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Invasive Follicular Variant Thyroid Gland Papillary Carcinoma

MedGen UID:
1655228
•Concept ID:
C4745261
•
Neoplastic Process
Synonym: Follicular Variant Thyroid Gland Papillary Carcinoma, Infiltrative Subtype

Definition

A nonencapsulated, infiltrating papillary carcinoma of the thyroid gland characterized by the predominance of follicular structures. The malignant follicular cells display the nuclear features that characterize the papillary adenocarcinomas of the thyroid gland. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVInvasive Follicular Variant Thyroid Gland Papillary Carcinoma

Professional guidelines

PubMed

A Preliminary Study of Quantitative Ultrasound for Cancer-Risk Assessment of Thyroid Nodules.
Goundan PN, Mamou J, Rohrbach D, Smith J, Patel H, Wallace KD, Feleppa EJ, Lee SL
Front Endocrinol (Lausanne) 2021;12:627698. Epub 2021 May 19 doi: 10.3389/fendo.2021.627698. PMID: 34093429Free PMC Article
Evolution of the histologic classification of thyroid neoplasms and its impact on clinical management.
Xu B, Ghossein R
Eur J Surg Oncol 2018 Mar;44(3):338-347. Epub 2017 May 18 doi: 10.1016/j.ejso.2017.05.002. PMID: 28554832Free PMC Article
Approach to and treatment of differentiated thyroid carcinoma.
Pacini F, Castagna MG
Med Clin North Am 2012 Mar;96(2):369-83. Epub 2012 Feb 10 doi: 10.1016/j.mcna.2012.01.002. PMID: 22443981

Recent clinical studies

Etiology

Update from the 2022 World Health Organization Classification of Thyroid Tumors: A Standardized Diagnostic Approach.
Jung CK, Bychkov A, Kakudo K
Endocrinol Metab (Seoul) 2022 Oct;37(5):703-718. Epub 2022 Oct 4 doi: 10.3803/EnM.2022.1553. PMID: 36193717Free PMC Article
Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
The thyroid cancer epidemic, 2017 perspective.
Roman BR, Morris LG, Davies L
Curr Opin Endocrinol Diabetes Obes 2017 Oct;24(5):332-336. doi: 10.1097/MED.0000000000000359. PMID: 28692457Free PMC Article
RAS-positive thyroid nodules.
Angell TE
Curr Opin Endocrinol Diabetes Obes 2017 Oct;24(5):372-376. doi: 10.1097/MED.0000000000000354. PMID: 28639967
Nomenclature Revision for Encapsulated Follicular Variant of Papillary Thyroid Carcinoma: A Paradigm Shift to Reduce Overtreatment of Indolent Tumors.
Nikiforov YE, Seethala RR, Tallini G, Baloch ZW, Basolo F, Thompson LD, Barletta JA, Wenig BM, Al Ghuzlan A, Kakudo K, Giordano TJ, Alves VA, Khanafshar E, Asa SL, El-Naggar AK, Gooding WE, Hodak SP, Lloyd RV, Maytal G, Mete O, Nikiforova MN, Nosé V, Papotti M, Poller DN, Sadow PM, Tischler AS, Tuttle RM, Wall KB, LiVolsi VA, Randolph GW, Ghossein RA
JAMA Oncol 2016 Aug 1;2(8):1023-9. doi: 10.1001/jamaoncol.2016.0386. PMID: 27078145Free PMC Article

Diagnosis

Update from the 2022 World Health Organization Classification of Thyroid Tumors: A Standardized Diagnostic Approach.
Jung CK, Bychkov A, Kakudo K
Endocrinol Metab (Seoul) 2022 Oct;37(5):703-718. Epub 2022 Oct 4 doi: 10.3803/EnM.2022.1553. PMID: 36193717Free PMC Article
Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
The thyroid cancer epidemic, 2017 perspective.
Roman BR, Morris LG, Davies L
Curr Opin Endocrinol Diabetes Obes 2017 Oct;24(5):332-336. doi: 10.1097/MED.0000000000000359. PMID: 28692457Free PMC Article
RAS-positive thyroid nodules.
Angell TE
Curr Opin Endocrinol Diabetes Obes 2017 Oct;24(5):372-376. doi: 10.1097/MED.0000000000000354. PMID: 28639967
Nomenclature Revision for Encapsulated Follicular Variant of Papillary Thyroid Carcinoma: A Paradigm Shift to Reduce Overtreatment of Indolent Tumors.
Nikiforov YE, Seethala RR, Tallini G, Baloch ZW, Basolo F, Thompson LD, Barletta JA, Wenig BM, Al Ghuzlan A, Kakudo K, Giordano TJ, Alves VA, Khanafshar E, Asa SL, El-Naggar AK, Gooding WE, Hodak SP, Lloyd RV, Maytal G, Mete O, Nikiforova MN, Nosé V, Papotti M, Poller DN, Sadow PM, Tischler AS, Tuttle RM, Wall KB, LiVolsi VA, Randolph GW, Ghossein RA
JAMA Oncol 2016 Aug 1;2(8):1023-9. doi: 10.1001/jamaoncol.2016.0386. PMID: 27078145Free PMC Article

Therapy

BRAFV600E Immunohistochemistry in Papillary Thyroid Carcinomas: Relationship Between Clinical and Morphological Parameters.
Kombak FE, Özkan N, Uğurlu MÜ, Kaya H
Turk Patoloji Derg 2019;35(2):83-91. doi: 10.5146/tjpath.2018.01448. PMID: 30632125
Outcome of Large Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features.
Xu B, Tallini G, Scognamiglio T, Roman BR, Tuttle RM, Ghossein RA
Thyroid 2017 Apr;27(4):512-517. Epub 2017 Feb 24 doi: 10.1089/thy.2016.0649. PMID: 28136139Free PMC Article
NONINVASIVE FOLLICULAR TUMOR WITH PAPILLARY-LIKE NUCLEAR FEATURES: NOT A TEMPEST IN A TEAPOT.
Agrawal N, Abbott CE, Liu C, Kang S, Tipton L, Patel K, Persky M, King L, Deng FM, Bannan M, Ogilvie JB, Heller K, Hodak SP
Endocr Pract 2017 Apr 2;23(4):451-457. Epub 2017 Jan 17 doi: 10.4158/EP161632.OR. PMID: 28095037
Approach to and treatment of differentiated thyroid carcinoma.
Pacini F, Castagna MG
Med Clin North Am 2012 Mar;96(2):369-83. Epub 2012 Feb 10 doi: 10.1016/j.mcna.2012.01.002. PMID: 22443981
Papillary and follicular variant of papillary carcinoma of the thyroid: Initial presentation and response to therapy.
Burningham AR, Krishnan J, Davidson BJ, Ringel MD, Burman KD
Otolaryngol Head Neck Surg 2005 Jun;132(6):840-4. doi: 10.1016/j.otohns.2005.02.002. PMID: 15944551

Prognosis

Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Thyroid Tumors You Don't Want to Miss.
Wong KS, Barletta JA
Surg Pathol Clin 2019 Dec;12(4):901-919. doi: 10.1016/j.path.2019.08.008. PMID: 31672297
Non-invasive follicular thyroid neoplasm with papillary-like nuclearfeatures (NIFTP): a review and update.
Geramizadeh B, Maleki Z
Endocrine 2019 Jun;64(3):433-440. Epub 2019 Mar 13 doi: 10.1007/s12020-019-01887-z. PMID: 30868412
RAS-positive thyroid nodules.
Angell TE
Curr Opin Endocrinol Diabetes Obes 2017 Oct;24(5):372-376. doi: 10.1097/MED.0000000000000354. PMID: 28639967
Encapsulated Thyroid Carcinoma of Follicular Cell Origin.
Xu B, Ghossein R
Endocr Pathol 2015 Sep;26(3):191-9. doi: 10.1007/s12022-015-9376-5. PMID: 26003547

Clinical prediction guides

Thyroid Tumors You Don't Want to Miss.
Wong KS, Barletta JA
Surg Pathol Clin 2019 Dec;12(4):901-919. doi: 10.1016/j.path.2019.08.008. PMID: 31672297
Non-invasive follicular thyroid neoplasm with papillary-like nuclearfeatures (NIFTP): a review and update.
Geramizadeh B, Maleki Z
Endocrine 2019 Jun;64(3):433-440. Epub 2019 Mar 13 doi: 10.1007/s12020-019-01887-z. PMID: 30868412
Nomenclature Revision for Encapsulated Follicular Variant of Papillary Thyroid Carcinoma: A Paradigm Shift to Reduce Overtreatment of Indolent Tumors.
Nikiforov YE, Seethala RR, Tallini G, Baloch ZW, Basolo F, Thompson LD, Barletta JA, Wenig BM, Al Ghuzlan A, Kakudo K, Giordano TJ, Alves VA, Khanafshar E, Asa SL, El-Naggar AK, Gooding WE, Hodak SP, Lloyd RV, Maytal G, Mete O, Nikiforova MN, Nosé V, Papotti M, Poller DN, Sadow PM, Tischler AS, Tuttle RM, Wall KB, LiVolsi VA, Randolph GW, Ghossein RA
JAMA Oncol 2016 Aug 1;2(8):1023-9. doi: 10.1001/jamaoncol.2016.0386. PMID: 27078145Free PMC Article
Follicular patterned lesions of the thyroid gland: a practical algorithmic approach.
Chetty R
J Clin Pathol 2011 Sep;64(9):737-41. Epub 2011 May 18 doi: 10.1136/jclinpath-2011-200121. PMID: 21593347
Papillary thyroid carcinoma with different histological patterns.
Lin JD, Hsueh C, Huang BY
Chang Gung Med J 2011 Jan-Feb;34(1):23-34. PMID: 21392471

Recent systematic reviews

Non-Invasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features Is Not a Cytological Diagnosis, but It Influences Cytological Diagnosis Outcomes: A Systematic Review and Meta-Analysis.
Haaga E, Kalfert D, Ludvíková M, Kholová I
Acta Cytol 2022;66(2):85-105. Epub 2021 Nov 15 doi: 10.1159/000519757. PMID: 34781293Free PMC Article
Pathological findings of the retrospective diagnosis of NIFTP (non-invasive follicular thyroid neoplasm with papillary-like nuclear features) in 84 cases from Turkey and systematic review.
Turan G, Özkara SK
Ann Diagn Pathol 2021 Aug;53:151764. Epub 2021 Jun 9 doi: 10.1016/j.anndiagpath.2021.151764. PMID: 34118581
Systematic Review and Meta-analysis of the Impact of Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features (NIFTP) on Cytological Diagnosis and Thyroid Cancer Prevalence.
Ruanpeng D, Cheungpasitporn W, Thongprayoon C, Hennessey JV, Shrestha RT
Endocr Pathol 2019 Sep;30(3):189-200. doi: 10.1007/s12022-019-09583-4. PMID: 31338752

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