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Refractory Lung Carcinoma

MedGen UID:
1639600
Concept ID:
C4683497
Neoplastic Process

Definition

Lung carcinoma that does not respond to treatment. [from NCI]

Professional guidelines

PubMed

Yu Y, Chen K, Fan Y
Int J Cancer 2023 Jun 1;152(11):2243-2256. Epub 2022 Nov 29 doi: 10.1002/ijc.34346. PMID: 36346100
Wang S, Zimmermann S, Parikh K, Mansfield AS, Adjei AA
Mayo Clin Proc 2019 Aug;94(8):1599-1622. doi: 10.1016/j.mayocp.2019.01.034. PMID: 31378235
Champiat S, Lambotte O, Barreau E, Belkhir R, Berdelou A, Carbonnel F, Cauquil C, Chanson P, Collins M, Durrbach A, Ederhy S, Feuillet S, François H, Lazarovici J, Le Pavec J, De Martin E, Mateus C, Michot JM, Samuel D, Soria JC, Robert C, Eggermont A, Marabelle A
Ann Oncol 2016 Apr;27(4):559-74. Epub 2015 Dec 28 doi: 10.1093/annonc/mdv623. PMID: 26715621

Recent clinical studies

Etiology

Li BT, Smit EF, Goto Y, Nakagawa K, Udagawa H, Mazières J, Nagasaka M, Bazhenova L, Saltos AN, Felip E, Pacheco JM, Pérol M, Paz-Ares L, Saxena K, Shiga R, Cheng Y, Acharyya S, Vitazka P, Shahidi J, Planchard D, Jänne PA; DESTINY-Lung01 Trial Investigators
N Engl J Med 2022 Jan 20;386(3):241-251. Epub 2021 Sep 18 doi: 10.1056/NEJMoa2112431. PMID: 34534430Free PMC Article
Wang S, Zimmermann S, Parikh K, Mansfield AS, Adjei AA
Mayo Clin Proc 2019 Aug;94(8):1599-1622. doi: 10.1016/j.mayocp.2019.01.034. PMID: 31378235
Suresh K, Naidoo J, Lin CT, Danoff S
Chest 2018 Dec;154(6):1416-1423. Epub 2018 Sep 4 doi: 10.1016/j.chest.2018.08.1048. PMID: 30189190Free PMC Article
Hasskarl J
Recent Results Cancer Res 2018;211:101-123. doi: 10.1007/978-3-319-91442-8_8. PMID: 30069763
Hsieh JJ, Purdue MP, Signoretti S, Swanton C, Albiges L, Schmidinger M, Heng DY, Larkin J, Ficarra V
Nat Rev Dis Primers 2017 Mar 9;3:17009. doi: 10.1038/nrdp.2017.9. PMID: 28276433Free PMC Article

Diagnosis

Wang XS, Bai YF, Verma V, Yu RL, Tian W, Ao R, Deng Y, Zhu XQ, Liu H, Pan HX, Yang L, Bai HS, Luo X, Guo Y, Zhou MX, Sun YM, Zhang ZC, Li SM, Cheng X, Tan BX, Han LF, Liu YY, Zhang K, Zeng FX, Jia L, Hao XB, Wang YY, Feng G, Xie K, Lu Y, Zeng M
J Natl Cancer Inst 2023 Jun 8;115(6):742-748. doi: 10.1093/jnci/djac015. PMID: 35094066Free PMC Article
Hallin J, Engstrom LD, Hargis L, Calinisan A, Aranda R, Briere DM, Sudhakar N, Bowcut V, Baer BR, Ballard JA, Burkard MR, Fell JB, Fischer JP, Vigers GP, Xue Y, Gatto S, Fernandez-Banet J, Pavlicek A, Velastagui K, Chao RC, Barton J, Pierobon M, Baldelli E, Patricoin EF 3rd, Cassidy DP, Marx MA, Rybkin II, Johnson ML, Ou SI, Lito P, Papadopoulos KP, Jänne PA, Olson P, Christensen JG
Cancer Discov 2020 Jan;10(1):54-71. Epub 2019 Oct 28 doi: 10.1158/2159-8290.CD-19-1167. PMID: 31658955Free PMC Article
Wang S, Zimmermann S, Parikh K, Mansfield AS, Adjei AA
Mayo Clin Proc 2019 Aug;94(8):1599-1622. doi: 10.1016/j.mayocp.2019.01.034. PMID: 31378235
Owen DH, Giffin MJ, Bailis JM, Smit MD, Carbone DP, He K
J Hematol Oncol 2019 Jun 18;12(1):61. doi: 10.1186/s13045-019-0745-2. PMID: 31215500Free PMC Article
Hsieh JJ, Purdue MP, Signoretti S, Swanton C, Albiges L, Schmidinger M, Heng DY, Larkin J, Ficarra V
Nat Rev Dis Primers 2017 Mar 9;3:17009. doi: 10.1038/nrdp.2017.9. PMID: 28276433Free PMC Article

Therapy

Häuser W, Welsch P, Radbruch L, Fisher E, Bell RF, Moore RA
Cochrane Database Syst Rev 2023 Jun 5;6(6):CD014915. doi: 10.1002/14651858.CD014915.pub2. PMID: 37283486Free PMC Article
Subbiah V, Iannotti NO, Gutierrez M, Smith DC, Féliz L, Lihou CF, Tian C, Silverman IM, Ji T, Saleh M
Ann Oncol 2022 May;33(5):522-533. Epub 2022 Feb 14 doi: 10.1016/j.annonc.2022.02.001. PMID: 35176457
Markham A
Drugs 2021 Nov;81(17):2063-2068. doi: 10.1007/s40265-021-01628-5. PMID: 34709602
Hallin J, Engstrom LD, Hargis L, Calinisan A, Aranda R, Briere DM, Sudhakar N, Bowcut V, Baer BR, Ballard JA, Burkard MR, Fell JB, Fischer JP, Vigers GP, Xue Y, Gatto S, Fernandez-Banet J, Pavlicek A, Velastagui K, Chao RC, Barton J, Pierobon M, Baldelli E, Patricoin EF 3rd, Cassidy DP, Marx MA, Rybkin II, Johnson ML, Ou SI, Lito P, Papadopoulos KP, Jänne PA, Olson P, Christensen JG
Cancer Discov 2020 Jan;10(1):54-71. Epub 2019 Oct 28 doi: 10.1158/2159-8290.CD-19-1167. PMID: 31658955Free PMC Article
Kato K, Cho BC, Takahashi M, Okada M, Lin CY, Chin K, Kadowaki S, Ahn MJ, Hamamoto Y, Doki Y, Yen CC, Kubota Y, Kim SB, Hsu CH, Holtved E, Xynos I, Kodani M, Kitagawa Y
Lancet Oncol 2019 Nov;20(11):1506-1517. Epub 2019 Sep 30 doi: 10.1016/S1470-2045(19)30626-6. PMID: 31582355

Prognosis

Li BT, Smit EF, Goto Y, Nakagawa K, Udagawa H, Mazières J, Nagasaka M, Bazhenova L, Saltos AN, Felip E, Pacheco JM, Pérol M, Paz-Ares L, Saxena K, Shiga R, Cheng Y, Acharyya S, Vitazka P, Shahidi J, Planchard D, Jänne PA; DESTINY-Lung01 Trial Investigators
N Engl J Med 2022 Jan 20;386(3):241-251. Epub 2021 Sep 18 doi: 10.1056/NEJMoa2112431. PMID: 34534430Free PMC Article
Lantuejoul S, Pissaloux D, Ferretti GR, McLeer A
Semin Diagn Pathol 2021 Sep;38(5):72-82. Epub 2021 Jun 16 doi: 10.1053/j.semdp.2021.06.005. PMID: 34176698
Hallin J, Engstrom LD, Hargis L, Calinisan A, Aranda R, Briere DM, Sudhakar N, Bowcut V, Baer BR, Ballard JA, Burkard MR, Fell JB, Fischer JP, Vigers GP, Xue Y, Gatto S, Fernandez-Banet J, Pavlicek A, Velastagui K, Chao RC, Barton J, Pierobon M, Baldelli E, Patricoin EF 3rd, Cassidy DP, Marx MA, Rybkin II, Johnson ML, Ou SI, Lito P, Papadopoulos KP, Jänne PA, Olson P, Christensen JG
Cancer Discov 2020 Jan;10(1):54-71. Epub 2019 Oct 28 doi: 10.1158/2159-8290.CD-19-1167. PMID: 31658955Free PMC Article
Wang S, Zimmermann S, Parikh K, Mansfield AS, Adjei AA
Mayo Clin Proc 2019 Aug;94(8):1599-1622. doi: 10.1016/j.mayocp.2019.01.034. PMID: 31378235
Hsieh JJ, Purdue MP, Signoretti S, Swanton C, Albiges L, Schmidinger M, Heng DY, Larkin J, Ficarra V
Nat Rev Dis Primers 2017 Mar 9;3:17009. doi: 10.1038/nrdp.2017.9. PMID: 28276433Free PMC Article

Clinical prediction guides

Parisi C, Mahjoubi L, Gazzah A, Barlesi F
Cancer Treat Rev 2023 Jul;118:102572. Epub 2023 May 19 doi: 10.1016/j.ctrv.2023.102572. PMID: 37230055
Hallin J, Engstrom LD, Hargis L, Calinisan A, Aranda R, Briere DM, Sudhakar N, Bowcut V, Baer BR, Ballard JA, Burkard MR, Fell JB, Fischer JP, Vigers GP, Xue Y, Gatto S, Fernandez-Banet J, Pavlicek A, Velastagui K, Chao RC, Barton J, Pierobon M, Baldelli E, Patricoin EF 3rd, Cassidy DP, Marx MA, Rybkin II, Johnson ML, Ou SI, Lito P, Papadopoulos KP, Jänne PA, Olson P, Christensen JG
Cancer Discov 2020 Jan;10(1):54-71. Epub 2019 Oct 28 doi: 10.1158/2159-8290.CD-19-1167. PMID: 31658955Free PMC Article
Hsieh JJ, Purdue MP, Signoretti S, Swanton C, Albiges L, Schmidinger M, Heng DY, Larkin J, Ficarra V
Nat Rev Dis Primers 2017 Mar 9;3:17009. doi: 10.1038/nrdp.2017.9. PMID: 28276433Free PMC Article
Brahmer JR, Drake CG, Wollner I, Powderly JD, Picus J, Sharfman WH, Stankevich E, Pons A, Salay TM, McMiller TL, Gilson MM, Wang C, Selby M, Taube JM, Anders R, Chen L, Korman AJ, Pardoll DM, Lowy I, Topalian SL
J Clin Oncol 2010 Jul 1;28(19):3167-75. Epub 2010 Jun 1 doi: 10.1200/JCO.2009.26.7609. PMID: 20516446Free PMC Article
Cortes JE, Pazdur R
J Clin Oncol 1995 Oct;13(10):2643-55. doi: 10.1200/JCO.1995.13.10.2643. PMID: 7595719

Recent systematic reviews

Häuser W, Welsch P, Radbruch L, Fisher E, Bell RF, Moore RA
Cochrane Database Syst Rev 2023 Jun 5;6(6):CD014915. doi: 10.1002/14651858.CD014915.pub2. PMID: 37283486Free PMC Article
Parisi C, Mahjoubi L, Gazzah A, Barlesi F
Cancer Treat Rev 2023 Jul;118:102572. Epub 2023 May 19 doi: 10.1016/j.ctrv.2023.102572. PMID: 37230055
Arunachalam A, Zhang I, Zhao B, Frederickson AM, Catherine Pietanza M
Lung Cancer 2023 Feb;176:132-139. Epub 2023 Jan 2 doi: 10.1016/j.lungcan.2023.01.003. PMID: 36638588
Yu G, Shen Y, Xu X, Zhong F
PLoS One 2020;15(11):e0242982. Epub 2020 Nov 30 doi: 10.1371/journal.pone.0242982. PMID: 33253313Free PMC Article
Dogan V, Rieckmann T, Münscher A, Busch CJ
Clin Otolaryngol 2018 Feb;43(1):13-21. Epub 2017 May 29 doi: 10.1111/coa.12895. PMID: 28464441

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