U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Metastatic Thyroid Gland Papillary Carcinoma

MedGen UID:
1650014
•Concept ID:
C4744568
•
Neoplastic Process

Definition

A papillary carcinoma that arises from the thyroid gland and has metastasized to another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Thyroid Gland Papillary Carcinoma

Professional guidelines

PubMed

Molecular Alterations and Comprehensive Clinical Management of Oncocytic Thyroid Carcinoma: A Review and Multidisciplinary 2023 Update.
Bischoff LA, Ganly I, Fugazzola L, Buczek E, Faquin WC, Haugen BR, McIver B, McMullen CP, Newbold K, Rocke DJ, Russell MD, Ryder M, Sadow PM, Sherman E, Shindo M, Shonka DC Jr, Singer MC, Stack BC Jr, Wirth LJ, Wong RJ, Randolph GW
JAMA Otolaryngol Head Neck Surg 2024 Mar 1;150(3):265-272. doi: 10.1001/jamaoto.2023.4323. PMID: 38206595
American Thyroid Association Guidelines and National Trends in Management of Papillary Thyroid Carcinoma.
Gordon AJ, Dublin JC, Patel E, Papazian M, Chow MS, Persky MJ, Jacobson AS, Patel KN, Suh I, Morris LGT, Givi B
JAMA Otolaryngol Head Neck Surg 2022 Dec 1;148(12):1156-1163. doi: 10.1001/jamaoto.2022.3360. PMID: 36326739Free PMC Article
Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer.
American Thyroid Association (ATA) Guidelines Taskforce on Thyroid Nodules and Differentiated Thyroid Cancer, Cooper DS, Doherty GM, Haugen BR, Kloos RT, Lee SL, Mandel SJ, Mazzaferri EL, McIver B, Pacini F, Schlumberger M, Sherman SI, Steward DL, Tuttle RM
Thyroid 2009 Nov;19(11):1167-214. doi: 10.1089/thy.2009.0110. PMID: 19860577

Recent clinical studies

Etiology

Aggressive Subtypes of Papillary Thyroid Carcinoma Smaller Than 1 cm.
Lee JS, Lee JS, Yun HJ, Kim SM, Chang H, Lee YS, Chang HS, Park CS
J Clin Endocrinol Metab 2023 May 17;108(6):1370-1375. doi: 10.1210/clinem/dgac739. PMID: 36546348Free PMC Article
Comparison of Lobectomy vs Total Thyroidectomy for Intermediate-Risk Papillary Thyroid Carcinoma With Lymph Node Metastasis.
Xu S, Huang H, Huang Y, Qian J, Wang X, Xu Z, Liu S, Liu J
JAMA Surg 2023 Jan 1;158(1):73-79. doi: 10.1001/jamasurg.2022.5781. PMID: 36449303Free PMC Article
American Thyroid Association Guidelines and National Trends in Management of Papillary Thyroid Carcinoma.
Gordon AJ, Dublin JC, Patel E, Papazian M, Chow MS, Persky MJ, Jacobson AS, Patel KN, Suh I, Morris LGT, Givi B
JAMA Otolaryngol Head Neck Surg 2022 Dec 1;148(12):1156-1163. doi: 10.1001/jamaoto.2022.3360. PMID: 36326739Free PMC Article
Risk Factors for Lymph Node Metastasis in Papillary Thyroid Carcinoma: A Systematic Review and Meta-Analysis.
Mao J, Zhang Q, Zhang H, Zheng K, Wang R, Wang G
Front Endocrinol (Lausanne) 2020;11:265. Epub 2020 May 15 doi: 10.3389/fendo.2020.00265. PMID: 32477264Free PMC Article
Update on Fundamental Mechanisms of Thyroid Cancer.
Prete A, Borges de Souza P, Censi S, Muzza M, Nucci N, Sponziello M
Front Endocrinol (Lausanne) 2020;11:102. Epub 2020 Mar 13 doi: 10.3389/fendo.2020.00102. PMID: 32231639Free PMC Article

Diagnosis

Pathomics and single-cell analysis of papillary thyroid carcinoma reveal the pro-metastatic influence of cancer-associated fibroblasts.
Wang Y, Li X, Gang Q, Huang Y, Liu M, Zhang H, Shen S, Qi Y, Zhang J
BMC Cancer 2024 Jun 10;24(1):710. doi: 10.1186/s12885-024-12459-4. PMID: 38858612Free PMC Article
American Thyroid Association Guidelines and National Trends in Management of Papillary Thyroid Carcinoma.
Gordon AJ, Dublin JC, Patel E, Papazian M, Chow MS, Persky MJ, Jacobson AS, Patel KN, Suh I, Morris LGT, Givi B
JAMA Otolaryngol Head Neck Surg 2022 Dec 1;148(12):1156-1163. doi: 10.1001/jamaoto.2022.3360. PMID: 36326739Free PMC Article
Update on Fundamental Mechanisms of Thyroid Cancer.
Prete A, Borges de Souza P, Censi S, Muzza M, Nucci N, Sponziello M
Front Endocrinol (Lausanne) 2020;11:102. Epub 2020 Mar 13 doi: 10.3389/fendo.2020.00102. PMID: 32231639Free PMC Article
Unusual cutaneous metastatic carcinoma.
Ruiz SJ, Al Salihi S, Prieto VG, Nagarajan P, Tetzlaff MT, Curry JL, Ivan D, Torres-Cabala CA, Aung PP
Ann Diagn Pathol 2019 Dec;43:151399. Epub 2019 Aug 12 doi: 10.1016/j.anndiagpath.2019.08.003. PMID: 31675677
Papillary thyroid carcinoma of the isthmus: Total thyroidectomy or isthmusectomy?
Vasileiadis I, Boutzios G, Karalaki M, Misiakos E, Karatzas T
Am J Surg 2018 Jul;216(1):135-139. Epub 2017 Sep 19 doi: 10.1016/j.amjsurg.2017.09.008. PMID: 28954712

Therapy

Comparison of Lobectomy vs Total Thyroidectomy for Intermediate-Risk Papillary Thyroid Carcinoma With Lymph Node Metastasis.
Xu S, Huang H, Huang Y, Qian J, Wang X, Xu Z, Liu S, Liu J
JAMA Surg 2023 Jan 1;158(1):73-79. doi: 10.1001/jamasurg.2022.5781. PMID: 36449303Free PMC Article
American Thyroid Association Guidelines and National Trends in Management of Papillary Thyroid Carcinoma.
Gordon AJ, Dublin JC, Patel E, Papazian M, Chow MS, Persky MJ, Jacobson AS, Patel KN, Suh I, Morris LGT, Givi B
JAMA Otolaryngol Head Neck Surg 2022 Dec 1;148(12):1156-1163. doi: 10.1001/jamaoto.2022.3360. PMID: 36326739Free PMC Article
Efficacy and safety of larotrectinib in patients with TRK fusion-positive thyroid carcinoma.
Waguespack SG, Drilon A, Lin JJ, Brose MS, McDermott R, Almubarak M, Bauman J, Casanova M, Krishnamurthy A, Kummar S, Leyvraz S, Oh DY, Park K, Sohal D, Sherman E, Norenberg R, Silvertown JD, Brega N, Hong DS, Cabanillas ME
Eur J Endocrinol 2022 Apr 29;186(6):631-643. doi: 10.1530/EJE-21-1259. PMID: 35333737Free PMC Article
Pralsetinib: First Approval.
Markham A
Drugs 2020 Nov;80(17):1865-1870. doi: 10.1007/s40265-020-01427-4. PMID: 33136236
Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer.
American Thyroid Association (ATA) Guidelines Taskforce on Thyroid Nodules and Differentiated Thyroid Cancer, Cooper DS, Doherty GM, Haugen BR, Kloos RT, Lee SL, Mandel SJ, Mazzaferri EL, McIver B, Pacini F, Schlumberger M, Sherman SI, Steward DL, Tuttle RM
Thyroid 2009 Nov;19(11):1167-214. doi: 10.1089/thy.2009.0110. PMID: 19860577

Prognosis

Papillary Thyroid Carcinoma With Breast and Bone Metastasis.
Zhang D, Zhu XL, Jiang J
Ear Nose Throat J 2023 Apr;102(4):259-262. Epub 2022 Dec 7 doi: 10.1177/01455613221145273. PMID: 36476071
Comparison of Lobectomy vs Total Thyroidectomy for Intermediate-Risk Papillary Thyroid Carcinoma With Lymph Node Metastasis.
Xu S, Huang H, Huang Y, Qian J, Wang X, Xu Z, Liu S, Liu J
JAMA Surg 2023 Jan 1;158(1):73-79. doi: 10.1001/jamasurg.2022.5781. PMID: 36449303Free PMC Article
Radioactive Iodine for Papillary Thyroid Carcinoma.
Chan WWL, Kwong DLW
Methods Mol Biol 2022;2534:225-241. doi: 10.1007/978-1-0716-2505-7_16. PMID: 35670979
Risk Factors for Lymph Node Metastasis in Papillary Thyroid Carcinoma: A Systematic Review and Meta-Analysis.
Mao J, Zhang Q, Zhang H, Zheng K, Wang R, Wang G
Front Endocrinol (Lausanne) 2020;11:265. Epub 2020 May 15 doi: 10.3389/fendo.2020.00265. PMID: 32477264Free PMC Article
Update on Fundamental Mechanisms of Thyroid Cancer.
Prete A, Borges de Souza P, Censi S, Muzza M, Nucci N, Sponziello M
Front Endocrinol (Lausanne) 2020;11:102. Epub 2020 Mar 13 doi: 10.3389/fendo.2020.00102. PMID: 32231639Free PMC Article

Clinical prediction guides

A Misleading Case of NTRK-Rearranged Papillary Thyroid Carcinoma.
Germani MM, Boccaccio C, Matrone A, Molinaro E, Alì G, Giordano M, Elisei R, Fontanini G, Cremolini C
Oncologist 2024 Jan 5;29(1):84-88. doi: 10.1093/oncolo/oyad310. PMID: 38037189Free PMC Article
Aggressive Subtypes of Papillary Thyroid Carcinoma Smaller Than 1 cm.
Lee JS, Lee JS, Yun HJ, Kim SM, Chang H, Lee YS, Chang HS, Park CS
J Clin Endocrinol Metab 2023 May 17;108(6):1370-1375. doi: 10.1210/clinem/dgac739. PMID: 36546348Free PMC Article
Comparison of Lobectomy vs Total Thyroidectomy for Intermediate-Risk Papillary Thyroid Carcinoma With Lymph Node Metastasis.
Xu S, Huang H, Huang Y, Qian J, Wang X, Xu Z, Liu S, Liu J
JAMA Surg 2023 Jan 1;158(1):73-79. doi: 10.1001/jamasurg.2022.5781. PMID: 36449303Free PMC Article
American Thyroid Association Guidelines and National Trends in Management of Papillary Thyroid Carcinoma.
Gordon AJ, Dublin JC, Patel E, Papazian M, Chow MS, Persky MJ, Jacobson AS, Patel KN, Suh I, Morris LGT, Givi B
JAMA Otolaryngol Head Neck Surg 2022 Dec 1;148(12):1156-1163. doi: 10.1001/jamaoto.2022.3360. PMID: 36326739Free PMC Article
Risk Factors for Lymph Node Metastasis in Papillary Thyroid Carcinoma: A Systematic Review and Meta-Analysis.
Mao J, Zhang Q, Zhang H, Zheng K, Wang R, Wang G
Front Endocrinol (Lausanne) 2020;11:265. Epub 2020 May 15 doi: 10.3389/fendo.2020.00265. PMID: 32477264Free PMC Article

Recent systematic reviews

Tyrosine kinase inhibitors for radioiodine refractory differentiated thyroid cancer: A systematic review and meta-analysis.
Yu J, Liu Z, Su Y, Peng X, Xie Y
Clin Endocrinol (Oxf) 2024 Apr;100(4):379-388. Epub 2024 Feb 13 doi: 10.1111/cen.15027. PMID: 38351437
Prevalence of Occult Central Lymph Node Metastasis by Tumor Size in Papillary Thyroid Carcinoma: A Systematic Review and Meta-Analysis.
Tang L, Qu RW, Park J, Simental AA, Inman JC
Curr Oncol 2023 Aug 2;30(8):7335-7350. doi: 10.3390/curroncol30080532. PMID: 37623013Free PMC Article
Assessment of Radiofrequency Ablation for Papillary Microcarcinoma of the Thyroid: A Systematic Review and Meta-analysis.
van Dijk SPJ, Coerts HI, Gunput STG, van Velsen EFS, Medici M, Moelker A, Peeters RP, Verhoef C, van Ginhoven TM
JAMA Otolaryngol Head Neck Surg 2022 Apr 1;148(4):317-325. doi: 10.1001/jamaoto.2021.4381. PMID: 35142816Free PMC Article
Risk Factors for Lymph Node Metastasis in Papillary Thyroid Carcinoma: A Systematic Review and Meta-Analysis.
Mao J, Zhang Q, Zhang H, Zheng K, Wang R, Wang G
Front Endocrinol (Lausanne) 2020;11:265. Epub 2020 May 15 doi: 10.3389/fendo.2020.00265. PMID: 32477264Free PMC Article
Sorafenib in metastatic thyroid cancer: a systematic review.
Thomas L, Lai SY, Dong W, Feng L, Dadu R, Regone RM, Cabanillas ME
Oncologist 2014 Mar;19(3):251-8. Epub 2014 Feb 21 doi: 10.1634/theoncologist.2013-0362. PMID: 24563075Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...