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Metastatic neoplasm

MedGen UID:
422476
•Concept ID:
C2939420
•
Neoplastic Process
Synonyms: metastatic disease; Metastatic Neoplasm; metastatic neoplasm; Metastatic Tumor; metastatic tumor; Neoplasm, metastatic; Neoplasm, secondary; Tumor, metastatic; Tumor, secondary
SNOMED CT: Neoplasm, metastatic (14799000); Tumor, metastatic (14799000); Neoplasm, secondary (14799000); Tumor, secondary (14799000)
 
Monarch Initiative: MONDO:0024883

Definition

A tumor that has spread from its original (primary) site of growth to another site, close to or distant from the primary site. Metastasis is characteristic of advanced malignancies, but in rare instances can be seen in neoplasms lacking malignant morphology. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic neoplasm

Professional guidelines

PubMed

Histopathologic diagnosis of brain metastases: current trends in management and future considerations.
Bekaert L, Emery E, Levallet G, Lechapt-Zalcman E
Brain Tumor Pathol 2017 Jan;34(1):8-19. Epub 2016 Nov 22 doi: 10.1007/s10014-016-0275-3. PMID: 27878432
Emergence of CA125 immunoreactivity in recurrent or metastatic primary ovarian mucinous neoplasms of the intestinal type.
Miller K, Millar J, McCluggage WG
Am J Surg Pathol 2011 Sep;35(9):1331-6. doi: 10.1097/PAS.0b013e3182233fce. PMID: 21836488
The impact of a comprehensive evaluation in the management of cancer pain.
Gonzales GR, Elliott KJ, Portenoy RK, Foley KM
Pain 1991 Nov;47(2):141-144. doi: 10.1016/0304-3959(91)90197-6. PMID: 1762807

Recent clinical studies

Etiology

The Utility of Myoepithelial Cell Layer Identification in Adnexal Carcinomas.
Plaza JA, Chung C, Wick M, Sangueza M, Gru A
Am J Dermatopathol 2022 Mar 1;44(3):155-162. doi: 10.1097/DAD.0000000000001844. PMID: 35171883
Coping strategies and depressive symptoms in cancer patients.
Ghanem I, Castelo B, Jimenez-Fonseca P, Carmona-Bayonas A, Higuera O, Beato C, García T, Hernández R, Calderon C
Clin Transl Oncol 2020 Mar;22(3):330-336. Epub 2019 May 10 doi: 10.1007/s12094-019-02123-w. PMID: 31077086
Histology as Prognostic Factor in Early-Stage Cervical Carcinoma. Experience in a Third-Level Institution.
Barquet-Muñoz SA, Cruz-Rodríguez E, Cantú De León DF, Isla-Ortiz D, Montalvo-Esquivel G, Herrera-Montalvo LA, Pérez-Plasencia C, Pérez-Montiel D, Herrera-Gómez Á
Rev Invest Clin 2017 Sep-Oct;69(5):286-292. doi: 10.24875/ric.17002143. PMID: 29077701
Diffuse Cystic Lung Diseases: Diagnostic Considerations.
Xu KF, Feng R, Cui H, Tian X, Wang H, Zhao J, Huang H, Zhang W, Lo BH
Semin Respir Crit Care Med 2016 Jun;37(3):457-67. Epub 2016 May 27 doi: 10.1055/s-0036-1580690. PMID: 27231867
Perioperative mortality for management of hepatic neoplasm: a simple risk score.
Simons JP, Hill JS, Ng SC, Shah SA, Zhou Z, Whalen GF, Tseng JF
Ann Surg 2009 Dec;250(6):929-34. doi: 10.1097/SLA.0b013e3181bc9c2f. PMID: 19855257

Diagnosis

Immunocytochemistry for diagnostic cytopathology-A practical guide.
Kanber Y, Pusztaszeri M, Auger M
Cytopathology 2021 Sep;32(5):562-587. Epub 2021 Jun 3 doi: 10.1111/cyt.12993. PMID: 34033162
Single-Cell Transcriptomic Analysis Identifies a Unique Pulmonary Lymphangioleiomyomatosis Cell.
Guo M, Yu JJ, Perl AK, Wikenheiser-Brokamp KA, Riccetti M, Zhang EY, Sudha P, Adam M, Potter A, Kopras EJ, Giannikou K, Potter SS, Sherman S, Hammes SR, Kwiatkowski DJ, Whitsett JA, McCormack FX, Xu Y
Am J Respir Crit Care Med 2020 Nov 15;202(10):1373-1387. doi: 10.1164/rccm.201912-2445OC. PMID: 32603599Free PMC Article
Update on the pathology of liver neoplasms.
Matsukuma KE, Yeh MM
Ann Diagn Pathol 2019 Feb;38:126-137. Epub 2018 Oct 12 doi: 10.1016/j.anndiagpath.2018.10.005. PMID: 30597357
Diffuse Cystic Lung Diseases: Diagnostic Considerations.
Xu KF, Feng R, Cui H, Tian X, Wang H, Zhao J, Huang H, Zhang W, Lo BH
Semin Respir Crit Care Med 2016 Jun;37(3):457-67. Epub 2016 May 27 doi: 10.1055/s-0036-1580690. PMID: 27231867
Diagnosis of metastatic neoplasms: a clinicopathologic and morphologic approach.
Marchevsky AM, Gupta R, Balzer B
Arch Pathol Lab Med 2010 Feb;134(2):194-206. doi: 10.5858/134.2.194. PMID: 20121607

Therapy

Blood transfusion is an independent predictor of morbidity and mortality after hepatectomy.
Martin AN, Kerwin MJ, Turrentine FE, Bauer TW, Adams RB, Stukenborg GJ, Zaydfudim VM
J Surg Res 2016 Nov;206(1):106-112. Epub 2016 Jul 15 doi: 10.1016/j.jss.2016.07.013. PMID: 27916348Free PMC Article
Thrombolysis for ischemic stroke in patients with brain tumors.
Etgen T, Steinich I, Gsottschneider L
J Stroke Cerebrovasc Dis 2014 Feb;23(2):361-6. Epub 2013 Jun 12 doi: 10.1016/j.jstrokecerebrovasdis.2013.05.004. PMID: 23763899
Incidence and risk factors for gastrointestinal hemorrhage after lumbar fusion.
Fineberg SJ, Kurd MF, Patel AA, Singh K
Spine (Phila Pa 1976) 2013 Aug 15;38(18):1584-9. doi: 10.1097/BRS.0b013e318298768d. PMID: 23632338
Perioperative mortality for management of hepatic neoplasm: a simple risk score.
Simons JP, Hill JS, Ng SC, Shah SA, Zhou Z, Whalen GF, Tseng JF
Ann Surg 2009 Dec;250(6):929-34. doi: 10.1097/SLA.0b013e3181bc9c2f. PMID: 19855257
Role of photodynamic therapy in unresectable esophageal and lung cancer.
Chen M, Pennathur A, Luketich JD
Lasers Surg Med 2006 Jun;38(5):396-402. doi: 10.1002/lsm.20364. PMID: 16788924

Prognosis

Metastatic Neoplasm Volume Kinetics Following 2-Stage Stereotactic Radiosurgery.
Damron EP, Dono A, Chafi H, Martir M, Yu TK, Khwaja S, Amsbaugh M, Tandon N, Esquenazi Y, Blanco AI
World Neurosurg 2022 May;161:e210-e219. Epub 2022 Feb 3 doi: 10.1016/j.wneu.2022.01.109. PMID: 35123024
Immunocytochemistry for diagnostic cytopathology-A practical guide.
Kanber Y, Pusztaszeri M, Auger M
Cytopathology 2021 Sep;32(5):562-587. Epub 2021 Jun 3 doi: 10.1111/cyt.12993. PMID: 34033162
Single-Cell Transcriptomic Analysis Identifies a Unique Pulmonary Lymphangioleiomyomatosis Cell.
Guo M, Yu JJ, Perl AK, Wikenheiser-Brokamp KA, Riccetti M, Zhang EY, Sudha P, Adam M, Potter A, Kopras EJ, Giannikou K, Potter SS, Sherman S, Hammes SR, Kwiatkowski DJ, Whitsett JA, McCormack FX, Xu Y
Am J Respir Crit Care Med 2020 Nov 15;202(10):1373-1387. doi: 10.1164/rccm.201912-2445OC. PMID: 32603599Free PMC Article
Histology as Prognostic Factor in Early-Stage Cervical Carcinoma. Experience in a Third-Level Institution.
Barquet-Muñoz SA, Cruz-Rodríguez E, Cantú De León DF, Isla-Ortiz D, Montalvo-Esquivel G, Herrera-Montalvo LA, Pérez-Plasencia C, Pérez-Montiel D, Herrera-Gómez Á
Rev Invest Clin 2017 Sep-Oct;69(5):286-292. doi: 10.24875/ric.17002143. PMID: 29077701
Mucinous tumors of the ovary: a review.
Hart WR
Int J Gynecol Pathol 2005 Jan;24(1):4-25. PMID: 15626914

Clinical prediction guides

Metastatic Neoplasm Volume Kinetics Following 2-Stage Stereotactic Radiosurgery.
Damron EP, Dono A, Chafi H, Martir M, Yu TK, Khwaja S, Amsbaugh M, Tandon N, Esquenazi Y, Blanco AI
World Neurosurg 2022 May;161:e210-e219. Epub 2022 Feb 3 doi: 10.1016/j.wneu.2022.01.109. PMID: 35123024
Immunocytochemistry for diagnostic cytopathology-A practical guide.
Kanber Y, Pusztaszeri M, Auger M
Cytopathology 2021 Sep;32(5):562-587. Epub 2021 Jun 3 doi: 10.1111/cyt.12993. PMID: 34033162
Single-Cell Transcriptomic Analysis Identifies a Unique Pulmonary Lymphangioleiomyomatosis Cell.
Guo M, Yu JJ, Perl AK, Wikenheiser-Brokamp KA, Riccetti M, Zhang EY, Sudha P, Adam M, Potter A, Kopras EJ, Giannikou K, Potter SS, Sherman S, Hammes SR, Kwiatkowski DJ, Whitsett JA, McCormack FX, Xu Y
Am J Respir Crit Care Med 2020 Nov 15;202(10):1373-1387. doi: 10.1164/rccm.201912-2445OC. PMID: 32603599Free PMC Article
Coping strategies and depressive symptoms in cancer patients.
Ghanem I, Castelo B, Jimenez-Fonseca P, Carmona-Bayonas A, Higuera O, Beato C, García T, Hernández R, Calderon C
Clin Transl Oncol 2020 Mar;22(3):330-336. Epub 2019 May 10 doi: 10.1007/s12094-019-02123-w. PMID: 31077086
Diagnosis of metastatic neoplasms: a clinicopathologic and morphologic approach.
Marchevsky AM, Gupta R, Balzer B
Arch Pathol Lab Med 2010 Feb;134(2):194-206. doi: 10.5858/134.2.194. PMID: 20121607

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