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Hip pain

MedGen UID:
1643075
Concept ID:
C4551516
Sign or Symptom
HPO: HP:0030838

Definition

An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the hip. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHip pain

Conditions with this feature

Protrusio acetabuli
MedGen UID:
98369
Concept ID:
C0409495
Anatomical Abnormality
Intrapelvic bulging of the medial acetabular wall.
Deficiency of hyaluronoglucosaminidase
MedGen UID:
226942
Concept ID:
C1291490
Disease or Syndrome
Mucopolysaccharidosis type IX (MPS9) is a rare progressive lysosomal storage disorder caused by the deficiency of the enzyme hyaluronoglucosaminidase-1, which degrades hyaluronan (summary by Imundo et al., 2011).
Multiple epiphyseal dysplasia type 5
MedGen UID:
335542
Concept ID:
C1846843
Disease or Syndrome
Autosomal dominant multiple epiphyseal dysplasia (MED) presents in early childhood, usually with pain in the hips and/or knees after exercise. Affected children complain of fatigue with long-distance walking. Waddling gait may be present. Adult height is either in the lower range of normal or mildly shortened. The limbs are relatively short in comparison to the trunk. Pain and joint deformity progress, resulting in early-onset osteoarthritis, particularly of the large weight-bearing joints.
Spondyloepiphyseal dysplasia tarda, autosomal dominant
MedGen UID:
355785
Concept ID:
C1866717
Disease or Syndrome
Autosomal domiant spondyloepiphyseal dysplasia tarda (autosomal dominant SEDT) is an inherited condition that affects bone growth. Signs and symptoms are generally physically apparent by puberty; however, abnormalities may be seen on X-ray at an earlier age. Affected people may have skeletal abnormalities, short stature (with a short neck and trunk, specifically), scoliosis, kyphosis, lumbar hyperlordosis (exaggerated curvature of the lower back), and early-onset progressive osteoarthritis of the hips and knees. Some cases of autosomal dominant SEDT may be caused by changes (mutations) in the COL2A1 gene. As the name suggests, the condition is inherited in an autosomal dominant manner. Treatment is based on the signs and symptoms present in each person and may include surgery and pain management strategies.
Developmental dysplasia of the hip 2
MedGen UID:
811575
Concept ID:
C3715079
Disease or Syndrome
Developmental dysplasia of the hip (DDH) is a debilitating condition characterized by incomplete formation of the acetabulum leading to dislocation of the femur, suboptimal joint function, and accelerated wear of the articular cartilage, resulting in arthritis. Undetected hip dysplasia is the leading cause of osteoarthritis of the hip in young individuals, causing over 40% of cases in that age group (summary by Feldman et al., 2013). For discussion of genetic heterogeneity of developmental dysplasia of the hip, see DDH1 (142700).
Avascular necrosis of femoral head, primary, 1
MedGen UID:
1639295
Concept ID:
C4551562
Disease or Syndrome
Avascular necrosis of the femoral head (ANFH) is a debilitating disease that usually leads to destruction of the hip joint in the third to fifth decade of life. The disorder is characterized by progressive pain in the groin, mechanical failure of the subchondral bone, and degeneration of the hip joint. Nearly one-half of patients require hip replacement before 40 years of age. ANFH represents a specific form of the broader disease category of osteonecrosis (summary by Mont and Hungerford, 1995). Genetic Heterogeneity of Primary Avascular Necrosis of the Femoral Head ANFH2 is caused by mutation in the TRPV4 gene (605427) on chromosome 12q24. Mutation in COL2A1 has also been found in Legg-Calves-Perthes disease (LCPD; 150600), a form of ANFH in growing children.
Inclusion body myopathy with Paget disease of bone and frontotemporal dementia type 1
MedGen UID:
1641069
Concept ID:
C4551951
Disease or Syndrome
Inclusion body myopathy associated with Paget disease of bone (PDB) and/or frontotemporal dementia (IBMPFD) is characterized by adult-onset proximal and distal muscle weakness (clinically resembling a limb-girdle muscular dystrophy syndrome), early-onset PDB, and premature frontotemporal dementia (FTD). Muscle weakness progresses to involve other limb and respiratory muscles. PDB involves focal areas of increased bone turnover that typically lead to spine and/or hip pain and localized enlargement and deformity of the long bones; pathologic fractures occur on occasion. Early stages of FTD are characterized by dysnomia, dyscalculia, comprehension deficits, and paraphasic errors, with minimal impairment of episodic memory; later stages are characterized by inability to speak, auditory comprehension deficits for even one-step commands, alexia, and agraphia. Mean age at diagnosis for muscle disease and PDB is 42 years; for FTD, 56 years. Dilated cardiomyopathy, amyotrophic lateral sclerosis, and Parkinson disease are now known to be part of the spectrum of findings associated with IBMPFD.

Professional guidelines

PubMed

Duong V, Oo WM, Ding C, Culvenor AG, Hunter DJ
JAMA 2023 Oct 24;330(16):1568-1580. doi: 10.1001/jama.2023.19675. PMID: 37874571
Chamberlain R
Am Fam Physician 2021 Jan 15;103(2):81-89. PMID: 33448767
Grimaldi A, Mellor R, Hodges P, Bennell K, Wajswelner H, Vicenzino B
Sports Med 2015 Aug;45(8):1107-19. doi: 10.1007/s40279-015-0336-5. PMID: 25969366

Recent clinical studies

Etiology

Lespasio MJ
Perm J 2022 Jun 29;26(2):83-88. Epub 2022 Jun 15 doi: 10.7812/TPP/21.110. PMID: 35933677Free PMC Article
Sunil Kumar KH, Rawal J, Nakano N, Sarmento A, Khanduja V
Knee Surg Sports Traumatol Arthrosc 2021 Aug;29(8):2408-2416. Epub 2020 Dec 19 doi: 10.1007/s00167-020-06354-1. PMID: 33341914Free PMC Article
Morrison C, Brown B, Lin DY, Jaarsma R, Kroon H
Reg Anesth Pain Med 2021 Feb;46(2):169-175. Epub 2020 Oct 27 doi: 10.1136/rapm-2020-101826. PMID: 33109730
Trigg SD, Schroeder JD, Hulsopple C
Curr Sports Med Rep 2020 Sep;19(9):360-366. doi: 10.1249/JSR.0000000000000748. PMID: 32925375
Grimaldi A, Fearon A
J Orthop Sports Phys Ther 2015 Nov;45(11):910-22. Epub 2015 Sep 17 doi: 10.2519/jospt.2015.5829. PMID: 26381486

Diagnosis

Lespasio MJ
Perm J 2022 Jun 29;26(2):83-88. Epub 2022 Jun 15 doi: 10.7812/TPP/21.110. PMID: 35933677Free PMC Article
Chamberlain R
Am Fam Physician 2021 Jan 15;103(2):81-89. PMID: 33448767
Sunil Kumar KH, Rawal J, Nakano N, Sarmento A, Khanduja V
Knee Surg Sports Traumatol Arthrosc 2021 Aug;29(8):2408-2416. Epub 2020 Dec 19 doi: 10.1007/s00167-020-06354-1. PMID: 33341914Free PMC Article
Gómez-Hoyos J, Martin RL, Martin HD
J Am Acad Orthop Surg 2018 Sep 1;26(17):597-609. doi: 10.5435/JAAOS-D-15-00629. PMID: 30080760
Grimaldi A, Fearon A
J Orthop Sports Phys Ther 2015 Nov;45(11):910-22. Epub 2015 Sep 17 doi: 10.2519/jospt.2015.5829. PMID: 26381486

Therapy

Morrison C, Brown B, Lin DY, Jaarsma R, Kroon H
Reg Anesth Pain Med 2021 Feb;46(2):169-175. Epub 2020 Oct 27 doi: 10.1136/rapm-2020-101826. PMID: 33109730
Matar HE, Rajpura A, Board TN
Br J Hosp Med (Lond) 2019 Oct 2;80(10):584-588. doi: 10.12968/hmed.2019.80.10.584. PMID: 31589500
Griffin DR, Dickenson EJ, Wall PDH, Achana F, Donovan JL, Griffin J, Hobson R, Hutchinson CE, Jepson M, Parsons NR, Petrou S, Realpe A, Smith J, Foster NE; FASHIoN Study Group
Lancet 2018 Jun 2;391(10136):2225-2235. Epub 2018 Jun 1 doi: 10.1016/S0140-6736(18)31202-9. PMID: 29893223Free PMC Article
Remler K
J Pediatr Health Care 2017 Nov-Dec;31(6):713-716. doi: 10.1016/j.pedhc.2017.08.004. PMID: 29056201
Grimaldi A, Mellor R, Hodges P, Bennell K, Wajswelner H, Vicenzino B
Sports Med 2015 Aug;45(8):1107-19. doi: 10.1007/s40279-015-0336-5. PMID: 25969366

Prognosis

Iwasaka-Neder J, Bedoya MA, Tsai A, Bixby SD
Radiology 2024 Feb;310(2):e230628. doi: 10.1148/radiol.230628. PMID: 38411515
Hoit G, Whelan DB, Dwyer T, Ajrawat P, Chahal J
Am J Sports Med 2020 Jul;48(8):2042-2050. Epub 2019 Nov 27 doi: 10.1177/0363546519882668. PMID: 31774704
Ganderton C, Semciw A, Cook J, Moreira E, Pizzari T
J Womens Health (Larchmt) 2018 Jun;27(6):815-829. Epub 2018 May 1 doi: 10.1089/jwh.2017.6729. PMID: 29715073
Grimaldi A, Fearon A
J Orthop Sports Phys Ther 2015 Nov;45(11):910-22. Epub 2015 Sep 17 doi: 10.2519/jospt.2015.5829. PMID: 26381486
Roberts WN, Williams RB
Prim Care 1988 Dec;15(4):783-93. PMID: 3068695

Clinical prediction guides

Zhou R, Zhang L, Sun Y, Yan J, Jiang H
Nutrients 2023 Aug 24;15(17) doi: 10.3390/nu15173709. PMID: 37686741Free PMC Article
Zhu Y, Su P, Xu T, Zhang L, Fu W
J Orthop Surg Res 2022 Jun 3;17(1):296. doi: 10.1186/s13018-022-03187-1. PMID: 35659016Free PMC Article
Pennock AT, Bomar JD, Johnson KP, Randich K, Upasani VV
Am J Sports Med 2018 Dec;46(14):3415-3422. Epub 2018 Nov 6 doi: 10.1177/0363546518804805. PMID: 30398893
Ganderton C, Semciw A, Cook J, Moreira E, Pizzari T
J Womens Health (Larchmt) 2018 Jun;27(6):815-829. Epub 2018 May 1 doi: 10.1089/jwh.2017.6729. PMID: 29715073
Dasgupta B, Cimmino MA, Maradit-Kremers H, Schmidt WA, Schirmer M, Salvarani C, Bachta A, Dejaco C, Duftner C, Jensen HS, Duhaut P, Poór G, Kaposi NP, Mandl P, Balint PV, Schmidt Z, Iagnocco A, Nannini C, Cantini F, Macchioni P, Pipitone N, Amo MD, Espígol-Frigolé G, Cid MC, Martínez-Taboada VM, Nordborg E, Direskeneli H, Aydin SZ, Ahmed K, Hazleman B, Silverman B, Pease C, Wakefield RJ, Luqmani R, Abril A, Michet CJ, Marcus R, Gonter NJ, Maz M, Carter RE, Crowson CS, Matteson EL
Ann Rheum Dis 2012 Apr;71(4):484-92. doi: 10.1136/annrheumdis-2011-200329. PMID: 22388996Free PMC Article

Recent systematic reviews

Zhu Y, Su P, Xu T, Zhang L, Fu W
J Orthop Surg Res 2022 Jun 3;17(1):296. doi: 10.1186/s13018-022-03187-1. PMID: 35659016Free PMC Article
Dzakpasu FQS, Carver A, Brakenridge CJ, Cicuttini F, Urquhart DM, Owen N, Dunstan DW
Int J Behav Nutr Phys Act 2021 Dec 13;18(1):159. doi: 10.1186/s12966-021-01191-y. PMID: 34895248Free PMC Article
Herchenröder M, Wilfling D, Steinhäuser J
J Foot Ankle Res 2021 Nov 29;14(1):57. doi: 10.1186/s13047-021-00499-z. PMID: 34844639Free PMC Article
Park JW, Lee YK, Lee YJ, Shin S, Kang Y, Koo KH
Bone Joint J 2020 May;102-B(5):556-567. doi: 10.1302/0301-620X.102B5.BJJ-2019-1212.R1. PMID: 32349600
Aiyer R, Noori SA, Chang KV, Jung B, Rasheed A, Bansal N, Ottestad E, Gulati A
Pain Med 2020 Nov 7;21(7):1437-1448. doi: 10.1093/pm/pnz102. PMID: 31095336

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