10.3109/00365519209090132. PMID: 1411265

Recent clinical studies

Etiology

Dose-dependent action of cordycepin on the microbiome-gut-brain-adipose axis in mice exposed to stress.
Jing X, Hong F, Xie Y, Xie Y, Shi F, Wang R, Wang L, Chen Z, Liu XA
Biomed Pharmacother 2023 Dec;168:115796. Epub 2023 Oct 31 doi: 10.1016/j.biopha.2023.115796. PMID: 38294969
Fatty acid composition of cholesterol esters reflects dietary fat intake after dietary interventions in a multinational population.
Salamone D, Annuzzi G, Vessby B, Rivellese AA, Bozzetto L, Costabile G, Hermansen K, Uusitupa M, Meyer BJ, Riccardi G; KANWU Study Group
J Clin Lipidol 2023 Jul-Aug;17(4):466-474. Epub 2023 May 20 doi: 10.1016/j.jacl.2023.05.095. PMID: 37263854
Impact of Fatty Acids on Obesity-Associated Diseases and Radical Weight Reduction.
Wrzosek M, Zawadzka Z, Sawicka A, Bobrowska-Korczak B, Białek A
Obes Surg 2022 Feb;32(2):428-440. Epub 2021 Nov 23 doi: 10.1007/s11695-021-05789-w. PMID: 34813039Free PMC Article
Increased serum cholesterol and long-chain fatty acid levels are associated with the efficacy of nivolumab in patients with non-small cell lung cancer.
Karayama M, Inui N, Inoue Y, Yoshimura K, Mori K, Hozumi H, Suzuki Y, Furuhashi K, Fujisawa T, Enomoto N, Nakamura Y, Asada K, Uto T, Fujii M, Matsui T, Matsuura S, Hashimoto D, Toyoshima M, Kusagaya H, Matsuda H, Inami N, Kaida Y, Niwa M, Ito Y, Suda T
Cancer Immunol Immunother 2022 Jan;71(1):203-217. Epub 2021 Jun 5 doi: 10.1007/s00262-021-02979-4. PMID: 34091744Free PMC Article
Changes in fatty acid levels (saturated, monounsaturated and polyunsaturated) during pregnancy.
Aparicio E, Martín-Grau C, Hernández-Martinez C, Voltas N, Canals J, Arija V
BMC Pregnancy Childbirth 2021 Nov 17;21(1):778. doi: 10.1186/s12884-021-04251-0. PMID: 34789176Free PMC Article

Diagnosis

The Ameliorative Effects of Arctiin and Arctigenin on the Oxidative Injury of Lung Induced by Silica via TLR-4/NLRP3/TGF-β Signaling Pathway.
Liu X, Wang J, Dou P, Zhang X, Ran X, Liu L, Dou D
Oxid Med Cell Longev 2021;2021:5598980. Epub 2021 Jul 17 doi: 10.1155/2021/5598980. PMID: 34336106Free PMC Article
Peripheral serum metabolomic profiles inform central cognitive impairment.
Wang J, Wei R, Xie G, Arnold M, Kueider-Paisley A, Louie G, Mahmoudian Dehkordi S, Blach C, Baillie R, Han X, De Jager PL, Bennett DA, Kaddurah-Daouk R, Jia W
Sci Rep 2020 Aug 20;10(1):14059. doi: 10.1038/s41598-020-70703-w. PMID: 32820198Free PMC Article
Serum metabolomics study of polycystic ovary syndrome based on UPLC-QTOF-MS coupled with a pattern recognition approach.
Dong F, Deng D, Chen H, Cheng W, Li Q, Luo R, Ding S
Anal Bioanal Chem 2015 Jun;407(16):4683-95. Epub 2015 Apr 10 doi: 10.1007/s00216-015-8670-x. PMID: 25860656
GC-MS with ethyl chloroformate derivatization for comprehensive analysis of metabolites in serum and its application to human uremia.
Tao X, Liu Y, Wang Y, Qiu Y, Lin J, Zhao A, Su M, Jia W
Anal Bioanal Chem 2008 Aug;391(8):2881-9. Epub 2008 Jul 14 doi: 10.1007/s00216-008-2220-8. PMID: 18622754
Relation of smoking and alcohol consumption to serum fatty acids.
Simon JA, Fong J, Bernert JT Jr, Browner WS
Am J Epidemiol 1996 Aug 15;144(4):325-34. doi: 10.1093/oxfordjournals.aje.a008933. PMID: 8712189

Therapy

Fatty acid composition of cholesterol esters reflects dietary fat intake after dietary interventions in a multinational population.
Salamone D, Annuzzi G, Vessby B, Rivellese AA, Bozzetto L, Costabile G, Hermansen K, Uusitupa M, Meyer BJ, Riccardi G; KANWU Study Group
J Clin Lipidol 2023 Jul-Aug;17(4):466-474. Epub 2023 May 20 doi: 10.1016/j.jacl.2023.05.095. PMID: 37263854
Changes in fatty acid levels (saturated, monounsaturated and polyunsaturated) during pregnancy.
Aparicio E, Martín-Grau C, Hernández-Martinez C, Voltas N, Canals J, Arija V
BMC Pregnancy Childbirth 2021 Nov 17;21(1):778. doi: 10.1186/s12884-021-04251-0. PMID: 34789176Free PMC Article
The Ameliorative Effects of Arctiin and Arctigenin on the Oxidative Injury of Lung Induced by Silica via TLR-4/NLRP3/TGF-β Signaling Pathway.
Liu X, Wang J, Dou P, Zhang X, Ran X, Liu L, Dou D
Oxid Med Cell Longev 2021;2021:5598980. Epub 2021 Jul 17 doi: 10.1155/2021/5598980. PMID: 34336106Free PMC Article
A comparative study of serum lipid contents in pre and post IFN-alpha treated acute hepatitis C patients.
Arain SQ, Talpur FN, Channa NA
Lipids Health Dis 2015 Sep 24;14:117. doi: 10.1186/s12944-015-0119-x. PMID: 26403989Free PMC Article
Myristic acid conjugation of [D-Leu-4]-OB3, a biologically active leptin-related synthetic peptide amide, significantly improves its pharmacokinetic profile and efficacy.
Novakovic ZM, Anderson BM, Grasso P
Peptides 2014 Dec;62:176-82. doi: 10.1016/j.peptides.2014.10.007. PMID: 25453979

Prognosis

Increased serum cholesterol and long-chain fatty acid levels are associated with the efficacy of nivolumab in patients with non-small cell lung cancer.
Karayama M, Inui N, Inoue Y, Yoshimura K, Mori K, Hozumi H, Suzuki Y, Furuhashi K, Fujisawa T, Enomoto N, Nakamura Y, Asada K, Uto T, Fujii M, Matsui T, Matsuura S, Hashimoto D, Toyoshima M, Kusagaya H, Matsuda H, Inami N, Kaida Y, Niwa M, Ito Y, Suda T
Cancer Immunol Immunother 2022 Jan;71(1):203-217. Epub 2021 Jun 5 doi: 10.1007/s00262-021-02979-4. PMID: 34091744Free PMC Article
Peripheral serum metabolomic profiles inform central cognitive impairment.
Wang J, Wei R, Xie G, Arnold M, Kueider-Paisley A, Louie G, Mahmoudian Dehkordi S, Blach C, Baillie R, Han X, De Jager PL, Bennett DA, Kaddurah-Daouk R, Jia W
Sci Rep 2020 Aug 20;10(1):14059. doi: 10.1038/s41598-020-70703-w. PMID: 32820198Free PMC Article
Serum cholesterol levels in children are associated with dietary fat and fatty acid intake.
Nicklas TA, Dwyer J, Feldman HA, Luepker RV, Kelder SH, Nader PR
J Am Diet Assoc 2002 Apr;102(4):511-7. doi: 10.1016/s0002-8223(02)90117-3. PMID: 11985407
Relation of smoking and alcohol consumption to serum fatty acids.
Simon JA, Fong J, Bernert JT Jr, Browner WS
Am J Epidemiol 1996 Aug 15;144(4):325-34. doi: 10.1093/oxfordjournals.aje.a008933. PMID: 8712189
Nutrition in lipid disorders.
Mensink RP
Ther Umsch 1995 Aug;52(8):509-14. PMID: 7676394

Clinical prediction guides

Increased serum cholesterol and long-chain fatty acid levels are associated with the efficacy of nivolumab in patients with non-small cell lung cancer.
Karayama M, Inui N, Inoue Y, Yoshimura K, Mori K, Hozumi H, Suzuki Y, Furuhashi K, Fujisawa T, Enomoto N, Nakamura Y, Asada K, Uto T, Fujii M, Matsui T, Matsuura S, Hashimoto D, Toyoshima M, Kusagaya H, Matsuda H, Inami N, Kaida Y, Niwa M, Ito Y, Suda T
Cancer Immunol Immunother 2022 Jan;71(1):203-217. Epub 2021 Jun 5 doi: 10.1007/s00262-021-02979-4. PMID: 34091744Free PMC Article
Changes in fatty acid levels (saturated, monounsaturated and polyunsaturated) during pregnancy.
Aparicio E, Martín-Grau C, Hernández-Martinez C, Voltas N, Canals J, Arija V
BMC Pregnancy Childbirth 2021 Nov 17;21(1):778. doi: 10.1186/s12884-021-04251-0. PMID: 34789176Free PMC Article
Peripheral serum metabolomic profiles inform central cognitive impairment.
Wang J, Wei R, Xie G, Arnold M, Kueider-Paisley A, Louie G, Mahmoudian Dehkordi S, Blach C, Baillie R, Han X, De Jager PL, Bennett DA, Kaddurah-Daouk R, Jia W
Sci Rep 2020 Aug 20;10(1):14059. doi: 10.1038/s41598-020-70703-w. PMID: 32820198Free PMC Article
Effects of stearic acid on plasma lipid and lipoproteins in humans.
Mensink RP
Lipids 2005 Dec;40(12):1201-5. doi: 10.1007/s11745-005-1486-x. PMID: 16477803
Relation of smoking and alcohol consumption to serum fatty acids.
Simon JA, Fong J, Bernert JT Jr, Browner WS
Am J Epidemiol 1996 Aug 15;144(4):325-34. doi: 10.1093/oxfordjournals.aje.a008933. PMID: 8712189

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