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Optic nerve gray crescent

MedGen UID:
1647792
•Concept ID:
C4703712
•
Finding
Synonyms: Optic nerve grey crescent; Temporal gray pigmentary crescent; Temporal grey pigmentary crescent
 
HPO: HP:0500086

Definition

Having a characteristic appearance of a slate gray area of pigmentation within the disk margins that commonly appears along the inferotemporal or temporal neuroretinal rim areas. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOptic nerve gray crescent

Recent clinical studies

Etiology

Prevalence and factors associated with optic disc grey crescent in the Primary Open-Angle African Ancestry Glaucoma Genetics (POAAGG) Study.
Daniel E, Gao J, Maguire MG, Ying GS, Gudiseva HV, Salowe R, Addis V, Sankar PS, Lee R, Smith EJ, O'Brien J
BMJ Open Ophthalmol 2023 Feb;8(1) doi: 10.1136/bmjophth-2022-001183. PMID: 37278424Free PMC Article
Gray Optic Disc Crescent: Evaluation of Anatomic Correlate by Spectral-Domain OCT.
Davies IJ, Muir KW, Halabis JA, Stinnett SS, Allingham RR, Shields MB
Ophthalmol Glaucoma 2019 Mar-Apr;2(2):120-125. Epub 2018 Nov 17 doi: 10.1016/j.ogla.2018.11.005. PMID: 32672605
Shields Gray Crescents Masquerading as Glaucomatous Cupping of the Optic Nerve Head.
Sayed MS, Margolis M, Chen JL, Gregori G, Lee RK
Ophthalmol Glaucoma 2018 Sep-Oct;1(2):99-107. Epub 2018 Aug 7 doi: 10.1016/j.ogla.2018.08.001. PMID: 32677615Free PMC Article
Compressed 3D and 2D digital images versus standard 3D slide film for the evaluation of glaucomatous optic nerve features.
Sandhu S, Rudnisky C, Arora S, Kassam F, Douglas G, Edwards MC, Verstraten K, Wong B, Damji KF
Br J Ophthalmol 2018 Mar;102(3):364-368. Epub 2017 Aug 23 doi: 10.1136/bjophthalmol-2017-310447. PMID: 28835424
Gray optic disc crescent: influence of ethnicity in a glaucoma population.
Higginbotham L, Shafranov G, Shields MB
J Glaucoma 2007 Sep;16(6):572-6. doi: 10.1097/IJG.0b013e31805342cb. PMID: 17873721

Diagnosis

Gray Optic Disc Crescent: Evaluation of Anatomic Correlate by Spectral-Domain OCT.
Davies IJ, Muir KW, Halabis JA, Stinnett SS, Allingham RR, Shields MB
Ophthalmol Glaucoma 2019 Mar-Apr;2(2):120-125. Epub 2018 Nov 17 doi: 10.1016/j.ogla.2018.11.005. PMID: 32672605
Shields Gray Crescents Masquerading as Glaucomatous Cupping of the Optic Nerve Head.
Sayed MS, Margolis M, Chen JL, Gregori G, Lee RK
Ophthalmol Glaucoma 2018 Sep-Oct;1(2):99-107. Epub 2018 Aug 7 doi: 10.1016/j.ogla.2018.08.001. PMID: 32677615Free PMC Article
Anatomical Features of Gray Crescent.
Torres LA, Sharpe GP, Vianna JR, Nicolela MT, Chauhan BC
JAMA Ophthalmol 2018 Dec 1;136(12):1419-1420. doi: 10.1001/jamaophthalmol.2018.3403. PMID: 30193362
Optic Nerve Gray Crescent.
Roddy GW, Brodsky MC, Chen JJ
Ophthalmology 2017 Jul;124(7):1022. doi: 10.1016/j.ophtha.2016.12.037. PMID: 28645338
Optic nerve gray crescent can confound neuroretinal rim interpretation: review of the literature.
Arora S, Rayat J, Damji KF
Can J Ophthalmol 2014 Jun;49(3):238-42. doi: 10.1016/j.jcjo.2014.02.004. PMID: 24862768

Therapy

Compressed 3D and 2D digital images versus standard 3D slide film for the evaluation of glaucomatous optic nerve features.
Sandhu S, Rudnisky C, Arora S, Kassam F, Douglas G, Edwards MC, Verstraten K, Wong B, Damji KF
Br J Ophthalmol 2018 Mar;102(3):364-368. Epub 2017 Aug 23 doi: 10.1136/bjophthalmol-2017-310447. PMID: 28835424
Epidemiology of the optic nerve grey crescent in the Reykjavik Eye Study.
Jonsson O, Damji KF, Jonasson F, Arnarsson A, Eysteinsson T, Sasaki H, Sasaki K
Br J Ophthalmol 2005 Jan;89(1):36-9. doi: 10.1136/bjo.2004.044305. PMID: 15615743Free PMC Article

Prognosis

Shields Gray Crescents Masquerading as Glaucomatous Cupping of the Optic Nerve Head.
Sayed MS, Margolis M, Chen JL, Gregori G, Lee RK
Ophthalmol Glaucoma 2018 Sep-Oct;1(2):99-107. Epub 2018 Aug 7 doi: 10.1016/j.ogla.2018.08.001. PMID: 32677615Free PMC Article

Clinical prediction guides

Gray Optic Disc Crescent: Evaluation of Anatomic Correlate by Spectral-Domain OCT.
Davies IJ, Muir KW, Halabis JA, Stinnett SS, Allingham RR, Shields MB
Ophthalmol Glaucoma 2019 Mar-Apr;2(2):120-125. Epub 2018 Nov 17 doi: 10.1016/j.ogla.2018.11.005. PMID: 32672605
Optic disc morphology of patients with OPA1 autosomal dominant optic atrophy.
Votruba M, Thiselton D, Bhattacharya SS
Br J Ophthalmol 2003 Jan;87(1):48-53. doi: 10.1136/bjo.87.1.48. PMID: 12488262Free PMC Article
Disc excavation in dominant optic atrophy: differentiation from normal tension glaucoma.
Fournier AV, Damji KF, Epstein DL, Pollock SC
Ophthalmology 2001 Sep;108(9):1595-602. doi: 10.1016/s0161-6420(01)00696-0. PMID: 11535456

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