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Increased level of hippuric acid in blood

MedGen UID:
1644325
•Concept ID:
C4703631
•
Finding
Synonym: Increased level of N-benzoylglycine in blood
 
HPO: HP:0410065

Definition

An increase in the level of hippuric acid in the blood. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased level of hippuric acid in blood

Professional guidelines

PubMed

Occupational risk assessment of oxidative stress and genotoxicity in workers exposed to paints during a working week.
Cassini C, Calloni C, Bortolini G, Garcia SC, Dornelles MA, Henriques JA, Erdtmann B, Salvador M
Int J Occup Med Environ Health 2011 Sep;24(3):308-19. Epub 2011 Jul 21 doi: 10.2478/s13382-011-0030-2. PMID: 21833695
Evaluation of genetic damage in Brazilian footwear-workers: biomarkers of exposure, effect, and susceptibility.
Heuser VD, Erdtmann B, Kvitko K, Rohr P, da Silva J
Toxicology 2007 Apr 11;232(3):235-47. Epub 2007 Jan 19 doi: 10.1016/j.tox.2007.01.011. PMID: 17292523

Recent clinical studies

Etiology

Predictive value of protein-bound uremic toxins for heart failure in patients with chronic kidney disease.
Zwaenepoel B, De Backer T, Glorieux G, Verbeke F
ESC Heart Fail 2024 Feb;11(1):466-474. Epub 2023 Dec 2 doi: 10.1002/ehf2.14566. PMID: 38041505Free PMC Article
Washed microbiota transplantation improves renal function in patients with renal dysfunction: a retrospective cohort study.
Zhong HJ, Xie X, Chen WJ, Zhuang YP, Hu X, Cai YL, Zeng HL, Xiao C, Li Y, Ding Y, Xue L, Chen M, Zhang J, Wu Q, He XX
J Transl Med 2023 Oct 19;21(1):740. doi: 10.1186/s12967-023-04570-0. PMID: 37858192Free PMC Article
Hippuric acid: Could became a barometer for frailty and geriatric syndromes?
De Simone G, Balducci C, Forloni G, Pastorelli R, Brunelli L
Ageing Res Rev 2021 Dec;72:101466. Epub 2021 Sep 22 doi: 10.1016/j.arr.2021.101466. PMID: 34560280
Indole-3 acetic acid increased risk of impaired cognitive function in patients receiving hemodialysis.
Lin YT, Wu PH, Lee HH, Mubanga M, Chen CS, Kuo MC, Chiu YW, Kuo PL, Hwang SJ
Neurotoxicology 2019 Jul;73:85-91. Epub 2019 Feb 28 doi: 10.1016/j.neuro.2019.02.019. PMID: 30826344
Association between hippuric acid and left ventricular hypertrophy in maintenance hemodialysis patients.
Yu TH, Tang WH, Lu YC, Wang CP, Hung WC, Wu CC, Tsai IT, Chung FM, Houng JY, Lan WC, Lee YJ
Clin Chim Acta 2018 Sep;484:47-51. Epub 2018 May 29 doi: 10.1016/j.cca.2018.05.022. PMID: 29758204

Diagnosis

Hippuric acid: Could became a barometer for frailty and geriatric syndromes?
De Simone G, Balducci C, Forloni G, Pastorelli R, Brunelli L
Ageing Res Rev 2021 Dec;72:101466. Epub 2021 Sep 22 doi: 10.1016/j.arr.2021.101466. PMID: 34560280
Indole-3 acetic acid increased risk of impaired cognitive function in patients receiving hemodialysis.
Lin YT, Wu PH, Lee HH, Mubanga M, Chen CS, Kuo MC, Chiu YW, Kuo PL, Hwang SJ
Neurotoxicology 2019 Jul;73:85-91. Epub 2019 Feb 28 doi: 10.1016/j.neuro.2019.02.019. PMID: 30826344
Association between hippuric acid and left ventricular hypertrophy in maintenance hemodialysis patients.
Yu TH, Tang WH, Lu YC, Wang CP, Hung WC, Wu CC, Tsai IT, Chung FM, Houng JY, Lan WC, Lee YJ
Clin Chim Acta 2018 Sep;484:47-51. Epub 2018 May 29 doi: 10.1016/j.cca.2018.05.022. PMID: 29758204
Systems biology analysis of omeprazole therapy in cirrhosis demonstrates significant shifts in gut microbiota composition and function.
Bajaj JS, Cox IJ, Betrapally NS, Heuman DM, Schubert ML, Ratneswaran M, Hylemon PB, White MB, Daita K, Noble NA, Sikaroodi M, Williams R, Crossey MM, Taylor-Robinson SD, Gillevet PM
Am J Physiol Gastrointest Liver Physiol 2014 Nov 15;307(10):G951-7. Epub 2014 Sep 25 doi: 10.1152/ajpgi.00268.2014. PMID: 25258407Free PMC Article
A metabolic profiling analysis of symptomatic gout in human serum and urine using high performance liquid chromatography-diode array detector technique.
Liu Y, Sun X, Di D, Quan J, Zhang J, Yang X
Clin Chim Acta 2011 Nov 20;412(23-24):2132-40. Epub 2011 Aug 16 doi: 10.1016/j.cca.2011.07.031. PMID: 21867696

Therapy

Blood serum levels of selected biomarkers of oxidative stress among printing workers occupationally exposed to low-levels of toluene and xylene.
Dehghan Haghighi J, Hormozi M, Payandeh A
Toxicol Ind Health 2022 May;38(5):299-307. Epub 2022 Apr 24 doi: 10.1177/07482337221092501. PMID: 35466827
Safety and pharmacodynamics of an engineered E. coli Nissle for the treatment of phenylketonuria: a first-in-human phase 1/2a study.
Puurunen MK, Vockley J, Searle SL, Sacharow SJ, Phillips JA 3rd, Denney WS, Goodlett BD, Wagner DA, Blankstein L, Castillo MJ, Charbonneau MR, Isabella VM, Sethuraman VV, Riese RJ, Kurtz CB, Brennan AM
Nat Metab 2021 Aug;3(8):1125-1132. Epub 2021 Jul 22 doi: 10.1038/s42255-021-00430-7. PMID: 34294923
Indole-3 acetic acid increased risk of impaired cognitive function in patients receiving hemodialysis.
Lin YT, Wu PH, Lee HH, Mubanga M, Chen CS, Kuo MC, Chiu YW, Kuo PL, Hwang SJ
Neurotoxicology 2019 Jul;73:85-91. Epub 2019 Feb 28 doi: 10.1016/j.neuro.2019.02.019. PMID: 30826344
Association between hippuric acid and left ventricular hypertrophy in maintenance hemodialysis patients.
Yu TH, Tang WH, Lu YC, Wang CP, Hung WC, Wu CC, Tsai IT, Chung FM, Houng JY, Lan WC, Lee YJ
Clin Chim Acta 2018 Sep;484:47-51. Epub 2018 May 29 doi: 10.1016/j.cca.2018.05.022. PMID: 29758204
OUR EXPERIENCE WITH THE USE OF 40% BENZOIC ACID FOR NECRECTOMY IN DEEP BURNS.
Jelínková Z, Kaloudová Y, Řihová H, Suchánek I, Brychta P
Acta Chir Plast 2017 Summer;59(1):5-10. PMID: 28869382

Prognosis

Predictive value of protein-bound uremic toxins for heart failure in patients with chronic kidney disease.
Zwaenepoel B, De Backer T, Glorieux G, Verbeke F
ESC Heart Fail 2024 Feb;11(1):466-474. Epub 2023 Dec 2 doi: 10.1002/ehf2.14566. PMID: 38041505Free PMC Article
Indole-3 acetic acid increased risk of impaired cognitive function in patients receiving hemodialysis.
Lin YT, Wu PH, Lee HH, Mubanga M, Chen CS, Kuo MC, Chiu YW, Kuo PL, Hwang SJ
Neurotoxicology 2019 Jul;73:85-91. Epub 2019 Feb 28 doi: 10.1016/j.neuro.2019.02.019. PMID: 30826344
OUR EXPERIENCE WITH THE USE OF 40% BENZOIC ACID FOR NECRECTOMY IN DEEP BURNS.
Jelínková Z, Kaloudová Y, Řihová H, Suchánek I, Brychta P
Acta Chir Plast 2017 Summer;59(1):5-10. PMID: 28869382
Systems biology analysis of omeprazole therapy in cirrhosis demonstrates significant shifts in gut microbiota composition and function.
Bajaj JS, Cox IJ, Betrapally NS, Heuman DM, Schubert ML, Ratneswaran M, Hylemon PB, White MB, Daita K, Noble NA, Sikaroodi M, Williams R, Crossey MM, Taylor-Robinson SD, Gillevet PM
Am J Physiol Gastrointest Liver Physiol 2014 Nov 15;307(10):G951-7. Epub 2014 Sep 25 doi: 10.1152/ajpgi.00268.2014. PMID: 25258407Free PMC Article
A metabolic profiling analysis of symptomatic gout in human serum and urine using high performance liquid chromatography-diode array detector technique.
Liu Y, Sun X, Di D, Quan J, Zhang J, Yang X
Clin Chim Acta 2011 Nov 20;412(23-24):2132-40. Epub 2011 Aug 16 doi: 10.1016/j.cca.2011.07.031. PMID: 21867696

Clinical prediction guides

Predictive value of protein-bound uremic toxins for heart failure in patients with chronic kidney disease.
Zwaenepoel B, De Backer T, Glorieux G, Verbeke F
ESC Heart Fail 2024 Feb;11(1):466-474. Epub 2023 Dec 2 doi: 10.1002/ehf2.14566. PMID: 38041505Free PMC Article
Blood serum levels of selected biomarkers of oxidative stress among printing workers occupationally exposed to low-levels of toluene and xylene.
Dehghan Haghighi J, Hormozi M, Payandeh A
Toxicol Ind Health 2022 May;38(5):299-307. Epub 2022 Apr 24 doi: 10.1177/07482337221092501. PMID: 35466827
Safety and pharmacodynamics of an engineered E. coli Nissle for the treatment of phenylketonuria: a first-in-human phase 1/2a study.
Puurunen MK, Vockley J, Searle SL, Sacharow SJ, Phillips JA 3rd, Denney WS, Goodlett BD, Wagner DA, Blankstein L, Castillo MJ, Charbonneau MR, Isabella VM, Sethuraman VV, Riese RJ, Kurtz CB, Brennan AM
Nat Metab 2021 Aug;3(8):1125-1132. Epub 2021 Jul 22 doi: 10.1038/s42255-021-00430-7. PMID: 34294923
Indole-3 acetic acid increased risk of impaired cognitive function in patients receiving hemodialysis.
Lin YT, Wu PH, Lee HH, Mubanga M, Chen CS, Kuo MC, Chiu YW, Kuo PL, Hwang SJ
Neurotoxicology 2019 Jul;73:85-91. Epub 2019 Feb 28 doi: 10.1016/j.neuro.2019.02.019. PMID: 30826344
OUR EXPERIENCE WITH THE USE OF 40% BENZOIC ACID FOR NECRECTOMY IN DEEP BURNS.
Jelínková Z, Kaloudová Y, Řihová H, Suchánek I, Brychta P
Acta Chir Plast 2017 Summer;59(1):5-10. PMID: 28869382

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