U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Unresectable Craniopharyngioma

MedGen UID:
1646850
•Concept ID:
C4688353
•
Neoplastic Process

Definition

A craniopharyngioma that is not amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUnresectable Craniopharyngioma

Professional guidelines

PubMed

Successful Use of BRAF/MEK Inhibitors as a Neoadjuvant Approach in the Definitive Treatment of Papillary Craniopharyngioma.
Khaddour K, Chicoine MR, Huang J, Dahiya S, Ansstas G
J Natl Compr Canc Netw 2020 Dec;18(12):1590-1595. Epub 2020 Dec 2 doi: 10.6004/jnccn.2020.7624. PMID: 33285519
Benign Intracranial Lesions - Radiotherapy: An Overview of Treatment Options, Indications and Therapeutic Results.
Tzikoulis V, Gkantaifi A, Alongi F, Tsoukalas N, Saraireh HH, Charalampakis N, Tzikoulis G, Andreou E, Tsapakidis K, Kardamakis D, Tsanadis K, Kyrgias G, Tolia M
Rev Recent Clin Trials 2020;15(2):93-121. doi: 10.2174/1574887114666191111100635. PMID: 31713498
Stereotactic treatment of brain lesions. Biopsy, interstitial radiotherapy (iridium-192 and iodine-125) and drainage procedures.
Mundinger F, Ostertag CB, Birg W, Weigel K
Appl Neurophysiol 1980;43(3-5):198-204. PMID: 7027939

Recent clinical studies

Etiology

A narrative review of targeted therapy in meningioma, pituitary adenoma, and craniopharyngioma of the skull base.
Martinez NL, Khanna O, Farrell CJ
Chin Clin Oncol 2020 Dec;9(6):75. Epub 2020 Aug 17 doi: 10.21037/cco-20-168. PMID: 32819111

Diagnosis

Benign Intracranial Lesions - Radiotherapy: An Overview of Treatment Options, Indications and Therapeutic Results.
Tzikoulis V, Gkantaifi A, Alongi F, Tsoukalas N, Saraireh HH, Charalampakis N, Tzikoulis G, Andreou E, Tsapakidis K, Kardamakis D, Tsanadis K, Kyrgias G, Tolia M
Rev Recent Clin Trials 2020;15(2):93-121. doi: 10.2174/1574887114666191111100635. PMID: 31713498
Robotically guided radiosurgery for children.
Giller CA, Berger BD, Pistenmaa DA, Sklar F, Weprin B, Shapiro K, Winick N, Mulne AF, Delp JL, Gilio JP, Gall KP, Dicke KA, Swift D, Sacco D, Harris-Henderson K, Bowers D
Pediatr Blood Cancer 2005 Sep;45(3):304-10. doi: 10.1002/pbc.20267. PMID: 15558704
Neuroendoscopic placement of Ommaya reservoir into a cystic craniopharyngioma.
Joki T, Oi S, Babapour B, Kaito N, Ohashi K, Ebara M, Kato M, Abe T
Childs Nerv Syst 2002 Nov;18(11):629-33. Epub 2002 Sep 28 doi: 10.1007/s00381-002-0638-4. PMID: 12420123
Correlation between magnetic resonance imaging of posterior pituitary and neurohypophyseal function in children with diabetes insipidus.
Maghnie M, Villa A, Arico M, Larizza D, Pezzotta S, Beluffi G, Genovese E, Severi F
J Clin Endocrinol Metab 1992 Apr;74(4):795-800. doi: 10.1210/jcem.74.4.1548343. PMID: 1548343
Stereotactic treatment of brain lesions. Biopsy, interstitial radiotherapy (iridium-192 and iodine-125) and drainage procedures.
Mundinger F, Ostertag CB, Birg W, Weigel K
Appl Neurophysiol 1980;43(3-5):198-204. PMID: 7027939

Therapy

Successful Use of BRAF/MEK Inhibitors as a Neoadjuvant Approach in the Definitive Treatment of Papillary Craniopharyngioma.
Khaddour K, Chicoine MR, Huang J, Dahiya S, Ansstas G
J Natl Compr Canc Netw 2020 Dec;18(12):1590-1595. Epub 2020 Dec 2 doi: 10.6004/jnccn.2020.7624. PMID: 33285519
Phase II study of peginterferon alpha-2b for patients with unresectable or recurrent craniopharyngiomas: a Pediatric Brain Tumor Consortium report.
Goldman S, Pollack IF, Jakacki RI, Billups CA, Poussaint TY, Adesina AM, Panigrahy A, Parsons DW, Broniscer A, Robinson GW, Robison NJ, Partap S, Kilburn LB, Onar-Thomas A, Dunkel IJ, Fouladi M
Neuro Oncol 2020 Nov 26;22(11):1696-1704. doi: 10.1093/neuonc/noaa119. PMID: 32393959Free PMC Article
BRAF-V600E mutant papillary craniopharyngioma dramatically responds to combination BRAF and MEK inhibitors.
Roque A, Odia Y
CNS Oncol 2017 Apr;6(2):95-99. doi: 10.2217/cns-2016-0034. PMID: 28425764Free PMC Article
Stereotactic treatment of brain lesions. Biopsy, interstitial radiotherapy (iridium-192 and iodine-125) and drainage procedures.
Mundinger F, Ostertag CB, Birg W, Weigel K
Appl Neurophysiol 1980;43(3-5):198-204. PMID: 7027939

Prognosis

Phase II study of peginterferon alpha-2b for patients with unresectable or recurrent craniopharyngiomas: a Pediatric Brain Tumor Consortium report.
Goldman S, Pollack IF, Jakacki RI, Billups CA, Poussaint TY, Adesina AM, Panigrahy A, Parsons DW, Broniscer A, Robinson GW, Robison NJ, Partap S, Kilburn LB, Onar-Thomas A, Dunkel IJ, Fouladi M
Neuro Oncol 2020 Nov 26;22(11):1696-1704. doi: 10.1093/neuonc/noaa119. PMID: 32393959Free PMC Article

Clinical prediction guides

Successful Use of BRAF/MEK Inhibitors as a Neoadjuvant Approach in the Definitive Treatment of Papillary Craniopharyngioma.
Khaddour K, Chicoine MR, Huang J, Dahiya S, Ansstas G
J Natl Compr Canc Netw 2020 Dec;18(12):1590-1595. Epub 2020 Dec 2 doi: 10.6004/jnccn.2020.7624. PMID: 33285519
Correlation between magnetic resonance imaging of posterior pituitary and neurohypophyseal function in children with diabetes insipidus.
Maghnie M, Villa A, Arico M, Larizza D, Pezzotta S, Beluffi G, Genovese E, Severi F
J Clin Endocrinol Metab 1992 Apr;74(4):795-800. doi: 10.1210/jcem.74.4.1548343. PMID: 1548343
Steroid receptors in human brain and spinal cord tumors.
Kornblum JA, Bay JW, Gupta MK
Neurosurgery 1988 Aug;23(2):185-8. doi: 10.1227/00006123-198808000-00010. PMID: 3185877

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...