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Metastatic neoplasm

MedGen UID:
422476
•Concept ID:
C2939420
•
Neoplastic Process
Synonyms: metastatic disease; Metastatic Neoplasm; metastatic neoplasm; Metastatic Tumor; metastatic tumor; metastatic tumour; Neoplasm, metastatic; Neoplasm, secondary; Tumor, metastatic; Tumor, secondary
SNOMED CT: Neoplasm, metastatic (14799000); Tumor, metastatic (14799000); Neoplasm, secondary (14799000); Tumor, secondary (14799000)
 
Monarch Initiative: MONDO:0024883

Definition

A tumor that has spread from its original (primary) site of growth to another site, close to or distant from the primary site. Metastasis is characteristic of advanced malignancies, but in rare instances can be seen in neoplasms lacking malignant morphology. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic neoplasm

Professional guidelines

PubMed

Histopathologic diagnosis of brain metastases: current trends in management and future considerations.
Bekaert L, Emery E, Levallet G, Lechapt-Zalcman E
Brain Tumor Pathol 2017 Jan;34(1):8-19. Epub 2016 Nov 22 doi: 10.1007/s10014-016-0275-3. PMID: 27878432
Emergence of CA125 immunoreactivity in recurrent or metastatic primary ovarian mucinous neoplasms of the intestinal type.
Miller K, Millar J, McCluggage WG
Am J Surg Pathol 2011 Sep;35(9):1331-6. doi: 10.1097/PAS.0b013e3182233fce. PMID: 21836488
The impact of a comprehensive evaluation in the management of cancer pain.
Gonzales GR, Elliott KJ, Portenoy RK, Foley KM
Pain 1991 Nov;47(2):141-144. doi: 10.1016/0304-3959(91)90197-6. PMID: 1762807

Recent clinical studies

Therapy

Safety of TNF-α inhibitors: A real-world study based on the US FDA Adverse Event Reporting System Database.
Zheng B, Liu M, Dai D, Shang Y, Dou X, Liu B, Zhong Z, Huang S, Luo D
Medicine (Baltimore) 2024 Jul 19;103(29):e39012. doi: 10.1097/MD.0000000000039012. PMID: 39029031Free PMC Article
Blood transfusion is an independent predictor of morbidity and mortality after hepatectomy.
Martin AN, Kerwin MJ, Turrentine FE, Bauer TW, Adams RB, Stukenborg GJ, Zaydfudim VM
J Surg Res 2016 Nov;206(1):106-112. Epub 2016 Jul 15 doi: 10.1016/j.jss.2016.07.013. PMID: 27916348Free PMC Article
Thrombolysis for ischemic stroke in patients with brain tumors.
Etgen T, Steinich I, Gsottschneider L
J Stroke Cerebrovasc Dis 2014 Feb;23(2):361-6. Epub 2013 Jun 12 doi: 10.1016/j.jstrokecerebrovasdis.2013.05.004. PMID: 23763899
Role of photodynamic therapy in unresectable esophageal and lung cancer.
Chen M, Pennathur A, Luketich JD
Lasers Surg Med 2006 Jun;38(5):396-402. doi: 10.1002/lsm.20364. PMID: 16788924
Primary sternal osteomyelitis.
Skoutelis AT, Dougenis D, Gogos CA, Bassaris HP
Eur J Cardiothorac Surg 1993;7(9):501-2. doi: 10.1016/1010-7940(93)90283-h. PMID: 8217231

Prognosis

Metastatic Neoplasm Volume Kinetics Following 2-Stage Stereotactic Radiosurgery.
Damron EP, Dono A, Chafi H, Martir M, Yu TK, Khwaja S, Amsbaugh M, Tandon N, Esquenazi Y, Blanco AI
World Neurosurg 2022 May;161:e210-e219. Epub 2022 Feb 3 doi: 10.1016/j.wneu.2022.01.109. PMID: 35123024
Immunocytochemistry for diagnostic cytopathology-A practical guide.
Kanber Y, Pusztaszeri M, Auger M
Cytopathology 2021 Sep;32(5):562-587. Epub 2021 Jun 3 doi: 10.1111/cyt.12993. PMID: 34033162
Single-Cell Transcriptomic Analysis Identifies a Unique Pulmonary Lymphangioleiomyomatosis Cell.
Guo M, Yu JJ, Perl AK, Wikenheiser-Brokamp KA, Riccetti M, Zhang EY, Sudha P, Adam M, Potter A, Kopras EJ, Giannikou K, Potter SS, Sherman S, Hammes SR, Kwiatkowski DJ, Whitsett JA, McCormack FX, Xu Y
Am J Respir Crit Care Med 2020 Nov 15;202(10):1373-1387. doi: 10.1164/rccm.201912-2445OC. PMID: 32603599Free PMC Article
Coping strategies and depressive symptoms in cancer patients.
Ghanem I, Castelo B, Jimenez-Fonseca P, Carmona-Bayonas A, Higuera O, Beato C, García T, Hernández R, Calderon C
Clin Transl Oncol 2020 Mar;22(3):330-336. Epub 2019 May 10 doi: 10.1007/s12094-019-02123-w. PMID: 31077086
Role of photodynamic therapy in unresectable esophageal and lung cancer.
Chen M, Pennathur A, Luketich JD
Lasers Surg Med 2006 Jun;38(5):396-402. doi: 10.1002/lsm.20364. PMID: 16788924

Clinical prediction guides

Metastatic Neoplasm Volume Kinetics Following 2-Stage Stereotactic Radiosurgery.
Damron EP, Dono A, Chafi H, Martir M, Yu TK, Khwaja S, Amsbaugh M, Tandon N, Esquenazi Y, Blanco AI
World Neurosurg 2022 May;161:e210-e219. Epub 2022 Feb 3 doi: 10.1016/j.wneu.2022.01.109. PMID: 35123024
Immunocytochemistry for diagnostic cytopathology-A practical guide.
Kanber Y, Pusztaszeri M, Auger M
Cytopathology 2021 Sep;32(5):562-587. Epub 2021 Jun 3 doi: 10.1111/cyt.12993. PMID: 34033162
Single-Cell Transcriptomic Analysis Identifies a Unique Pulmonary Lymphangioleiomyomatosis Cell.
Guo M, Yu JJ, Perl AK, Wikenheiser-Brokamp KA, Riccetti M, Zhang EY, Sudha P, Adam M, Potter A, Kopras EJ, Giannikou K, Potter SS, Sherman S, Hammes SR, Kwiatkowski DJ, Whitsett JA, McCormack FX, Xu Y
Am J Respir Crit Care Med 2020 Nov 15;202(10):1373-1387. doi: 10.1164/rccm.201912-2445OC. PMID: 32603599Free PMC Article
Coping strategies and depressive symptoms in cancer patients.
Ghanem I, Castelo B, Jimenez-Fonseca P, Carmona-Bayonas A, Higuera O, Beato C, García T, Hernández R, Calderon C
Clin Transl Oncol 2020 Mar;22(3):330-336. Epub 2019 May 10 doi: 10.1007/s12094-019-02123-w. PMID: 31077086
Mesenchymal-epithelial transition (MET) as a mechanism for metastatic colonisation in breast cancer.
Gunasinghe NP, Wells A, Thompson EW, Hugo HJ
Cancer Metastasis Rev 2012 Dec;31(3-4):469-78. doi: 10.1007/s10555-012-9377-5. PMID: 22729277

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