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Advanced Small Intestinal Neuroendocrine Carcinoma

MedGen UID:
1651574
•Concept ID:
C4744988
•
Neoplastic Process

Definition

A small intestinal neuroendocrine carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdvanced Small Intestinal Neuroendocrine Carcinoma

Professional guidelines

PubMed

High-Grade Gastrointestinal Neuroendocrine Carcinoma Management and Outcomes: A National Cancer Database Study.
Alese OB, Jiang R, Shaib W, Wu C, Akce M, Behera M, El-Rayes BF
Oncologist 2019 Jul;24(7):911-920. Epub 2018 Nov 27 doi: 10.1634/theoncologist.2018-0382. PMID: 30482824Free PMC Article
Heterogeneity of grade 3 gastroenteropancreatic neuroendocrine carcinomas: New insights and treatment implications.
Fazio N, Milione M
Cancer Treat Rev 2016 Nov;50:61-67. Epub 2016 Aug 28 doi: 10.1016/j.ctrv.2016.08.006. PMID: 27636009

Recent clinical studies

Etiology

Site-specific trends in gastroenteropancreatic neuroendocrine neoplasms in Bavaria, Germany.
Grundmann N, Voigtländer S, Hakimhashemi A, Pape UF, Meyer M, Müller-Nordhorn J
Cancer Med 2023 Oct;12(19):19949-19958. Epub 2023 Sep 22 doi: 10.1002/cam4.6510. PMID: 37737059Free PMC Article
Primary small-cell neuroendocrine carcinoma of the bladder: Case report and literature review.
Olivieri V, Fortunati V, Bellei L, Massarelli M, Ruggiero G, Abate D, Serra N, Griffa D, Forte F, Corongiu E
Arch Ital Urol Androl 2020 Oct 2;92(3) doi: 10.4081/aiua.2020.3.211. PMID: 33016048
High-Grade Gastrointestinal Neuroendocrine Carcinoma Management and Outcomes: A National Cancer Database Study.
Alese OB, Jiang R, Shaib W, Wu C, Akce M, Behera M, El-Rayes BF
Oncologist 2019 Jul;24(7):911-920. Epub 2018 Nov 27 doi: 10.1634/theoncologist.2018-0382. PMID: 30482824Free PMC Article
Peritoneal carcinomatosis from small intestinal neuroendocrine tumors: Clinical course and genetic profiling.
Norlén O, Edfeldt K, Akerstrom G, Westin G, Hellman P, Bjorklund P, Stalberg P
Surgery 2014 Dec;156(6):1512-21; discussion 1521-2. Epub 2014 Nov 11 doi: 10.1016/j.surg.2014.08.090. PMID: 25456945
Pediatric intestinal foregut and small bowel solid tumors: a review of 105 cases.
Zhuge Y, Cheung MC, Yang R, Eldick D, Koniaris LG, Sola JE
J Surg Res 2009 Sep;156(1):95-102. Epub 2009 May 3 doi: 10.1016/j.jss.2009.03.054. PMID: 19560163

Diagnosis

Management and outcomes of mixed adenoneuroendocrine carcinoma of the ampulla of Vater: A systematic review and pooled analysis of 56 patients.
Ziogas IA, Rallis KS, Tasoudis PT, Moris D, Schulick RD, Del Chiaro M
Eur J Surg Oncol 2023 Apr;49(4):682-687. Epub 2023 Jan 9 doi: 10.1016/j.ejso.2023.01.005. PMID: 36646615
Primary small-cell neuroendocrine carcinoma of the bladder: Case report and literature review.
Olivieri V, Fortunati V, Bellei L, Massarelli M, Ruggiero G, Abate D, Serra N, Griffa D, Forte F, Corongiu E
Arch Ital Urol Androl 2020 Oct 2;92(3) doi: 10.4081/aiua.2020.3.211. PMID: 33016048
Surgical Principles in the Management of Small Bowel Neuroendocrine Tumors.
Gangi A, Anaya DA
Curr Treat Options Oncol 2020 Aug 29;21(11):88. doi: 10.1007/s11864-020-00784-2. PMID: 32862334
Mixed adenoneuroendocrine carcinoma of the ampulla of Vater: a case report and literature review.
Yoshimachi S, Ohtsuka H, Aoki T, Miura T, Ariake K, Masuda K, Ishida M, Mizuma M, Hayashi H, Nakagawa K, Morikawa T, Motoi F, Kanno A, Masamune A, Fujishima F, Sasano H, Kamei T, Naitoh T, Unno M
Clin J Gastroenterol 2020 Feb;13(1):37-45. Epub 2019 Jul 24 doi: 10.1007/s12328-019-01009-2. PMID: 31342462
Primary Biliary Mixed Adenoneuroendocrine Carcinoma (MANEC): A Short Review.
Acosta AM, Wiley EL
Arch Pathol Lab Med 2016 Oct;140(10):1157-62. doi: 10.5858/arpa.2015-0102-RS. PMID: 27684986

Therapy

Surgical Principles in the Management of Small Bowel Neuroendocrine Tumors.
Gangi A, Anaya DA
Curr Treat Options Oncol 2020 Aug 29;21(11):88. doi: 10.1007/s11864-020-00784-2. PMID: 32862334
Heterogeneity of grade 3 gastroenteropancreatic neuroendocrine carcinomas: New insights and treatment implications.
Fazio N, Milione M
Cancer Treat Rev 2016 Nov;50:61-67. Epub 2016 Aug 28 doi: 10.1016/j.ctrv.2016.08.006. PMID: 27636009
Organ recipients suffering from undifferentiated neuroendocrine small-cell carcinoma of donor origin: a case report.
Foltys D, Linkermann A, Heumann A, Hoppe-Lotichius M, Heise M, Schad A, Schneider J, Bender K, Schmid M, Mauer D, Peixoto N, Otto G
Transplant Proc 2009 Jul-Aug;41(6):2639-42. doi: 10.1016/j.transproceed.2009.06.026. PMID: 19715991
Caecal metastasis from a primary small-cell lung carcinoma.
Lau CP, Leung WK
Hong Kong Med J 2008 Apr;14(2):152-3. PMID: 18382025
Neuroendocrine carcinoma of the stomach with peripancreatic lymph node metastases successfully treated with pancreaticoduodenectomy.
Ma J, Kimura W, Takeshita A, Hirai I, Moriya T, Mizutani M
Hepatogastroenterology 2007 Oct-Nov;54(79):1945-50. PMID: 18251134

Prognosis

Primary small-cell neuroendocrine carcinoma of the bladder: Case report and literature review.
Olivieri V, Fortunati V, Bellei L, Massarelli M, Ruggiero G, Abate D, Serra N, Griffa D, Forte F, Corongiu E
Arch Ital Urol Androl 2020 Oct 2;92(3) doi: 10.4081/aiua.2020.3.211. PMID: 33016048
High-Grade Gastrointestinal Neuroendocrine Carcinoma Management and Outcomes: A National Cancer Database Study.
Alese OB, Jiang R, Shaib W, Wu C, Akce M, Behera M, El-Rayes BF
Oncologist 2019 Jul;24(7):911-920. Epub 2018 Nov 27 doi: 10.1634/theoncologist.2018-0382. PMID: 30482824Free PMC Article
Primary Biliary Mixed Adenoneuroendocrine Carcinoma (MANEC): A Short Review.
Acosta AM, Wiley EL
Arch Pathol Lab Med 2016 Oct;140(10):1157-62. doi: 10.5858/arpa.2015-0102-RS. PMID: 27684986
Heterogeneity of grade 3 gastroenteropancreatic neuroendocrine carcinomas: New insights and treatment implications.
Fazio N, Milione M
Cancer Treat Rev 2016 Nov;50:61-67. Epub 2016 Aug 28 doi: 10.1016/j.ctrv.2016.08.006. PMID: 27636009
Peritoneal carcinomatosis from small intestinal neuroendocrine tumors: Clinical course and genetic profiling.
Norlén O, Edfeldt K, Akerstrom G, Westin G, Hellman P, Bjorklund P, Stalberg P
Surgery 2014 Dec;156(6):1512-21; discussion 1521-2. Epub 2014 Nov 11 doi: 10.1016/j.surg.2014.08.090. PMID: 25456945

Clinical prediction guides

Pediatric intestinal foregut and small bowel solid tumors: a review of 105 cases.
Zhuge Y, Cheung MC, Yang R, Eldick D, Koniaris LG, Sola JE
J Surg Res 2009 Sep;156(1):95-102. Epub 2009 May 3 doi: 10.1016/j.jss.2009.03.054. PMID: 19560163
How age changes the content of neuroendocrine peptides in the murine gastrointestinal tract.
El-Salhy M, Sandström O
Gerontology 1999 Jan-Feb;45(1):17-22. doi: 10.1159/000022050. PMID: 9852376

Recent systematic reviews

Management and outcomes of mixed adenoneuroendocrine carcinoma of the ampulla of Vater: A systematic review and pooled analysis of 56 patients.
Ziogas IA, Rallis KS, Tasoudis PT, Moris D, Schulick RD, Del Chiaro M
Eur J Surg Oncol 2023 Apr;49(4):682-687. Epub 2023 Jan 9 doi: 10.1016/j.ejso.2023.01.005. PMID: 36646615

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