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Unresectable Neuroblastoma

MedGen UID:
1658777
•Concept ID:
C4725878
•
Neoplastic Process

Definition

Neuroblastoma which is not amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUnresectable Neuroblastoma

Professional guidelines

PubMed

Piloting the European Unified Patient Identity Management (EUPID) Concept to Facilitate Secondary Use of Neuroblastoma Data from Clinical Trials and Biobanking.
Ebner H, Hayn D, Falgenhauer M, Nitzlnader M, Schleiermacher G, Haupt R, Erminio G, Defferrari R, Mazzocco K, Kohler J, Tonini GP, Ladenstein R, Schreier G
Stud Health Technol Inform 2016;223:31-8. PMID: 27139382
Localized unresectable neuroblastoma: results of treatment based on clinical prognostic factors.
Garaventa A, Boni L, Lo Piccolo MS, Tonini GP, Gambini C, Mancini A, Tonegatti L, Carli M, di Montezemolo LC, Di Cataldo A, Casale F, Mazzocco K, Cecchetto G, Rizzo A, Bernardi B; Italian Cooperative Group for Neuroblastoma
Ann Oncol 2002 Jun;13(6):956-64. doi: 10.1093/annonc/mdf165. PMID: 12123342
Localized but unresectable neuroblastoma: treatment and outcome of 145 cases. Italian Cooperative Group for Neuroblastoma.
Garaventa A, De Bernardi B, Pianca C, Donfrancesco A, Cordero di Montezemolo L, Di Tullio MT, Bagnulo S, Mancini A, Carli M, Pession A, Arrighini A, Di Cataldo A, Tamaro P, Iasonni V, Taccone A, Rogers D, Boni L; Italian Cooperative Group dor Neuroblastoma
J Clin Oncol 1993 Sep;11(9):1770-9. doi: 10.1200/JCO.1993.11.9.1770. PMID: 8355044

Recent clinical studies

Etiology

Role of surgery in localized initially unresectable neuroblastoma.
Ahmed G, Fawzy M, Elmenawi S, Elzomor H, Yosif Y, Elkinaai N, Refaat A, Hegazy M, El Shafiey M
J Pediatr Urol 2018 Jun;14(3):231-236. Epub 2018 Mar 31 doi: 10.1016/j.jpurol.2018.03.008. PMID: 29636298
Image-defined risk factors in unresectable neuroblastoma: SIOPEN study on incidence, chemotherapy-induced variation, and impact on surgical outcomes.
Avanzini S, Pio L, Erminio G, Granata C, Holmes K, Gambart M, Buffa P, Castel V, Valteau Couanet D, Garaventa A, Pistorio A, Cecchetto G, Martucciello G, Mattioli G, Sarnacki S
Pediatr Blood Cancer 2017 Nov;64(11) Epub 2017 Apr 25 doi: 10.1002/pbc.26605. PMID: 28440012
Localised and unresectable neuroblastoma in infants: excellent outcome with low-dose primary chemotherapy.
Rubie H, Coze C, Plantaz D, Munzer C, Defachelles AS, Bergeron C, Thomas C, Chastagner P, Valteau-Couanet D, Michon J, Mosseri V, Hartmann O; Neuroblastoma Study Group, Société Française d'Oncologie Pédiatrique
Br J Cancer 2003 Nov 3;89(9):1605-9. doi: 10.1038/sj.bjc.6601259. PMID: 14583756Free PMC Article
Localised and unresectable neuroblastoma in infants: excellent outcome with primary chemotherapy. Neuroblastoma Study Group, Société Française d'Oncologie Pédiatrique.
Rubie H, Plantaz D, Coze C, Michon J, Frappaz D, Baranzelli MC, Chastagner P, Peyroulet MC, Hartmann O; Neuroblastoma Study Group, Société Française d'Oncologie Pédiatrique
Med Pediatr Oncol 2001 Jan;36(1):247-50. doi: 10.1002/1096-911X(20010101)36:1<247::AID-MPO1061>3.0.CO;2-Z. PMID: 11464897
Localized but unresectable neuroblastoma: treatment and outcome of 145 cases. Italian Cooperative Group for Neuroblastoma.
Garaventa A, De Bernardi B, Pianca C, Donfrancesco A, Cordero di Montezemolo L, Di Tullio MT, Bagnulo S, Mancini A, Carli M, Pession A, Arrighini A, Di Cataldo A, Tamaro P, Iasonni V, Taccone A, Rogers D, Boni L; Italian Cooperative Group dor Neuroblastoma
J Clin Oncol 1993 Sep;11(9):1770-9. doi: 10.1200/JCO.1993.11.9.1770. PMID: 8355044

Diagnosis

Role of surgery in localized initially unresectable neuroblastoma.
Ahmed G, Fawzy M, Elmenawi S, Elzomor H, Yosif Y, Elkinaai N, Refaat A, Hegazy M, El Shafiey M
J Pediatr Urol 2018 Jun;14(3):231-236. Epub 2018 Mar 31 doi: 10.1016/j.jpurol.2018.03.008. PMID: 29636298
Excellent outcome with reduced treatment in infants with nonmetastatic and unresectable neuroblastoma without MYCN amplification: results of the prospective INES 99.1.
Rubie H, De Bernardi B, Gerrard M, Canete A, Ladenstein R, Couturier J, Ambros P, Munzer C, Pearson AD, Garaventa A, Brock P, Castel V, Valteau-Couanet D, Holmes K, Di Cataldo A, Brichard B, Mosseri V, Marquez C, Plantaz D, Boni L, Michon J
J Clin Oncol 2011 Feb 1;29(4):449-55. Epub 2010 Dec 20 doi: 10.1200/JCO.2010.29.5196. PMID: 21172879
Long-term renal and hearing toxicity of carboplatin in infants treated for localized and unresectable neuroblastoma: results of the SFOP NBL90 study.
Bergeron C, Dubourg L, Chastagner P, Mechinaud F, Plouvier E, Desfachelles AS, Dusol F, Pautard B, Edan C, Plantaz D, Froehlich P, Rubie H
Pediatr Blood Cancer 2005 Jul;45(1):32-6. doi: 10.1002/pbc.20379. PMID: 15768383
Localised and unresectable neuroblastoma in infants: excellent outcome with low-dose primary chemotherapy.
Rubie H, Coze C, Plantaz D, Munzer C, Defachelles AS, Bergeron C, Thomas C, Chastagner P, Valteau-Couanet D, Michon J, Mosseri V, Hartmann O; Neuroblastoma Study Group, Société Française d'Oncologie Pédiatrique
Br J Cancer 2003 Nov 3;89(9):1605-9. doi: 10.1038/sj.bjc.6601259. PMID: 14583756Free PMC Article
Localized but unresectable neuroblastoma: treatment and outcome of 145 cases. Italian Cooperative Group for Neuroblastoma.
Garaventa A, De Bernardi B, Pianca C, Donfrancesco A, Cordero di Montezemolo L, Di Tullio MT, Bagnulo S, Mancini A, Carli M, Pession A, Arrighini A, Di Cataldo A, Tamaro P, Iasonni V, Taccone A, Rogers D, Boni L; Italian Cooperative Group dor Neuroblastoma
J Clin Oncol 1993 Sep;11(9):1770-9. doi: 10.1200/JCO.1993.11.9.1770. PMID: 8355044

Therapy

Image-defined risk factors in unresectable neuroblastoma: SIOPEN study on incidence, chemotherapy-induced variation, and impact on surgical outcomes.
Avanzini S, Pio L, Erminio G, Granata C, Holmes K, Gambart M, Buffa P, Castel V, Valteau Couanet D, Garaventa A, Pistorio A, Cecchetto G, Martucciello G, Mattioli G, Sarnacki S
Pediatr Blood Cancer 2017 Nov;64(11) Epub 2017 Apr 25 doi: 10.1002/pbc.26605. PMID: 28440012
Excellent outcome with reduced treatment in infants with nonmetastatic and unresectable neuroblastoma without MYCN amplification: results of the prospective INES 99.1.
Rubie H, De Bernardi B, Gerrard M, Canete A, Ladenstein R, Couturier J, Ambros P, Munzer C, Pearson AD, Garaventa A, Brock P, Castel V, Valteau-Couanet D, Holmes K, Di Cataldo A, Brichard B, Mosseri V, Marquez C, Plantaz D, Boni L, Michon J
J Clin Oncol 2011 Feb 1;29(4):449-55. Epub 2010 Dec 20 doi: 10.1200/JCO.2010.29.5196. PMID: 21172879
Localised and unresectable neuroblastoma in infants: excellent outcome with low-dose primary chemotherapy.
Rubie H, Coze C, Plantaz D, Munzer C, Defachelles AS, Bergeron C, Thomas C, Chastagner P, Valteau-Couanet D, Michon J, Mosseri V, Hartmann O; Neuroblastoma Study Group, Société Française d'Oncologie Pédiatrique
Br J Cancer 2003 Nov 3;89(9):1605-9. doi: 10.1038/sj.bjc.6601259. PMID: 14583756Free PMC Article
Localised and unresectable neuroblastoma in infants: excellent outcome with primary chemotherapy. Neuroblastoma Study Group, Société Française d'Oncologie Pédiatrique.
Rubie H, Plantaz D, Coze C, Michon J, Frappaz D, Baranzelli MC, Chastagner P, Peyroulet MC, Hartmann O; Neuroblastoma Study Group, Société Française d'Oncologie Pédiatrique
Med Pediatr Oncol 2001 Jan;36(1):247-50. doi: 10.1002/1096-911X(20010101)36:1<247::AID-MPO1061>3.0.CO;2-Z. PMID: 11464897
Localized but unresectable neuroblastoma: treatment and outcome of 145 cases. Italian Cooperative Group for Neuroblastoma.
Garaventa A, De Bernardi B, Pianca C, Donfrancesco A, Cordero di Montezemolo L, Di Tullio MT, Bagnulo S, Mancini A, Carli M, Pession A, Arrighini A, Di Cataldo A, Tamaro P, Iasonni V, Taccone A, Rogers D, Boni L; Italian Cooperative Group dor Neuroblastoma
J Clin Oncol 1993 Sep;11(9):1770-9. doi: 10.1200/JCO.1993.11.9.1770. PMID: 8355044

Prognosis

Role of surgery in localized initially unresectable neuroblastoma.
Ahmed G, Fawzy M, Elmenawi S, Elzomor H, Yosif Y, Elkinaai N, Refaat A, Hegazy M, El Shafiey M
J Pediatr Urol 2018 Jun;14(3):231-236. Epub 2018 Mar 31 doi: 10.1016/j.jpurol.2018.03.008. PMID: 29636298
Image-defined risk factors in unresectable neuroblastoma: SIOPEN study on incidence, chemotherapy-induced variation, and impact on surgical outcomes.
Avanzini S, Pio L, Erminio G, Granata C, Holmes K, Gambart M, Buffa P, Castel V, Valteau Couanet D, Garaventa A, Pistorio A, Cecchetto G, Martucciello G, Mattioli G, Sarnacki S
Pediatr Blood Cancer 2017 Nov;64(11) Epub 2017 Apr 25 doi: 10.1002/pbc.26605. PMID: 28440012
Excellent outcome with reduced treatment in infants with nonmetastatic and unresectable neuroblastoma without MYCN amplification: results of the prospective INES 99.1.
Rubie H, De Bernardi B, Gerrard M, Canete A, Ladenstein R, Couturier J, Ambros P, Munzer C, Pearson AD, Garaventa A, Brock P, Castel V, Valteau-Couanet D, Holmes K, Di Cataldo A, Brichard B, Mosseri V, Marquez C, Plantaz D, Boni L, Michon J
J Clin Oncol 2011 Feb 1;29(4):449-55. Epub 2010 Dec 20 doi: 10.1200/JCO.2010.29.5196. PMID: 21172879
Localised and unresectable neuroblastoma in infants: excellent outcome with low-dose primary chemotherapy.
Rubie H, Coze C, Plantaz D, Munzer C, Defachelles AS, Bergeron C, Thomas C, Chastagner P, Valteau-Couanet D, Michon J, Mosseri V, Hartmann O; Neuroblastoma Study Group, Société Française d'Oncologie Pédiatrique
Br J Cancer 2003 Nov 3;89(9):1605-9. doi: 10.1038/sj.bjc.6601259. PMID: 14583756Free PMC Article
Localised and unresectable neuroblastoma in infants: excellent outcome with primary chemotherapy. Neuroblastoma Study Group, Société Française d'Oncologie Pédiatrique.
Rubie H, Plantaz D, Coze C, Michon J, Frappaz D, Baranzelli MC, Chastagner P, Peyroulet MC, Hartmann O; Neuroblastoma Study Group, Société Française d'Oncologie Pédiatrique
Med Pediatr Oncol 2001 Jan;36(1):247-50. doi: 10.1002/1096-911X(20010101)36:1<247::AID-MPO1061>3.0.CO;2-Z. PMID: 11464897

Clinical prediction guides

Image-defined risk factors in unresectable neuroblastoma: SIOPEN study on incidence, chemotherapy-induced variation, and impact on surgical outcomes.
Avanzini S, Pio L, Erminio G, Granata C, Holmes K, Gambart M, Buffa P, Castel V, Valteau Couanet D, Garaventa A, Pistorio A, Cecchetto G, Martucciello G, Mattioli G, Sarnacki S
Pediatr Blood Cancer 2017 Nov;64(11) Epub 2017 Apr 25 doi: 10.1002/pbc.26605. PMID: 28440012
Influence of segmental chromosome abnormalities on survival in children over the age of 12 months with unresectable localised peripheral neuroblastic tumours without MYCN amplification.
Defferrari R, Mazzocco K, Ambros IM, Ambros PF, Bedwell C, Beiske K, Bénard J, Berbegall AP, Bown N, Combaret V, Couturier J, Erminio G, Gambini C, Garaventa A, Gross N, Haupt R, Kohler J, Jeison M, Lunec J, Marques B, Martinsson T, Noguera R, Parodi S, Schleiermacher G, Tweddle DA, Valent A, Van Roy N, Vicha A, Villamon E, Tonini GP
Br J Cancer 2015 Jan 20;112(2):290-5. Epub 2014 Nov 4 doi: 10.1038/bjc.2014.557. PMID: 25356804Free PMC Article
Localised and unresectable neuroblastoma in infants: excellent outcome with low-dose primary chemotherapy.
Rubie H, Coze C, Plantaz D, Munzer C, Defachelles AS, Bergeron C, Thomas C, Chastagner P, Valteau-Couanet D, Michon J, Mosseri V, Hartmann O; Neuroblastoma Study Group, Société Française d'Oncologie Pédiatrique
Br J Cancer 2003 Nov 3;89(9):1605-9. doi: 10.1038/sj.bjc.6601259. PMID: 14583756Free PMC Article
Loss of chromosome 1p may have a prognostic value in localised neuroblastoma: results of the French NBL 90 Study. Neuroblastoma Study Group of the Société Française d'Oncologie Pédiatrique (SFOP).
Rubie H, Delattre O, Hartmann O, Combaret V, Michon J, Bénard J, Peyroulet MC, Plantaz D, Coze C, Chastagner P, Baranzelli MC, Frappaz D, Lemerle J, Sommelet D
Eur J Cancer 1997 Oct;33(12):1917-22. doi: 10.1016/s0959-8049(97)00295-5. PMID: 9516824
Cellular DNA content as a predictor of response to chemotherapy in infants with unresectable neuroblastoma.
Look AT, Hayes FA, Nitschke R, McWilliams NB, Green AA
N Engl J Med 1984 Jul 26;311(4):231-5. doi: 10.1056/NEJM198407263110405. PMID: 6738617

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