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Metastatic neoplasm

MedGen UID:
422476
•Concept ID:
C2939420
•
Neoplastic Process
Synonyms: metastatic disease; Metastatic Neoplasm; metastatic neoplasm; Metastatic Tumor; metastatic tumor; metastatic tumour; Neoplasm, metastatic; Neoplasm, secondary; Tumor, metastatic; Tumor, secondary
SNOMED CT: Neoplasm, metastatic (14799000); Tumor, metastatic (14799000); Neoplasm, secondary (14799000); Tumor, secondary (14799000)
 
Monarch Initiative: MONDO:0024883

Definition

A tumor that has spread from its original (primary) site of growth to another site, close to or distant from the primary site. Metastasis is characteristic of advanced malignancies, but in rare instances can be seen in neoplasms lacking malignant morphology. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic neoplasm

Professional guidelines

PubMed

Histopathologic diagnosis of brain metastases: current trends in management and future considerations.
Bekaert L, Emery E, Levallet G, Lechapt-Zalcman E
Brain Tumor Pathol 2017 Jan;34(1):8-19. Epub 2016 Nov 22 doi: 10.1007/s10014-016-0275-3. PMID: 27878432
Emergence of CA125 immunoreactivity in recurrent or metastatic primary ovarian mucinous neoplasms of the intestinal type.
Miller K, Millar J, McCluggage WG
Am J Surg Pathol 2011 Sep;35(9):1331-6. doi: 10.1097/PAS.0b013e3182233fce. PMID: 21836488
The impact of a comprehensive evaluation in the management of cancer pain.
Gonzales GR, Elliott KJ, Portenoy RK, Foley KM
Pain 1991 Nov;47(2):141-144. doi: 10.1016/0304-3959(91)90197-6. PMID: 1762807

Recent clinical studies

Etiology

Renal resistive index as a predictor of postoperative complications in liver resection surgery. Observational study.
Giustiniano E, Procopio F, Morenghi E, Gollo Y, Rocchi L, Ruggieri N, Lascari V, Torzilli G, Cecconi M
J Clin Monit Comput 2021 Aug;35(4):731-740. Epub 2020 May 20 doi: 10.1007/s10877-020-00529-4. PMID: 32430788
Thrombolysis for ischemic stroke in patients with brain tumors.
Etgen T, Steinich I, Gsottschneider L
J Stroke Cerebrovasc Dis 2014 Feb;23(2):361-6. Epub 2013 Jun 12 doi: 10.1016/j.jstrokecerebrovasdis.2013.05.004. PMID: 23763899
Pulmonary parenchymal splenosis.
Sarda R, Sproat I, Kurtycz DF, Hafez R
Diagn Cytopathol 2001 May;24(5):352-5. doi: 10.1002/dc.1076. PMID: 11335968
Tuberculosis of the ribs: CT appearance.
Lee G, Im JG, Kim JS, Kang HS, Han MC
J Comput Assist Tomogr 1993 May-Jun;17(3):363-6. doi: 10.1097/00004728-199305000-00004. PMID: 8491894
Spinal cord compression due to metastatic neoplasm.
Tabbara IA, Sibley DS, Quesenberry PJ
South Med J 1990 May;83(5):519-23. doi: 10.1097/00007611-199005000-00010. PMID: 2343331

Diagnosis

Single-Cell Transcriptomic Analysis Identifies a Unique Pulmonary Lymphangioleiomyomatosis Cell.
Guo M, Yu JJ, Perl AK, Wikenheiser-Brokamp KA, Riccetti M, Zhang EY, Sudha P, Adam M, Potter A, Kopras EJ, Giannikou K, Potter SS, Sherman S, Hammes SR, Kwiatkowski DJ, Whitsett JA, McCormack FX, Xu Y
Am J Respir Crit Care Med 2020 Nov 15;202(10):1373-1387. doi: 10.1164/rccm.201912-2445OC. PMID: 32603599Free PMC Article
Thrombolysis for ischemic stroke in patients with brain tumors.
Etgen T, Steinich I, Gsottschneider L
J Stroke Cerebrovasc Dis 2014 Feb;23(2):361-6. Epub 2013 Jun 12 doi: 10.1016/j.jstrokecerebrovasdis.2013.05.004. PMID: 23763899
Pulmonary parenchymal splenosis.
Sarda R, Sproat I, Kurtycz DF, Hafez R
Diagn Cytopathol 2001 May;24(5):352-5. doi: 10.1002/dc.1076. PMID: 11335968
The pathology of benign and malignant pleural disease.
Hammar SP
Chest Surg Clin N Am 1994 Aug;4(3):405-30. PMID: 7953476
Immunohistochemical markers for prostatic cancer.
Nadji M, Morales AR
Ann N Y Acad Sci 1983;420:134-9. doi: 10.1111/j.1749-6632.1983.tb22197.x. PMID: 6586093

Therapy

Renal resistive index as a predictor of postoperative complications in liver resection surgery. Observational study.
Giustiniano E, Procopio F, Morenghi E, Gollo Y, Rocchi L, Ruggieri N, Lascari V, Torzilli G, Cecconi M
J Clin Monit Comput 2021 Aug;35(4):731-740. Epub 2020 May 20 doi: 10.1007/s10877-020-00529-4. PMID: 32430788
Thrombolysis for ischemic stroke in patients with brain tumors.
Etgen T, Steinich I, Gsottschneider L
J Stroke Cerebrovasc Dis 2014 Feb;23(2):361-6. Epub 2013 Jun 12 doi: 10.1016/j.jstrokecerebrovasdis.2013.05.004. PMID: 23763899
Chickenpox-related pulmonary granulomas in immunocompetent adults: clinicopathologic and molecular features of an underrated occurrence.
Rossi G, Cavazza A, Gennari W, Marchioni A, Graziano P, Caminati A, Mengoli MC, Magnani R, Colby TV
Am J Surg Pathol 2012 Oct;36(10):1497-502. doi: 10.1097/PAS.0b013e31825fa4d8. PMID: 22982893
Research trends in the treatment of neoplasms of the exocrine pancreas.
Cellini N, Morganti AG, Luzi S, Macchia G, Smaniotto D, Trodella L
Rays 2000 Jul-Sep;25(3):375-7. PMID: 11367905
Primary sternal osteomyelitis.
Skoutelis AT, Dougenis D, Gogos CA, Bassaris HP
Eur J Cardiothorac Surg 1993;7(9):501-2. doi: 10.1016/1010-7940(93)90283-h. PMID: 8217231

Prognosis

Renal resistive index as a predictor of postoperative complications in liver resection surgery. Observational study.
Giustiniano E, Procopio F, Morenghi E, Gollo Y, Rocchi L, Ruggieri N, Lascari V, Torzilli G, Cecconi M
J Clin Monit Comput 2021 Aug;35(4):731-740. Epub 2020 May 20 doi: 10.1007/s10877-020-00529-4. PMID: 32430788
Single-Cell Transcriptomic Analysis Identifies a Unique Pulmonary Lymphangioleiomyomatosis Cell.
Guo M, Yu JJ, Perl AK, Wikenheiser-Brokamp KA, Riccetti M, Zhang EY, Sudha P, Adam M, Potter A, Kopras EJ, Giannikou K, Potter SS, Sherman S, Hammes SR, Kwiatkowski DJ, Whitsett JA, McCormack FX, Xu Y
Am J Respir Crit Care Med 2020 Nov 15;202(10):1373-1387. doi: 10.1164/rccm.201912-2445OC. PMID: 32603599Free PMC Article
Role of photodynamic therapy in unresectable esophageal and lung cancer.
Chen M, Pennathur A, Luketich JD
Lasers Surg Med 2006 Jun;38(5):396-402. doi: 10.1002/lsm.20364. PMID: 16788924
Metastatic choriocarcinoma to the pancreas.
Alvarez NR, Lambrou N, Solorzano CC
Am Surg 2005 Apr;71(4):330-2. PMID: 15943408
Alfa-antitrypsin increase in lung cancer.
Daddi G, Mancini PA, Parola D, Contini A
Boll Ist Sieroter Milan 1976;55(6):510-2. PMID: 1088073

Clinical prediction guides

Renal resistive index as a predictor of postoperative complications in liver resection surgery. Observational study.
Giustiniano E, Procopio F, Morenghi E, Gollo Y, Rocchi L, Ruggieri N, Lascari V, Torzilli G, Cecconi M
J Clin Monit Comput 2021 Aug;35(4):731-740. Epub 2020 May 20 doi: 10.1007/s10877-020-00529-4. PMID: 32430788
Single-Cell Transcriptomic Analysis Identifies a Unique Pulmonary Lymphangioleiomyomatosis Cell.
Guo M, Yu JJ, Perl AK, Wikenheiser-Brokamp KA, Riccetti M, Zhang EY, Sudha P, Adam M, Potter A, Kopras EJ, Giannikou K, Potter SS, Sherman S, Hammes SR, Kwiatkowski DJ, Whitsett JA, McCormack FX, Xu Y
Am J Respir Crit Care Med 2020 Nov 15;202(10):1373-1387. doi: 10.1164/rccm.201912-2445OC. PMID: 32603599Free PMC Article
PET/CT analysis of 21 patients with breast cancer: physiological distribution of (18)F-choline and diagnostic pitfalls.
Ahmad Saad FF, Zakaria MH, Appanna B
J Int Med Res 2018 Aug;46(8):3138-3148. Epub 2018 May 20 doi: 10.1177/0300060518773019. PMID: 29781364Free PMC Article
Characteristic histologic triad in liver adjacent to metastatic neoplasm.
Gerber MA, Thung SN, Bodenheimer HC Jr, Kapelman B, Schaffner F
Liver 1986 Apr;6(2):85-8. doi: 10.1111/j.1600-0676.1986.tb00273.x. PMID: 3736355
Clinical decision making with transbronchial lung biopsies. The value of nonspecific histologic examination.
Haponik EF, Summer WR, Terry PB, Wang KP
Am Rev Respir Dis 1982 May;125(5):524-9. doi: 10.1164/arrd.1982.125.5.524. PMID: 7081811

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