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Refractory Lung Carcinoma

MedGen UID:
1639600
•Concept ID:
C4683497
•
Neoplastic Process

Definition

Lung carcinoma that does not respond to treatment. [from NCI]

Professional guidelines

PubMed

Extensive-stage small-cell lung cancer: Current management and future directions.
Yu Y, Chen K, Fan Y
Int J Cancer 2023 Jun 1;152(11):2243-2256. Epub 2022 Nov 29 doi: 10.1002/ijc.34346. PMID: 36346100
Current Diagnosis and Management of Small-Cell Lung Cancer.
Wang S, Zimmermann S, Parikh K, Mansfield AS, Adjei AA
Mayo Clin Proc 2019 Aug;94(8):1599-1622. doi: 10.1016/j.mayocp.2019.01.034. PMID: 31378235
Management of immune checkpoint blockade dysimmune toxicities: a collaborative position paper.
Champiat S, Lambotte O, Barreau E, Belkhir R, Berdelou A, Carbonnel F, Cauquil C, Chanson P, Collins M, Durrbach A, Ederhy S, Feuillet S, François H, Lazarovici J, Le Pavec J, De Martin E, Mateus C, Michot JM, Samuel D, Soria JC, Robert C, Eggermont A, Marabelle A
Ann Oncol 2016 Apr;27(4):559-74. Epub 2015 Dec 28 doi: 10.1093/annonc/mdv623. PMID: 26715621

Recent clinical studies

Etiology

Trastuzumab Deruxtecan in HER2-Mutant Non-Small-Cell Lung Cancer.
Li BT, Smit EF, Goto Y, Nakagawa K, Udagawa H, Mazières J, Nagasaka M, Bazhenova L, Saltos AN, Felip E, Pacheco JM, Pérol M, Paz-Ares L, Saxena K, Shiga R, Cheng Y, Acharyya S, Vitazka P, Shahidi J, Planchard D, Jänne PA; DESTINY-Lung01 Trial Investigators
N Engl J Med 2022 Jan 20;386(3):241-251. Epub 2021 Sep 18 doi: 10.1056/NEJMoa2112431. PMID: 34534430Free PMC Article
Steroid-refractory PD-(L)1 pneumonitis: incidence, clinical features, treatment, and outcomes.
Balaji A, Hsu M, Lin CT, Feliciano J, Marrone K, Brahmer JR, Forde PM, Hann C, Zheng L, Lee V, Illei PB, Danoff SK, Suresh K, Naidoo J
J Immunother Cancer 2021 Jan;9(1) doi: 10.1136/jitc-2020-001731. PMID: 33414264Free PMC Article
Nivolumab versus chemotherapy in patients with advanced oesophageal squamous cell carcinoma refractory or intolerant to previous chemotherapy (ATTRACTION-3): a multicentre, randomised, open-label, phase 3 trial.
Kato K, Cho BC, Takahashi M, Okada M, Lin CY, Chin K, Kadowaki S, Ahn MJ, Hamamoto Y, Doki Y, Yen CC, Kubota Y, Kim SB, Hsu CH, Holtved E, Xynos I, Kodani M, Kitagawa Y
Lancet Oncol 2019 Nov;20(11):1506-1517. Epub 2019 Sep 30 doi: 10.1016/S1470-2045(19)30626-6. PMID: 31582355
Current Diagnosis and Management of Small-Cell Lung Cancer.
Wang S, Zimmermann S, Parikh K, Mansfield AS, Adjei AA
Mayo Clin Proc 2019 Aug;94(8):1599-1622. doi: 10.1016/j.mayocp.2019.01.034. PMID: 31378235
Renal cell carcinoma.
Hsieh JJ, Purdue MP, Signoretti S, Swanton C, Albiges L, Schmidinger M, Heng DY, Larkin J, Ficarra V
Nat Rev Dis Primers 2017 Mar 9;3:17009. doi: 10.1038/nrdp.2017.9. PMID: 28276433Free PMC Article

Diagnosis

Steroid-refractory PD-(L)1 pneumonitis: incidence, clinical features, treatment, and outcomes.
Balaji A, Hsu M, Lin CT, Feliciano J, Marrone K, Brahmer JR, Forde PM, Hann C, Zheng L, Lee V, Illei PB, Danoff SK, Suresh K, Naidoo J
J Immunother Cancer 2021 Jan;9(1) doi: 10.1136/jitc-2020-001731. PMID: 33414264Free PMC Article
The KRAS(G12C) Inhibitor MRTX849 Provides Insight toward Therapeutic Susceptibility of KRAS-Mutant Cancers in Mouse Models and Patients.
Hallin J, Engstrom LD, Hargis L, Calinisan A, Aranda R, Briere DM, Sudhakar N, Bowcut V, Baer BR, Ballard JA, Burkard MR, Fell JB, Fischer JP, Vigers GP, Xue Y, Gatto S, Fernandez-Banet J, Pavlicek A, Velastagui K, Chao RC, Barton J, Pierobon M, Baldelli E, Patricoin EF 3rd, Cassidy DP, Marx MA, Rybkin II, Johnson ML, Ou SI, Lito P, Papadopoulos KP, Jänne PA, Olson P, Christensen JG
Cancer Discov 2020 Jan;10(1):54-71. Epub 2019 Oct 28 doi: 10.1158/2159-8290.CD-19-1167. PMID: 31658955Free PMC Article
Current Diagnosis and Management of Small-Cell Lung Cancer.
Wang S, Zimmermann S, Parikh K, Mansfield AS, Adjei AA
Mayo Clin Proc 2019 Aug;94(8):1599-1622. doi: 10.1016/j.mayocp.2019.01.034. PMID: 31378235
DLL3: an emerging target in small cell lung cancer.
Owen DH, Giffin MJ, Bailis JM, Smit MD, Carbone DP, He K
J Hematol Oncol 2019 Jun 18;12(1):61. doi: 10.1186/s13045-019-0745-2. PMID: 31215500Free PMC Article
Renal cell carcinoma.
Hsieh JJ, Purdue MP, Signoretti S, Swanton C, Albiges L, Schmidinger M, Heng DY, Larkin J, Ficarra V
Nat Rev Dis Primers 2017 Mar 9;3:17009. doi: 10.1038/nrdp.2017.9. PMID: 28276433Free PMC Article

Therapy

Cannabis-based medicines and medical cannabis for adults with cancer pain.
Häuser W, Welsch P, Radbruch L, Fisher E, Bell RF, Moore RA
Cochrane Database Syst Rev 2023 Jun 5;6(6):CD014915. doi: 10.1002/14651858.CD014915.pub2. PMID: 37283486Free PMC Article
FIGHT-101, a first-in-human study of potent and selective FGFR 1-3 inhibitor pemigatinib in pan-cancer patients with FGF/FGFR alterations and advanced malignancies.
Subbiah V, Iannotti NO, Gutierrez M, Smith DC, Féliz L, Lihou CF, Tian C, Silverman IM, Ji T, Saleh M
Ann Oncol 2022 May;33(5):522-533. Epub 2022 Feb 14 doi: 10.1016/j.annonc.2022.02.001. PMID: 35176457
Zimberelimab: First Approval.
Markham A
Drugs 2021 Nov;81(17):2063-2068. doi: 10.1007/s40265-021-01628-5. PMID: 34709602
The KRAS(G12C) Inhibitor MRTX849 Provides Insight toward Therapeutic Susceptibility of KRAS-Mutant Cancers in Mouse Models and Patients.
Hallin J, Engstrom LD, Hargis L, Calinisan A, Aranda R, Briere DM, Sudhakar N, Bowcut V, Baer BR, Ballard JA, Burkard MR, Fell JB, Fischer JP, Vigers GP, Xue Y, Gatto S, Fernandez-Banet J, Pavlicek A, Velastagui K, Chao RC, Barton J, Pierobon M, Baldelli E, Patricoin EF 3rd, Cassidy DP, Marx MA, Rybkin II, Johnson ML, Ou SI, Lito P, Papadopoulos KP, Jänne PA, Olson P, Christensen JG
Cancer Discov 2020 Jan;10(1):54-71. Epub 2019 Oct 28 doi: 10.1158/2159-8290.CD-19-1167. PMID: 31658955Free PMC Article
Nivolumab versus chemotherapy in patients with advanced oesophageal squamous cell carcinoma refractory or intolerant to previous chemotherapy (ATTRACTION-3): a multicentre, randomised, open-label, phase 3 trial.
Kato K, Cho BC, Takahashi M, Okada M, Lin CY, Chin K, Kadowaki S, Ahn MJ, Hamamoto Y, Doki Y, Yen CC, Kubota Y, Kim SB, Hsu CH, Holtved E, Xynos I, Kodani M, Kitagawa Y
Lancet Oncol 2019 Nov;20(11):1506-1517. Epub 2019 Sep 30 doi: 10.1016/S1470-2045(19)30626-6. PMID: 31582355

Prognosis

Trastuzumab Deruxtecan in HER2-Mutant Non-Small-Cell Lung Cancer.
Li BT, Smit EF, Goto Y, Nakagawa K, Udagawa H, Mazières J, Nagasaka M, Bazhenova L, Saltos AN, Felip E, Pacheco JM, Pérol M, Paz-Ares L, Saxena K, Shiga R, Cheng Y, Acharyya S, Vitazka P, Shahidi J, Planchard D, Jänne PA; DESTINY-Lung01 Trial Investigators
N Engl J Med 2022 Jan 20;386(3):241-251. Epub 2021 Sep 18 doi: 10.1056/NEJMoa2112431. PMID: 34534430Free PMC Article
Steroid-refractory PD-(L)1 pneumonitis: incidence, clinical features, treatment, and outcomes.
Balaji A, Hsu M, Lin CT, Feliciano J, Marrone K, Brahmer JR, Forde PM, Hann C, Zheng L, Lee V, Illei PB, Danoff SK, Suresh K, Naidoo J
J Immunother Cancer 2021 Jan;9(1) doi: 10.1136/jitc-2020-001731. PMID: 33414264Free PMC Article
The KRAS(G12C) Inhibitor MRTX849 Provides Insight toward Therapeutic Susceptibility of KRAS-Mutant Cancers in Mouse Models and Patients.
Hallin J, Engstrom LD, Hargis L, Calinisan A, Aranda R, Briere DM, Sudhakar N, Bowcut V, Baer BR, Ballard JA, Burkard MR, Fell JB, Fischer JP, Vigers GP, Xue Y, Gatto S, Fernandez-Banet J, Pavlicek A, Velastagui K, Chao RC, Barton J, Pierobon M, Baldelli E, Patricoin EF 3rd, Cassidy DP, Marx MA, Rybkin II, Johnson ML, Ou SI, Lito P, Papadopoulos KP, Jänne PA, Olson P, Christensen JG
Cancer Discov 2020 Jan;10(1):54-71. Epub 2019 Oct 28 doi: 10.1158/2159-8290.CD-19-1167. PMID: 31658955Free PMC Article
Current Diagnosis and Management of Small-Cell Lung Cancer.
Wang S, Zimmermann S, Parikh K, Mansfield AS, Adjei AA
Mayo Clin Proc 2019 Aug;94(8):1599-1622. doi: 10.1016/j.mayocp.2019.01.034. PMID: 31378235
Renal cell carcinoma.
Hsieh JJ, Purdue MP, Signoretti S, Swanton C, Albiges L, Schmidinger M, Heng DY, Larkin J, Ficarra V
Nat Rev Dis Primers 2017 Mar 9;3:17009. doi: 10.1038/nrdp.2017.9. PMID: 28276433Free PMC Article

Clinical prediction guides

TROP-2 directed antibody-drug conjugates (ADCs): The revolution of smart drug delivery in advanced non-small cell lung cancer (NSCLC).
Parisi C, Mahjoubi L, Gazzah A, Barlesi F
Cancer Treat Rev 2023 Jul;118:102572. Epub 2023 May 19 doi: 10.1016/j.ctrv.2023.102572. PMID: 37230055
NUT carcinoma of the lung.
Lantuejoul S, Pissaloux D, Ferretti GR, McLeer A
Semin Diagn Pathol 2021 Sep;38(5):72-82. Epub 2021 Jun 16 doi: 10.1053/j.semdp.2021.06.005. PMID: 34176698
The KRAS(G12C) Inhibitor MRTX849 Provides Insight toward Therapeutic Susceptibility of KRAS-Mutant Cancers in Mouse Models and Patients.
Hallin J, Engstrom LD, Hargis L, Calinisan A, Aranda R, Briere DM, Sudhakar N, Bowcut V, Baer BR, Ballard JA, Burkard MR, Fell JB, Fischer JP, Vigers GP, Xue Y, Gatto S, Fernandez-Banet J, Pavlicek A, Velastagui K, Chao RC, Barton J, Pierobon M, Baldelli E, Patricoin EF 3rd, Cassidy DP, Marx MA, Rybkin II, Johnson ML, Ou SI, Lito P, Papadopoulos KP, Jänne PA, Olson P, Christensen JG
Cancer Discov 2020 Jan;10(1):54-71. Epub 2019 Oct 28 doi: 10.1158/2159-8290.CD-19-1167. PMID: 31658955Free PMC Article
Renal cell carcinoma.
Hsieh JJ, Purdue MP, Signoretti S, Swanton C, Albiges L, Schmidinger M, Heng DY, Larkin J, Ficarra V
Nat Rev Dis Primers 2017 Mar 9;3:17009. doi: 10.1038/nrdp.2017.9. PMID: 28276433Free PMC Article
Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates.
Brahmer JR, Drake CG, Wollner I, Powderly JD, Picus J, Sharfman WH, Stankevich E, Pons A, Salay TM, McMiller TL, Gilson MM, Wang C, Selby M, Taube JM, Anders R, Chen L, Korman AJ, Pardoll DM, Lowy I, Topalian SL
J Clin Oncol 2010 Jul 1;28(19):3167-75. Epub 2010 Jun 1 doi: 10.1200/JCO.2009.26.7609. PMID: 20516446Free PMC Article

Recent systematic reviews

Efficacy and safety of immune checkpoint inhibitors for individuals with advanced EGFR-mutated non-small-cell lung cancer who progressed on EGFR tyrosine-kinase inhibitors: a systematic review, meta-analysis, and network meta-analysis.
Zhao Y, He Y, Wang W, Cai Q, Ge F, Chen Z, Zheng J, Zhang Y, Deng H, Chen Y, Lao S, Liang H, Liang W, He J
Lancet Oncol 2024 Oct;25(10):1347-1356. Epub 2024 Aug 16 doi: 10.1016/S1470-2045(24)00379-6. PMID: 39159630
A systematic review of antibody-drug conjugates and bispecific antibodies in head and neck squamous cell carcinoma and nasopharyngeal carcinoma: Charting the course of future therapies.
Jiménez-Labaig P, Rullan A, Hernando-Calvo A, Llop S, Bhide S, O'Leary B, Braña I, Harrington KJ
Cancer Treat Rev 2024 Jul;128:102772. Epub 2024 May 26 doi: 10.1016/j.ctrv.2024.102772. PMID: 38820656
Cannabis-based medicines and medical cannabis for adults with cancer pain.
Häuser W, Welsch P, Radbruch L, Fisher E, Bell RF, Moore RA
Cochrane Database Syst Rev 2023 Jun 5;6(6):CD014915. doi: 10.1002/14651858.CD014915.pub2. PMID: 37283486Free PMC Article
TROP-2 directed antibody-drug conjugates (ADCs): The revolution of smart drug delivery in advanced non-small cell lung cancer (NSCLC).
Parisi C, Mahjoubi L, Gazzah A, Barlesi F
Cancer Treat Rev 2023 Jul;118:102572. Epub 2023 May 19 doi: 10.1016/j.ctrv.2023.102572. PMID: 37230055
Current studies of immunotherapy in head and neck cancer.
Dogan V, Rieckmann T, Münscher A, Busch CJ
Clin Otolaryngol 2018 Feb;43(1):13-21. Epub 2017 May 29 doi: 10.1111/coa.12895. PMID: 28464441

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